BGC0001207: teixobactin biosynthetic gene cluster from Eleftheria terrae
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Location: 1 - 52,035 nt. (total: 52,035 nt).
This entry is originally from NCBI GenBank KP006601.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001207
Short description teixobactin biosynthetic gene cluster from Eleftheria terrae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KP006601.1
via
Compounds
  • teixobactin
Species Eleftheria terrae [taxonomy]
References
Chemical products information
teixobactin Evidence: NMR [1]
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C58H95N15O15
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AJF34459.1
 86 - 850 (+) superoxide dismutase
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    • AJF34460.1
    		 1562 - 3106 (+) outer membrane protein
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      • AJF34461.1
      		 3113 - 4333 (+) RND family efflux transporter MFP subunit
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        • AJF34462.1
        		 4320 - 7445 (+) acriflavin resistance protein
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          • AJF34463.1
          		 7977 - 27245 (+) Txo1
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            • AJF34464.1
            		 27250 - 46377 (+) Txo2
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              • AJF34465.1
              		 46452 - 48293 (+) ABC transporter
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                • AJF34466.1
                		 48325 - 49377 (+) fatty acid desaturase
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                  • AJF34467.1
                  		 49501 - 50619 (+) cystathione beta lyase
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                    • AJF34468.1
                    		 50635 - 51945 (-) hypothetical protein
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      AJF34463.1
                      Substrates
                      phenylalanine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      AJF34463.1
                      Substrates
                      isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      AJF34463.1
                      Substrates
                      serine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      AJF34463.1
                      Substrates
                      glutamine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk05
                      Type
                      nrps-type1
                      Genes
                      AJF34463.1
                      Substrates
                      isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk06
                      Type
                      nrps-type1
                      Genes
                      AJF34463.1
                      Substrates
                      isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk07
                      Type
                      nrps-type1
                      Genes
                      AJF34464.1
                      Substrates
                      serine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk08
                      Type
                      nrps-type1
                      Genes
                      AJF34464.1
                      Substrates
                      threonine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk09
                      Type
                      nrps-type1
                      Genes
                      AJF34464.1
                      Substrates
                      alanine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk10
                      Type
                      nrps-type1
                      Genes
                      AJF34464.1
                      Substrates
                      enduracididine (evidence: Structure-based inference [2])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk11
                      Type
                      nrps-type1
                      Genes
                      AJF34464.1
                      Substrates
                      isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: next

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2024-05-14
                      MIBiG v4 annotathon
                      • (ID: XT5AK2O5S2OAA2Y6GD4DTV5X)
                      • (ID: HSOJFFPY5IUT4HBQLSN7DGJX)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-08-17
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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