BGC0001204 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001204 (Streptomyces versipellis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	108,225	versipelostatin	PKS	100%

BGC0001204 - Region 1 - T1PKS

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Location: 1 - 108,225 nt. (total: 108,225 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 108,226
Label		BGC0001204

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001204	0.99	Polyketide	versipelostatin	Streptomyces versipellis
BGC0000041	0.40	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000016	0.39	Other	amphotericin B	Streptomyces nodosus
BGC0001850	0.35	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0000067	0.35	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000122	0.35	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000286	0.32	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0002435	0.32	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0002554	0.31	Alkaloid	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0001903	0.31	Other	neocarazostatin A	Streptomyces sp. MA37

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001204	1.00	Polyketide	versipelostatin	Streptomyces versipellis
BGC0000041	0.72	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000016	0.71	Other	amphotericin B	Streptomyces nodosus
BGC0001850	0.68	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0000067	0.68	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000122	0.68	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000286	0.66	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0002435	0.65	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0002554	0.65	Alkaloid	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0001903	0.65	Other	neocarazostatin A	Streptomyces sp. MA37

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 107861:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - Me-ccmal - redmal - Me-redmal) + (Me-ccmal - Me-redmal - Me-ccmal - Me-ccmal) + (ccmal - ccmal) + (Me-ccmal - Me-ccmal) + (ohmal)
Non-colinear ordering:: vstA1 + vstA2 + vstA3 + vstA4 + vstA5

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

vstA1

PKS_AT (538..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 83.3%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.7
inactive: 115.5
Methoxymalonyl-CoA: 68.1
Methylmalonyl-CoA: 43.5
Propionyl-CoA: 32.6
Isobutyryl-CoA: 30.5
Acetyl-CoA: 19.6
fatty_acid: 13.6
Ethylmalonyl-CoA: 12.7
2-Methylbutyryl-CoA: 12.0
Benzoyl-CoA: 10.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1697..2004): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 216.6
Methylmalonyl-CoA: 216.5
Methoxymalonyl-CoA: 176.0
2-Methylbutyryl-CoA: 163.0
trans-1,2-CPDA: 130.1
Propionyl-CoA: 116.0
CHC-CoA: 110.5
Malonyl-CoA: 99.9
Isobutyryl-CoA: 75.2
Benzoyl-CoA: 57.6
fatty_acid: 44.2
3-Methylbutyryl-CoA: 37.4
Acetyl-CoA: 34.3
inactive: 20.8

PKS_AT (3547..3849): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 163.8
Ethylmalonyl-CoA: 145.6
Methoxymalonyl-CoA: 135.5
Propionyl-CoA: 116.3
2-Methylbutyryl-CoA: 101.0
Malonyl-CoA: 86.3
CHC-CoA: 85.8
trans-1,2-CPDA: 75.6
Isobutyryl-CoA: 50.1
Benzoyl-CoA: 43.4
inactive: 33.7
Acetyl-CoA: 23.9
3-Methylbutyryl-CoA: 17.1
fatty_acid: 16.3

PKS_AT (5278..5575): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 157.0
inactive: 73.6
Methoxymalonyl-CoA: 68.5
Methylmalonyl-CoA: 52.7
Propionyl-CoA: 39.2
Ethylmalonyl-CoA: 24.7
Isobutyryl-CoA: 23.9
fatty_acid: 19.8
Acetyl-CoA: 15.6
CHC-CoA: 13.7
Benzoyl-CoA: 10.1
trans-1,2-CPDA: 8.3
2-Methylbutyryl-CoA: 4.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (7318..7624): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 167.3
Ethylmalonyl-CoA: 145.9
Methoxymalonyl-CoA: 138.3
Propionyl-CoA: 120.9
2-Methylbutyryl-CoA: 110.1
Malonyl-CoA: 87.9
CHC-CoA: 87.4
trans-1,2-CPDA: 78.4
Isobutyryl-CoA: 56.1
Benzoyl-CoA: 44.3
inactive: 33.4
3-Methylbutyryl-CoA: 21.3
Acetyl-CoA: 20.9
fatty_acid: 17.4

vstA2

PKS_AT (568..874): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 167.3
Ethylmalonyl-CoA: 145.9
Methoxymalonyl-CoA: 138.3
Propionyl-CoA: 120.9
2-Methylbutyryl-CoA: 110.1
Malonyl-CoA: 87.9
CHC-CoA: 87.4
trans-1,2-CPDA: 78.4
Isobutyryl-CoA: 56.1
Benzoyl-CoA: 44.3
inactive: 33.4
3-Methylbutyryl-CoA: 21.3
Acetyl-CoA: 20.9
fatty_acid: 17.4

PKS_AT (2382..2688): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 164.4
Ethylmalonyl-CoA: 146.7
Methoxymalonyl-CoA: 134.8
Propionyl-CoA: 119.0
2-Methylbutyryl-CoA: 106.3
Malonyl-CoA: 87.5
CHC-CoA: 87.0
trans-1,2-CPDA: 79.0
Isobutyryl-CoA: 54.0
Benzoyl-CoA: 44.3
inactive: 33.5
3-Methylbutyryl-CoA: 20.4
Acetyl-CoA: 20.0
fatty_acid: 17.4

PKS_AT (4484..4783): mmal

ATSignature: Methylmalonyl-CoA, Ethylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 79.2%; Malonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 148.6
Ethylmalonyl-CoA: 138.0
Methoxymalonyl-CoA: 128.6
2-Methylbutyryl-CoA: 115.8
Propionyl-CoA: 90.6
trans-1,2-CPDA: 86.0
CHC-CoA: 81.4
Malonyl-CoA: 60.6
Isobutyryl-CoA: 52.5
Benzoyl-CoA: 41.3
Acetyl-CoA: 35.8
inactive: 13.9
3-Methylbutyryl-CoA: 5.0
fatty_acid: 0.0

PKS_AT (6261..6567): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 165.4
Ethylmalonyl-CoA: 146.3
Methoxymalonyl-CoA: 135.6
Propionyl-CoA: 118.0
2-Methylbutyryl-CoA: 105.9
Malonyl-CoA: 86.0
CHC-CoA: 83.8
trans-1,2-CPDA: 79.5
Isobutyryl-CoA: 54.2
Benzoyl-CoA: 44.4
inactive: 32.7
3-Methylbutyryl-CoA: 20.4
Acetyl-CoA: 19.9
fatty_acid: 16.7

vstA3

PKS_AT (627..924): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 157.0
inactive: 73.6
Methoxymalonyl-CoA: 68.5
Methylmalonyl-CoA: 52.7
Propionyl-CoA: 39.2
Ethylmalonyl-CoA: 24.7
Isobutyryl-CoA: 23.9
fatty_acid: 19.8
Acetyl-CoA: 15.6
CHC-CoA: 13.7
Benzoyl-CoA: 10.1
trans-1,2-CPDA: 8.3
2-Methylbutyryl-CoA: 4.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2347..2644): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 155.7
inactive: 72.3
Methoxymalonyl-CoA: 68.5
Methylmalonyl-CoA: 52.6
Propionyl-CoA: 37.5
Isobutyryl-CoA: 24.1
Ethylmalonyl-CoA: 23.1
fatty_acid: 19.6
Acetyl-CoA: 15.6
CHC-CoA: 13.6
Benzoyl-CoA: 10.6
trans-1,2-CPDA: 6.9
2-Methylbutyryl-CoA: 5.5
3-Methylbutyryl-CoA: 0.0

vstA4

PKS_AT (580..886): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Malonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 167.6
Ethylmalonyl-CoA: 150.4
Methoxymalonyl-CoA: 138.6
Propionyl-CoA: 120.2
2-Methylbutyryl-CoA: 108.2
Malonyl-CoA: 91.6
CHC-CoA: 88.3
trans-1,2-CPDA: 78.8
Isobutyryl-CoA: 54.9
Benzoyl-CoA: 43.8
inactive: 32.6
3-Methylbutyryl-CoA: 21.3
Acetyl-CoA: 20.8
fatty_acid: 16.2

PKS_AT (2331..2630): mmal

ATSignature: Methylmalonyl-CoA, Ethylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 79.2%; Malonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 148.6
Ethylmalonyl-CoA: 138.0
Methoxymalonyl-CoA: 128.6
2-Methylbutyryl-CoA: 115.8
Propionyl-CoA: 90.6
trans-1,2-CPDA: 86.0
CHC-CoA: 81.4
Malonyl-CoA: 60.6
Isobutyryl-CoA: 52.5
Benzoyl-CoA: 41.3
Acetyl-CoA: 35.8
inactive: 13.9
3-Methylbutyryl-CoA: 5.0
fatty_acid: 0.0

vstA5

PKS_AT (576..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 228.6
inactive: 115.1
Methoxymalonyl-CoA: 76.2
Methylmalonyl-CoA: 57.7
Isobutyryl-CoA: 40.4
Propionyl-CoA: 32.5
Ethylmalonyl-CoA: 31.5
Acetyl-CoA: 24.8
2-Methylbutyryl-CoA: 18.4
fatty_acid: 17.8
Benzoyl-CoA: 17.2
CHC-CoA: 10.9
trans-1,2-CPDA: 9.0
3-Methylbutyryl-CoA: 7.4