LOCUS       BGC0001222              3537 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Lactobacillus acidophilus strain M46 plasmid pCV461 acidocin B gene
            cluster, complete sequence.
ACCESSION   BGC0001222
VERSION     BGC0001222
KEYWORDS    .
SOURCE      Lactobacillus acidophilus
  ORGANISM  Lactobacillus acidophilus
            Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
            Lactobacillus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:09:39
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 3537
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..3537
                     /db_xref="taxon:1579"
                     /host="Homo sapiens"
                     /isolation_source="dental plaque"
                     /mol_type="genomic DNA"
                     /organism="Lactobacillus acidophilus"
                     /plasmid="pCV461"
                     /strain="M46"
     misc_feature    1..3537
                     /note="acidocin B gene cluster"
     protocluster    1..3537
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[988:1264]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      989..1264
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..3537
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..3537
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001222"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..3537
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            138..662
                     /gene="aciB"
     CDS             138..662
                     /codon_start=1
                     /gene="aciB"
                     /product="AciB"
                     /protein_id="AJP07148.1"
                     /transl_table=11
                     /translation="MSKNKNYFKWILGISSAVLIFYLRVLVSLKVDDNQLKNIQENQTL
                     LSVLFTIGLLAIVFFSILGTYFVSLYMLKNVFDKTTIHTKVKLIIYKVYFTCYSIYNLI
                     YFIYILIFNKLMQPMEQNYFSILLYVAIAIGLYSSIRKLEKKDTDKALLIYTMVIFVVN
                     SILPIFSLLGR"
     gene            700..882
                     /gene="aciC"
     CDS             700..882
                     /codon_start=1
                     /gene="aciC"
                     /product="AciC"
                     /protein_id="AJP07149.1"
                     /transl_table=11
                     /translation="MDKKTKILFEVLYIICIIGPQFILFVTAKNNMYQLVGSFVGIVWF
                     SYIFWYIFFKQHKKM"
     gene            989..1264
                     /gene="aciA"
     CDS             989..1264
                     /codon_start=1
                     /gene="aciA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: BacteriocIIc_cy"
                     /gene_kind="biosynthetic"
                     /note="acidocin B precursor; circular bacteriocin"
                     /product="AciA"
                     /protein_id="AJP07153.1"
                     /sec_met_domain="BacteriocIIc_cy (E-value: 2.8e-53,
                     bitscore: 167.2, seeds: 3, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTKYGRNLGLSKVELFAIWAVLVVALLLATANIYWIADQFGIHL
                     ATGTARKLLDAVASGASLGTAFAAILGVTLPAWALAAAGALGATAA"
     gene            1348..1836
                     /gene="aciD"
     CDS             1348..1836
                     /codon_start=1
                     /gene="aciD"
                     /note="DUF95 family membrane protein"
