BGC0001211: albachelin biosynthetic gene cluster from Amycolatopsis alba DSM 44262
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 6,412,272 - 6,475,882 nt. (total: 63,611 nt).
This entry is originally from NCBI GenBank NZ_KB913032.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001211
Short description albachelin biosynthetic gene cluster from Amycolatopsis alba DSM 44262
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_KB913032.1
6431187 - 6464849
via
Compounds
  • albachelin
Species Amycolatopsis alba DSM 44262 [taxonomy]
References
Chemical products information
albachelin Evidence: NMR [1]
Copy SMILES
C28H49N9O14
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AMYAL_RS0130200
  • WP_020635017.1
 6431187 - 6432134 (-) methionyl-tRNA formyltransferase
    copy AA seq
    copy Nt seq
    • AMYAL_RS0130205
    • WP_039794392.1
    		 6432272 - 6433615 (+) Ornithine N-monooxygenase
      copy AA seq
      copy Nt seq
      • AMYAL_RS0130210
      • WP_084702182.1
      		 6433644 - 6455882 (+) non-ribosomal peptide synthetase
        copy AA seq
        copy Nt seq
        • AMYAL_RS0130215
        • WP_020635020.1
        		 6455879 - 6456088 (+) MbtH family protein
          copy AA seq
          copy Nt seq
          • AMYAL_RS0130220
          • WP_026467576.1
          		 6456588 - 6457622 (+) DUF4073 domain-containing protein
            copy AA seq
            copy Nt seq
            • AMYAL_RS0130225
            • WP_020635022.1
            		 6458005 - 6459090 (-) iron-siderophore ABC transporter substrate-binding protein
              copy AA seq
              copy Nt seq
              • AMYAL_RS0130230
              • WP_020635023.1
              		 6459204 - 6460961 (-) ABC transporter ATP-binding protein
                copy AA seq
                copy Nt seq
                • AMYAL_RS0130235
                • WP_020635024.1
                		 6460958 - 6462634 (-) ABC transporter ATP-binding protein
                  copy AA seq
                  copy Nt seq
                  • AMYAL_RS0130240
                  • WP_020635025.1
                  		 6462727 - 6463770 (+) iron chelate uptake ABC transporter family permease subunit
                    copy AA seq
                    copy Nt seq
                    • AMYAL_RS0130245
                    • WP_039795885.1
                    		 6463812 - 6464849 (+) iron chelate uptake ABC transporter family permease subunit
                      copy AA seq
                      copy Nt seq
                      • AMYAL_RS0130250
                      • WP_020635027.1
                      		 6464830 - 6465681 (-) DMT family transporter
                        copy AA seq
                        copy Nt seq
                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        Unk01
                        Type
                        nrps-type1
                        Genes
                        AMYAL_RS0130210
                        Substrates
                        N5-formyl-N5-hydroxyornithine (evidence: Structure-based inference [2])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk02
                        Type
                        nrps-type1
                        Genes
                        AMYAL_RS0130210
                        Substrates
                        serine (evidence: Structure-based inference [2])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk03
                        Type
                        nrps-type1
                        Genes
                        AMYAL_RS0130210
                        Substrates
                        N5-hydroxyornithine (evidence: Structure-based inference [2])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk04
                        Type
                        nrps-type1
                        Genes
                        AMYAL_RS0130210
                        Substrates
                        serine (evidence: Structure-based inference [2])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk05
                        Type
                        nrps-type1
                        Genes
                        AMYAL_RS0130210
                        Substrates
                        serine (evidence: Structure-based inference [2])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk06
                        Type
                        nrps-type1
                        Genes
                        AMYAL_RS0130210
                        Substrates
                        N5-hydroxyornithine (evidence: Structure-based inference, Homology)
                        Integrated Monomers
                        Domains
                        adenylation
                        Annotation changelog

                        Entry version: 5

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2024-03-20
                        MIBiG v4 annotathon
                        • (ID: PL22PZN7MFQ3CRD6SUY3IEQ3)
                        • (ID: CVBS4CX3MGQ2Y6Q45INSO263)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 4

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Updated bioactivity data
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Added NRP substrate specificities
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-08-17
                        Submitted
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Similar known clusters from MIBiG 4.0
                        Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                        Detailed help and explanations are available here.

                        Click on reference genes to show details of similarities to genes within the current region.
                        Double click on a reference drawing to reverse the display of the genes.

                        Click on an accession to open that entry in the MIBiG database.


                        Location:

                        Identifier
                        Identity
                        Coverage
                        Detailed domain annotation
                        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                        A domain glossary is available here, and an explanation of the visualisation is available here.
                        Selected features only
                        Show module domains