LOCUS       BGC0001216             25280 bp    DNA     linear   BCT 04-APR-2015
DEFINITION  Streptomyces sp. CNQ431 splenocin biosynthesis gene cluster,
            complete sequence.
ACCESSION   BGC0001216
VERSION     BGC0001216
KEYWORDS    .
SOURCE      Streptomyces sp. CNQ431
  ORGANISM  Streptomyces sp. CNQ431
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 15:08:50
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 6355
            Orig. end    :: 31635
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..522)
                     /gene="spnA"
     CDS             complement(1..522)
                     /codon_start=1
                     /gene="spnA"
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 95.2;
                     E-value: 6e-29)"
                     /gene_kind="regulatory"
                     /product="putative RNA polymerase sigma factor"
                     /protein_id="AKA54624.1"
                     /transl_table=11
                     /translation="MNTAHELPAPVDRLLPRARAGDEQAMNDLLLHITPYVTRVCRSVA
                     HDNGSDARQEALLAIYRGLPGLREPAAFYGWVRSVTVREAVRTARRLGRETTSPEVDSR
                     HEPHSLDAVHINDVLDRMSEAHRQVLTLRVYGLNEVEMAETLALPVGTVRSRLHRARRR
                     FQEAWQPTAA"
     misc_feature    1..25280
                     /note="splenocin biosynthesis gene cluster"
     subregion       1..25280
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="NRPS, PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..25280
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(580..1881)
                     /gene="spnB"
     CDS             complement(580..1881)
                     /NRPS_PKS="Domain: Condensation_LCL (21-246). E-value:
                     1.1e-21. Score: 69.1. Matches aSDomain:
                     nrpspksdomains_spnB_Condensation_LCL.1"
                     /codon_start=1
                     /gene="spnB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     105.2; E-value: 7.8e-32)"
                     /gene_kind="biosynthetic-additional"
                     /product="acyltransferase"
                     /protein_id="AKA54625.1"
                     /sec_met_domain="Condensation (E-value: 7.5e-20, bitscore:
                     61.2, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRALCPVENLYVAQRSRAFLSCALRGDIDSSALASAFDALTTEH
                     PTLRSRIVPAEGGHALELLPEDERPRLILKEGGDEAYIEELNVPLPVGGPLSRAALVTT
                     GPETRLLTVTIDHTVTDGHSAITLMNALWDRYSDLVGTVPAQTPPVPVAEGDWPRPVSE
                     LLPPADAEDTEKYLRRRIEETSAHPVELLAYDTPRDRPADPSEHRIEVRRLVLGAEETT
                     RLRSAARDAGVSVHGLVAAALMTAARARLDGDGPRTLGCMSPVDLRARLTPPVSPSVMV
                     ASVTSHLQAVPVGGETDPLDLARKISSRLRESVERGDHFHEMRIMPRVPAHPTLQMGSV
                     IVTNMGATAAPRFPEGLEATDVRLVPARESYFPQAGRSPVMACVVSFDNQLAVELPHHT
                     ACFTPQYMRAFRDDVRTALLAFTEDTAPAPVTAG"
     aSDomain        complement(1144..1818)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnB_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="1.10E-21"
                     /label="spnB_Condensation_LCL.1"
                     /locus_tag="spnB"
                     /protein_end="246"
                     /protein_start="21"
                     /score="69.1"
                     /tool="antismash"
                     /translation="SCALRGDIDSSALASAFDALTTEHPTLRSRIVPAEGGHALELLPE
                     DERPRLILKEGGDEAYIEELNVPLPVGGPLSRAALVTTGPETRLLTVTIDHTVTDGHSA
                     ITLMNALWDRYSDLVGTVPAQTPPVPVAEGDWPRPVSELLPPADAEDTEKYLRRRIEET
                     SAHPVELLAYDTPRDRPADPSEHRIEVRRLVLGAEETTRLRSAARDAGVSVHGLVAAAL
                     MTA"
     CDS_motif       complement(1723..1818)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnB_0001"
                     /evalue="5.70E-08"
                     /label="C2_DCL_024-062"
                     /locus_tag="spnB"
                     /protein_end="53"
                     /protein_start="21"
                     /score="25.1"
                     /tool="antismash"
                     /translation="SCALRGDIDSSALASAFDALTTEHPTLRSRIV"
     gene            2525..11218
                     /gene="spnC"
     CDS             2525..11218
                     /NRPS_PKS="Domain: Condensation_Starter (7-301). E-value:
                     1.9e-101. Score: 331.2. Matches aSDomain:
                     nrpspksdomains_spnC_Condensation_Starter.1"
                     /NRPS_PKS="Domain: AMP-binding (461-875). E-value:
                     7.8e-113. Score: 369.0. Matches aSDomain:
                     nrpspksdomains_spnC_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (982-1052). E-value: 5.2e-22. Score:
                     69.7. Matches aSDomain: nrpspksdomains_spnC_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (1071-1369). E-value:
                     2.1e-94. Score: 307.7. Matches aSDomain:
                     nrpspksdomains_spnC_Condensation_LCL.1"
                     /NRPS_PKS="Domain: CAL_domain (1710-2121). E-value:
                     1.4e-84. Score: 275.7. Matches aSDomain:
                     nrpspksdomains_spnC_CAL_domain.1"
                     /NRPS_PKS="Domain: PKS_KR (2463-2656). E-value: 2e-46.
                     Score: 150.0. Matches aSDomain:
                     nrpspksdomains_spnC_PKS_KR.1"
                     /NRPS_PKS="Domain: PCP (2774-2843). E-value: 2.6e-20.
                     Score: 64.3. Matches aSDomain: nrpspksdomains_spnC_PCP.2"
                     /codon_start=1
                     /gene="spnC"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     59; E-value: 8.6e-18)"
                     /gene_kind="biosynthetic"
                     /note="NRPS (C-A-PCP-C-A-KR-PCP)"
                     /product="NRPS"
                     /protein_id="AKA54626.1"
                     /sec_met_domain="AMP-binding (E-value: 3.8e-125, bitscore:
                     407.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.2e-17, bitscore:
                     53.5, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 3e-59, bitscore:
                     190.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2.1e-42, bitscore:
                     135.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGNEDDRRPLSGAQEGLWYAHRLAPGTAAYNTGEYVEIHGPLDT
                     AVFETALRRTVREADTFALRFLDTPDGPRAVRDGDPDEMPVHRVDVSGAADPAAAAEEW
                     IRRDLATPVDVAAGPLFSHALLTLAPDRFIWFLRAHHILLDGYSYKLVARRLADTYTAL
                     AAGEEPPPAGFESSDRLAAEEAAYLGSDRHQRDRAYWTERLAGLPEPARLTDRTAPPRA
                     PFLRRTAVLSPAETRALDEAAKGMGVARTDLLVAAVAAFLHRMTGADDLVLGLATMSRL
                     GSAALRTPGTASDILPLRIAASADTPVGLFVRAVADDLRGLRTHQRYRGESIRRDLGVL
                     GRGRRVHGPVVNIVPFSEDLTFGGHPSTSHHLSGGAVDDLQISVRPGAEADTVWLAFDA
                     HPDLYEEDGLALFLERFLKVLRELRTAPEELPLGETPVLLPGEEPVRRDEPAPRVTRTL
                     PQLFEARVADGPGRTAVSYAGETLSYAELNAEANRLARLLVERGAGPGRFVALALPRGL
                     PLVAALLAVLKTGAAYLPLDPGHPAERLRLVMADAEPVAVVTDTAGSGRLPATDAQVVV
                     VDDTETMADLAGRAPHDLTDADRAGATDPYDTAYVIHTSGSTGRPKGVPVPHAHVVRLF
                     EASGEHFRFGADDVWTLFHSYAFDFSVWELWGPLLHGGRLVVVPYEVSRSPREFLRLLD
                     EEGVTVLNQTPSAFEQLVLADAETDRSAGSLRYVVLGGEPLVAERLRPWAGRHGLDAPE
                     LVNMYGITETTVHVTFHRLVRADLEDPRRRGVIGRPLADLRVYVLDTDGRPVPPGATGE
                     MYVSGPGVAPGYLNRPELTEERFLPDPYGTPGTRMYRSGDLARWRPDGTLVHAGRADQQ
                     VKIRGFRIEPGEIEAVLTAHPAVAGGAVVPRTAEDGLTQLVAYAVPAGEGPADPAGLRA
                     HLAARLPAYMVPAACVLVDALPLTANGKLDTAALPAPDFGGVTDGAPPTTPEERLVCGL
                     FEEVLRLPADSVGTGGNFFDLGGHSLLATRLLARLRERTGTDVPISALFDTPTPAALAE
                     RLAAGPDAGRPLPALTASERPSLVPASFAQERMWFLSRMDGAAATYNIPLPVPLRHPLD
                     LDALRAALGDVADRHESLRTVFGEENGAIHQRVLPPGTLRPELHVVDCPDEERAAHVAA
                     AMGRSFDLTRDSALWAGVFGTGDTRTLLLVLHHSAADGWSLRPLADDLGTAYAARRAGA
                     APDWVPPALQYADFALWQRRVLAPAPEGPGRLERLTSFWRQALGGLPEESAPPPDRPRP
                     AAPSGRGGGVTVPLDAGTHRELLRLADHENASLFMVLHGALALLLNRWGAGEDIVVGTP
                     VAGRSEPALDEVVGLLTNTLVLRADASGDPTFRELLARVRAFDVQALDHQDLPFDRLVD
                     EMNPRRHPARHPLFQVMLALQNNERAVLTLGENRVPLRPAATGTAKFDLFVDVLERHDA
                     DGTADGLDLHVEYAADLYAPATAERFAGALRDLLAMVCADPEVRPGALPRAERPSPAAA
                     DTTALAGALARSVLEVPGVGDAVVLPGPDGEPATVYVVPNRTGAVDRTEQVVSSVAPGT
                     RVVAVSGLPRTAEGSLDDGALRDLPVVDAVAAGAWRERLAHLPGVREAEVVLEEVPEEL
                     GRRHAGRPRPVGAEAGQDAPSVRRPAAVPALSEGPALPEPSVSGWAEALLRAADRPDGE
                     VVHVRADGSETRRSYASLIPEASRVLAGLRRRGLRPGDRVILQCEDTEDFVATLWGCVL
                     GGFVAVPLTVPVSYATTSAAVSKLEGIWEMLDRPWIVTSAAGEPGLRELAARREWSGLR
                     LTTADALREEPEDRDWYEARPDDLVLMLMTSGSTGLPKAVRLTHRNVLTRAAATEAMNG
                     LGSGDVSLNWIPLDHVTGVVMFHLRDVYLGCRQIHAPTSWILEDPVRWPELADRHRVSV
                     TWAPNFAFGLLAEQARRFHDRDWDLSPMRLVMNAGEVVVASAARRFLHVLAPFGMPQDV
                     MHPGWGMSETCSVVTDSVLASEAPDHDEAFVSCGLPYPGFAMRVVDDQDALLSEGEVGR
                     LQVRGTSVTRGYHDNERANAESFTEDGWFDTGDLAFLREGELYITGRAKDVIIVNGVNH
                     YSHEIEACVEELPSVVRSFTAAVAVRSDASASTDELALFLRLAPGQDPAGALREIAGKV
                     TREIGVSPAFLIPVEADTIPKTEIGKIQRTKLRKSFEAGDFDGAVRETQLLLGTAATLP
                     DWFLHPVWRRAENLHGATLPTGHRVLVLASPAPHAHAVAGEIAAAVRDADGLCTVVTQG
                     PAPERNGAAAYRVRPGEAGDLAAVLERLDADGRTPDTVVHLAAAAGAEDGAAPGSDVSL
                     LLLAQALAGRTGGDRPVDLLFVTAGAQAVTPEDRPTLSHAAAGALLKSLREELPWLRGV
                     HLDLSGGGAGDQAAAVLAEAAGFPADTEVARRDGLRYVRRLVPLPDPAPRTAPVPADGF
                     HLVSGGLGGVGSEVAAHLLKEPGTRLLLIGRTGLPPEDTWQRHLADAGPASARIEAFRR
                     LRRLGEVRYETADVTDAAQVRAAVRRAADAWGVPLVSVLHLAGALDERPVRELTPQDWR
                     EALAAKVDGAWTLHRVAADHPVASFVTFSSVNGFFGGAMNAAYSAANAALDDLAVRRRR
                     EGLPGQSLAWSMWRERGMSLGYQLTSLTEARGYRVLDTQAALRSFDLARTLDLPHLLIG
                     ADRTAPWVRSHVLAPVRQVRRTAARVVLDEGTDLGALYRAAARAAGPEGTFVLRSAGSA
                     DRSEDTGGADEMRRLEGELAAVWCTVLGRDRVGRDENFFDLGGNSLLLVAAQTAVNKTL
                     GCDLGVVDLFSRPTVRALARHLSQQGAAAAPRHAASGPVSDDPAPPPSGLERAKQQAER
                     QRAARSARRSAQQRKDRRHG"
     aSDomain        2546..3427
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnC_Condensation_Starter.1"
                     /domain_subtypes="Condensation_Starter"
                     /evalue="1.90E-101"
                     /label="spnC_Condensation_Starter.1"
                     /locus_tag="spnC"
                     /protein_end="301"
                     /protein_start="7"
                     /score="331.2"
                     /tool="antismash"
                     /translation="RRPLSGAQEGLWYAHRLAPGTAAYNTGEYVEIHGPLDTAVFETAL
                     RRTVREADTFALRFLDTPDGPRAVRDGDPDEMPVHRVDVSGAADPAAAAEEWIRRDLAT
                     PVDVAAGPLFSHALLTLAPDRFIWFLRAHHILLDGYSYKLVARRLADTYTALAAGEEPP
                     PAGFESSDRLAAEEAAYLGSDRHQRDRAYWTERLAGLPEPARLTDRTAPPRAPFLRRTA
                     VLSPAETRALDEAAKGMGVARTDLLVAAVAAFLHRMTGADDLVLGLATMSRLGSAALRT
                     PGTASDILPLRIA"
     aSModule        2546..5680
                     /complete
                     /domains="nrpspksdomains_spnC_Condensation_Starter.1"
                     /domains="nrpspksdomains_spnC_AMP-binding.1"
                     /domains="nrpspksdomains_spnC_PCP.1"
                     /locus_tags="spnC"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       2558..2587
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0001"
                     /evalue="1.50E+01"
                     /label="C1_LCL_004-017"
                     /locus_tag="spnC"
                     /protein_end="21"
                     /protein_start="11"
                     /score="-0.1"
                     /tool="antismash"
                     /translation="SGAQEGLWYA"
     CDS_motif       2609..2728
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0002"
                     /evalue="3.70E-17"
                     /label="C2_starter_024-063"
                     /locus_tag="spnC"
                     /protein_end="68"
                     /protein_start="28"
                     /score="54.8"
                     /tool="antismash"
                     /translation="AAYNTGEYVEIHGPLDTAVFETALRRTVREADTFALRFLD"
     CDS_motif       2939..3004
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0003"
                     /evalue="7.90E-09"
                     /label="C3_starter_134-155"
                     /locus_tag="spnC"
                     /protein_end="160"
                     /protein_start="138"
                     /score="28.3"
                     /tool="antismash"
                     /translation="AHHILLDGYSYKLVARRLADTY"
     CDS_motif       3332..3421
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0004"
                     /evalue="1.20E-07"
                     /label="C5_starter_265-294"
                     /locus_tag="spnC"
                     /protein_end="299"