                     /product="AciD"
                     /protein_id="AJP07154.1"
                     /transl_table=11
                     /translation="MIRINNVKILIPLVLFIGILVGAGYEYYSSGNFQVEMMKEVNINQ
                     LMALSSIILKNTAAFLLLGLTLIVGKWFIILFFLINGFNIGMFSVHLSIIEFIVLFLPH
                     GIFEYVVFYYESKVFIIDLDGSPSKAWLFKRLGFIYLGLVLAALVEVFITPLIVQYVI"
     gene            1858..2019
                     /gene="aciI"
     CDS             1858..2019
                     /codon_start=1
                     /gene="aciI"
                     /note="immunity protein"
                     /product="AciI"
                     /protein_id="AJP07150.1"
                     /transl_table=11
                     /translation="MQKLLRIIALISLIAAIISFFIFKINYITYILIGIFIGSGFIYQI
                     RAQGRNRK"
     gene            2042..2722
                     /gene="aciT"
     CDS             2042..2722
                     /codon_start=1
                     /gene="aciT"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 132.3; E-value:
                     3.7e-40)"
                     /gene_kind="transport"
                     /note="ATP-binding protein"
                     /product="AciT"
                     /protein_id="AJP07151.1"
                     /transl_table=11
                     /translation="MTRNMFVDIKNVSKNLTDFSLENLNISFEKGEIIGLVGENGAGKT
                     TLLNLISGILKPDKGQILLSSNNIGYCFDALPEPENLTIEQLNTIFTGLLAVWDSDTYF
                     SFVDEFKLPKGKPIGVFSKGMKMQLNISITLSHNPTLLLLDEVTAGLDPIVRRTVLNTI
                     KEYAISSECIVIMTTHNLEDISDICNRLILLNNGSILLDDNFEDKSSKEIELIFRKTLG
                     YGDM"
     gene            2725..3363
                     /gene="aciE"
     CDS             2725..3363
                     /codon_start=1
                     /gene="aciE"
                     /note="permease"
                     /product="AciE"
                     /protein_id="AJP07152.1"
                     /transl_table=11
                     /translation="MKGLVQKDIYQLTSSWFRPVRIFFVIAVLAAGMIFLKQDSSIILV
                     LLLLLMVNNIQSLFIKDSTNRWLSLLKSLKISTFAVIGSRYITLVVICVCGAILNFVYM
                     LFGMFLFNTSTGIDVLVISSICLWVSLIYGLVIIPFLYAFKQNGLTLAIIIMFSCVALL
                     IKFSSAITKLAYIIHSYSYIQLILIAIVALIGIGIVSMVVSYLIVEKEK"
ORIGIN
        1 tttagaacat aataatatat caattttcaa cctctttgta caaattacac agtgaagaaa
       61 atcctattca aaagatataa tataattaaa ttgctataga ttgggaattt aacggtgtat
      121 aaggagggaa tacgaaattg agtaaaaata agaattattt taagtggata ttgggtatat
      181 caagtgcagt gctaattttt tatttgagag ttttagtatc tctcaaagtt gatgataatc
      241 agttgaagaa tattcaggaa aatcaaaccc tattatcggt tttatttacc attggactgt
      301 tagctatagt ctttttttca atccttggaa catattttgt atccctatat atgttaaaga
      361 atgtatttga caagacgact atacatacca aagtaaaatt aataatttat aaggtatatt
      421 ttacttgtta ttcaatttat aatctgattt attttatata tatactaatt tttaataaac
      481 taatgcaacc gatggaacag aactatttca gtatattgtt atacgtggct atagctattg
      541 gattatattc ttcaataaga aagcttgaga agaaagatac cgataaggcc ttattgattt
      601 acacgatggt catttttgtt gtcaattcta ttctcccgat attttcactt ttaggaaggt
      661 agcatgtagg taaataatct ttaaggagac aaatcaggca tggataagaa aacaaaaata
      721 ttatttgaag tattatacat catctgtata ataggccctc aatttatatt atttgtgact
      781 gcaaaaaaca atatgtatca gttggtgggt tcgtttgttg gaatagtatg gttttcgtat
