BGC0001205 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001205 (Penicillium expansum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS,indole	1	48,797	High	communesin A/communesin B/communesin C/communesin D/communesin E/communesin G/communesin H	PKS

BGC0001205 - Region 1 - T1PKS,indole

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Location: 1 - 48,797 nt. (total: 48,797 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 48,798
Label		BGC0001205

Tailoring functions

Oxidoreductases: oxidase oxygenase

PEXP_030460: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

PEXP_030480: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

PEXP_030580: dioxygenase, TauD/TfdA

smcogs: SMCOG1121: dioxygenase, TauD/TfdA

PEXP_030610: dioxygenase, TauD/TfdA

smcogs: SMCOG1121: dioxygenase, TauD/TfdA

Transferases: methyltransferase

PEXP_030500: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: decarboxylase

PEXP_030470: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase synthase

PEXP_030520: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

PEXP_030540: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001205.3	1.20	PKS	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum
BGC0001166.5	0.48	NRPS	HC-toxin	Alternaria jesenskae
BGC0001267.3	0.36	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis
BGC0000811.3	0.35	other (other)	fumigaclavine C	Aspergillus fumigatus Af293
BGC0002191.2	0.34	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.32	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002192.3	0.32	PKS	FR901512	fungal sp. No.14919
BGC0002238.3	0.31	PKS	2,4'-dihydroxy-3'-methoxypropiophenone	Aspergillus oryzae RIB40
BGC0001254.3	0.30	PKS	ACT-Toxin II	Alternaria alternata
BGC0001874.4	0.30	NRPS, PKS	α-cyclopiazonic acid	Aspergillus flavus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001205.3	0.99	PKS	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002192.3	0.65	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001268.4	0.62	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0000056.3	0.53	PKS	esperamicin	Actinomadura verrucosospora

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 1256 - 48797:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PEXP_030520: X

AMP-binding (39..375): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SFVYIGGPAK
Nearest Stachelhaus code(s):: Lin AYVYIGGVFK (47% 8Å match)
Stachelhaus code match:: 60% (weak)

PEXP_030540: pk

PKS_AT (548..867): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 81.4
Methoxymalonyl-CoA: 80.4
Malonyl-CoA: 59.6
Isobutyryl-CoA: 56.1
Ethylmalonyl-CoA: 52.3
Propionyl-CoA: 35.9
Benzoyl-CoA: 27.8
2-Methylbutyryl-CoA: 26.5
inactive: 22.7
Acetyl-CoA: 16.4
trans-1,2-CPDA: 15.5
fatty_acid: 12.8
3-Methylbutyryl-CoA: 10.7
CHC-CoA: 0.0

Link to PARAS substrate predictor