BGC0001220: aculeacin A biosynthetic gene cluster from Aspergillus japonicus
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Location: 1,840,826 - 1,901,106 nt. (total: 60,281 nt).
This entry is originally from NCBI GenBank NW_017962980.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001220
Short description aculeacin A biosynthetic gene cluster from Aspergillus japonicus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NW_017962980.1
1840826 - 1901106
via
Compounds
  • aculeacin A
Species Aspergillus japonicus [taxonomy]
References
Chemical products information
aculeacin A Evidence:
Copy SMILES
C50H81N7O16
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ASPACDRAFT_51502
  • XP_020058092.1
 1841725 - 1843474 (+) uncharacterized protein
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    • ASPACDRAFT_42018
    • XP_020058093.1
    		 1844623 - 1845763 (+) uncharacterized protein
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      • ASPACDRAFT_26446
      • XP_020058094.1
      		 1846238 - 1848027 (-) uncharacterized protein
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        • ASPACDRAFT_51504
        • XP_020058095.1
        		 1848716 - 1850129 (+) uncharacterized protein
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          • ASPACDRAFT_2707
          • XP_020058096.1
          		 1850997 - >1853456 (+) uncharacterized protein
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            • ASPACDRAFT_42022
            • XP_020058097.1
            		 1853742 - 1854287 (-) uncharacterized protein
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              • ASPACDRAFT_77431
              • XP_020058098.1
              		 1855688 - 1856705 (+) uncharacterized protein
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                • ASPACDRAFT_4483
                • XP_020058099.1
                		 1856873 - >1858613 (-) uncharacterized protein
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                  • ASPACDRAFT_42025
                  • XP_020058100.1
                  		 1859951 - 1882030 (+) uncharacterized protein
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                    • ASPACDRAFT_77432
                    • XP_020058101.1
                    		 1882421 - 1883595 (+) uncharacterized protein
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                      • ASPACDRAFT_42027
                      • XP_020058102.1
                      		 1884114 - 1885862 (+) uncharacterized protein
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                        • ASPACDRAFT_42028
                        • XP_020058103.1
                        		 1886553 - 1888565 (-) uncharacterized protein
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                          • ASPACDRAFT_42029
                          • XP_020058104.1
                          		 1890798 - 1893088 (+) uncharacterized protein
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                            • ASPACDRAFT_59413
                            • XP_020058105.1
                            		 1893713 - 1894873 (-) uncharacterized protein
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                              • ASPACDRAFT_25680
                              • XP_020058106.1
                              		 1895323 - 1900629 (+) uncharacterized protein
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                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                Unk01
                                Type
                                nrps-type1
                                Genes
                                ASPACDRAFT_42025
                                Substrates
                                ornithine (evidence: Structure-based inference [1], [2])
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk02
                                Type
                                nrps-type1
                                Genes
                                ASPACDRAFT_42025
                                Substrates
                                threonine (evidence: Structure-based inference [1], [2])
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk03
                                Type
                                nrps-type1
                                Genes
                                ASPACDRAFT_42025
                                Substrates
                                4R-hydroxyproline (evidence: Structure-based inference, Homology, In-vitro experiments)
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk04
                                Type
                                nrps-type1
                                Genes
                                ASPACDRAFT_42025
                                Substrates
                                3R-hydroxyhomotyrosine (evidence: Structure-based inference, Homology, In-vitro experiments)
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk05
                                Type
                                nrps-type1
                                Genes
                                ASPACDRAFT_42025
                                Substrates
                                threonine (evidence: Structure-based inference [1], [2])
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk06
                                Type
                                nrps-type1
                                Genes
                                ASPACDRAFT_42025
                                Substrates
                                3S-hydroxy-4S-methylproline (evidence: Structure-based inference, Homology, Knock-out studies)
                                Integrated Monomers
                                Domains
                                adenylation
                                Annotation changelog

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Replaced locus with better representation from existing references
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Added NRP substrate specificities
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2019-10-16
                                Updated reference publication(s) (MIBiG Annotathon)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2019-10-16
                                Updated compound(s) information (NPAtlas curation)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-08-17
                                Submitted
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                Detailed domain annotation
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