BGC0001211: albachelin biosynthetic gene cluster from Amycolatopsis alba DSM 44262
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Location: 6,431,187 - 6,464,849 nt. (total: 33,663 nt).
This entry is originally from NCBI GenBank NZ_KB913032.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001211
Short description albachelin biosynthetic gene cluster from Amycolatopsis alba DSM 44262
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_KB913032.1
6431187 - 6464849
via
Compounds
  • albachelin
Species Amycolatopsis alba DSM 44262 [taxonomy]
References
Chemical products information
albachelin Evidence: NMR [1]
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C28H49N9O14
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AMYAL_RS0130200
  • WP_020635017.1
 6431187 - 6432134 (-) methionyl-tRNA formyltransferase
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    • AMYAL_RS0130205
    • WP_039794392.1
    		 6432272 - 6433615 (+) Ornithine N-monooxygenase
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      • AMYAL_RS0130210
      • WP_084702182.1
      		 6433644 - 6455882 (+) non-ribosomal peptide synthetase
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        • AMYAL_RS0130215
        • WP_020635020.1
        		 6455879 - 6456088 (+) MbtH family protein
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          • AMYAL_RS0130220
          • WP_026467576.1
          		 6456588 - 6457622 (+) DUF4073 domain-containing protein
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            • AMYAL_RS0130225
            • WP_020635022.1
            		 6458005 - 6459090 (-) iron-siderophore ABC transporter substrate-binding protein
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              • AMYAL_RS0130230
              • WP_020635023.1
              		 6459204 - 6460961 (-) ABC transporter ATP-binding protein
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                • AMYAL_RS0130235
                • WP_020635024.1
                		 6460958 - 6462634 (-) ABC transporter ATP-binding protein
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                  • AMYAL_RS0130240
                  • WP_020635025.1
                  		 6462727 - 6463770 (+) iron chelate uptake ABC transporter family permease subunit
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                    • AMYAL_RS0130245
                    • WP_039795885.1
                    		 6463812 - 6464849 (+) iron chelate uptake ABC transporter family permease subunit
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      AMYAL_RS0130210
                      Substrates
                      N5-formyl-N5-hydroxyornithine (evidence: Structure-based inference [2])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      AMYAL_RS0130210
                      Substrates
                      serine (evidence: Structure-based inference [2])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      AMYAL_RS0130210
                      Substrates
                      N5-hydroxyornithine (evidence: Structure-based inference [2])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      AMYAL_RS0130210
                      Substrates
                      serine (evidence: Structure-based inference [2])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk05
                      Type
                      nrps-type1
                      Genes
                      AMYAL_RS0130210
                      Substrates
                      serine (evidence: Structure-based inference [2])
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk06
                      Type
                      nrps-type1
                      Genes
                      AMYAL_RS0130210
                      Substrates
                      N5-hydroxyornithine (evidence: Structure-based inference, Homology)
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: next

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2024-03-20
                      MIBiG v4 annotathon
                      • (ID: PL22PZN7MFQ3CRD6SUY3IEQ3)
                      • (ID: CVBS4CX3MGQ2Y6Q45INSO263)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-08-17
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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