                     /protein_start="269"
                     /score="24.2"
                     /tool="antismash"
                     /translation="DLVLGLATMSRLGSAALRTPGTASDILPLR"
     CDS_motif       3473..3583
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0005"
                     /evalue="1.30E-13"
                     /label="C67_starter_14fromHMM"
                     /locus_tag="spnC"
                     /protein_end="353"
                     /protein_start="316"
                     /score="43.4"
                     /tool="antismash"
                     /translation="DDLRGLRTHQRYRGESIRRDLGVLGRGRRVHGPVVNI"
     aSDomain        3908..5149
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnC_AMP-binding.1"
                     /evalue="7.80E-113"
                     /label="spnC_AMP-binding.1"
                     /locus_tag="spnC"
                     /protein_end="875"
                     /protein_start="461"
                     /score="369.0"
                     /tool="antismash"
                     /translation="FEARVADGPGRTAVSYAGETLSYAELNAEANRLARLLVERGAGPG
                     RFVALALPRGLPLVAALLAVLKTGAAYLPLDPGHPAERLRLVMADAEPVAVVTDTAGSG
                     RLPATDAQVVVVDDTETMADLAGRAPHDLTDADRAGATDPYDTAYVIHTSGSTGRPKGV
                     PVPHAHVVRLFEASGEHFRFGADDVWTLFHSYAFDFSVWELWGPLLHGGRLVVVPYEVS
                     RSPREFLRLLDEEGVTVLNQTPSAFEQLVLADAETDRSAGSLRYVVLGGEPLVAERLRP
                     WAGRHGLDAPELVNMYGITETTVHVTFHRLVRADLEDPRRRGVIGRPLADLRVYVLDTD
                     GRPVPPGATGEMYVSGPGVAPGYLNRPELTEERFLPDPYGTPGTRMYRSGDLARWRPDG
                     TLVHAGRADQQVKIR"
     CDS_motif       4094..4135
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0006"
                     /evalue="6.20E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="spnC"
                     /protein_end="537"
                     /protein_start="523"
                     /score="16.3"
                     /tool="antismash"
                     /translation="LAVLKTGAAYLPLD"
     CDS_motif       4349..4408
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0007"
                     /evalue="1.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="spnC"
                     /protein_end="628"
                     /protein_start="608"
                     /score="26.7"
                     /tool="antismash"
                     /translation="AYVIHTSGSTGRPKGVPVPH"
     CDS_motif       4940..5029
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0008"
                     /evalue="4.10E-16"
                     /label="NRPS-A_a6"
                     /locus_tag="spnC"
                     /protein_end="835"
                     /protein_start="805"
                     /score="51.1"
                     /tool="antismash"
                     /translation="PPGATGEMYVSGPGVAPGYLNRPELTEERF"
     CDS_motif       5117..5179
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0009"
                     /evalue="2.40E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="spnC"
                     /protein_end="885"
                     /protein_start="864"
                     /score="35.6"
                     /tool="antismash"
                     /translation="AGRADQQVKIRGFRIEPGEIE"
     CDS_motif       5336..5416
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0010"
                     /evalue="1.10E+01"
                     /label="C2_DCL_024-062"
                     /locus_tag="spnC"
                     /protein_end="964"
                     /protein_start="937"
                     /score="-1.6"
                     /tool="antismash"
                     /translation="AYMVPAACVLVDALPLTANGKLDTAAL"
     aSDomain        5471..5680
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnC_PCP.1"
                     /evalue="5.20E-22"
                     /label="spnC_PCP.1"
                     /locus_tag="spnC"
                     /protein_end="1052"
                     /protein_start="982"
                     /score="69.7"
                     /tool="antismash"
                     /translation="ERLVCGLFEEVLRLPADSVGTGGNFFDLGGHSLLATRLLARLRER
                     TGTDVPISALFDTPTPAALAERLAA"
     aSDomain        5738..6631
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnC_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="2.10E-94"
                     /label="spnC_Condensation_LCL.1"
                     /locus_tag="spnC"
                     /protein_end="1369"
                     /protein_start="1071"
                     /score="307.7"
                     /tool="antismash"
                     /translation="VPASFAQERMWFLSRMDGAAATYNIPLPVPLRHPLDLDALRAALG
                     DVADRHESLRTVFGEENGAIHQRVLPPGTLRPELHVVDCPDEERAAHVAAAMGRSFDLT
                     RDSALWAGVFGTGDTRTLLLVLHHSAADGWSLRPLADDLGTAYAARRAGAAPDWVPPAL
                     QYADFALWQRRVLAPAPEGPGRLERLTSFWRQALGGLPEESAPPPDRPRPAAPSGRGGG
                     VTVPLDAGTHRELLRLADHENASLFMVLHGALALLLNRWGAGEDIVVGTPVAGRSEPAL
                     DEVVGLLTNTLVLRADA"
     CDS_motif       5747..5776
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0011"
                     /evalue="7.90E-03"
                     /label="C1_LCL_004-017"
                     /locus_tag="spnC"
                     /protein_end="1084"
                     /protein_start="1074"
                     /score="9.0"
                     /tool="antismash"
                     /translation="SFAQERMWFL"
     CDS_motif       5798..5911
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0012"
                     /evalue="4.10E-14"
                     /label="C2_LCL_024-062"
                     /locus_tag="spnC"
                     /protein_end="1129"
                     /protein_start="1091"
                     /score="44.9"
                     /tool="antismash"
                     /translation="ATYNIPLPVPLRHPLDLDALRAALGDVADRHESLRTVF"
     CDS_motif       6113..6178
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0013"
                     /evalue="6.60E-08"
                     /label="C3_LCL_132-143"
                     /locus_tag="spnC"
                     /protein_end="1218"
                     /protein_start="1196"
                     /score="25.1"
                     /tool="antismash"
                     /translation="LHHSAADGWSLRPLADDLGTAY"
     CDS_motif       6227..6265
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0014"
                     /evalue="1.30E-05"
                     /label="C4_LCL_164-176"
                     /locus_tag="spnC"
                     /protein_end="1247"
                     /protein_start="1234"
                     /score="17.7"
                     /tool="antismash"
                     /translation="QYADFALWQRRVL"
     CDS_motif       6533..6622
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0015"
                     /evalue="5.40E-13"
                     /label="C5_LCL_267-296"
                     /locus_tag="spnC"
                     /protein_end="1366"
                     /protein_start="1336"
                     /score="41.3"
                     /tool="antismash"
                     /translation="DIVVGTPVAGRSEPALDEVVGLLTNTLVLR"
     CDS_motif       6683..6790
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0016"
                     /evalue="4.20E-16"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="spnC"
                     /protein_end="1422"
                     /protein_start="1386"
                     /score="51.3"
                     /tool="antismash"
                     /translation="VQALDHQDLPFDRLVDEMNPRRHPARHPLFQVMLAL"
     aSDomain        7655..8887
                     /aSDomain="CAL_domain"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnC_CAL_domain.1"
                     /evalue="1.40E-84"
                     /label="spnC_CAL_domain.1"
                     /locus_tag="spnC"
                     /protein_end="2121"
                     /protein_start="1710"
                     /score="275.7"
                     /tool="antismash"
                     /translation="SYASLIPEASRVLAGLRRRGLRPGDRVILQCEDTEDFVATLWGCV
                     LGGFVAVPLTVPVSYATTSAAVSKLEGIWEMLDRPWIVTSAAGEPGLRELAARREWSGL
                     RLTTADALREEPEDRDWYEARPDDLVLMLMTSGSTGLPKAVRLTHRNVLTRAAATEAMN
                     GLGSGDVSLNWIPLDHVTGVVMFHLRDVYLGCRQIHAPTSWILEDPVRWPELADRHRVS
                     VTWAPNFAFGLLAEQARRFHDRDWDLSPMRLVMNAGEVVVASAARRFLHVLAPFGMPQD
                     VMHPGWGMSETCSVVTDSVLASEAPDHDEAFVSCGLPYPGFAMRVVDDQDALLSEGEVG
                     RLQVRGTSVTRGYHDNERANAESFTEDGWFDTGDLAFLREGELYITGRAKDVIIVNGVN
                     HYSHEIEACVEE"
     aSModule        7655..11053
                     /domains="nrpspksdomains_spnC_CAL_domain.1"
                     /domains="nrpspksdomains_spnC_PKS_KR.1"
                     /domains="nrpspksdomains_spnC_PCP.2"
                     /incomplete
                     /locus_tags="spnC"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     CDS_motif       7778..7816
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0017"
                     /evalue="3.30E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="spnC"
                     /protein_end="1764"
                     /protein_start="1751"
                     /score="-0.9"
                     /tool="antismash"
                     /translation="WGCVLGGFVAVPL"
     CDS_motif       8048..8101
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0018"
                     /evalue="1.80E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="spnC"
                     /protein_end="1859"
                     /protein_start="1841"
                     /score="14.5"
                     /tool="antismash"
                     /translation="MLMTSGSTGLPKAVRLTH"
     CDS_motif       8663..8746
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0019"
                     /evalue="7.40E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="spnC"
                     /protein_end="2074"
                     /protein_start="2046"
                     /score="21.6"
                     /tool="antismash"
                     /translation="GEVGRLQVRGTSVTRGYHDNERANAESF"
     CDS_motif       8810..8872
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0020"
                     /evalue="4.90E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="spnC"
                     /protein_end="2116"
                     /protein_start="2095"
                     /score="9.8"
                     /tool="antismash"
                     /translation="TGRAKDVIIVNGVNHYSHEIE"
     aSDomain        9914..10492
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnC_PKS_KR.1"
                     /evalue="2.00E-46"
                     /label="spnC_PKS_KR.1"
                     /locus_tag="spnC"
                     /protein_end="2656"
                     /protein_start="2463"
                     /score="150.0"
                     /tool="antismash"
                     /translation="FHLVSGGLGGVGSEVAAHLLKEPGTRLLLIGRTGLPPEDTWQRHL
                     ADAGPASARIEAFRRLRRLGEVRYETADVTDAAQVRAAVRRAADAWGVPLVSVLHLAGA
                     LDERPVRELTPQDWREALAAKVDGAWTLHRVAADHPVASFVTFSSVNGFFGGAMNAAYS
                     AANAALDDLAVRRRREGLPGQSLAWSMWRE"
     CDS_motif       9917..10012
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0021"
                     /evalue="1.90E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="spnC"
                     /protein_end="2496"
                     /protein_start="2464"
                     /score="23.7"
                     /tool="antismash"
                     /translation="HLVSGGLGGVGSEVAAHLLKEPGTRLLLIGRT"
     CDS_motif       10343..10444
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnC_0022"
                     /evalue="9.70E-09"
                     /label="PKSI-KR_m4"
                     /locus_tag="spnC"
                     /protein_end="2640"
                     /protein_start="2606"
                     /score="27.8"
                     /tool="antismash"
                     /translation="FVTFSSVNGFFGGAMNAAYSAANAALDDLAVRRR"
     aSDomain        10847..11053
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnC_PCP.2"
                     /evalue="2.60E-20"
                     /label="spnC_PCP.2"
                     /locus_tag="spnC"
                     /protein_end="2843"
                     /protein_start="2774"
                     /score="64.3"
                     /tool="antismash"
                     /translation="EGELAAVWCTVLGRDRVGRDENFFDLGGNSLLLVAAQTAVNKTLG
                     CDLGVVDLFSRPTVRALARHLSQQ"
     gene            11211..15032
                     /gene="spnD"
     CDS             11211..15032
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (14-444). E-value:
                     7.6e-154. Score: 504.5. Matches aSDomain:
                     nrpspksdomains_spnD_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (543-825). E-value: 1.1e-80.
