BGC0001214 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001214 (Streptomyces drozdowiczii)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	47,529	marformycin A/marformycin B/marformycin C/marformycin D/marformycin E/marformycin F	NRPS:Type I	100%

BGC0001214 - Region 1 - NRPS

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Location: 1 - 47,529 nt. (total: 47,529 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 47,530
Label		BGC0001214

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001214	1.00	NRP	marformycin A, marformycin B, marformycin C, marformycin D, marformycin E, marformycin F	Streptomyces drozdowiczii
BGC0001133	0.41	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.39	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001050	0.39	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000426	0.37	NRP	sevadicin	Paenibacillus larvae
BGC0001925	0.34	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0002518	0.34	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.34	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.34	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001629	0.32	NRP	jessenipeptin	Pseudomonas sp. QS1027

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001214	1.00	NRP	marformycin A, marformycin B, marformycin C, marformycin D, marformycin E, marformycin F	Streptomyces drozdowiczii
BGC0001133	0.73	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.71	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001050	0.71	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0000426	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0001925	0.67	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0002518	0.67	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.67	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.67	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0001629	0.65	NRP	jessenipeptin	Pseudomonas sp. QS1027

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 47529:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - Thr - D-Tyr) + (D-X) + (Leu - NMe-Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AJV88375.1

Search NORINE for peptide: strict or relaxed

AMP-binding (447..843): X

nrpys: Val, aIle

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DALWWGGVFK
Nearest Stachelhaus code(s):: Val or aIle DALWWGGVFK (100% 8Å match); Ile DALWWGGVFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1926): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2589..2990): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAPIFVAVCK
Nearest Stachelhaus code(s):: Tyr DAPIFVAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AJV88376.1

AMP-binding (471..866): X

nrpys: Val, aIle

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAYFLGVTFK
Nearest Stachelhaus code(s):: Val or aIle DAYFLGVTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AJV88377.1

Search NORINE for peptide: strict or relaxed

AMP-binding (1320..1718): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DALFVGAVAK
Nearest Stachelhaus code(s):: Leu DALFVGAVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2379..2777): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAAWWGGTFK
Nearest Stachelhaus code(s):: Val DAAWWGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AJV88383.1

AMP-binding (31..428): X

nrpys: Piz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFNAHMVK
Nearest Stachelhaus code(s):: Piz DVQFNAHMVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)