BGC0001202: landepoxcin A biosynthetic gene cluster from uncultured bacterium AR_412
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Location: 1 - 27,730 nt. (total: 27,730 nt).
This entry is originally from NCBI GenBank KP830093.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001202
Short description landepoxcin A biosynthetic gene cluster from uncultured bacterium AR_412
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
KP830093.1
via
Compounds
  • landepoxcin A
  • landepoxcin B
Species uncultured bacterium AR_412 [taxonomy]
References
Chemical products information
landepoxcin A Evidence: NMR [1]
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C17H28N2O5
landepoxcin B Evidence: NMR [1]
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C18H30N2O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AKA59427.1
 1 - 1164 (-) kynureninase
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    • AKA59428.1
    		 1161 - 1952 (-) tryptophan 2,3-dioxygenase
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      • AKA59429.1
      		 1949 - 2746 (-) phenylacetic acid degradation operon negative regulatory protein paaX
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        • AKA59430.1
        		 2797 - 3528 (+) creatinine amidohydrolase
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          • AKA59431.1
          		 3528 - 5024 (+) benzoate-CoA ligase
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            • AKA59432.1
            		 5021 - 5845 (+) enoyl-CoA hydratase
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              • AKA59433.1
              		 5914 - 6750 (+) proteasome subunit beta
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                • AKA59434.1
                		 6850 - 8445 (+) FAD-linked oxidase
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                  • AKA59435.1
                  		 8641 - 10329 (+) acyl-CoA dehydrogenase
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                    • AKA59436.1
                    		 10326 - 17990 (+) non-ribosomal peptide synthetase
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                      • AKA59437.1
                      		 17987 - 20365 (+) polyketide synthase
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                        • AKA59438.1
                        		 20455 - 22221 (+) polyketide synthase
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                          • AKA59439.1
                          		 22218 - 22565 (+) thioesterase
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                            • AKA59440.1
                            		 22596 - 24317 (+) non-ribosomal peptide synthetase
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                              • AKA59441.1
                              		 24318 - 25523 (+) cytochrome P450 hydroxylase
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                                • AKA59442.1
                                		 25520 - 26275 (+) thioesterase
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                                  • AKA59443.1
                                  		 26285 - 27115 (+) hypothetical protein
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                                    • AKA59444.1
                                    		 27140 - 27730 (+) hypothetical protein
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      Unk01
                                      Type
                                      nrps-type1
                                      Genes
                                      AKA59436.1
                                      Substrates
                                      leucine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk02
                                      Type
                                      nrps-type1
                                      Genes
                                      AKA59436.1
                                      Substrates
                                      threonine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk03
                                      Type
                                      nrps-type1
                                      Genes
                                      AKA59440.1
                                      Substrates
                                      leucine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Annotation changelog

                                      Entry version: next

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2024-03-19
                                      MIBiG v4 annotathon
                                      • (ID: A7MF26CMS75H6APVYNE75JID)
                                      • (ID: DKBFG3K6XTYSVEQEQVCFZBWY)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Added NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2015-08-17
                                      Submitted
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
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