BGC0001210 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001210 (Bacillus pseudomycoides DSM 12442)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	1	23,222	High	pseudomycoicidin	ribosomal:RiPP

BGC0001210 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 23,222 nt. (total: 23,222 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 23,223
Label		BGC0001210

Tailoring functions

Lyases: cyclase

bpmyx0001_45470: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001210.5	1.00	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000500.5	0.52	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000525.5	0.51	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000539.5	0.51	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0002005.2	0.50	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000588.5	0.50	ribosomal	microcin L	Escherichia coli
BGC0000527.5	0.50	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001210.5	1.00	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000500.5	0.52	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000525.5	0.51	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000539.5	0.51	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0002005.2	0.50	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000588.5	0.50	ribosomal	microcin L	Escherichia coli
BGC0000527.5	0.50	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for bpmyx0001_45470

bpmyx0001_45460

Leader:

MNDKIIQYWNDPAKRSTLSAAELSKMPVNPAGDILAELSDADLDKVVGA

Core:

GDCGGTCTWTKDCSICPSWSCWSWSC

Core with dehydrations:

GDCysGGDhbCysDhbWDhbKDCysDhaICysPDhaWDhaCysWDhaWDhaCys

antiSMASH-DB 4.0 matches for bpmyx0001_45460

100.0%

NZ_CM000745.1:

Lanthipeptides: BPMYX0001_RS22355_lanthipeptide

GDCGGTCTWTKDCSICPSWSCWSWSC

84.6%

NZ_BMEX01000022.1:

Lanthipeptides: IEV46_RS16225_lanthipeptide

CGGTCTWTKDCSICPSWSCWSWSC

CG CTWTKDCSICPSWSCWSWSC

CGNVCTWTKDCSICPSWSCWSWSC

84.6%

NZ_CP033045.1and 2 others:

NZ_JAGGRC010000008.1 Lanthipeptides: J7E71_RS18575_lanthipeptideNZ_SLVV01000018.1 Lanthipeptides: EV146_RS24615_lanthipeptide

Lanthipeptides: D9829_RS27635_lanthipeptide

GDCGGTCTWTKDCSICPSWSCWSWSC

DC CTWTKDCSICPSWSCWSWSC

ADCANVCTWTKDCSICPSWSCWSWSC

with 45 more sequence matches

Only the first 10 are displayed here.

40.6%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15515_lanthipeptide

GDCGGTCTWTKDCSICPSWSCWS

G+ G CT T +CSICP+ +CWS

GNDGKWCTLTWECSICPTKTCWS

38.7%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

GDCGGTCTWTKDCSICPSWSCW

G+ G CT T +CSICP+ +CW

GNDGHQCTITWECSICPTHTCW

37.5%

NZ_BOSN01000007.1and 5 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptideNZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

GDCGGTCTWTKDCSICPSWSCW

G+ G CT T +CSICP+ +CW

GNDGKYCTITWECSICPTHTCW

37.5%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

GDCGGTCTWTKDCSICPSWSCW

G+ G CT T +CSICP+ +CW

GNDGKWCTVTWECSICPTHTCW

34.4%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

GGTCTWTKDCSICPSWSCW

G CT T +CSICP+ +CW

GKYCTLTWECSICPTHTCW

32.4%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

GDCGGTCTWTKDCSICPSWSCW

G+ G CT T +C ICPS +C+

GNTGKVCTLTWECGICPSHTCF

31.2%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

GDCGGTCTWTKDCSICPSWSCW

G+ G CT T +CS+CP+ +C+

GNDGKYCTLTWECSVCPTLTCF

30.3%

NZ_AUCI01000015.1and 3 others:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptideNZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptideNZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

GDCGGTCTWTKDCSICPSWSCW

G+ G CT T +C +CP+ +CW

GNDGDYCTITWECGMCPTHTCW

29.0%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

GDCGGTCTWTKDCSICPSWSCW

G+ G CT T +C +CP+ +C+

GNDGKVCTLTWECGLCPTHTCF

28.6%

NZ_FOBE01000018.1:

Lanthipeptides: BMW61_RS13085_lanthipeptide

GDCGGTCTWTKDCSIC

G+ G CT TK+C C

GNRGSYCTLTKECQAC

MIBiG 4.0 matches for bpmyx0001_45460

26.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

GDCGGTCTWTKDCS

G+ GG CT TK+C

GNNGGWCTLTKECQ

15.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

ICPSWSCWS

CP+ C S

FCPTTKCTS

10.8%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

SICPSWSCWS

+ CP+ C S

AFCPTTKCTS

with 1 more sequence matches

10.3%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTWTKDCS

CT +K+C

CTLSKECQ

allorf_03361_03492

Leader:

MERKKEKGKRNYDSLQTGNKIQKNLGAIRYS

Core:

RSSASCANFCRY

Core with dehydrations:

RDhaDhaADhaCysANFCysRY

antiSMASH-DB 4.0 matches for allorf_03361_03492

30.8%

NC_015711.1:

Lanthipeptides: allorf_5233543_5233650_lanthipeptide

RSSASCANFCR

RSSA CA F R

RSSAHCAAFAR

26.3%

NC_019684.1:

Lassopeptides: allorf_0789291_0789491_lassopeptide

SSASCANFCRY

+S SC FC++

ASKSCFTFCKF

allorf_07639_07707

Leader:

MLDKKANYWGA

Core:

SLCQNTKLSSN

Core with dehydrations:

DhaLCysQNDhbKLDhaDhaN

antiSMASH-DB 4.0 matches for allorf_07639_07707

100.0%

NZ_CM000745.1:

Lanthipeptides: allorf_4369325_4369393_lanthipeptide

SLCQNTKLSSN

allorf_13847_13939

Leader:

MLSSAVERVEHLAGA

Core:

FQYWMILSCVKLPLL

Core with dehydrations:

FQYWMILDhaCysVKLPLL

antiSMASH-DB 4.0 matches for allorf_13847_13939

33.3%

NZ_KE159748.1:

Lanthipeptides: allorf_219294_219452_lanthipeptide

WMILSCVKLPL

+I +CV +PL

GIITTCVNVPL

11.1%

NZ_LIPB01000002.1and 2 others:

NZ_LIPB01000002.1 Lanthipeptides: allorf_1142638_1142808_lanthipeptideNZ_LIPB01000002.1 Lanthipeptides: allorf_1142638_1142808_lanthipeptide

Lanthipeptides: allorf_1142638_1142808_lanthipeptide

FQYWMILSCVKLP

F+ W++L C P

FRKWLLLDCRAEP

allorf_14146_14322

Leader:

MLCTLCCDTTIASCCYNLTKHFFA

Core:

NITSCENTRNFRFHTFICFNITIFICNAKLNKWF

Core with dehydrations:

NIDhbDhaCysENDhbRNFRFHDhbFICysFNIDhbIFICysNAKLNKWF

antiSMASH-DB 4.0 matches for allorf_14146_14322

15.8%

NZ_CP036019.1and 5 others:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27150_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27145_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27155_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27150_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27145_lanthipeptide

Lanthipeptides: EXW52_RS27155_lanthipeptide

NITSCENTRNFRFHTFICFNITIF

NI+S + +N T+ T++

NISSADTPKNITPQTYAIDTPTVY

11.9%

NZ_FNGC01000009.1:

Lanthipeptides: allorf_108834_108992_lanthipeptide

CFNITIFICNAKLNKW

CF T +C + W

CFEETATVCGEQAGVW

MIBiG 4.0 matches for allorf_14146_14322

11.8%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

SCENTRNFRFHTFICFNIT

+CE +C I+

TCECVGLLTLLNTVCIGIS

allorf_14744_14890

Leader:

MYSFLPATTVLYS

Core:

LPSMTSFTSPYAYSAPNFFACSNILFDKSGPKIDS

Core with dehydrations:

LPDhaMDhbDhaFDhbDhaPYAYDhaAPNFFACysDhaNILFDKDhaGPKIDDha

antiSMASH-DB 4.0 matches for allorf_14744_14890

27.8%

NZ_FNUW01000038.1and 3 others:

NZ_JH792281.1 Lanthipeptides: IC1_RS35090_lanthipeptideNZ_MSTN01000008.1 Lanthipeptides: BVF97_RS20515_lanthipeptideNZ_PVRL01000007.1 Lanthipeptides: C6351_RS17055_lanthipeptide

Lanthipeptides: C4S65_RS30135_lanthipeptide

YAYSAPNFFACSNILFDKSGPKIDS

YA+ P AC K GP DS

YAFCTPGTCAC------KEGPTFDS

27.8%

NZ_MOOL01000072.1:

Lanthipeptides: BK733_RS26615_lanthipeptide

YAYSAPNFFACSNILFDKSGPKIDS

YA+ P AC K GP DS

YAFCTPGTCAC------KDGPTFDS

allorf_19697_19870

Leader:

MYQLDDEFLPHHLLIPIEIAQLNLLSLLSAYVNLHSAAGS

Core:

FSFDVKFHSNRYCTIFF

Core with dehydrations:

FDhaFDVKFHDhaNRYCysDhbIFF

antiSMASH-DB 4.0 matches for allorf_19697_19870

13.6%

NZ_FNPT01000004.1:

Lanthipeptides: allorf_355996_356196_lanthipeptide

FDVKFHSNRYCTIF

FD S R+C +F

FDTSRTSKRFCNLF

allorf_21192_21311

Leader:

MVVVRLAAVMGL

Core:

LKLKCISYRMYMFHVKYVMENVIIVKR

Core with dehydrations:

LKLKCysIDhaYRMYMFHVKYVMENVIIVKR

antiSMASH-DB 4.0 matches for allorf_21192_21311

14.7%

NZ_JALAJI010000006.1and 3 others:

NZ_JALAOO010000008.1 Lanthipeptides: MOC69_RS16910_lanthipeptideNZ_JALAXE010000008.1 Lanthipeptides: MOF11_RS14910_lanthipeptideNZ_JALAXI010000013.1 Lanthipeptides: MOE73_RS14185_lanthipeptide

Lanthipeptides: MOB90_RS08905_lanthipeptide

CISYRMYMFHVKYV

C+S R+ + +KY

CVSLRLCKWSIKYC

allorf_22706_22768

Leader:

MKENIRGS

Core:

NSPIEKPQCGQA

Core with dehydrations:

NDhaPIEKPQCysGQA

antiSMASH-DB 4.0 matches for allorf_22706_22768

16.0%

NZ_LIWC01000001.1:

Lanthipeptides: allorf_1205972_1206109_lanthipeptide

IEKPQCG

+E+P+CG

VERPECG

allorf_22836_22940

Leader:

MHFQENLQGG

Core:

LQPLLSQRYGQLRLQWNASCFYLT

Core with dehydrations:

LQPLLDhaQRYGQLRLQWNADhaCysFYLDhb

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

bpmyx0001_45460 - Class II

Cleavage pHMM score: -0.70

RODEO score: 0

Monoisotopic mass: 2714.0 Da

Molecular weight: 2716.0 Da

Number of bridges: 6

Alternative weights: (assuming N unmodified Ser/Thr residues); 2734.0 Da N = 1; 2752.1 Da N = 2

allorf_03361_03492 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 1309.6 Da

Molecular weight: 1310.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1328.5 Da N = 1

allorf_07639_07707 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 1121.6 Da

Molecular weight: 1122.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1140.3 Da N = 1; 1158.3 Da N = 2; 1176.3 Da N = 3

allorf_13847_13939 - Class II

Cleavage pHMM score: -2.50

RODEO score: 0

Monoisotopic mass: 1835.0 Da

Molecular weight: 1836.3 Da

Number of bridges: 1

allorf_14146_14322 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 4065.0 Da

Molecular weight: 4067.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4085.7 Da N = 1; 4103.7 Da N = 2

allorf_14744_14890 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 3640.8 Da

Molecular weight: 3643.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3661.1 Da N = 1; 3679.1 Da N = 2; 3697.1 Da N = 3; 3715.1 Da N = 4; 3733.2 Da N = 5; 3751.2 Da N = 6; 3769.2 Da N = 7; 3787.2 Da N = 8

allorf_19697_19870 - Class II

Cleavage pHMM score: -2.90

RODEO score: 0

Monoisotopic mass: 2103.0 Da

Molecular weight: 2104.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2122.4 Da N = 1; 2140.4 Da N = 2

allorf_21192_21311 - Class II

Cleavage pHMM score: -6.50

RODEO score: 0

Monoisotopic mass: 3385.9 Da

Molecular weight: 3388.2 Da

Number of bridges: 1

allorf_22706_22768 - Class II

Cleavage pHMM score: -5.30

RODEO score: 0

Monoisotopic mass: 1252.6 Da

Molecular weight: 1253.4 Da

Number of bridges: 1

allorf_22836_22940 - Class II

Cleavage pHMM score: -0.10

RODEO score: 0

Monoisotopic mass: 2843.5 Da

Molecular weight: 2845.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2863.3 Da N = 1; 2881.3 Da N = 2