      841 attttttggt atattttttt caaacaacat aaaaaaatgt agtataccac ttgtttattg
      901 atttattaag ggcttataat aatggtgtaa tatttactac aaaaaggtac gtacactcgt
      961 aatggatttc ctatgggagg aagatactat ggttactaag tacggacgta atttaggttt
     1021 gagcaaggta gagttgtttg caatttgggc ggttttagta gttgctcttt tattggccac
     1081 agcgaacatt tattggattg ctgatcaatt cgggattcat ttagcgactg gaacagcccg
     1141 taagttatta gatgcagtgg cttctggtgc ctcattggga actgcctttg ctgctatttt
     1201 gggcgtgaca ttacctgcat gggctttggc agctgcagga gcattgggag cgactgcggc
     1261 ttagtgatta taaagcttta tgaatagact attcaaaaaa ggctaatagg tattaatacc
     1321 tattagcctt tttcttagga gacagatttg attagaatta ataacgtaaa gatactaatt
     1381 ccattagtcc tgtttattgg aatactcgtt ggtgccggat atgaatacta tagttcagga
     1441 aattttcaag ttgagatgat gaaggaagtc aatataaatc aattaatggc tctatctagc
     1501 attatcttaa aaaatactgc cgcgttccta ttactgggtt taacattgat tgttggaaaa
     1561 tggttcataa tactattctt tttaataaat ggatttaaca taggaatgtt cagtgttcat
     1621 ttatcaataa ttgagtttat agtattgttt ttaccacatg gaatttttga gtatgtagta
     1681 ttctattatg agagtaaagt tttcataata gatttagatg gatcgcctag taaagcttgg
     1741 ttatttaagc gtctaggttt tatctatttg ggcttagttt tagcagcgtt agtggaagtg
     1801 tttataacac cattaattgt gcagtacgtt atttaagaat aagaaagagg ttaaaaaatg
     1861 caaaaactat tacggattat tgctttgatt agtttaatag ctgctataat atcattcttt
     1921 atatttaaaa ttaattatat aacatatatc cttataggaa tatttattgg ttctggcttc
     1981 atttatcaaa ttagagcaca aggcagaaat agaaagtaac aaaggataaa gggtagatgt
     2041 tatgacaaga aatatgtttg tagacattaa aaatgttagc aaaaacctta ctgatttttc
     2101 attggaaaat ctaaacatca gctttgaaaa aggtgaaatt attggattag ttggtgaaaa
     2161 tggagccgga aagactactt tgttaaactt aatatctgga atattaaaac cggataaggg
     2221 acagatactt cttagttcta ataatattgg atattgtttt gatgcattac ctgagccaga
     2281 aaatttaaca atagagcaac ttaatacgat atttactgga ttactagcag tatgggatag
     2341 tgatacttat ttttctttcg tggatgaatt taaattacct aaaggaaagc caatcggggt
     2401 cttttctaaa ggaatgaaaa tgcaattaaa tatatcaata acgttatccc ataatcctac
     2461 acttttgctc ttagatgaag tcacggcggg attagatcca atagtgcgaa gaaccgtact
     2521 aaatacaata aaagaatacg caatttcatc agagtgtatc gttattatga caacacacaa
     2581 cctagaggat atttctgata tatgtaaccg attaattctt ttgaataacg gcagcatatt
     2641 gttagatgat aattttgagg ataaaagttc aaaagaaata gaattaatct ttcgaaagac
     2701 tttaggatat ggagatatgt aggcatgaaa ggattagtac aaaaagatat ttaccagtta
     2761 accagtagct ggtttcgtcc tgtaaggata ttttttgtaa tagctgtatt ggctgcgggt
     2821 atgatttttt taaaacaaga tagttcaatt attttagttt tattgctgtt gttgatggta
     2881 aataatattc aatcattgtt tataaaagat agtacgaaca gatggttatc tctacttaaa
     2941 tcgttgaaaa tcagtacatt tgctgttata gggtcacgct atattacatt agtagttatc
     3001 tgcgtatgtg gtgcaatact caattttgta tacatgcttt ttggtatgtt tttattcaac
     3061 accagcactg gtattgacgt attagtaatc agtagcatat gtttatgggt atctttaatt
     3121 tatggattag taataattcc atttttatat gcttttaagc aaaatgggtt gactttggcc
     3181 ataatcatta tgtttagctg tgtcgcttta ctgataaagt tttcttcagc aataactaaa
     3241 ttagcttata tcatacattc gtatagttat atacagttaa ttttgatcgc aattgttgca
     3301 ctgattggca taggaatagt ttcaatggta gtgtcatact taattgtcga aaaagaaaag
     3361 tgatgaaaga accaccaagc cattaagtta tgacacagtt tatatattca tttagcggac
     3421 attgacccat ttattaataa aaactggaat tagaatgcgt ttctcaaacg tcaaaacatg
     3481 aagaaacgca acaaataaga agatagaaaa actaaggagg aatgttatta agccatt
//
