BGC0001205 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001205 (Penicillium expansum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,indole	1	47,244	communesin A/communesin B/communesin C/communesin D/communesin E/communesin G/communesin H	PKS	100%

BGC0001205 - Region 1 - T1PKS,indole

Download region GenBank file

Download region SVG

Location: 1 - 47,244 nt. (total: 47,244 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
indole: (indsynth or dmat or indole_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 47,245
Label		BGC0001205

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001205	1.30	Polyketide	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum
BGC0000249	0.51	Polyketide	nogalamycin	Streptomyces nogalater
BGC0001775	0.45	Terpene	sespendole	Cordana terrestris
BGC0000811	0.36	Alkaloid	fumigaclavine C	Aspergillus fumigatus Af293
BGC0001267	0.36	Terpene	lysergic acid, elymoclavine	Claviceps fusiformis
BGC0001529	0.34	Alkaloid	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0002711	0.33	Polyketide	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001544	0.33	NRP, Polyketide	chlorflavonin	Aspergillus campestris IBT 28561
BGC0001573	0.33	Alkaloid	dihydrolysergic acid	Claviceps africana
BGC0002180	0.32	Polyketide	(+)-asperlin, (2Z,4Z,6E)-octa-2,4,6-trienoic acid	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001205	1.00	Polyketide	communesin A, communesin B, communesin C, communesin D, communesin E, communesin G, communesin H	Penicillium expansum
BGC0000249	0.66	Polyketide	nogalamycin	Streptomyces nogalater
BGC0002180	0.66	Polyketide	(+)-asperlin, (2Z,4Z,6E)-octa-2,4,6-trienoic acid	Aspergillus nidulans FGSC A4
BGC0000046	0.65	Polyketide	depudecin	Alternaria brassicicola
BGC0001340	0.65	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0001749	0.65	Polyketide	epipyriculol	Pyricularia oryzae 70-15
BGC0001067	0.63	Polyketide, Terpene	fumagillin, β-trans-bergamotene, fumagillol	Aspergillus fumigatus Af293
BGC0002233	0.63	Polyketide	trichoxide	Trichoderma virens Gv29-8
BGC0002234	0.63	Polyketide	flavoglaucin	Aspergillus ruber CBS 135680
BGC0001913	0.62	Polyketide	phomoidride	fungal sp. ATCC 74256

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 1256 - 47244:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PEXP_030520

AMP-binding (39..375): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SFVYIGGPAK
Nearest Stachelhaus code(s):: Lin AYVYIGGVFK (47% 8Å match)
Stachelhaus code match:: 60% (weak)

PEXP_030540

PKS_AT (548..867): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 81.4
Methoxymalonyl-CoA: 80.4
Malonyl-CoA: 59.6
Isobutyryl-CoA: 56.1
Ethylmalonyl-CoA: 52.3
Propionyl-CoA: 35.9
Benzoyl-CoA: 27.8
2-Methylbutyryl-CoA: 26.5
inactive: 22.7
Acetyl-CoA: 16.4
trans-1,2-CPDA: 15.5
fatty_acid: 12.8
3-Methylbutyryl-CoA: 10.7
CHC-CoA: 0.0