Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001208.1:
Cluster 1NRP110890
The following clusters are from record BGC0001208.2:
Cluster 2NRP133715

BGC0001208, poaeamide biosynthetic gene cluster from Pseudomonas poae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: poaeamide A
SMILES string: Copy to clipboard
Molecular formula: C61H108N10O17
Exact molecular mass: 1275.7792 Da ([M+Na]+)
Molecular activity: Antifungal, Other

Class-specific details

Biosynthetic class(es):
NRP
Nonribosomal peptide subclass:
Other lipopeptide (cyclic)
3-OH decanoic acid
Thioesterase type:
Type I & II
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
poaA (AGE26255.1)
Module 1
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Starter
Module 2
A specificity: Glutamate
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Dual
poaB (AGE25479.1)
Module 3
A specificity: Threonine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Dual
Module 4
A specificity: Leucine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Dual
Module 5
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 6
A specificity: Serine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Dual
poaC (AGE25480.1)
Module 10
A specificity: Isoleucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 7
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 8
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 9
A specificity: Serine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL

Gene cluster description

poaeamide (BGC0001208). Gene Cluster 1. Biosynthetic class = NRP. GenBank CP004045. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Harald Gross (University of Tuebingen)

Literature references

1. Zachow C et al. (2015) The Novel Lipopeptide Poaeamide of the Endophyte Pseudomonas poae RE*1-1-14 Is Involved in Pathogen Suppression and Root Colonization. Mol Plant Microbe Interact 28(7):800-10. doi:

BGC0001208, poaeamide biosynthetic gene cluster from Pseudomonas poae. Locus 2. Full MIBiG entry.

Chemical compounds

Compound: poaeamide A
SMILES string: Copy to clipboard
Molecular formula: C61H108N10O17
Exact molecular mass: 1275.7792 Da ([M+Na]+)
Molecular activity: Antifungal, Other

Class-specific details

Biosynthetic class(es):
NRP
Nonribosomal peptide subclass:
Other lipopeptide (cyclic)
3-OH decanoic acid
Thioesterase type:
Type I & II
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
poaA (AGE26255.1)
Module 1
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Starter
Module 2
A specificity: Glutamate
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Dual
poaB (AGE25479.1)
Module 3
A specificity: Threonine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Dual
Module 4
A specificity: Leucine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Dual
Module 5
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 6
A specificity: Serine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Dual
poaC (AGE25480.1)
Module 10
A specificity: Isoleucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 7
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: Dual
Module 8
A specificity: Leucine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 9
A specificity: Serine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: LCL

Gene cluster description

poaeamide (BGC0001208). Gene Cluster 2. Biosynthetic class = NRP. GenBank CP004045. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Harald Gross (University of Tuebingen)

Literature references

1. Zachow C et al. (2015) The Novel Lipopeptide Poaeamide of the Endophyte Pseudomonas poae RE*1-1-14 Is Involved in Pathogen Suppression and Root Colonization. Mol Plant Microbe Interact 28(7):800-10. doi: