BGC0001213 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001213 (Streptomyces sp. Tu 6176)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PKS-like,T1PKS,hglE-KS	1	45,517	nataxazole	PKS	100%

BGC0001213 - Region 1 - PKS-like,T1PKS,hglE-KS

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Location: 1 - 45,517 nt. (total: 45,517 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
hglE-KS: (hglE or hglD)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 45,518
Label		BGC0001213

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001213	2.49	Polyketide	nataxazole	Streptomyces sp. Tu 6176
BGC0001444	1.09	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0001273	1.05	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275	1.04	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244	1.03	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001137	0.92	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000996	0.88	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000170	0.87	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0002493	0.87	NRP	parabactin	Paracoccus denitrificans PD1222
BGC0002615	0.85	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001213	1.00	Polyketide	nataxazole	Streptomyces sp. Tu 6176
BGC0001444	0.73	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0001273	0.68	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275	0.68	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244	0.67	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001137	0.65	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000996	0.63	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0002615	0.63	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre
BGC0000170	0.63	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0002493	0.62	NRP	parabactin	Paracoccus denitrificans PD1222

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 6287 - 45517:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 9937 - 45517:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 22644 - 45517:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CF54_07370

Search NORINE for peptide: strict or relaxed

AMP-binding (31..439): Hpr

nrpys: Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: pip (Hpr)

Stachelhaus prediction details:

Stachelhaus sequence:: AFPAQGVLTK
Nearest Stachelhaus code(s):: Hpr PFPSQGVLTK (76% 8Å match)
Stachelhaus code match:: 80% (moderate)

CF54_07380

AMP-binding (65..248): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TGAWFAETIK
Nearest Stachelhaus code(s):: nohBza or oh-nitroBza AGAWYAEPLK (41% 8Å match)
Stachelhaus code match:: 60% (weak)

CF54_07385

PKS_AT (504..794): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 70.8%; Propionyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 125.9
Methoxymalonyl-CoA: 103.8
Ethylmalonyl-CoA: 103.8
Malonyl-CoA: 91.8
2-Methylbutyryl-CoA: 60.5
Propionyl-CoA: 56.8
Isobutyryl-CoA: 55.6
trans-1,2-CPDA: 51.9
CHC-CoA: 45.8
fatty_acid: 32.9
3-Methylbutyryl-CoA: 32.9
Acetyl-CoA: 24.4
inactive: 23.9
Benzoyl-CoA: 23.1

CF54_07415

PKS_AT (570..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 93.1
Methoxymalonyl-CoA: 48.8
inactive: 40.4
Methylmalonyl-CoA: 37.0
trans-1,2-CPDA: 16.1
Propionyl-CoA: 14.6
fatty_acid: 13.3
Isobutyryl-CoA: 10.3
Ethylmalonyl-CoA: 5.8
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
CHC-CoA: -2.1