BGC0001199 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001199 (Streptomyces sp. NBRC 109706)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	63,400	akaeolide	PKS	100%

BGC0001199 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 63,400 nt. (total: 63,400 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 63,401
Label		BGC0001199

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001199	1.00	Polyketide	akaeolide	Streptomyces sp. NBRC 109706
BGC0000016	0.38	Other	amphotericin B	Streptomyces nodosus
BGC0001850	0.34	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0000286	0.31	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0002031	0.31	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000160	0.31	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000068	0.31	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001273	0.30	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002229	0.30	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001199	1.00	Polyketide	akaeolide	Streptomyces sp. NBRC 109706
BGC0000016	0.71	Other	amphotericin B	Streptomyces nodosus
BGC0001850	0.68	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0000286	0.65	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0002031	0.65	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000160	0.65	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000068	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001273	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002229	0.64	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 63400:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - Me-redmal) + (ccmal - Me-ccmal) + (mal - pk) + (mal)
Non-colinear ordering:: ctg1_orf521 + ctg1_orf522 + ctg1_orf523 + ctg1_orf524

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_orf521

PKS_AT (548..841): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 168.5
inactive: 89.6
Methylmalonyl-CoA: 56.5
Methoxymalonyl-CoA: 49.1
Isobutyryl-CoA: 30.2
Ethylmalonyl-CoA: 26.6
Propionyl-CoA: 22.9
Benzoyl-CoA: 18.8
fatty_acid: 16.0
Acetyl-CoA: 15.0
trans-1,2-CPDA: 7.5
CHC-CoA: 5.1
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (1556..1855): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.7
Ethylmalonyl-CoA: 190.6
Methoxymalonyl-CoA: 162.9
trans-1,2-CPDA: 118.4
2-Methylbutyryl-CoA: 118.2
Propionyl-CoA: 93.4
Malonyl-CoA: 91.6
CHC-CoA: 90.2
Isobutyryl-CoA: 73.6
Benzoyl-CoA: 66.8
Acetyl-CoA: 54.9
fatty_acid: 41.0
3-Methylbutyryl-CoA: 36.4
inactive: 27.1

PKS_AT (3304..3603): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.6
Ethylmalonyl-CoA: 189.2
Methoxymalonyl-CoA: 166.6
trans-1,2-CPDA: 118.6
2-Methylbutyryl-CoA: 116.8
Malonyl-CoA: 98.3
Propionyl-CoA: 93.4
CHC-CoA: 87.7
Isobutyryl-CoA: 76.1
Benzoyl-CoA: 72.4
Acetyl-CoA: 50.6
fatty_acid: 41.0
3-Methylbutyryl-CoA: 37.9
inactive: 28.2

ctg1_orf522

PKS_AT (561..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.7
inactive: 87.3
Methylmalonyl-CoA: 53.9
Methoxymalonyl-CoA: 45.3
Benzoyl-CoA: 27.7
Isobutyryl-CoA: 26.0
Propionyl-CoA: 20.1
Ethylmalonyl-CoA: 19.4
Acetyl-CoA: 13.3
fatty_acid: 11.1
CHC-CoA: 7.9
trans-1,2-CPDA: 6.2
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2304..2603): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.6
Ethylmalonyl-CoA: 189.2
Methoxymalonyl-CoA: 166.6
trans-1,2-CPDA: 118.6
2-Methylbutyryl-CoA: 116.8
Malonyl-CoA: 98.3
Propionyl-CoA: 93.4
CHC-CoA: 87.7
Isobutyryl-CoA: 76.1
Benzoyl-CoA: 72.4
Acetyl-CoA: 50.6
fatty_acid: 41.0
3-Methylbutyryl-CoA: 37.9
inactive: 28.2

ctg1_orf523

PKS_AT (569..863): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 170.8
inactive: 79.2
Methylmalonyl-CoA: 48.7
Methoxymalonyl-CoA: 44.5
Isobutyryl-CoA: 26.3
Ethylmalonyl-CoA: 22.7
Benzoyl-CoA: 17.4
Propionyl-CoA: 17.3
Acetyl-CoA: 15.8
fatty_acid: 15.7
CHC-CoA: 11.9
trans-1,2-CPDA: 7.7
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (1597..1896): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 227.2
Methylmalonyl-CoA: 208.1
Methoxymalonyl-CoA: 174.7
2-Methylbutyryl-CoA: 167.9
trans-1,2-CPDA: 152.2
CHC-CoA: 122.0
Propionyl-CoA: 116.5
Malonyl-CoA: 102.4
Isobutyryl-CoA: 92.0
Benzoyl-CoA: 72.7
Acetyl-CoA: 59.3
3-Methylbutyryl-CoA: 42.0
inactive: 36.9
fatty_acid: 27.2

ctg1_orf524

PKS_AT (561..855): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 170.7
inactive: 80.8
Methylmalonyl-CoA: 49.4
Methoxymalonyl-CoA: 42.0
Isobutyryl-CoA: 30.0
Propionyl-CoA: 21.6
Ethylmalonyl-CoA: 20.0
Acetyl-CoA: 18.6
Benzoyl-CoA: 16.4
fatty_acid: 15.6
CHC-CoA: 13.5
trans-1,2-CPDA: 13.2
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0