Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001216.1:
Cluster 1NRP / Polyketide125280

BGC0001216, splenocin biosynthetic gene cluster from Streptomyces sp. CNQ431. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: splenocin

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Polyketide synthase subclass:
Type I

Gene cluster description

splenocin (BGC0001216). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank KP719128, positions 6356-31635. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Chang C et al. (2015) Uncovering the formation and selection of benzylmalonyl-CoA from the biosynthesis of splenocin and enterocin reveals a versatile way to introduce amino acids into polyketide carbon scaffolds. J Am Chem Soc 137(12):4183-90. doi: 10.1021/jacs.5b00728. Epub 2015