                     Score: 263.0. Matches aSDomain:
                     nrpspksdomains_spnD_PKS_AT.1"
                     /NRPS_PKS="Domain: PCP (925-989). E-value: 5.7e-18. Score:
                     56.8. Matches aSDomain: nrpspksdomains_spnD_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (1016-1258). E-value:
                     2.3e-36. Score: 118.2. Matches aSDomain:
                     nrpspksdomains_spnD_Thioesterase.1"
                     /codon_start=1
                     /gene="spnD"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 232.1; E-value: 2.4e-70)"
                     /gene_kind="biosynthetic"
                     /note="PKS (KS-AT-ACP-TE)"
                     /product="PKS"
                     /protein_id="AKA54627.1"
                     /sec_met_domain="hyb_KS (E-value: 1.8e-154, bitscore:
                     504.7, seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 3.2e-81, bitscore: 263.0,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.7e-14, bitscore:
                     44.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDDPQALPEDEAPAVAVIGMAARFPGADDVDAFWDNLARGHESVR
                     PVSDEEFLAAGGDPEDLDDPSLIRMASVIEGIDRFDSGFFGYSPAEAAVVDPQQRLLLE
                     TAYHALEDAGHLGEDTPSGTTGVYAGSGDSRYYPAHVHPRFAGQPGSVALVHAATANSL
                     GTLATRVSYELGLTGPSLSLQTACSTGLVALHTAFQDLVEYRCDTALAAAVSLNPSAHL
                     GYRHVPDGPFSPDGHCRTFADDAAGTSSGDGVGAVVLKRLEDALTDGDRIRAVVRATAV
                     NNDGRRKVGFTAPSTQGQTEVVLAAQAQAGIDADTIGLVEAHGTATRIGDPIEVAALTE
                     AFRQSTDRRGYCALGSVKTNIGHLGAAAGMAGLVKAVLALEHRRIPPSLHFDRPNPLID
                     FASGPFRVPTTLEEWPQEAGHPRRAAVSAFGVGGTNAHVILEEAPPVAPAPPRPSEEGR
                     RLVLPVSARTSGALRGQAHALARRLEERPGLRLDDVAGALRADRPALRHRLTVSASSVP
                     EAVEALRAAVPAVPPVPDEPPKVAFLLPGGGTQYVGMGSGLYRENDVYRDTVDRCAAVL
                     RPALGSDLRTALFEEVEPGSTAAFMALFVTEYALARTLMEEGVRPDALIGHSLGEYTAA
                     CLAGVMEIDEALPVVAERIRLIASSGGATVGVAACADTVLPLLGEGLSLAAVNSPVACT
                     VAGDTDAVDRLEAELTRRGVPFRRLRMPAAAHSHVLDPILESFAGHLRTLTLRPPRIPY
                     VTNVTGDWATDAQATDVGHWVDHTRRTVRFADGIAALWERERPVLVEIGPGDSLTKLAR
                     ARLDGEGPVTVTTMRHAKAQAADGFVLAEALGRLWSAGVDAALPHVPRPPRGAGRVPLP
                     GYAFERHRHWIDAPGARAPEESGTRPKTPAPGGGTGLAPRPHLATAHVAPSTPRERAVA
                     ELWEESLGIGGIGVHDNFFDLGGDSMRAVLLVGRLRQKGVLDVPAASLLAAPTVAGLLA
                     AGEPAEGAVAGPGALAPLLPLRAEGGRRPLFCVHPGAGVSWRYSGLLPHLGADQPVFGL
                     QAAGLDGTGQPARDAREMVEGYLDLVRTVQPSGPYRLLGWSYGGFVAHAMACALQERGE
                     EVELLALLDAPLPHGSAHNPSTAERQVAGLLSRVAGLPADEAGPPGVEDVLDRVGEAHA
                     AGSSPVSRDEAASIAAVMRNNLRIAPEFTPGVFRGDALFFSATRDLVPAADARDLSLAA
                     GKADAWRPYVRGAFEDHAVPCGHYDMTEPDPIARIGEVVAKALRPASG"
     aSDomain        11253..12542
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnD_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="7.60E-154"
                     /label="spnD_PKS_KS.1"
                     /locus_tag="spnD"
                     /protein_end="444"
                     /protein_start="14"
                     /score="504.5"
                     /tool="antismash"
                     /translation="VAVIGMAARFPGADDVDAFWDNLARGHESVRPVSDEEFLAAGGDP
                     EDLDDPSLIRMASVIEGIDRFDSGFFGYSPAEAAVVDPQQRLLLETAYHALEDAGHLGE
                     DTPSGTTGVYAGSGDSRYYPAHVHPRFAGQPGSVALVHAATANSLGTLATRVSYELGLT
                     GPSLSLQTACSTGLVALHTAFQDLVEYRCDTALAAAVSLNPSAHLGYRHVPDGPFSPDG
                     HCRTFADDAAGTSSGDGVGAVVLKRLEDALTDGDRIRAVVRATAVNNDGRRKVGFTAPS
                     TQGQTEVVLAAQAQAGIDADTIGLVEAHGTATRIGDPIEVAALTEAFRQSTDRRGYCAL
                     GSVKTNIGHLGAAAGMAGLVKAVLALEHRRIPPSLHFDRPNPLIDFASGPFRVPTTLEE
                     WPQEAGHPRRAAVSAFGVGGTNAHVILEEAP"
     aSModule        11253..14984
                     /complete
                     /domains="nrpspksdomains_spnD_PKS_KS.1"
                     /domains="nrpspksdomains_spnD_PKS_AT.1"
                     /domains="nrpspksdomains_spnD_PCP.1"
                     /domains="nrpspksdomains_spnD_Thioesterase.1"
                     /final_module
                     /locus_tags="spnD"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       11742..11789
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnD_0001"
                     /evalue="1.20E-04"
                     /label="PKSI-KS_m3"
                     /locus_tag="spnD"
                     /protein_end="193"
                     /protein_start="177"
                     /score="14.5"
                     /tool="antismash"
                     /translation="GPSLSLQTACSTGLVA"
     CDS_motif       12168..12212
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnD_0002"
                     /evalue="1.30E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="spnD"
                     /protein_end="334"
                     /protein_start="319"
                     /score="11.3"
                     /tool="antismash"
                     /translation="VEAHGTATRIGDPIE"
     CDS_motif       12273..12317
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnD_0003"
                     /evalue="2.10E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="spnD"
                     /protein_end="369"
                     /protein_start="354"
                     /score="10.7"
                     /tool="antismash"
                     /translation="GSVKTNIGHLGAAAG"
     CDS_motif       12834..12887
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnD_0004"
                     /evalue="1.60E-03"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="spnD"
                     /protein_end="559"
                     /protein_start="541"
                     /score="11.3"
                     /tool="antismash"
                     /translation="FLLPGGGTQYVGMGSGLY"
     aSDomain        12840..13685
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnD_PKS_AT.1"
                     /evalue="1.10E-80"
                     /label="spnD_PKS_AT.1"
                     /locus_tag="spnD"
                     /protein_end="825"
                     /protein_start="543"
                     /score="263.0"
                     /tool="antismash"
                     /translation="LPGGGTQYVGMGSGLYRENDVYRDTVDRCAAVLRPALGSDLRTAL
                     FEEVEPGSTAAFMALFVTEYALARTLMEEGVRPDALIGHSLGEYTAACLAGVMEIDEAL
                     PVVAERIRLIASSGGATVGVAACADTVLPLLGEGLSLAAVNSPVACTVAGDTDAVDRLE
                     AELTRRGVPFRRLRMPAAAHSHVLDPILESFAGHLRTLTLRPPRIPYVTNVTGDWATDA
                     QATDVGHWVDHTRRTVRFADGIAALWERERPVLVEIGPGDSLTKLARARLDGEGPVTVT
                     T"
     CDS_motif       13062..13181
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnD_0005"
                     /evalue="2.90E-21"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="spnD"
                     /protein_end="657"
                     /protein_start="617"
                     /score="67.7"
                     /tool="antismash"
                     /translation="GVRPDALIGHSLGEYTAACLAGVMEIDEALPVVAERIRLI"
     aSDomain        13986..14177
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnD_PCP.1"
                     /evalue="5.70E-18"
                     /label="spnD_PCP.1"
                     /locus_tag="spnD"
                     /protein_end="989"
                     /protein_start="925"
                     /score="56.8"
                     /tool="antismash"
                     /translation="ERAVAELWEESLGIGGIGVHDNFFDLGGDSMRAVLLVGRLRQKGV
                     LDVPAASLLAAPTVAGLLA"
     aSDomain        14259..14984
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnD_Thioesterase.1"
                     /evalue="2.30E-36"
                     /label="spnD_Thioesterase.1"
                     /locus_tag="spnD"
                     /protein_end="1258"
                     /protein_start="1016"
                     /score="118.2"
                     /tool="antismash"
                     /translation="RPLFCVHPGAGVSWRYSGLLPHLGADQPVFGLQAAGLDGTGQPAR
                     DAREMVEGYLDLVRTVQPSGPYRLLGWSYGGFVAHAMACALQERGEEVELLALLDAPLP
                     HGSAHNPSTAERQVAGLLSRVAGLPADEAGPPGVEDVLDRVGEAHAAGSSPVSRDEAAS
                     IAAVMRNNLRIAPEFTPGVFRGDALFFSATRDLVPAADARDLSLAAGKADAWRPYVRGA
                     FEDHAVPCGHYDMTEPDPIA"
     CDS_motif       14262..14291
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnD_0006"
                     /evalue="2.60E-03"
                     /label="NRPS-beforete1"
                     /locus_tag="spnD"
                     /protein_end="1027"
                     /protein_start="1017"
                     /score="10.8"
                     /tool="antismash"
                     /translation="PLFCVHPGAG"
     CDS_motif       14442..14516
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnD_0007"
                     /evalue="1.80E-13"
                     /label="NRPS-te1"
                     /locus_tag="spnD"
                     /protein_end="1102"
                     /protein_start="1077"
                     /score="42.7"
                     /tool="antismash"
                     /translation="QPSGPYRLLGWSYGGFVAHAMACAL"
     gene            15088..16308
                     /gene="spnE"
     CDS             15088..16308
                     /NRPS_PKS="Domain: PKS_ER (42-393). E-value: 6.5e-19.
                     Score: 60.0. Matches aSDomain:
                     nrpspksdomains_spnE_PKS_ER.1"
                     /codon_start=1
                     /gene="spnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 279.5; E-value: 5.8e-85)"
                     /gene_kind="biosynthetic-additional"
                     /product="crotonyl-CoA reductive carboxylase"
                     /protein_id="AKA54628.1"
                     /sec_met_domain="ADH_N (E-value: 2.8e-11, bitscore: 33.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.5e-22, bitscore:
                     68.6, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKDLYELGDAPPLGTAPKQMYASLIRQERYGRPVDAFRTEVVDV
                     PPVGPGQVLVKVMAAGVNYNNVWAALGEPLDVIAARQKQGATEDFHIGGSDLSGIVWAV
                     GEGVSLKPGAEVVVLACRWDESAQDIRLGADPVTSSTQRVWGYEENYGSFAQFAVVDEY
                     MCHPKPQRLSWAAASCYMATAATAYRQLFGWEPHTVRPGDPVLIWGGAGGLGSIAIQLV
                     RHVGGIPVAVVSSEERGEFCVRLGAKGWIDRREFDHWGRLPDTTDEEAMKKWLDGARAF
                     GRRFWEVLGERRAPRIVLEHSGADTIPTSIYMADNAGMVVICGGTTGYNGDVDLRFLWM
                     RQKRLQGSHVASAREAREITRLIDQGAIDPCLSRTFGFEEIGLAHQLIHDNQHPSGNMA
                     VLVNATE"
     aSDomain        15214..16266
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnE_PKS_ER.1"
                     /evalue="6.50E-19"
                     /label="spnE_PKS_ER.1"
                     /locus_tag="spnE"
                     /protein_end="393"
                     /protein_start="42"
                     /score="60.0"
                     /tool="antismash"
                     /translation="VDVPPVGPGQVLVKVMAAGVNYNNVWAALGEPLDVIAARQKQGAT
                     EDFHIGGSDLSGIVWAVGEGVSLKPGAEVVVLACRWDESAQDIRLGADPVTSSTQRVWG
                     YEENYGSFAQFAVVDEYMCHPKPQRLSWAAASCYMATAATAYRQLFGWEPHTVRPGDPV
                     LIWGGAGGLGSIAIQLVRHVGGIPVAVVSSEERGEFCVRLGAKGWIDRREFDHWGRLPD
                     TTDEEAMKKWLDGARAFGRRFWEVLGERRAPRIVLEHSGADTIPTSIYMADNAGMVVIC
                     GGTTGYNGDVDLRFLWMRQKRLQGSHVASAREAREITRLIDQGAIDPCLSRTFGFEEIG
                     LAHQLIHDNQH"
     CDS_motif       15691..15750
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnE_0001"
                     /evalue="9.20E-05"
                     /label="PKSI-ER_m5"
                     /locus_tag="spnE"
                     /protein_end="221"
                     /protein_start="201"
                     /score="15.1"
                     /tool="antismash"
                     /translation="GDPVLIWGGAGGLGSIAIQL"
     CDS_motif       15916..15984
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnE_0002"
                     /evalue="7.60E-01"
                     /label="PKSI-KR_m1"
                     /locus_tag="spnE"
                     /protein_end="299"
                     /protein_start="276"
                     /score="2.6"
                     /tool="antismash"
                     /translation="GARAFGRRFWEVLGERRAPRIVL"
     CDS             complement(16412..16753)
                     /codon_start=1
                     /note="3"
                     /product="transposase"
                     /protein_id="AKA54629.1"
                     /transl_table=11
                     /translation="MLVLQFVEGLTDRQAAEAARARVDWKYALGLELTDTGFDYAVPAG
                     AGGPAAGVGPALPPGRWRGGAPWPKRPAVGRDAPGQASSTNSPARRSASSASTSGSPAH
                     STLEPVPAT"
     gene            complement(16923..18209)
                     /gene="spnF"
     CDS             complement(16923..18209)
                     /NRPS_PKS="Domain: AMP-binding (2-338). E-value: 2.2e-72.
                     Score: 235.7. Matches aSDomain:
                     nrpspksdomains_spnF_AMP-binding.1"
                     /codon_start=1
                     /gene="spnF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     325.8; E-value: 6.3e-99)"
                     /gene_kind="biosynthetic-additional"
                     /product="AMP dependent CoA-ligase"
                     /protein_id="AKA54630.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-88, bitscore:
                     287.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESYFALARLGALFVPLNHSLAVPEVAGIIERVGAVAVLGESALL
                     DRHTSLPASVRIRVPLDKPVFEALGTVDEPVELPEVADTDPVAILHTSATTGQAKGVTV
                     DGGSFRAIALGWLVLARPTDDIVMVNCCPLYHGSMVVSLTYMAAGATIVLMPGFTPQRA
                     LAAVEENRATHMWMVPQMVRFMLQAKGSRSTDLGSLREILYGAAPMPLDVYAEAVERLG
                     CGFRQVYGMTEVGGPFVTLGPDEHPEPGDVAARIPCGRVVPGMSARAVGQDGQEVPRGE
                     IGEIVVRGPGVMQGYWNDPEATEEVTADGWVLTGDLGFVDESGRIHLVDRSKDVIIRAG
                     QNVYPSEIERALTAHPDVRDAAVVGVPDEDYGEVPLAYVVVEEGTTTATLLAHVRENLA
                     PYKRPRSFEFIERVPRNPAGKILKKALRT"
     CDS_motif       complement(17049..17081)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnF_0003"
                     /evalue="1.80E+01"
                     /label="NRPS-A_a3"
                     /locus_tag="spnF"
                     /protein_end="387"
                     /protein_start="376"
                     /score="-0.7"
                     /tool="antismash"
                     /translation="AYVVVEEGTTT"
     aSDomain        complement(17196..18203)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnF_AMP-binding.1"
                     /evalue="2.20E-72"
                     /label="spnF_AMP-binding.1"
                     /locus_tag="spnF"
                     /protein_end="338"
                     /protein_start="2"
                     /score="235.7"
                     /tool="antismash"
                     /translation="SYFALARLGALFVPLNHSLAVPEVAGIIERVGAVAVLGESALLDR
                     HTSLPASVRIRVPLDKPVFEALGTVDEPVELPEVADTDPVAILHTSATTGQAKGVTVDG
                     GSFRAIALGWLVLARPTDDIVMVNCCPLYHGSMVVSLTYMAAGATIVLMPGFTPQRALA
                     AVEENRATHMWMVPQMVRFMLQAKGSRSTDLGSLREILYGAAPMPLDVYAEAVERLGCG
                     FRQVYGMTEVGGPFVTLGPDEHPEPGDVAARIPCGRVVPGMSARAVGQDGQEVPRGEIG
                     EIVVRGPGVMQGYWNDPEATEEVTADGWVLTGDLGFVDESGRIHLVDRSKDVIIR"
     CDS_motif       complement(17292..17378)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnF_0002"
                     /evalue="1.40E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="spnF"
                     /protein_end="306"
                     /protein_start="277"
                     /score="39.8"
                     /tool="antismash"
                     /translation="PRGEIGEIVVRGPGVMQGYWNDPEATEEV"
     CDS_motif       complement(17898..17945)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnF_0001"
                     /evalue="1.40E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="spnF"
                     /protein_end="104"
                     /protein_start="88"
                     /score="11.8"
                     /tool="antismash"
                     /translation="ILHTSATTGQAKGVTV"
     gene            complement(18401..18649)
                     /gene="spnG"
     CDS             complement(18401..18649)
                     /NRPS_PKS="Domain: PP-binding (2-69). E-value: 3.4e-13.
                     Score: 41.9. Matches aSDomain:
                     nrpspksdomains_spnG_PP-binding.1"
                     /codon_start=1
                     /gene="spnG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="ACP"
                     /protein_id="AKA54631.1"
                     /sec_met_domain="PP-binding (E-value: 9.6e-14, bitscore:
                     41.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTIRELLVELTGTTEYAETLGDDVDLAGSGIDSGDLVRLVLLVE
                     QRTGVEITGDDMEELRTIADYERFVAERTTAGTAGGA"
     aSDomain        complement(18443..18643)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnG_PP-binding.1"
                     /evalue="3.40E-13"
                     /label="spnG_PP-binding.1"
                     /locus_tag="spnG"
                     /protein_end="69"
                     /protein_start="2"
                     /score="41.9"
                     /tool="antismash"
                     /translation="TIRELLVELTGTTEYAETLGDDVDLAGSGIDSGDLVRLVLLVEQR
                     TGVEITGDDMEELRTIADYERF"
     gene            18950..20005
                     /gene="spnH"
     CDS             18950..20005
                     /codon_start=1
                     /gene="spnH"
                     /product="phenylacetate-CoA oxygenase PaaA"
                     /protein_id="AKA54632.1"
                     /transl_table=11
                     /translation="MSGAPARATASPAADAEAASQARLTAEFEALLAEGETVEPRDWMP
                     DGYRRMLIRQIAQHAHSEIIGMQPEGAWLTRAPSLHRKSVLLAKVQDEAGHGLYLYSAA
                     ETLGVDRAELLAALHRGQQRYAATFNHPALTWADTGAVAWLTDGAAVINQAPLCHTSYG
                     PYARAMRRVCQEEAFHVRQGYDLMKALCEGTPAQKAMAQDAVDRWWLPAVALMFGPPDT
                     EAAGGDARTAALGAAVSRRAIAWGIKRHTNDELRQRFVDHCVPQAKRLGLTLPDPGIRW
                     NEERGHYDFGPVDWELYRGALGDDTHTARQRLAHRVAAHEDGAWVREAAAAYAARQSGE
                     DTAGTSTEAVA"
     gene            20110..20304
                     /gene="spnI"
     CDS             20110..20304
                     /codon_start=1
                     /gene="spnI"
                     /product="phenylacetate-CoA oxygenase PaaB"
                     /protein_id="AKA54633.1"
                     /transl_table=11
                     /translation="MALSHARDLYTRRGEPLSLWVVRSDTVYAASPGERDPFFSNAPHK
                     PYRYPEEFVPLSEGGEVDD"
     gene            20297..21085
                     /gene="spnJ"
     CDS             20297..21085
                     /codon_start=1
                     /gene="spnJ"
                     /product="phenylacetate-CoA oxygenase PaaC"
                     /protein_id="AKA54634.1"
                     /transl_table=11
                     /translation="MTETATGPARQGTDAALARYAVRLGDDALVLAQQLCGWITRAPTI
                     EEDLALSNIALDLVGHARTLLALGGRLDGTGRTEDDFAFLRTEREFTNALLVEIPDGDF
                     AGTVARQLAYTHHAVLLYEALAASTDPELAAFAVRAAKEVAYHRRHADDWVVRLGLGTA
                     ESARRMRAGLERVWPCTAELFEEDALVRGLTAAGAVPAPGPLRERWHEEVAAVLERAGL
                     PLPAPTWHAAGGRDGLHTEAFGPLVAELQSVHRQFPGGTW"
     gene            21178..21600
                     /gene="spnK"
     CDS             21178..21600
                     /codon_start=1
                     /gene="spnK"
                     /product="phenylacetate-CoA oxygenase PaaD"
                     /protein_id="AKA54635.1"
                     /transl_table=11
                     /translation="MIGLGDLGVVESVEVAADGNLEVAILPTFLGCPALPAITASVREV
                     LVRCGHPEGRVRHVLAPAWSSDRISERGRTALAAHGIAPPAPSDAPEPVRLGLGTPCPY
                     CGSLATRPHSAFGPARCQSMLHCAGCRETFPLMTAM"
     gene            21612..22715
                     /gene="spnL"
     CDS             21612..22715
                     /codon_start=1
                     /gene="spnL"
                     /gene_functions="other (smcogs) SMCOG1094:ferredoxin
                     (Score: 216.6; E-value: 7.1e-66)"
                     /gene_kind="other"
                     /product="phenylacetate-CoA oxygenase PaaE"
                     /protein_id="AKA54636.1"
                     /transl_table=11
                     /translation="MDTAVPRAAQTAPPRNSWYPLPVTLLDRLTEDTVAITLEVPDGLR
                     ERFVHRPGAHVVVRHRTGGRELRRSYSVCPPPEDPAALRLVVKRNTSDGFGAHALERLA
                     AGDLLEVGPPAGHFGLPPVRGAHHLLIAGGCGITPLAPMAAAALREDPTCRVSLVHAAR
                     TARGALLADEMAVLKDAYVDRFTALYVLSRERRETELFSGRIDAGRLTRLLTLLGARPG
                     PATRFAVCGPYGLVETVRSTLDGWGAEPDTVRFELFSTDGAPPEPEAEAPAVRRGRITT
                     VLAGRTGTVTTAPEDTTLLDTVLRSRPDAPYACRDGVCGNCRAKVVRGAVTLGRQHALD
                     AADLAAGYTLACRARPRTDDVTLDFDA"
     gene            22750..23526
                     /gene="spnM"
     CDS             22750..23526
                     /NRPS_PKS="Domain: PKS_KR (10-189). E-value: 1.1e-10.
                     Score: 33.6. Matches aSDomain:
                     nrpspksdomains_spnM_PKS_KR.1"
                     /codon_start=1
                     /gene="spnM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     223.4; E-value: 5.5e-68)"
                     /gene_kind="biosynthetic-additional"
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="AKA54637.1"
                     /sec_met_domain="adh_short (E-value: 6.2e-33, bitscore:
                     104.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTQRHQGRTALVTGGSRGIGRAISRRLAAEGALVAVHYGHDHA
                     AAERTVKEIEADGGRAFAVHTELGVPGDAATLWAAFDEALSGTGSGPGLDILVNNAGIT
                     LPRPIAAVTEEEYDRVFAVNTRAPFFIVQRSLERLRDGGRIISISSAATHTAYPAIVAY
                     SMSKGALDVLTPALAKQLGPRGITVNTVAPGFTETEINPTLSNPEIRKALSSASVFDRL
                     GAPADIADVVSFVASDEARWVTGQWIDASGGVGLGL"
     aSDomain        22780..23316
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_spnM_PKS_KR.1"
                     /evalue="1.10E-10"
                     /label="spnM_PKS_KR.1"
                     /locus_tag="spnM"
                     /protein_end="189"
                     /protein_start="10"
                     /score="33.6"
                     /tool="antismash"
                     /translation="TALVTGGSRGIGRAISRRLAAEGALVAVHYGHDHAAAERTVKEIE
                     ADGGRAFAVHTELGVPGDAATLWAAFDEALSGTGSGPGLDILVNNAGITLPRPIAAVTE
                     EEYDRVFAVNTRAPFFIVQRSLERLRDGGRIISISSAATHTAYPAIVAYSMSKGALDVL
                     TPALAKQLGPRGITVN"
     CDS_motif       22786..22851
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_spnM_0001"
                     /evalue="1.80E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="spnM"
                     /protein_end="34"
                     /protein_start="12"
                     /score="20.6"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAISRRLAAEGA"
     gene            23573..24421
                     /gene="spnN"
     CDS             23573..24421
                     /codon_start=1
                     /gene="spnN"
                     /product="tryptophan 2,3-dioxygenase"
                     /protein_id="AKA54638.1"
                     /transl_table=11
                     /translation="MNDGPSALAELAEDTTLTRPFSGASPYEEYVHASVLNTLQQPLTE
                     AADEMGFLVTTQVMELWFTLIVHEWRTAREAFVKDDLPAALDALTRSRRALSALNDSWQ
                     PIAALTPLQFEGFRAAFGRASGFQSAMYRHIEFLLGEKSEALVNAHRGDPAVHEALRDA
                     HREPPLYDEVLCFLHRQGLPVPAHVRERDVSLSYTSDPAVVELWRGVYAGSPYEAPALL
                     AEALTDIAELVARWRFDHLMVVRRAMGAKPGSGGTAGLAYLEQRARRVVFPELWEARGA
                     L"
     gene            24603..25280
                     /gene="spnO"
     CDS             24603..25280
                     /codon_start=1
                     /gene="spnO"
                     /product="esterase"
                     /protein_id="AKA54639.1"
                     /transl_table=11
                     /translation="MHLTPFAAYLAGQGLSTMLPGFRRSGGAGGYPETFDDVARLVDTL
                     PGGRPYILAGHCSGGHLALWCAARGLLPPGSPWHTSTLPTSVLALAPLTDLAATRRDGL
                     SDDAALQLMGGEEGFAAHMASVDPLTLLSDAGTTGVPTVLLHGEVDEEVPLTQFSDYAA
                     VHHDLRTVVLPGTGHYTLIEPGAPAAREVADTLWRMAREQRGAGATVGPTDTRAKAKGA
                     GLA"
ORIGIN
        1 tcaggcggcg gtgggctgcc atgcctcctg gaagcggcgg cgggcccggt ggagccggga
       61 gcggaccgtg ccgacgggga gggcgagggt ctcggccatc tccacctcgt tcaggccgta
      121 cacgcgaagg gtcagcacct gtcggtgggc ctcggacatg cggtccagga cgtcgttgat
      181 gtggacggcg tcgagcgagt ggggctcgtg ccgcgagtcc acctcggggc tcgtcgtctc
      241 gcggcccagg cgcctggccg tgcgcaccgc ctcccgcacg gtgaccgagc ggacccagcc
      301 gtagaaggca gcgggctccc gcaggcccgg caggccgcgg tagatcgcga ggagcgcctc
      361 ctgccgggcg tcggagccgt tgtcgtgggc gaccgagcgg cagacgcggg tgacgtaggg
      421 ggtgatgtgc agcagcaggt cgttcatcgc ctgctcgtcg cccgccctcg cccgcggcag
      481 caaccggtcc acgggggcgg gcagttcgtg cgcggtgttc atgggggtgc tctccttgcg
      541 gggaggacgg tgcgggcggg ccgggcgggc ggtccgcggt cagccggcgg tgaccggtgc
      601 cggggctgtg tcctcggtga aggccagcag cgcggtgcgg acgtcgtcgc ggaaggcccg
      661 catgtactgc ggggtgaagc aggccgtgtg gtgcgggagt tcgacggcga gctggttgtc
      721 gaaggagacg acgcaggcca tgaccgggct gcggccggcc tgggggaagt acgactcgcg
      781 agccgggacg aggcggacgt cggtggcttc gaggccctcg gggaagcggg gggcggccgt
      841 ggcgcccatg ttggtcacga tgaccgagcc catctgcagg gtggggtggg ccgggaccct
      901 cggcatgatg cgcatctcgt ggaagtggtc gccgcgctcg acggactccc gcaggcggct
      961 gctgatcttc cgggcgaggt ccagcgggtc ggtctcccca ccgaccggga cggcctggag
     1021 gtgggaggtc acggaggcca ccatcacgga cggtgagacg ggcggggtga gccgcgcacg
     1081 caggtcgacg ggcgacatgc agcccagggt ccgcggaccg tcgccgtcca ggcgcgcgcg
     1141 ggcagccgtc atcagggcgg cggcgaccag gccgtgcacc gagacgcccg cgtcgcgggc
     1201 ggcggagcgc agccgggtgg tctcctcggc gccgaggacc aggcggcgga cctcgatgcg
     1261 gtgctccgac gggtcggcgg gccggtcgcg gggggtgtcg taggcgagga gctcgaccgg
     1321 gtgggcgctc gtctcctcga tgcggcgccg gaggtacttc tcggtgtcct cggcgtcggc
     1381 cgggggcagc agctcactga cgggcctggg ccagtccccc tcggcgacgg ggacgggcgg
     1441 agtctgcgcc gggacggtcc cgacgagatc gctgtagcgg tcccagagcg cgttcatgag
     1501 ggtgatggcg ctgtgtccgt cggtgacggt gtggtcgatc gtcacggtca ggaggcgggt
     1561 ttccggcccg gtggtgacca gggccgcgcg gctgagcggt ccgcccaccg gaagcgggac
     1621 gttcagttcc tcgatgtacg cctcgtcccc gccctccttg aggatcaggc gcgggcgctc
     1681 gtcctccggg aggagttcca gggcgtggcc cccttctgcg gggacgatgc gggagcggag
     1741 ggtggggtgc tccgtcgtga gggcgtcgaa agcgctcgcc agcgccgagg agtcgatgtc
     1801 cccgcgcagg gcacaggaca ggaacgccct gctccgctgg gctacataga ggttttccac
     1861 gggacacagc gcgcgtcgca tttggcagcc cttccagccg tcaccgcacg gtccgcaccc
     1921 gcacggatgg cggttctcca cattgagtgc ggagcccctg ccacgcctca taccgagagg
     1981 gaacagcgaa aggccccgat cttgacatca ccctatgggc cacgcgttta gggattcacc
     2041 taagaacgac cgggcgtcgc accggacggc cgggcagggg agatgagcga ccggcagcct
     2101 cgctgctcag agcatgcacg acgcggatcc gtcgtggaga cgggcaggac ttcccgggaa
     2161 tccgacccca cggttcccga cagctcgtgg agtggccggc aggcgcttgc agacgctcac
     2221 gacgagtgtc gcgcagaaac tcaaggggcc cattccctcc ttgaattcca ggccaccggc
     2281 cgactcttcc tctttttctc ccgccgcttt cccaaacctc tccggacgca catcacagca
     2341 ccctctaggt atttccctgg aatgggccgc cgattgccgt ccgcgcttgc tccgcccgac
     2401 cgggcgaggg cagggtgagc cggggcacgg cccgcgacga ccggacgggg ctcctgcctc
     2461 cgggccgccg cgctcgccct gaccccccgt gagaagtacc tgctcgcaac cgagggttgg
     2521 tgtcatgtct ggcaacgagg acgatcgtcg gccgctttcc ggagcgcagg aggggctctg
     2581 gtacgcccat cggctcgcgc ccggcaccgc cgcctacaac accggtgagt acgtcgagat
     2641 ccacgggccc ctcgacaccg ccgtcttcga gacggcgctg cggcggaccg tccgcgaggc
     2701 cgacaccttc gccctgcgct tcctcgacac gcccgacgga ccgcgtgccg tgcgggacgg
     2761 cgatccggac gagatgccgg tgcaccgggt ggacgtcagt ggtgcggcgg acccggcggc
     2821 cgccgccgag gagtggatac gccgggatct ggcgactccg gtggacgtgg cggcgggacc
     2881 gctcttctcg cacgccctgc tgacgctcgc cccggaccgg ttcatctggt tcctgcgcgc
     2941 ccaccacatc ctgctggacg gctacagcta caagctggtg gcgcgccgtc tggccgacac
     3001 ctacacggcg ctggccgccg gggaggaacc gccgcccgcc ggcttcgagt cctcggaccg
     3061 cctcgccgcc gaggaggccg cctacctcgg ctccgaccgc catcagcgcg accgcgcgta
     3121 ctggacggag cggctggcgg ggctgccgga gccggcgcgg ctcaccgacc gcaccgcgcc
     3181 gcccagggct ccgttcctgc gccgcacggc ggtcctctcc cccgccgaga cgcgggccct
     3241 ggacgaggcc gccaagggga tgggggtcgc gcggaccgat ctgctggtcg ccgccgtcgc
     3301 cgccttcctg caccggatga ccggcgccga cgatctggtc ctcgggctcg ccacgatgag
     3361 ccggctgggc agcgcggcgc tgcgtacccc cggtacggcc tcggacatcc tgccgctgcg
     3421 gatcgcggcc tcggcggaca cgccggtcgg cctgttcgtc cgggcggtcg cggacgacct
     3481 gcgcgggctg cgtacccacc agcgctaccg cggtgagtcg atccgccgcg acctcggcgt
     3541 gctgggccgt ggccgccgtg tgcacggacc ggtcgtcaac atcgtcccct tcagcgagga
     3601 cctcaccttc ggcgggcacc cctcgacctc ccaccacctc tcgggcgggg ccgtcgacga
     3661 cctccagatc tcggtgcggc ccggcgcgga ggcggacacc gtctggctgg ccttcgacgc
     3721 ccaccccgac ctgtacgagg aggacggact cgccctgttc ctggagcggt tcctcaaggt
     3781 cctgcgcgaa ctgcggaccg cccccgagga gctgccgctg ggtgagactc ccgtgctgct
     3841 gcccggcgag gagcccgtcc gccgggacga gcccgcaccc cgcgtgacgc gcaccctccc
     3901 ccagctcttc gaggcccgcg tcgccgacgg ccccggccgc accgccgtgt cctacgccgg
     3961 ggagacgctg agctacgcgg aactgaacgc ggaggccaac cggctggccc ggctgctcgt
     4021 cgagcggggg gcgggacccg gccggttcgt cgccctggcc ctgccccggg gcctgccgct
     4081 cgtcgccgcg ctgctcgccg tcctcaagac gggcgccgcg taccttccgc tggaccccgg
     4141 gcaccccgcc gagcggctga ggctggtcat ggcggacgcg gagcccgtcg ccgtcgtcac
     4201 cgacaccgcc ggatcgggac ggctgcccgc gacggacgcg caggtcgtgg tggtcgacga
     4261 cacggagacc atggcagacc tggcgggccg cgcgccgcac gacctgacgg acgcggaccg
     4321 cgcgggcgcg accgacccct acgacaccgc ctacgtcatc cacacctccg gctcgacggg
     4381 gcgccccaag ggcgtgccgg tgccgcacgc ccacgtggtg cggctcttcg aggcgtccgg
     4441 ggagcacttc cgtttcggcg cggacgacgt gtggacgctg ttccactcgt acgccttcga
     4501 cttctcggtg tgggagctgt ggggcccgct gctgcacggc gggcggctgg tcgtggtgcc
     4561 ctacgaggtg agccgttcgc cccgggagtt cctgcggctg ctcgacgagg agggggtgac
     4621 ggtcctcaac cagacgccgt ccgccttcga gcagctggtc ctggcggacg ccgagacgga
     4681 ccgttccgcg ggctccctgc ggtacgtggt cctcggcggg gagccgctcg tggcggagcg
     4741 gctgcgcccg tgggccggcc ggcacggcct ggacgcgccg gagctggtca acatgtacgg
     4801 catcaccgag acgacggtgc acgtgacctt ccaccggctg gtccgtgccg acctggagga
     4861 cccgcgccgc cgcggcgtca tcggccggcc cctggccgac ctgcgggtgt acgtcctgga
     4921 cacggacggc cggccggtgc cgcccggggc gaccggcgag atgtacgtgt ccgggccggg
     4981 ggtggcgccc ggttacctga accggccgga gctgacggag gagcggttcc tgccggaccc
     5041 ctacggaacg ccgggcaccc ggatgtaccg ttccggcgac ctggcccggt ggcggcccga
     5101 cggcaccctc gtccacgcgg gccgcgccga ccagcaggtc aagatccgcg gcttccgtat
     5161 cgagccgggc gagatcgagg ccgtgctcac cgcccacccg gcggtcgccg gcggcgcggt
     5221 cgtcccacgc accgctgagg acggcctgac ccagctcgtc gcctacgcgg tgcccgccgg
     5281 ggagggcccg gctgaccccg ccgggttgcg ggcccacctg gcggcgcggc tgcccgccta
     5341 catggtcccc gcagcctgcg tgctcgtcga cgcgcttccc ctgaccgcca acggcaagct
     5401 cgacacggcg gccctgcccg cccccgactt cggcggcgtc acggacggtg ccccgcccac
     5461 gacgcccgag gagcgcctgg tgtgcggcct gttcgaggag gtgctgcggc tgcccgcgga
     5521 ctccgtcggc accggcggca acttcttcga cctcggcggc cactcgctgc tcgcgacccg
     5581 gctgctggcc cggctgaggg aacggaccgg cacggacgtc ccgatctcgg cgctcttcga
     5641 cacgccgacc ccggcggccc tggccgaacg cctcgccgcc ggaccggacg ccggccggcc
     5701 gctgcccgcg ctgacggcgt ccgagcgccc gtccctggtg cccgcctcct tcgcccagga
     5761 acgcatgtgg ttcctcagcc gcatggacgg cgcggcggcc acctacaaca ttcccctgcc
     5821 cgtccccctg cggcatccac tggacctgga cgcgctgcgc gccgccctgg gagacgtcgc
     5881 cgaccgccac gagagcctgc gcaccgtctt cggggaggag aacggtgcga tccaccagcg
     5941 ggtcctgcca cccggcacgc tccggcccga actgcacgtg gtggactgcc ccgacgagga
     6001 acgcgccgcg cacgtggccg cggcgatggg gcgctccttc gacctgacgc gtgacagcgc
     6061 gctgtgggcg ggggtgttcg gtaccggtga cacgcgcacc ctgctgctcg tgctgcacca
     6121 cagcgcggcc gacggctggt cgctgcgccc gctcgccgac gacctcggca ccgcctacgc
     6181 cgcgcgccgc gcgggtgcgg cgcctgactg ggtgccgccg gcccttcagt acgccgactt
     6241 cgcgctctgg cagcggcggg tgctcgcgcc cgccccggag gggccggggc ggctggagcg
     6301 gctgacctcg ttctggcgcc aggcgctggg cgggctgccc gaggagagtg cgccgccccc
     6361 ggaccgcccc cggccggcgg ccccatccgg gcgcggtggc ggcgtgaccg tgcccctgga
     6421 cgccgggacg caccgggagc tgctgcgcct ggcggaccac gagaacgcca gcctcttcat
     6481 ggtgctgcac ggtgcgctgg ccctgctgct gaaccggtgg ggcgcaggtg aggacatcgt
     6541 cgtcggcacc cctgtggccg gacgttccga gcccgcactc gacgaggtcg tcgggctgtt
     6601 gaccaacacc ctcgtgctgc gcgcggacgc ctcgggcgac cccaccttcc gcgaactcct
     6661 cgcccgcgtg agggcgttcg acgtgcaggc gctggaccac caggatctgc cgttcgaccg
     6721 gctggtcgac gagatgaacc cgcgccgcca ccctgcccgg catccgctgt tccaggtgat
     6781 gctggccctg cagaacaacg agcgggccgt gctcacgctc ggcgagaacc gggtgccgct
     6841 acgcccggcc gcgaccggca ccgccaagtt cgacctcttc gtcgacgtcc tggagcggca
     6901 cgacgcggac ggcaccgccg acgggctcga cctgcacgtc gagtacgcgg ccgacctcta
     6961 cgccccggcc accgccgaga ggttcgcggg cgcgctgcgc gacctgctgg ccatggtctg
     7021 cgccgacccc gaggtgcggc ccggcgccct gccgcgtgcg gagcgcccct cccctgccgc
     7081 cgcggacacc accgccctgg ccggggcgct ggcccgctcc gtcctggagg tgcccggggt
     7141 gggggacgcg gtcgtcctgc ctggtccgga cggggagccc gccacggtgt acgtggtgcc
     7201 gaaccggacc ggcgccgtcg accggaccga gcaggtggtc tcctccgtcg cgccgggaac
     7261 acgggtcgtc gcggtcagtg gactgccccg tacggccgag ggttccctgg acgacggcgc
     7321 gttgagggac cttcccgtcg tcgacgcggt ggcggcgggt gcctggcggg agcgactcgc
     7381 ccacctgccg ggcgtccgcg aggccgaggt ggtcctggag gaggtgcccg aggagctggg
     7441 gcgccgccac gcgggacgcc cccggcccgt cggggcggag gccgggcagg acgcgccgtc
     7501 cgtcaggcgt ccggcggccg tccccgcgct cagcgagggc cccgcgctgc ccgagccgtc
     7561 ggtctccggc tgggccgagg cgctgctccg cgccgcggac cgcccggacg gcgaggtcgt
     7621 gcacgtgcgc gcggacggct cggagacccg gcgttcgtac gcgagtctca tccccgaggc
     7681 ctcacgtgtc ctggcgggcc tgcgccgacg gggcctcagg ccgggtgacc gggtcatcct
     7741 ccagtgcgag gacaccgagg acttcgtcgc cacgctgtgg ggctgcgtcc tcggcggctt
     7801 cgtcgccgtc ccgctgacgg tgcccgtctc gtacgccacc acctcggccg ccgtcagcaa
     7861 gctcgaaggc atctgggaga tgctggaccg gccctggatc gtgacctcgg ccgccggtga
     7921 gccggggctg cgggagctgg ccgcccggcg cgagtggtcc gggctccggc tcaccacggc
     7981 cgacgcgctg cgcgaggagc ccgaggaccg cgactggtac gaggcccggc ccgacgacct
     8041 ggtcctgatg ctgatgacct cgggcagcac cggtctgccg aaggcggtgc ggctcaccca
     8101 ccgcaacgta ctgacccgag ccgcggccac cgaggcgatg aacgggctgg gctccggtga
     8161 cgtctccctg aactggatcc cgctcgacca cgtgaccggc gtggtcatgt tccacctgcg
     8221 cgacgtctac ctcggctgcc ggcagatcca cgcgccgacc tcctggatcc tggaggaccc
     8281 ggtgcgatgg ccggaactgg ccgaccgcca tcgcgtgagc gtcacctggg ccccgaactt
     8341 cgccttcggg ctcctcgccg agcaggcccg acgcttccac gaccgcgact gggacctctc
     8401 tcccatgcgg ctggtgatga acgccggcga ggtggtcgtg gcctccgcgg cacgacggtt
     8461 cctgcacgtc ctcgcgccgt tcggcatgcc ccaggacgtc atgcacccgg gctggggcat
     8521 gtcggagacc tgctcggtgg tgaccgacag cgtgctggcc tccgaggcgc cggaccacga
     8581 cgaggcgttc gtcagctgcg gcctgcccta tcccggattc gccatgcgcg tcgtcgacga
     8641 ccaggacgcg ctcctgtcgg agggcgaggt gggccggctc caggtccgcg gcacctcggt
     8701 gacacgcggc taccacgaca acgagcgggc caacgccgag tcgttcaccg aggacggctg
     8761 gttcgacacc ggcgacctgg cgttcctgcg cgagggcgag ctgtacatca ccgggcgcgc
     8821 caaggacgtc atcatcgtca acggcgtcaa ccactacagc cacgagatcg aggcctgcgt
     8881 cgaggaactg cccagcgtcg tgcggagctt cacggccgcg gtcgccgtcc ggtccgacgc
     8941 gtcggcatcc accgacgaac tggcgctctt cctccgtctg gcccccggcc aggacccggc
     9001 cggtgcgctc cgtgagatcg ccggcaaggt cacccgggag atcggggtga gccccgcgtt
     9061 cctgatcccc gtcgaggccg acaccatccc gaagacggag atcggcaaga tccagcggac
     9121 caagctgcgc aagtccttcg aggcgggcga cttcgacggc gccgtccgcg agacgcagct
     9181 gttgctcggc acggccgcca ccctgcctga ctggttcctg cacccggtgt ggcggcgcgc
     9241 cgagaacctg cacggggcca ctcttccgac gggccaccgc gtcctcgtcc tcgccagtcc
     9301 cgcgcctcac gcccacgcgg tggccgggga gatcgccgcg gcggtgcgcg acgccgacgg
     9361 actgtgcacg gtcgtcactc agggcccggc ccccgagcgg aacggcgcgg ccgcctaccg
     9421 cgtacgtccc ggcgaggccg gggacctcgc ggcggtgctg gagaggctgg acgcggacgg
     9481 gcgtacgccg gacaccgtgg tgcacctcgc cgcggcggcc ggcgcggaag acggcgcggc
     9541 ccccggaagc gacgtgtcgc tgctgctgct ggcacaggca ctcgccggcc ggaccggcgg
     9601 cgaccggccg gtggacctgc tgttcgtgac cgccggcgcc caggccgtga cgcccgagga
     9661 ccggcccacg ctctcgcacg ccgcggccgg ggcactgctc aagtcgctgc gcgaggagct
     9721 gccgtggctg cgcggcgtcc acctcgacct ctccggcggg ggcgccgggg accaggcggc
     9781 ggcagtgctg gcggaggcgg ccgggttccc ggccgacacc gaggtcgccc ggcgcgacgg
     9841 cctgaggtac gtgcggcggc tggtcccgct gcccgacccg gcgccccgga ccgcacccgt
     9901 cccggccgac ggcttccacc tggtcagcgg tggtctcggc ggcgtcggca gcgaggtggc
     9961 cgcacacctg ctgaaggagc ccggcacacg gctgctgctc atcggccgca ccgggctgcc
    10021 ccccgaggac acctggcagc ggcacctggc ggacgcgggg cccgcctcgg cccgtatcga
    10081 ggcgttccgc cggctgcgac ggctcggcga ggtccgttac gagaccgccg acgtcaccga
    10141 cgccgcgcag gtgcgggcgg ccgtgcggcg ggccgccgac gcctggggcg tcccgctggt
    10201 gtcggtgctg cacctggccg gcgccctcga cgagcggccg gtgcgggaac tcaccccgca
    10261 ggactggcgt gaggcgctcg cggccaaggt cgacggggcg tggaccctgc accgggtcgc
    10321 cgccgaccac ccggtcgcct cgttcgtcac cttctcctcc gtcaacgggt tcttcggcgg
    10381 cgcgatgaac gcggcctact cggcggccaa cgcggcgctg gacgacctcg ccgtccggcg
    10441 ccggcgcgag ggcctgccgg gacagagcct cgcctggagc atgtggcgcg agcgggggat
    10501 gagcctcggc taccagctca cctcgctcac cgaggcgcgc ggctaccggg tgctggacac
    10561 ccaggcggca ctgcgctcct tcgacctcgc gcgcacgctg gacctcccgc acctgctcat
    10621 cggcgccgac cgcaccgccc cctgggtgcg ctcgcacgtc ctcgcaccgg tacggcaggt
    10681 acggcgcacg gccgcccggg tcgtcctcga cgagggcacc gatctgggcg ccctgtaccg
    10741 cgcggccgcg cgggcggccg gaccggaggg cacgttcgtc ctgcggtcgg ccggctccgc
    10801 cgaccggagc gaggacaccg gcggcgccga cgagatgcgc cggctggagg gcgagctggc
    10861 cgcggtgtgg tgcacggtcc tgggccgcga ccgggtgggg cgggacgaga acttcttcga
    10921 cctgggcggc aactcactgc tgctcgtggc ggcgcagacc gcggtcaaca agaccctcgg
    10981 gtgcgatctg ggcgtcgtgg acctcttctc ccgtcccacc gtgcgggccc tcgcccggca
    11041 cctgtcccag cagggggcgg cggccgcgcc acggcacgcc gcgtccgggc cggtctcgga
    11101 cgaccccgct cccccgccct ccgggctgga gcgggccaag cagcaggcag agcggcaacg
    11161 ggcggcgcgg agcgcccgcc ggtccgcgca gcagaggaag gaccgacgcc atggatgacc
    11221 cgcaggccct gccggaggac gaggcgcccg ccgtcgccgt gatcggcatg gcggcgcgct
    11281 tccccggcgc cgacgacgtc gacgcgttct gggacaatct cgccaggggg cacgagtccg
    11341 tacggccggt cagcgacgag gagttcctcg cggccggcgg tgacccggag gacctcgacg
    11401 acccgtccct gatccggatg gcgtcggtga tcgagggcat cgaccgcttc gactcgggct
    11461 tcttcgggta cagcccggcc gaggcggcgg tcgtcgatcc gcagcagcgg ttgctgctgg
    11521 agacggccta ccacgcgctg gaggacgcgg ggcacctcgg cgaggacacc ccgtccggca
    11581 cgaccggggt gtacgcgggc agcggcgaca gccgctacta ccccgcgcac gtgcaccccc
    11641 ggttcgccgg gcagcccggc tcggtggccc tggtccacgc ggccaccgcc aactcgctgg
    11701 gcacgctcgc cacccgggtc tcctacgagc tgggcctgac cgggccgagc ctgtcgctcc
    11761 agaccgcctg ctccaccggg ctggtcgcgc tgcacaccgc cttccaggat ctcgtcgagt
    11821 accgctgcga cacggcactg gcggcggcgg tctcgctgaa tccctcggcc cacctcggct
    11881 accgccacgt gcccgacggc ccgttctccc ccgacgggca ctgccgtacc ttcgccgacg
    11941 acgcggcggg cacctcgtcc ggcgacggcg tgggcgcggt ggtcctcaag cggctggagg
    12001 acgcactgac cgacggggac cgcatccggg ccgtcgtccg cgccacggcc gtcaacaacg
    12061 acggccgacg caaggtcggc ttcaccgcgc cgagcacgca gggccagacg gaggtggtgc
    12121 tcgccgcgca ggcgcaggcc gggatcgacg cggacaccat cggtctggtc gaggcgcacg
    12181 gcaccgccac ccgcatcggc gaccccatcg aggtggcggc gctcaccgag gcgttccgcc
    12241 agagcaccga ccggcgcggc tactgcgccc tcggctcggt caagaccaac atcgggcacc
    12301 tgggcgcggc ggcgggaatg gccgggctcg tcaaggcggt gctcgcgctg gagcaccgcc
    12361 ggatcccgcc gagcctgcac ttcgaccggc cgaacccgct gatcgacttc gcctccggcc
    12421 cgttccgcgt gccgaccacg ctggaggagt ggccgcagga ggccggtcat ccccggcgtg
    12481 ccgcggtcag cgccttcggg gtcggcggca ccaacgcgca cgtgatcctg gaggaggctc
    12541 caccggtcgc accggccccg ccgcgcccct cggaggaggg ccgccggctc gtcctgccgg
    12601 tgtcggcgcg gacctcgggg gcgttgcggg ggcaggccca cgccctagcg cgccggctgg
    12661 aggagcggcc cgggctccgg ctggacgacg tggcgggcgc gctgcgcgcc gaccggcccg
    12721 ccctgcggca ccgtctcacc gtgtcggctt cttcggtgcc ggaggcggtg gaagcactgc
    12781 gcgcggcggt gcccgccgtg ccgccggtgc ccgacgagcc gccgaaggtg gcgttcctgc
    12841 tgccgggcgg cggcacccag tacgtcggca tgggcagtgg gctgtaccgg gagaacgacg
    12901 tgtaccggga caccgtggac cggtgtgccg cggtcctgcg gccggcactc ggctcggacc
    12961 tgcgcaccgc cctgttcgag gaggtggagc cgggcagcac ggccgccttc atggcgctgt
    13021 tcgtcaccga gtacgcgctg gcccgcaccc tgatggagga gggggtccgg cccgacgccc
    13081 tgatcgggca ctcgctgggc gagtacaccg ccgcctgtct ggccggggtg atggagatcg
    13141 acgaggcgct gccggtggtg gccgagcgca tccggctcat cgcctcctcg ggcggagcca
    13201 ccgtcggcgt cgcggcctgt gccgacaccg tcctcccgct gctgggcgag gggctgtcgc
    13261 tggcggcggt caacagcccg gtggcgtgca cggtcgccgg cgacaccgac gcggtcgacc
    13321 ggctggaggc ggaactgacc cgccgcggcg tgccgttccg ccgcctgcgc atgcccgccg
    13381 ccgcccactc gcacgtgctc gacccgatcc tggagagctt cgccggtcac ctgcgcacgc
    13441 tgacactacg gccgcctcgc attccctacg tcacgaacgt gacgggcgac tgggccactg
    13501 acgcgcaggc gacggatgtc ggtcactggg tggaccacac ccggcgcacc gtccggttcg
    13561 ccgacggcat cgcggcgctg tgggaacggg agcggccggt cctcgtcgag atcggccccg
    13621 gcgacagcct caccaagctg gcgcgggcgc ggctcgacgg cgagggcccg gtgaccgtga
    13681 cgaccatgcg gcacgccaag gcgcaggcgg cggacggctt cgtactggcc gaggcgctgg
    13741 ggcggctgtg gagcgccggt gtggacgccg cgctcccgca cgtcccgcgg ccgccgcgcg
    13801 gcgcggggcg ggtgccgctg cccgggtacg ccttcgagcg ccaccgccac tggatcgacg
    13861 cacccggggc gcgcgccccg gaggagtccg gcacccggcc caagacgccg gccccgggcg
    13921 ggggcaccgg gctcgcgccg cgtccgcacc tggcgaccgc ccacgtggct cccagcaccc
    13981 cgcgcgagcg ggcggtggcc gaactgtggg aggagtccct cgggatcggt ggcatcgggg
    14041 tccacgacaa cttcttcgac ctgggcggcg actcgatgcg cgccgtgctc ctggtggggc
    14101 ggctgcggca gaagggtgtg ctggacgtgc cggccgcctc cctgctggcc gctccgacgg
    14161 tggcgggcct gctcgccgcc ggcgagcccg ccgagggcgc cgtcgccggg ccgggcgcgc
    14221 tggcgccgct gctgcccctg cgtgccgagg gcggccggcg gcccctgttc tgcgtgcacc
    14281 cgggcgccgg agtctcctgg cggtactccg ggctgctgcc acatctcggc gcggaccagc
    14341 cggtgttcgg cctccaggcc gccggtctgg acggcaccgg gcagccggcc cgcgacgccc
    14401 gggagatggt cgagggctat ctcgacctcg tccgcacggt ccagccgagc ggcccgtacc
    14461 ggctcctggg ctggtcgtac ggcggtttcg tcgcccacgc gatggcgtgc gccctgcagg
    14521 agcggggtga ggaggtcgag ttgctggcgc tgctcgacgc gccgctcccg cacgggagcg
    14581 cgcacaaccc gagcaccgcg gagaggcagg tcgcgggcct gctgtcgcgg gtggcggggc
    14641 tgccggccga cgaggccggc ccgcccggtg tcgaggacgt gctcgaccgg gtcggtgagg
    14701 cccacgccgc cggctcctca cccgtctccc gcgacgaggc ggcctccatc gccgccgtga
    14761 tgcgcaacaa ccttcggatc gcaccggagt tcacgcccgg tgtcttccgc ggcgacgcgt
    14821 tgttcttcag cgccacgcgg gacctggtcc cggccgccga tgcccgagac ctgtcgctcg
    14881 cggccggcaa ggccgacgcc tggcgcccgt acgtacgggg cgccttcgag gaccacgccg
    14941 tgccctgcgg ccactacgac atgaccgaac ccgacccgat cgcccgcatc ggcgaggtcg
    15001 tcgccaaggc cctccgcccg gcctccggct gacccggtgc cccggatccg acccgtccgc
    15061 cccgctccag aaggactccc cgtgaccgtg accaaggacc tctacgaact cggcgacgcg
    15121 ccgcccctcg gcaccgcgcc gaagcagatg tacgcctccc tgatccgcca ggaacgctac
    15181 ggccggcccg tcgacgcctt ccgcaccgag gtggtggacg taccgcccgt gggccccggg
    15241 caggtgctcg tcaaggtgat ggccgccggc gtcaactaca acaacgtgtg ggcggcgctc
    15301 ggtgagccgc tcgacgtgat cgcggcccgc cagaagcagg gtgccaccga ggacttccac
    15361 atcggcggct cggacctgtc gggcatcgtg tgggcggtcg gtgagggcgt gagcctcaag
    15421 cccggtgccg aggtggtcgt cctggcctgc cgctgggacg agtcggccca ggacatccgg
    15481 ctgggggccg acccggtcac ctcctccacg cagcgggtct gggggtacga ggagaactac
    15541 ggttctttcg cgcagttcgc cgtcgtcgac gagtacatgt gccacccgaa gccgcagcgg
    15601 ctctcgtggg cggcggcctc ctgctacatg gccaccgcgg cgaccgccta ccgccagctc
    15661 ttcggctggg agccgcacac cgtacggccc ggcgacccgg tcctgatctg gggcggcgcc
    15721 ggcggtctcg gcagtatcgc catccagctc gtgcgccatg tcggcgggat ccccgtggcc
    15781 gtggtctcca gcgaggagcg cggcgagttc tgcgtgcggc tcggggcgaa ggggtggatc
    15841 gaccggcgcg agttcgacca ctggggccgg ctgccggaca ccaccgacga ggaggcgatg
    15901 aagaagtggc tggacggcgc ccgcgccttc ggccgccgct tctgggaggt cctcggggaa
    15961 cgccgcgcac cgcgcatcgt cctggagcac tcgggtgccg acaccatccc gacctcgatc
    16021 tacatggccg acaacgcggg catggtcgtg atctgcggcg gcacgaccgg ctacaacggg
    16081 gacgtggacc tgcggttcct gtggatgcgg cagaagcgcc tgcagggctc gcacgtcgcc
    16141 agcgcccgtg aggcgcgcga gatcacgcgg ctgatcgacc agggcgcgat cgacccctgc
    16201 ctgtcgcgca ccttcggctt cgaggagatc gggctggccc accagctcat ccacgacaac
    16261 cagcacccct cgggcaacat ggcggtactg gtgaacgcca ccgagtagcg tcggtcggca
    16321 cgtgcgaggg ccggtacccc gagcgggatg ctgttggttg atccgggccc gtctgcttcg
    16381 ccccgtcgct gtgcggcggg gcgaagtgcc gtcaggtggc tggcacgggt tcgagcgtgg
    16441 agtgtgccgg tgagccagac gtcgatgcgg atgaggctga tcgccgcgcc ggtgagttgg
    16501 tgctggaggc ttgtccaggc gcgtcgcgcc cgacggccgg tcttttgggc cacggggcgc
    16561 cacctcgcca tcgaccgggt ggaagtgctg gacccacacc tgccgcagga cctccagctc
    16621 cggcagggac cgcgtagtcg aatcccgtgt ccgtgagttc caacccgagc gcgtacttcc
    16681 agtcgacacg ggcccgcgcc gcctccgcgg cctgccggtc ggtcagccct tccacgaact
    16741 gcagcaccaa caccagcgcc acccgaccgc atcgacacag acaccctccc caaacgacaa
    16801 cgtcggcccc cgagacacca acgggtctcg ggggccgacg tcacgcaagg gcccggattc
    16861 aacagtatcc cgagcggggt accgccctgt gtgtctcctg cggtggagcg gtaccggggc
    16921 gctcaggtgc gcagcgcctt cttcaggatc ttcccggcgg ggttgcgggg cacccgctcg
    16981 atgaactcga aggaccgggg ccgcttgtac ggagccaggt tctcgcggac gtgcgcgagc
    17041 agggtggccg tggtcgtccc ctcctcgacg acgacgtagg cgagcgggac ctcgccgtag
    17101 tcctcgtcgg gtacgccgac gacggccgcg tcgcggacgt ccggatgggc cgtcagggca
    17161 cgttcgatct ccgaggggta gacgttctgc ccggcccgga tgatgacgtc cttgctgcgg
    17221 tccaccagat ggatgcgtcc gctctcgtcg acgaagccca gatcgccggt gaggacccag
    17281 ccgtcggccg tgacctcctc ggtggcctcc gggtcgttcc agtacccctg catgacgccg
    17341 ggtccccgga cgacgatctc gccgatctcg ccgcgcggca cctcctgccc gtcctggccc
    17401 acggcgcggg cggacatgcc ggggacgacg cgtccgcagg ggatgcgcgc ggcgacgtcg
    17461 ccgggctcgg ggtgctcgtc cggacccagg gtgacgaagg gaccgccgac ctcggtcatg
    17521 ccgtacacct ggcggaagcc gcagccgagc cgttcgacgg cctccgcgta cacgtcgagc
    17581 ggcatgggcg cggcgccgta caggatctcc cgcagggagc cgaggtcggt gctgcgggag
    17641 cccttcgcct ggagcatgaa ccgcaccatc tgcgggacca tccacatgtg ggtggcccgg
    17701 ttctcctcca ccgcggcgag agcgcgctgc ggggtgaatc cgggcatcag cacgatggtg
    17761 gcgcccgcgg ccatgtaggt cagggagacg accatgctgc cgtggtagag cgggcagcag
    17821 ttgaccatca cgatgtcgtc cgtggggcgg gccaggacga gccagccgag ggcgatggcg
    17881 cggaaggagc cgccgtcgac ggtgacgccc ttggcctgtc cggtggtcgc ggaggtgtgc
    17941 aggatcgcga cggggtcggt gtcggcgacc tcgggcagtt cgacgggctc gtccaccgtg
    18001 ccgagcgcct cgaagacggg cttgtccagc ggcacccgga tgcgcacgga ggcgggcagc
    18061 gaggtgtgcc ggtcgagcag ggcggactcc ccgaggacgg cgacggcgcc gacccgctcg
    18121 atgatgccgg cgacctcggg gacggccaga ctgtggttga gcggcacgaa cagcgcgccg
    18181 agccgggcga gggcgaagta gctctccacc acctcgatcc ggtcctgggc gaggacggcg
    18241 acccggtcac cgcgccggat cccgagggcg gccaggcccc gggcgagttc gaccgtgcgg
    18301 tcgtggaact gggcccaggt gacgctacgc cgctcgtcga cgagggcggt gcggtcgggg
    18361 tggcactggc ggttgcgctc cgccaactgg gtcagccaca tcaggcaccg ccggccgtcc
    18421 cggccgtcgt gcgctcggcg acgaaccgct cgtagtcggc gatggtccgc agctcctcca
    18481 tgtcgtcccc ggtgatctcc actcccgtgc gctgttcgac caggaggacc aggcgcacca
    18541 ggtcgcccga gtcgatgccg ctgccggcca ggtcgacatc gtcaccgagg gtctcggcgt
    18601 actcggtggt gccggtgagt tcgaccagca actccctgat ggtgctcatg ccttctcctc
    18661 ttcgctcagc cgcggccgtc cgccggtccc ggccacacac gtgtgtgttg tcgcagagga
    18721 agaggcgcga gggggcggcg gcaatccccc gggcccgtgg tgacgctcgt cacgcggcgg
    18781 atcgggaggg cgagggatag cggaccgggg tggacgcctc ttccccgggt acgggggttc
    18841 cgcccttggc agcagaggat gtgatgcagg tgctcaggca gcgtgcgcag accgccgtcg
    18901 cggtccgcga caccggcccg gtgtggcccc ggcccgggac cggggccgta tgagcggcgc
    18961 accggcgcgg gcgacggcct ctccggccgc tgacgcagag gcggcgtcgc aggcccggct
    19021 caccgccgag ttcgaggcgc tgctcgccga gggcgagacg gtcgagcccc gggactggat
    19081 gccggacggc taccgccgca tgctgatccg gcagatcgcc cagcacgcgc actccgagat
    19141 catcggcatg cagccggagg gcgcctggct gacccgggca ccctcgctgc accggaagtc
    19201 cgtcctgctg gcgaaggtcc aggacgaggc gggccacggc ctgtacctgt actcggcggc
    19261 cgagacgctg ggcgtggacc gcgcggagtt gctggcggcc ctgcaccggg gccagcagcg
    19321 gtacgcggcg accttcaacc acccggcact gacctgggcc gacaccgggg ccgtcgcctg
    19381 gttgacggac ggcgccgcgg tgatcaacca ggcgccgctg tgccacacct cgtacgggcc
    19441 ctacgcgcgg gccatgcgcc gggtgtgcca ggaggaggcg ttccacgtgc ggcaggggta
    19501 cgacctgatg aaggccctct gtgagggcac gcccgcgcag aaggcgatgg cgcaggacgc
    19561 ggtggaccgc tggtggctgc cggcggtggc gctgatgttc gggccgccgg acacggaggc
    19621 ggccggcggc gacgcccgga cggccgcgct cggagcggcg gtctcccgcc gggccatcgc
    19681 gtggggcatc aagcggcaca ccaacgacga gctgcgccag cggttcgtcg accactgcgt
    19741 gccgcaggca aaacgcctcg gcctgaccct gcccgacccg ggcatccgct ggaacgagga
    19801 gcgcgggcac tacgacttcg gtcccgtcga ctgggagctg taccggggcg cgctgggcga
    19861 cgacacgcac accgcccggc agcggctggc ccaccgggtc gccgcgcacg aggacggcgc
    19921 gtgggtccgg gaggcggccg ccgcgtacgc ggcgcggcag tccggcgagg acacggcggg
    19981 cacgagcacg gaggcggtgg cgtgaacagg ccggcggagg gcgccccggc gtcctgggag
    20041 gtgttcctgc ggccccgccg cggactgtcc caccagcacg tgggttcggt gcgggcgagc
    20101 gaccccgaca tggcgctctc ccacgcccgc gacctgtaca cccggcgcgg cgagccgctg
    20161 tccctgtggg tcgtgcgctc ggacacggtg tacgcggcgt cgcccggtga acgcgacccg
    20221 ttcttcagca acgcgccgca caagccgtac cgctacccgg aggagttcgt accgctgtcg
    20281 gagggaggcg aggtcgatga ctgagacggc gaccgggccg gcccggcagg gtacggacgc
    20341 cgcgctggcg cggtacgcgg tgcggctcgg tgacgacgcg ctggtgctcg cgcagcagtt
    20401 gtgcgggtgg atcaccaggg cgccaaccat cgaggaggat ctggcgctct ccaacatcgc
    20461 gctcgacctg gtcggccatg cccggaccct gctggccctc ggcgggcgcc tggacggcac
    20521 cggccgtacc gaggacgact tcgcgttcct gcgcacggaa cgggagttca ccaacgcgct
    20581 gctcgtcgag atcccggacg gcgacttcgc cgggacggtg gcacggcagc tcgcctacac
    20641 ccaccacgcc gtgctcctgt acgaggccct ggccgcgagt acggacccgg agctggcggc
    20701 gttcgcggtc cgggcggcca aggaggtcgc ctaccaccgg cggcacgccg acgactgggt
    20761 cgtccggctg ggcctgggca ccgcggagag cgcgcggcgg atgcgggcgg ggctggagcg
    20821 ggtgtggccg tgcacggccg aactcttcga ggaggacgcg ctggtgcgcg ggctcaccgc
    20881 ggccggtgcc gtgcccgcac cgggcccgct gcgcgaacgc tggcacgagg aggtggcggc
    20941 cgtgctggag cgggccggtc tgccgctccc cgcgccgacg tggcacgccg ccggaggccg
    21001 cgacggcctg cacaccgagg cgttcggccc gctggtggcc gaactccagt cggtccaccg
    21061 gcagttcccg ggaggcacgt ggtgagcgtt ccctcgcacc cggaccgctc acctgccccg
    21121 ctgccgctgg cggaggtggc gcggcaggtg ggtgcggtgc ccgatccgga gctgccgatg
    21181 atcggcctcg gcgatctcgg ggtggtcgag tccgtggagg tcgcggccga cgggaacctc
    21241 gaagtggcga tcctgccgac ctttctgggc tgcccggccc tgcccgcgat caccgcctcc
    21301 gtgcgggagg tactggtgcg gtgcggtcac cccgagggcc gggtccggca cgtgctggcg
    21361 cccgcctgga gttcggaccg gatcagtgag cggggccgga ccgcgctggc cgcgcacggg
    21421 atcgcgccgc ccgcgccctc ggacgccccc gagcccgtac ggctcggtct cggtacgccc
    21481 tgcccgtact gcggttccct ggccacgcgt ccgcacagcg cgttcggccc cgcccgctgc
    21541 cagtcgatgc tccactgcgc cggctgccgg gagacctttc ccctcatgac ggcgatgtga
    21601 ggcgacaccc catggacact gcggtcccga gggcggcgca gacggcgccc ccgcgcaaca
    21661 gctggtaccc gctgccggtc accctgctcg accggctcac cgaggacacc gtcgcgatca
    21721 ccctggaggt tccggacggc ctgcgcgagc ggttcgtcca ccggcccggc gcccacgtcg
    21781 tcgtccggca ccggaccggc ggccgggaac tgcgccgcag ttactcggtg tgcccgccgc
    21841 ccgaggaccc ggcggcgctg cggctggtgg tcaagcgcaa cacctccgac ggtttcggcg
    21901 cgcacgccct ggaacggctc gcggccggtg acctcctgga ggtgggtccg cctgccggcc
    21961 acttcgggct gccgccggta cgcggcgcgc accacctgct gatcgccgga ggctgcggca
    22021 tcacgccgct ggctccgatg gcggcggccg cgttgcggga ggacccgacg tgccgggtct
    22081 ccctggtgca cgcggcgcgc accgcccggg gcgccctgct ggccgacgag atggccgtgc
    22141 tgaaggacgc gtacgtcgac cgcttcaccg cgctgtacgt gctctcccgc gaacggcgcg
    22201 agaccgagct gttcagcggc cggatcgacg ccggccggct gacgcggctg ctgaccctgc
    22261 tgggcgcccg gcccggcccc gcgacccggt tcgcggtgtg cggtccgtac ggcctggtgg
    22321 agacggtccg ctccacgctc gacgggtggg gggccgagcc ggacaccgtc cgtttcgagc
    22381 tgttctccac cgacggggcg ccgccggagc ccgaggccga ggcgcccgcc gtccgcaggg
    22441 gccggatcac caccgtgctc gccgggcgca ccggcacggt gacgacagcg ccggaggaca
    22501 ccacgctcct cgacaccgtg ctgcggtccc ggcccgacgc gccgtacgcc tgccgtgacg
    22561 gggtgtgcgg gaactgccgc gccaaggtcg tccggggggc cgtgaccctc ggccggcagc
    22621 acgcgctgga cgcggccgac ctcgcggcgg gctacaccct cgcgtgccgg gcccggccgc
    22681 gcaccgacga cgtgacgctc gacttcgacg cctgagcccc acttccacca cttccccgag
    22741 gagagtccca tgaccaccac ccagcgccac cagggcagaa ccgcactcgt caccggcggc
    22801 agccggggca tcggccgcgc catcagccgg cggctggccg ccgagggcgc cctggtcgcc
    22861 gtccactacg gccacgacca cgcggcggcc gagcggacgg tcaaggagat cgaggcggac
    22921 ggcggccgtg ccttcgccgt ccacaccgaa ctgggcgtgc ccggggacgc cgccacgctc
    22981 tgggcggcct tcgacgaggc gctgtcgggg acgggctccg ggccggggct ggacatcctg
    23041 gtcaacaacg ccggcatcac cctgccccgt cccatcgccg ccgtcaccga ggaggagtac
    23101 gaccgggtct tcgcggtgaa cacccgggcg ccgttcttca tcgtccagcg gtcgctggag
    23161 cggctgcgcg acggcggccg gatcatcagc atctcctccg ccgcgacgca caccgcctac
    23221 ccggcgatcg tcgcctactc gatgagcaag ggcgccctgg acgtgctcac gccggccctc
    23281 gccaagcagc tgggcccccg cggtatcacg gtcaacacgg tcgcgcccgg cttcaccgag
    23341 accgagatca acccgacgct gagcaacccg gagatccgca aagccctctc ctcggcgtcg
    23401 gtcttcgacc ggctcggcgc ccccgccgac atcgccgacg tcgtctcctt cgtggcgagc
    23461 gacgaggccc gctgggtcac cgggcagtgg atcgacgcct ccggcggtgt cggcctcggt
    23521 ctgtgaccgg ccgtccccgc gccccacacc ggtctgtccc taggagcccc cgatgaacga
    23581 cggcccgtcc gctctcgcgg aactcgccga ggacaccacg ctgacccgcc ccttctccgg
    23641 tgccagccct tacgaggagt acgtccacgc ctccgtcctc aacacgctgc aacagcccct
    23701 caccgaagcc gctgacgaga tgggattcct cgtcaccacg caggtgatgg agttgtggtt
    23761 caccctgatc gtccacgagt ggcgcacggc gcgcgaggcg ttcgtcaagg acgacctgcc
    23821 cgccgcgctc gacgccctga cccgcagccg gcgcgccctg tccgcgctca acgactcctg
    23881 gcagccgatc gccgcgctga cgcccctcca gttcgagggg ttccgggccg cgttcggccg
    23941 ggcctccggt ttccagtcgg cgatgtaccg gcacatcgag ttcctgctcg gcgagaagtc
    24001 ggaggccctg gtgaacgccc atcgcgggga cccggccgtc cacgaggcgc tgcgcgacgc
    24061 ccaccgcgag ccgcccctct acgacgaggt cctgtgcttc ctgcaccgcc agggcctgcc
    24121 cgtcccggcg cacgtccgcg aacgcgacgt gtccctctcc tacacctccg acccggccgt
    24181 ggtggaactg tggcgcggcg tctacgccgg atcgccgtac gaggcaccgg ccctgctcgc
    24241 ggaggcgctg accgacatcg ccgagttggt cgcccgctgg cggttcgacc acctgatggt
    24301 ggtgcgacgg gccatgggag ccaagcccgg cagcgggggc accgccggac tggcctacct
    24361 ggagcagcgc gcccggcgtg tggtcttccc cgagctgtgg gaggcacgcg gtgcgctcta
    24421 gggtcgtctc cgcgttcgcg gcggaggagg agaagcgtgt cctgagcctg aagccggtac
    24481 tggcgcctca ccacggcagg tacggcgacc acccgcacca ggtctatgac gcctggccgg
    24541 ccgaggaccc ggacgccccg ctggtgatcc tgctgcacgg cgggtactgg cggtacgacc
    24601 ggatgcatct gacgccgttc gccgcctacc tggccgggca ggggctctcc acgatgctcc
    24661 ccgggttccg caggtcgggc ggggcggggg gataccccga gaccttcgac gacgtcgccc
    24721 gtctcgtgga cacgctgccc ggggggcggc cgtacatcct cgccgggcac tgctcgggcg
    24781 gtcacctggc tctgtggtgc gcggcccgcg ggctgctgcc gccggggtca ccgtggcaca
    24841 cctccacgct ccccacgagc gtcctcgccc tggcaccgct caccgacctc gcggcgaccc
    24901 gccgggacgg gctgagcgac gacgccgcgc tgcaactgat gggcggggag gagggtttcg
    24961 cggcgcacat ggcatccgtg gacccgctca ccctgctcag cgacgcaggg acgacaggag
    25021 taccgaccgt gctgctccac ggcgaggtgg acgaggaggt gccgctgacc cagttctccg
    25081 actacgccgc cgtccaccac gatctgcgta cggtcgtcct gccgggcacg gggcactaca
    25141 cgctcatcga gccgggcgcg ccggcggccc gagaggtcgc cgacacgctg tggcggatgg
    25201 cacgcgagca gcggggtgcc ggcgccacgg tgggccccac ggacacgcgg gccaaggcga
    25261 agggcgccgg cctcgcctga
//
