BGC0001200 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001200 (Streptomyces sp. NBRC 109706)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	84,167	High	lorneic acid A	PKS

BGC0001200 - Region 1 - T1PKS

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Location: 1 - 84,167 nt. (total: 84,167 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 84,168
Label		BGC0001200

Tailoring functions

Oxidoreductases: oxygenase

ctg1_orf257: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Hydrolases: glucosidase hydrolase

ctg1_orf258: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

ctg1_orf259: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Ligases: synthase

ctg1_orf253: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ctg1_orf254: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ctg1_orf255: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

ctg1_orf256: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001200.4	1.00	PKS	lorneic acid A	Streptomyces sp. NBRC 109706
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0000041.3	0.75	PKS	oronofacic acid	Pseudomonas syringae
BGC0001276.3	0.75	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001200.4	1.00	PKS	lorneic acid A	Streptomyces sp. NBRC 109706
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0000041.3	0.75	PKS	oronofacic acid	Pseudomonas syringae
BGC0001276.3	0.75	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 84167:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - redmal) + (redmal - ccmal) + (Me-redmal) + (ccmal - ccmal - ccmal)
Non-colinear ordering:: ctg1_orf253 + ctg1_orf254 + ctg1_orf255 + ctg1_orf256

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_orf253: mal - mal

PKS_AT (511..805): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.3
inactive: 115.1
Methylmalonyl-CoA: 59.8
Methoxymalonyl-CoA: 59.0
Propionyl-CoA: 33.0
Isobutyryl-CoA: 27.2
Ethylmalonyl-CoA: 25.0
Acetyl-CoA: 19.7
Benzoyl-CoA: 19.4
fatty_acid: 18.3
CHC-CoA: 16.4
trans-1,2-CPDA: 11.3
2-Methylbutyryl-CoA: 10.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1526..1819): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 196.9
inactive: 122.2
Methylmalonyl-CoA: 58.5
Methoxymalonyl-CoA: 57.4
Propionyl-CoA: 32.2
Isobutyryl-CoA: 29.8
Ethylmalonyl-CoA: 25.2
Benzoyl-CoA: 21.2
CHC-CoA: 18.9
fatty_acid: 18.3
Acetyl-CoA: 15.4
trans-1,2-CPDA: 15.3
2-Methylbutyryl-CoA: 9.3
3-Methylbutyryl-CoA: 0.0

ctg1_orf254: mal - mal

PKS_AT (579..873): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.0
inactive: 115.6
Methoxymalonyl-CoA: 58.6
Methylmalonyl-CoA: 58.0
Propionyl-CoA: 36.0
Ethylmalonyl-CoA: 26.4
CHC-CoA: 22.1
fatty_acid: 21.9
Isobutyryl-CoA: 21.4
Benzoyl-CoA: 19.8
Acetyl-CoA: 15.6
trans-1,2-CPDA: 13.3
2-Methylbutyryl-CoA: 10.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2619..2912): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.3
inactive: 117.0
Methoxymalonyl-CoA: 56.7
Methylmalonyl-CoA: 56.4
Propionyl-CoA: 32.3
Isobutyryl-CoA: 27.8
Ethylmalonyl-CoA: 27.5
CHC-CoA: 23.6
Benzoyl-CoA: 22.9
fatty_acid: 22.8
Acetyl-CoA: 16.6
trans-1,2-CPDA: 15.1
2-Methylbutyryl-CoA: 9.9
3-Methylbutyryl-CoA: 0.0

ctg1_orf255: mmal

PKS_AT (584..884): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.2
Ethylmalonyl-CoA: 214.1
Methoxymalonyl-CoA: 167.6
2-Methylbutyryl-CoA: 157.6
trans-1,2-CPDA: 124.0
Propionyl-CoA: 116.4
Malonyl-CoA: 101.6
CHC-CoA: 88.6
Benzoyl-CoA: 62.3
Isobutyryl-CoA: 59.9
Acetyl-CoA: 50.5
3-Methylbutyryl-CoA: 31.6
inactive: 31.4
fatty_acid: 30.1

ctg1_orf256: mal - mal - mal

PKS_AT (564..857): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.9
inactive: 114.7
Methoxymalonyl-CoA: 57.5
Methylmalonyl-CoA: 53.6
Propionyl-CoA: 27.9
fatty_acid: 26.5
Ethylmalonyl-CoA: 24.7
Isobutyryl-CoA: 23.3
Benzoyl-CoA: 18.9
Acetyl-CoA: 16.7
CHC-CoA: 13.3
trans-1,2-CPDA: 12.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2271..2564): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.3
inactive: 113.3
Methoxymalonyl-CoA: 55.7
Methylmalonyl-CoA: 54.1
Propionyl-CoA: 29.7
Ethylmalonyl-CoA: 25.0
Benzoyl-CoA: 25.0
Isobutyryl-CoA: 24.5
CHC-CoA: 24.0
fatty_acid: 23.4
trans-1,2-CPDA: 17.4
Acetyl-CoA: 14.5
2-Methylbutyryl-CoA: 9.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (3985..4279): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.3
inactive: 113.6
Methylmalonyl-CoA: 54.0
Methoxymalonyl-CoA: 53.0
Propionyl-CoA: 31.8
Isobutyryl-CoA: 27.9
Ethylmalonyl-CoA: 24.3
Benzoyl-CoA: 20.5
CHC-CoA: 18.3
fatty_acid: 18.1
trans-1,2-CPDA: 15.5
Acetyl-CoA: 14.9
2-Methylbutyryl-CoA: 10.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor