LOCUS       BGC0001225             27354 bp    DNA     linear   BCT 07-MAR-2017
DEFINITION  Streptomyces caelestis strain ATCC 15084 celesticetin biosynthetic
            cluster, complete sequence.
ACCESSION   BGC0001225
VERSION     BGC0001225
KEYWORDS    .
SOURCE      Streptomyces caelestis
  ORGANISM  Streptomyces caelestis
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 00:06:58
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 27354
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1026
                     /codon_start=1
                     /gene_functions="resistance (resist)
                     Erm23S_rRNA_methyltrans (Score: 258.2; E-value: 4.3e-79)"
                     /gene_kind="resistance"
                     /note="celesticetin resistance protein; putative 23S rRNA
                     mehyltransferase"
                     /product="Ccr1"
                     /protein_id="ADB92556.1"
                     /transl_table=11
                     /translation="MTEWGPTHRKGPEQGKKSTGYGRSEAQRGPGFRTRGASAERGRTG
                     GGPAAPVTADERRRVWGQNFFKSKAAVRRFTAQIGAVEGLPTVEIGPGSGMITKELAKS
                     GEPLTVVEIDDQWARLLAEELPSHVTMVNEDFLSWGPETECFRMVGNLPFGASTEILRT
                     CLGYGPDRFLEGVFLVQLEFARKRAGAWGGNLFNAQWSPWFTFHMGHEFPRHCFRPVPK
                     TDTATLFVDPRRDPLLPWRERVAYQELVSAVFNTGQLTVGEAAQRVNVRKPADWLRRAE
                     VFPETRVKDLDAEDWSALFATHQPGRPRTGAGGRPSAGRRQGGRRGMPPPGGGPRHQRR
                     R"
     misc_feature    1..27354
                     /note="celesticetin biosynthetic cluster"
     subregion       1..27354
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001225"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..27354
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    301..303
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(1552..3006)
                     /codon_start=1
                     /note="similar to LmbIH in lincomycin biosynthetic cluster"
                     /product="CcbIH"
                     /protein_id="ADB92557.1"
                     /transl_table=11
                     /translation="MKGAEPLAGAAFSTAARLGADRTVVQLVRTTVEDTVVGADSAPGH
                     ARSDRFEIAVRVHRDGAVGVADGPLLDRHSVLDLTERAAELARASGAGRSVRPAQRPAP
                     GNPQERVYRSPVAIDPFSLSPGERAEPLREARARALAVAGCTHAVVRASAYRRESMLLS
                     SDGDRHHLESTQTGGWLTAAADGPSGPATRSYPDRTGRHDMGGWEHVHGLDLPGGAERA
                     AREAVLLSRAKPCPSGTGPAVIDSSQLTLQIHESIGHPLELDRILGWELDYAGGSFVGL
                     TDVGHLAYASDQVTVVADPVSGRGVGSMPWDDEGTPTAVTPLIDRGLLVGLLSSTTSTA
                     AAGLPSAPGSARTEGAGLPLVRMTNINLQPGSGSLGDLLSDMGDGLLISGNQSFSIDDD
                     RDRFHFSCELAWRVRGGRLVEPLRAPRYHGRTLDFWRSCQRVAGAEEWAMHSVTFCMKG
                     NPIQTARVGHGAAPALFSEVSYGSWE"
     CDS             complement(3003..3773)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248:methyltransferase (Score: 82.2; E-value:
                     6.8e-25)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative N-demethylcelesticetin methyltransferase,
                     SAM-dependent methyltransferase; similar to LmbJ in
                     lincomycin biosynthetic cluster"
                     /product="CcbJ"
                     /protein_id="ADB92558.1"
                     /transl_table=11
                     /translation="MRNYDETTYGDQIADVYDEWPGDAGPPPDGREAALFVAALAAARP
                     VLELGVGTGRVAFPLADLGVEVHGVESSEPMLDKLREKAAAHPNGNLVVPVLGNFAKLD
                     LGEQRYSVVFAAFNTLFCLLGQDEQIDCMRQARELLEPGGTFVVQCLNPAGQRLATGNT
                     FGTVELEDTAVHLEASKHDPLAQTLSAHHIVLSEGGGIRLFPYRLRYAYPAELDLMANV
                     AGLELVERHADFERRRFDASSRYHVSVYRAAASA"
     CDS             complement(3884..5197)
                     /codon_start=1
                     /product="Ccb1"
                     /protein_id="ADB92559.1"
                     /transl_table=11
                     /translation="MHLDPTTHSGGLTAADLALSAQDYDFLLIERPDFPGVIGVVHTYR
                     GQADASAVRKTLSRLAPYLGRLGAVLRRAPQDAAEPYFEPVPFDAGAHVDEWTTDEEWP
                     DAVLAEITRRQLPTDRPLMRVHVIQGPQRWWLVFSFHHVTIDGATMGRLLMTDPGRDPA
                     PAEPTALTADTALRVRRDAIGTAPPPARTDDSAAADDGFPAILPAHWKHRSLATATLGA
                     QWRRLREETGSTKGALAAWLSGAAIAGAVTTARGRCTTLGLNITVDLRRAAPPPVGGNW
                     TSTILCPWAPGMEPGENLAVIGARLSGTDRSALVDQALAYEHECRDVPYAARREAAASW
                     GENSFIVSPDGQRADWHAMVTVLPRLPAWHEPDDCTGHFVLPGAWLGAPWSLTWAVGED
                     SASVCALSSSAEEPAQALIEALLRAADTTPVLPRDDHR"
     CDS             5226..5783
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115:HAD-superfamily hydrolase, subfamily IA, variant
                     (Score: 52.8; E-value: 7e-16)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative histidinol phosphatase; similar to LmbK in
                     lincomycin biosynthetic cluster"
                     /product="CcbK"
                     /protein_id="ADB92560.1"
                     /transl_table=11
                     /translation="MSGRAAVLFDRDGVLVQALVRDGRPYPPRSLRELRLDEDAQDVVR
                     RLTEAGWGVAVVTNQPDVPRGLMTEETVHRINRAVAAGLGLSESCFFTCFHDDDSGCEC
                     RKPGPALLVEAARSLGADLARCTVVGDRWRDIGAAHRAGCGAVWIDRGYREQAPQPPYD
                     RVTSTAAAVDLVLGGRLRAESG"
     misc_feature    5325..5327
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(5799..7109)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152:nucleotide sugar dehydrogenase (Score: 231.7;
                     E-value: 2.1e-70)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative dehydrogenase; similar to LmbL in
                     lincomycin biosynthetic cluster"
                     /product="CcbL"
                     /protein_id="ADB92561.1"
                     /transl_table=11
                     /translation="MTSDDQGGAAALPAEISVCGLWHLGTTVAAGLLSRGHQVVGYDPD
                     DGLRRGAGRAQAPTGEPGVGDALAAGLREQRLRITGDIADWARSTLCLLTYDSAVDAEG
                     GVADDRLDAAVAAFAEYGPRGAVLVVLSQVPAGTHTRWRGGLLAGRPDLRIVHVPENLR
                     LGEALADFLEPPRLVIGAEDDTAARLAAALFPAVESANVSLTEAELVKHATNAYLGLCV
                     AFANELAWIGFRLGADPTVVARLLKTDPRISPRAPLLPGAAFSGSTLQRDLVALRRLGT
                     EHGRAELFDSVLSANQRHAYFAVDLLRAHYGGLAGRRVAVAGLTYKPTTRTLRDSLPLR
                     LVHQLLAEGAVVSAYDPLAEELPGDLAVERAGSLAACVKGADALLIGSALPELADTDWS
                     RLAPAERLVADGCVALSPEVLRAAGWQYLGMRQVSGS"
     CDS             complement(7106..8083)
                     /NRPS_PKS="Domain: NAD_binding_4 (5-228). E-value: 4.9e-15.
                     Score: 47.1. Matches aSDomain:
                     nrpspksdomains_ADB92562.1_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     193.5; E-value: 9.8e-59)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative dehydrogenase; similar to LmbM in
                     lincomycin biosynthetic cluster"
                     /product="CcbM"
                     /protein_id="ADB92562.1"
                     /transl_table=11
                     /translation="MTRYFVTGGAGFIGSHFVERLLSDAHTTSVIAYDDLSNSTTEWIE
                     PLLKDPRLTFVEADILDTPELTAAMSEAGMTDRDVVVHLASSVDMRKGLSDSSFDLRQC
                     ANGTLSVLEAMREVGPRKVLFSSSSTVYGEPTVLPTPEHAGPYAPISLYGAGKLSAEAL
                     LSAFCHLYGFTAHAFRFGNVVGGRMNHGVIYDFIVKLTEDSSRLHILGDGKQRKNYFLV
                     EECVEGILTTSEKLGEGFHVLNLGNPGTVTVDEIASVIIDEMGLQDVQITYEGGSRGWP
                     GDVPVVEYDLSKLGGLGWTAEHGCAAAVRECARRLLAERGWTQP"
     aSDomain        complement(7400..8068)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADB92562.1_NAD_binding_4.1"
                     /evalue="4.90E-15"
                     /label="ADB92562.1_NAD_binding_4.1"
                     /locus_tag="ADB92562.1"
                     /protein_end="228"
                     /protein_start="5"
                     /score="47.1"
                     /tool="antismash"
                     /translation="VTGGAGFIGSHFVERLLSDAHTTSVIAYDDLSNSTTEWIEPLLKD
                     PRLTFVEADILDTPELTAAMSEAGMTDRDVVVHLASSVDMRKGLSDSSFDLRQCANGTL
                     SVLEAMREVGPRKVLFSSSSTVYGEPTVLPTPEHAGPYAPISLYGAGKLSAEALLSAFC
                     HLYGFTAHAFRFGNVVGGRMNHGVIYDFIVKLTEDSSRLHILGDGKQRKNYFLVEECVE
                     G"
     CDS             complement(8080..8688)
                     /codon_start=1
                     /note="putative isomerase; similar to LmbN in lincomycin
                     biosynthetic cluster"
                     /product="CcbN"
                     /protein_id="ADB92563.1"
                     /transl_table=11
                     /translation="MNSVKNLLVDAIEHTTALDSGDIESAARLIFRTWQQGGTVISCGN
                     GGSASTASHFAADLAKLTIVPGCPRLRTLCLNDNASAFSAWTNDEGFDTVYTEQAEPWL
                     DDKATLISFSVHGGSRATDASAVSSNLGKVAELAKSRGSSVIAVTGFDGGAAGDVADAH
                     INVPHFTEPVATPLIESLHVLIHHALCVGVRQLIQEDAK"
     misc_feature    complement(8635..8637)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(8713..9996)
                     /NRPS_PKS="Domain: PP-binding (355-422). E-value: 2e-08.
                     Score: 26.6. Matches aSDomain:
                     nrpspksdomains_ADB92564.1_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079:oxidoreductase (Score: 188.8; E-value: 2.8e-57)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative oxidoreductase; C-terminal region codes for
                     putative acyl carrier protein"
                     /product="CcbZ"
                     /protein_id="ADB92564.1"
                     /transl_table=11
                     /translation="MTSPTRHDAPPRVGIIGTGLQARRRIAVAGANVVAVAGHDAAAGE
                     AFAAEHGIRAEKDWHALVGAADIDIVLVCTPPHLHAEMSIAALEAHKHVLCEKPFARTG
                     AEAERMLQAARTHGKALACGFNHRHHPALAELRRLVTQGRMGRVLWARFAYGIGGRDGY
                     ENEWRADPAQVAGGQLMEQGIHAVDLLRTLLGDVESTTAVRNTAVWPAMAPLEDDAMVL
                     LRHHGGAMSTIHSTLTQWVNLFRLELGGERATAEVQGLAGSYGTQTLTVWDRTDGPFSA
                     ARTEFRGGDRSWQQEWEYFLRLVDNPGDLSSAEDGAAAVRIVEAAYQGADGLSWARPAT
                     GADGSAAPAPSLLVDVLELLRPLLPSADTELTPDTELFSSQLLDSLALEEIQAAIESRW
                     VPLPPEELTLANFNTPAAIAETIARTST"
     aSDomain        complement(8731..8931)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADB92564.1_PP-binding.1"
                     /evalue="2.00E-08"
                     /label="ADB92564.1_PP-binding.1"
                     /locus_tag="ADB92564.1"
                     /protein_end="422"
                     /protein_start="355"
                     /score="26.6"
                     /tool="antismash"
                     /translation="VLELLRPLLPSADTELTPDTELFSSQLLDSLALEEIQAAIESRWV
                     PLPPEELTLANFNTPAAIAETI"
     CDS             complement(10023..11273)
                     /NRPS_PKS="Domain: Aminotran_1_2 (74-395). E-value:
                     1.3e-24. Score: 78.8. Matches aSDomain:
                     nrpspksdomains_ADB92565.1_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 98.2; E-value: 8e-30)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative aminotransferase; similar to LmbF in
                     lincomycin biosynthetic cluster"
                     /product="CcbF"
                     /protein_id="ADB92565.1"
                     /transl_table=11
                     /translation="MSDLAAVDDWSTLRRIAIDAVSTGRNPELKWLADHPEGTPAYALH
                     LADPLEGAPEGLRQCLREAWDEPLDSYVLSHHGLPELRQAMERWFADDENWPRRRRLLT
                     TATMTGTGPAMYDLLRTIKAREPEGPMAALVPRPGWDYRLFAHDVGYEPIGYHVPFTSP
                     TGPEPGDLDRAVEQTRAKGLRPTVLVLNPQHYATGGNWTPEFVRYALSLADTLGMWVLV
                     DNAYHGMTAAGTQPTSTVRLALDGGFEERLIHVRTLGKQFACNGWAVGSVTAMPDVIDE
                     FAHRWRGFREYPGHAREQAAFAGWLNNPESRKWADERREAIRSNGDALLDALAEVSNTT
                     RHCHGGSPFVLFEVPGGWSQEDFRQRLFADTGVLLASAQIPYAPDWVKVFLGRRPDRFL
                     PAVEALRTRPSRAWQPR"
     aSDomain        complement(10089..11051)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADB92565.1_Aminotran_1_2.1"
                     /evalue="1.30E-24"
                     /label="ADB92565.1_Aminotran_1_2.1"
                     /locus_tag="ADB92565.1"
                     /protein_end="395"
                     /protein_start="74"
                     /score="78.8"
                     /tool="antismash"
                     /translation="SHHGLPELRQAMERWFADDENWPRRRRLLTTATMTGTGPAMYDLL
                     RTIKAREPEGPMAALVPRPGWDYRLFAHDVGYEPIGYHVPFTSPTGPEPGDLDRAVEQT
                     RAKGLRPTVLVLNPQHYATGGNWTPEFVRYALSLADTLGMWVLVDNAYHGMTAAGTQPT
                     STVRLALDGGFEERLIHVRTLGKQFACNGWAVGSVTAMPDVIDEFAHRWRGFREYPGHA
                     REQAAFAGWLNNPESRKWADERREAIRSNGDALLDALAEVSNTTRHCHGGSPFVLFEVP
                     GGWSQEDFRQRLFADTGVLLASAQIPYAPDWVKVFLGRRP"
     misc_feature    complement(11262..11264)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             11393..12217
                     /codon_start=1
                     /note="similar to LmbE in lincomycin biosynthetic cluster"
                     /product="CcbE"
                     /protein_id="ADB92566.1"
                     /transl_table=11
                     /translation="MQRKILTVHAHPDDEVSRGGATIAHYTAQGVQAVLVTCTDGAAGE
                     ILNPDFGALPQGRTLAAQRAEELAASARALGYSTVHSLGFADSGFDGTAGGTDAFVKAS
                     TDAAAERLAALIEKEKPQVIVGYGTNHARDPHPDHIRANQVLTRCVELLGERDGSRVPD
                     VFHVAFSRRRHRVLHEACGTAGVPSPYAPGLREPDTSFDDAEINTVISLSETAIERRLS
                     ALRCHKTQIAANSGWFALSASELYQAFPYDEYIRVAAPPGGRPCDDLFVASS"
     CDS             complement(12226..13293)
                     /codon_start=1
                     /note="similar to LmbD in lincomycin biosynthetic cluster"
                     /product="CcbD"
                     /protein_id="ADB92567.1"
                     /transl_table=11
                     /translation="MAQSKGSVDQTLHAPHCEVGCAANVARRVGVDLARQVIGAHWASR
                     MLVREVGTFPQPLLDRTQVTFSAQGEGWPALLARMTGGEVTSRHVPREELLSTLHADRA
                     EGGTLLFMEDRACPWLDSAHSPGMLPHVVVPDGVAPDGSWQLIEGHSWWRGRYAMSEQD
                     LLAASYPDPDPHHVAGRVLSLRIRPSAERAAQLDTLARQELAAGLRTYLAAECGETETP
                     AGRIVWANGPQSVPLLVERLRGWDYLCPLAARNDLSTEHARDVALGRYLFLALTDELAF
                     AAYARAGTLRLVEGLGLAGAVGGLRPDEAWRLAWRSGQKLYRRLDRQNLSALFSALEKA
                     AEVDVEYARRLLKEL"
     misc_feature    complement(13120..13122)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             13292..14809
                     /NRPS_PKS="Domain: AMP-binding (15-410). E-value: 5.9e-82.
                     Score: 267.2. Matches aSDomain:
                     nrpspksdomains_ADB92568.1_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 313;
                     E-value: 5e-95)"
                     /gene_kind="biosynthetic-additional"
                     /note="contains free standing adenylation domain for
                     adenylation of proline; similar to LmbC in lincomycin
                     biosynthetic cluster"
                     /product="CcbC"
                     /protein_id="ADB92568.1"
                     /transl_table=11
                     /translation="MNTSTVRNSLSTLLADTAAATPGATALREPGGDTTYRDLAALAGG
                     IQTALAEAGVRPGDRVAVLAPQTAAAVAAVHAVLSAGAAYVPLDPASPPARWAAVCGMS
                     TPRAVVGTRDALAKLTAELPHLATVDLEAPWPEAPLAPVEREAADLGAVLPTSGSTGVP
                     KGVAISREALLAFASWMVDTFEVGADDVIAGFSPLHFDVSVFSLFGAALTGAALAPAPP
                     QLAGFPHELASWADDAGITVWYSVPYPLARLGTLDAVVLEQRLGRLRCVCFAGEVFPHR
                     QLATLMSKMPWVRYTNLYGPTETNVCTFEQVLAPPDEAIAIGSPACGAECWVERDGERV
                     DTEGAVGELIVAGPTVADGYWGNEDETARRFRFGREYRSGRAYATGDQVRILPDGRYAY
                     LGRQDHMVKIRGQRLELEEVESVLGTADGVTGCCVVAVTPPGRPALLCAAVVGDQLDHA
                     ALRSHCRGRLPSWAIPQRFLEVPAIPLTSTGKTDRQEVRRRVMAELV"
     aSDomain        13337..14521
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADB92568.1_AMP-binding.1"
                     /evalue="5.90E-82"
                     /label="ADB92568.1_AMP-binding.1"
                     /locus_tag="ADB92568.1"
                     /protein_end="410"
                     /protein_start="15"
                     /score="267.2"
                     /specificity="consensus: ala"
                     /tool="antismash"
                     /translation="DTAAATPGATALREPGGDTTYRDLAALAGGIQTALAEAGVRPGDR
                     VAVLAPQTAAAVAAVHAVLSAGAAYVPLDPASPPARWAAVCGMSTPRAVVGTRDALAKL
                     TAELPHLATVDLEAPWPEAPLAPVEREAADLGAVLPTSGSTGVPKGVAISREALLAFAS
                     WMVDTFEVGADDVIAGFSPLHFDVSVFSLFGAALTGAALAPAPPQLAGFPHELASWADD
                     AGITVWYSVPYPLARLGTLDAVVLEQRLGRLRCVCFAGEVFPHRQLATLMSKMPWVRYT
                     NLYGPTETNVCTFEQVLAPPDEAIAIGSPACGAECWVERDGERVDTEGAVGELIVAGPT
                     VADGYWGNEDETARRFRFGREYRSGRAYATGDQVRILPDGRYAYLGRQDHMVKIR"
     CDS_motif       13520..13558
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADB92568.1_0001"
                     /evalue="2.80E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="ADB92568.1"
                     /protein_end="89"
                     /protein_start="76"
                     /score="17.3"
                     /tool="antismash"
                     /translation="AVLSAGAAYVPLD"
     CDS_motif       13748..13798
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADB92568.1_0002"
                     /evalue="1.30E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="ADB92568.1"
                     /protein_end="169"
                     /protein_start="152"
                     /score="20.9"
                     /tool="antismash"
                     /translation="VLPTSGSTGVPKGVAIS"
     CDS_motif       13916..13948
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADB92568.1_0003"
                     /evalue="9.90E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="ADB92568.1"
                     /protein_end="219"
                     /protein_start="208"
                     /score="-3.0"
                     /tool="antismash"
                     /translation="GAALTGAALAP"
     CDS_motif       14321..14404
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADB92568.1_0004"
                     /evalue="5.60E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="ADB92568.1"
                     /protein_end="371"
                     /protein_start="343"
                     /score="41.1"
                     /tool="antismash"
                     /translation="GAVGELIVAGPTVADGYWGNEDETARRF"
     CDS_motif       14486..14551
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ADB92568.1_0005"
                     /evalue="5.60E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="ADB92568.1"
                     /protein_end="420"
                     /protein_start="398"
                     /score="31.4"
                     /tool="antismash"
                     /translation="YLGRQDHMVKIRGQRLELEEVE"
     CDS             complement(14817..15788)
                     /codon_start=1
                     /note="putative sugar kinase; similar to LmbP in lincomycin
                     biosynthetic cluster"
                     /product="CcbP"
                     /protein_id="ADB92569.1"
                     /transl_table=11
                     /translation="MITTTAPLRLSLAGGGTDLPEHYEEFGCRLLAVTLDLTVTVTVNG
                     APSGLRFSAFGAQEHAPHADSVANPLVRAALRHFGITDGVELTVQSDVLPGSGLGGSGA
                     FMVALTSALAQHIGKPVTTDEAARLAFHLEREKCGFPVGQQDHWTAACGGALELRIDRG
                     GNATTTELPELRKAVDTLLDSELLLLRTPITRAAGAPLAAHTRALKSRHGSGMGTIQNM
                     VDAFHSALTSGDIDRVGALLDQHWQAKRRFNSAVTSPQIDRWYETLLAHGALGAKVVGA
                     GGGGHLLVAVPAAHADRVSSALASEGLRRVAVRVSEDGVRTA"
     CDS             complement(15785..16483)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 73.8; E-value:
                     2.1e-22)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative nucleotidyltransferase; similar to LmbO in
                     lincomycin biosynthetic cluster"
                     /product="CcbO"
                     /protein_id="ADB92570.1"
                     /transl_table=11
                     /translation="MVALPGTPPLVVLAGGLGSRMLHHTRSTPKALLPVGGKPFLTGLL
                     CAFRDRGGIVEVVLCTGHKADQVRDEIGDGSQLGLRVIHSPEPEPLGPIGALRHAADLP
                     DAFLLTYCDVLPTIDPRWFAEQARSSGCQAAMAVGPAPTAAEANVRIRGGKVAAYAKKP
                     GPAGATDCDRGLLALEKRTLDRHPGRDEQEFYGSLARDGELAAIPVQDPVVDIGTAARY
                     EKYLRFAETI"
     CDS             complement(16490..17650)
                     /NRPS_PKS="Domain: Aminotran_1_2 (34-163). E-value: 2e-13.
                     Score: 42.0. Matches aSDomain:
                     nrpspksdomains_ADB92571.1_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     373.3; E-value: 2.3e-113)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative aminotransferase; similar to LmbS in
                     lincomycin biosynthetic cluster"
                     /product="CcbS"
                     /protein_id="ADB92571.1"
                     /transl_table=11
                     /translation="MSDYVPFAEPTLDEAEIDAVTRVLRSGWVSTGVEADSFEKEFANY
                     VGTRHAVALNSCTAALHLALLALGIGPGDEVIVPTITFTATAAAVVHAGATPVLADVEP
                     VHLTLDPEQVEKLIGKRTKAVVPVHFTGRMASPGPLRELCDQHGIALLEDAAHTLPASD
                     GPYRAGQVGDVSAFSFFATKPITTAEGGMLCTDDSRIAEEARVWSLHGLSRGAVNRYRP
                     GARAAYDVDRPGFKYNMSDVQAALGRVQLAKADRLHAARTTIAETYLRELDGLPNLRLP
                     APDTADNLSSWYLFPVQLRLENMQADRDAFRDELHELGVGTSVHFVPLHHFSWYAENVV
                     RDGQRFPVADAAAGRLLSLPIFPAMDDGAVERVVTAVRKAHEGTRS"
     aSDomain        complement(17162..17548)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADB92571.1_Aminotran_1_2.1"
                     /evalue="2.00E-13"
                     /label="ADB92571.1_Aminotran_1_2.1"
                     /locus_tag="ADB92571.1"
                     /protein_end="163"
                     /protein_start="34"
                     /score="42.0"
                     /tool="antismash"
                     /translation="ADSFEKEFANYVGTRHAVALNSCTAALHLALLALGIGPGDEVIVP
                     TITFTATAAAVVHAGATPVLADVEPVHLTLDPEQVEKLIGKRTKAVVPVHFTGRMASPG
                     PLRELCDQHGIALLEDAAHTLPASD"
     CDS             complement(17647..18315)
                     /codon_start=1
                     /note="putative transaldolase; similar to LmbR in
                     lincomycin biosynthetic cluster"
                     /product="CcbR"
                     /protein_id="ADB92572.1"
                     /transl_table=11
                     /translation="MKIFLDTTDMEAVAQWLPHGIVDGVTTNPTLLRKAGVRNAREIVR
                     ELAQRVAPGDVSVQVAGETHEEMVQQALGYRTLGENIVIKVPVIRPDGRPNLDVMTTLT
                     RQGVAVNATACLSLAQVLAAAKAGARYASLLWGRVADEGGSPEAVVADAARLLRQYGLP
                     TQLLIGSVRAAGDITKALSAGADVVTVPPALLERWLDHHYSRMTVQQFNSDAGMKMGTK
                     "
     misc_feature    complement(18082..18084)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(18381..19538)
                     /codon_start=1
                     /note="similar to LmbQ in lincomycin biosynthetic cluster"
                     /product="CcbQ"
                     /protein_id="ADB92573.1"
                     /transl_table=11
                     /translation="MNAASADVRTLRHVRSATLRFADSALTSHVEHDVVEYAERSAGSE
                     RTRYRVVGSQECLKEAGQLAEECADVVAAASRIGTRERMGLLRELASLGPGIYGRVEDV
                     YGATATVDDRERTGMGTMARRNVIVTTVRDGVRRTRAVSGSPDELDVRGLALAGKPLPQ
                     HEGPLPTQVVLEPLALAELLAEYASVGLAVQDPHTAREFHRRCMGQQVAAAGVDITDTP
                     AALGGWTLDIEGTPAAPLSLLRDGRITGYATDHRGAAALGQISNGRAARSVDGLRAYPA
                     ALTLECPPTTAPIGPYLRIERVQYISVVSAETGTVTGSTRDYCSVVENGAPRANVGTVR
                     FTISVPDLLRRITGGLGPARTVPVTWGGCVVRCPAVHCADLRLVP"
     CDS             complement(19568..20875)
                     /codon_start=1
                     /note="putative glcosyltransferase; similar to LmbT in
                     lincomycin biosynthetic cluster"
                     /product="CcbT"
                     /protein_id="ADB92574.1"
                     /transl_table=11
                     /translation="MAEAASKQRRIAVVWLMLEGGQVSQGGVARYVENLLRAQDSIRAE
                     WLAHDYEIDFILGEPFYRENAAGYDAQRWQRVVTHLAERGGRAVRLVSDSDGIEQWGGD
                     RFFHALSAAGAQLVLETAERYDGVIAISGTSAFAQVAGMVQRLGGPLAERILHVHTFGL
                     ATHETALPPSPAEIAADGDVAFWTRQTPNVTVAYISDYTARLYERTYAIPRRSLLPNRS
                     GIPLDDPLFTLLDKNTVAKRLAPLGLPDEGRLAVMWGRNSAPDLDKGYHLLLEAAADVP
                     GVVPVIANRRPAPDLQQYAERLGVQAVFLADQPFETISALLQSERTLAAAFLGEAEPGA
                     VSPMEAMWVTRRSGAVVIAADTGNLPELVDGGRAGILTARTGTAVAEALRTAQAMTGEE
                     RTRMRETAADVVREHCDFLANIRDLVSSAVSRWSDL"
     misc_feature    complement(20525..20527)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(20546..20548)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(20904..21617)
                     /codon_start=1
                     /note="similar to LmbV in lincomycin biosynthetic cluster"
                     /product="CcbV"
                     /protein_id="ADB92575.1"
                     /transl_table=11
                     /translation="MEGLRRLGSGISALDRETDRLRAWLTGADDGLWSRSTRCTEWDVH
                     DVVAHLASGELYNQHCLRNEIESLRSWGDWGDDDEAYNVLHVALRRPLTHHQVLDEWIE
                     RHTDVHAQWRAMAPDAQLSTSYGPYAVGLQCWHIASEYATHSDDMGVPVPAEDRAERLA
                     WRFAFSCFAVEERRVPVSLDVHDGTGTISVSDETAQLTLTAEQFVAAVSQRLPLESVTS
                     DPHIQLLVKKLKVLL"
     misc_feature    complement(21351..21353)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(21606..21608)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             22079..23725
                     /NRPS_PKS="Domain: AMP-binding (27-450). E-value: 3.5e-80.
                     Score: 261.4. Matches aSDomain:
                     nrpspksdomains_ADB92576.1_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 432;
                     E-value: 4.2e-131)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative salicyl-AMP ligase"
                     /product="Ccb2"
                     /protein_id="ADB92576.1"
                     /transl_table=11
                     /translation="MVPWPAESAAAYRSAGYWLDKSLGNHLWDWADRYGDRTALVDGER
                     RLSYRALAIRVDSLAENLLGLGLRPGQNVLVQLPNCWQFMVTVMACVRIGIAPVLALPA
                     HRRRELAHVATESEATAVVVPTSWKDFDYEGLAHEVAARCPGSPQVLVLGEPGREGSVA
                     LDPLIGTVDDSGPLRAEDVAARRRHLDAVDVDPEDVALLLLSGGTTGLPKLIGRTHNDY
                     EYNARRSGEVCGFGGDTVYLAVLPVAHNFPLACPGVLGTWGVGGRVVMAPSARPEVAFP
                     LIARERVNTTAVVPAVAQRWLQAAGTGPADLTSLRSLQVGGARLAPEIARRVPAELGCA
                     LVQVFGMAEGLLNYTRPDDPPEVVATTQGRPISPHDEILIVDENDVPVAQGESGALLTR
                     GPYTPPGYFRGGPHNKRAFTPDGWYRTGDVVRLHPGGNLVVAGRSKDLINRGGEKISAE
                     EVEDIAYSMPQVVEAAAIAVPDDELGERICLCVVLKENETLAMTDVVETFSRTSIARYK
                     FPEHLRILPSLPHTPVGKIDKKALRAEFMTL"
     aSDomain        22160..23428
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADB92576.1_AMP-binding.1"
                     /evalue="3.50E-80"
                     /label="ADB92576.1_AMP-binding.1"
                     /locus_tag="ADB92576.1"
                     /protein_end="450"
                     /protein_start="27"
                     /score="261.4"
                     /specificity="consensus: sal"
                     /tool="antismash"
                     /translation="WDWADRYGDRTALVDGERRLSYRALAIRVDSLAENLLGLGLRPGQ
                     NVLVQLPNCWQFMVTVMACVRIGIAPVLALPAHRRRELAHVATESEATAVVVPTSWKDF
                     DYEGLAHEVAARCPGSPQVLVLGEPGREGSVALDPLIGTVDDSGPLRAEDVAARRRHLD
                     AVDVDPEDVALLLLSGGTTGLPKLIGRTHNDYEYNARRSGEVCGFGGDTVYLAVLPVAH
                     NFPLACPGVLGTWGVGGRVVMAPSARPEVAFPLIARERVNTTAVVPAVAQRWLQAAGTG
                     PADLTSLRSLQVGGARLAPEIARRVPAELGCALVQVFGMAEGLLNYTRPDDPPEVVATT
                     QGRPISPHDEILIVDENDVPVAQGESGALLTRGPYTPPGYFRGGPHNKRAFTPDGWYRT
                     GDVVRLHPGGNLVVAGRSKDLINR"
     misc_feature    23720..23722
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             23722..25089
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018:isochorismate synthase (Score: 327.6; E-value:
                     2.7e-99)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative salicylate synthase"
                     /product="Ccb3"
                     /protein_id="ADB92577.1"
                     /transl_table=11
                     /translation="MRLARGIEKEDVLPTKYIYRHRREVPIVSDPLAVMARLVQASASE
                     THLLYESEKVWSFSSGVLAEIRLRRSGITYRCADDSRELPWPDDPLKTVEKLLAELPVE
                     DWRAYGWGGFELAYVNAGLTELVRDEQLLHLVVPRTEVRLDSGRALLRSVDQEHLQTLS
                     ELLAKPAELPVHRTRPVDVETALAEEYRASVGNAVEEIRSTKLQKVILSRRVPVDYSVD
                     LLGTYIEGRKANTPARSFLIGFPEMKAAGFSPEIVAEVSADGRVTSQPLAGTRALTGDA
                     ETDRASREVLLNDVKEVFEHAISVKVSCAEMTDVCRPGSVVVDDFMTIKERGTVQHLAS
                     SVSGQLADGLSAWSAFRALFPAVTASGVPKRDAYESISRNEQEPRGLYSGTVMTVDSSG
                     AMDSALVLRTIFTESGHSWLQAGAGIVEHSKPEREFRETCEKLLSAALHVVPAQNQ"
     misc_feature    24196..24198
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             25166..26275
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 288; E-value:
                     1.7e-87)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative O-methyltransferase"
                     /product="Ccb4"
                     /protein_id="ADB92578.1"
                     /transl_table=11
                     /translation="MKTPGTSHPGRDTHRELGKIMAISKDQHQEILSHLIFGTLRAQVF
                     RAAGQLKLADHLAKGPLTSVELAEQAQLNEPGLRRLLLALEKMDVVTLLEGEKYELTSL
                     GQRLREDVPDSVRDLVLCYNGEATWHCWSDLADIVRTGVNTFERVDNKNYFEYLKERPE
                     EYALFNGAMADDSRNSAESIASGFDFSRFETVMDVGGGNGTLISNIAAAHKSVQGIVFD
                     LPTAVDSAQKHFKSNGVADRCRAIGGDVFAEVPGGADAYVMKSFLHDWDDEHVTTILTN
                     IRKVIKAEGRVLIVEPLLPDNAHDVPSFFGIVTSDLDLLAATQGKIRTTEDFRELLRAT
                     GFELTDVTPLGSYEFSTHDHYNVLEATPC"
     CDS             26299..27354
                     /NRPS_PKS="Domain: PKS_ER (20-268). E-value: 3.2e-12.
                     Score: 38.0. Matches aSDomain:
                     nrpspksdomains_ADB92579.1_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 257.1; E-value:
                     3.5e-78)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative NADP-dependent alcohol dehydrogenase"
                     /product="Ccb5"
                     /protein_id="ADB92579.1"
                     /transl_table=11
                     /translation="MATVPALAAAAPGAELEPTSIRLRPVGDHDVLIQIAYVGICHSDI
                     HQVREEWGAASFPMVPGHEIAGVVTQAGSGVKRFSVGDRVGVGCFVDSCRSCVHCRRGE
                     EQFCEQGMTSTYNAVGRDGLPNYGGYSTHIVVDENYVLAIPDSLALDEAAPLLCAGITM
                     YAPLVRWGAGPGTRVAVVGLGGLGHLGVKFARAMGAEVTVLSRGSRKQRGALRLGADHF
                     RATEKPAVFEELSGAFDLVLSTVSASLELDSYLGLLTVGGTLVHVGVPPGPSSLSVAAL
                     VDGRKNLSGSFIGGTGETQAMLDFCAVHGIGAEVEVIDAKQANDAYARVVDGDVRYRFV
                     IDVTTLGRADS"
     aSDomain        26359..27102
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ADB92579.1_PKS_ER.1"
                     /evalue="3.20E-12"
                     /label="ADB92579.1_PKS_ER.1"
                     /locus_tag="ADB92579.1"
                     /protein_end="268"
                     /protein_start="20"
                     /score="38.0"
                     /tool="antismash"
                     /translation="IRLRPVGDHDVLIQIAYVGICHSDIHQVREEWGAASFPMVPGHEI
                     AGVVTQAGSGVKRFSVGDRVGVGCFVDSCRSCVHCRRGEEQFCEQGMTSTYNAVGRDGL
                     PNYGGYSTHIVVDENYVLAIPDSLALDEAAPLLCAGITMYAPLVRWGAGPGTRVAVVGL
                     GGLGHLGVKFARAMGAEVTVLSRGSRKQRGALRLGADHFRATEKPAVFEELSGAFDLVL
                     STVSASLELDSYLGLLTVGGTLVHVG"
ORIGIN
        1 atgacggagt ggggaccgac acaccggaaa ggcccggagc agggcaagaa gtcgactggc
       61 tatggcaggt cggaggccca gcgcgggccc ggatttcgta ccaggggcgc gagtgcggag
      121 cgcggccgta ctggaggtgg cccggcagcg ccggtcactg cggatgagcg gcggcgtgtc
      181 tgggggcaga attttttcaa gtccaaggcg gcggttcgcc gtttcacggc tcagatcggc
      241 gctgtcgagg ggctgccgac agtggagatc ggcccgggct cggggatgat caccaaggag
      301 ttagcgaaga gcggcgagcc gctgaccgtg gtggagatcg acgaccagtg ggcgcgcctt
      361 ctcgctgagg agctgccgtc ccacgtgacc atggtgaacg aggactttct gtcctggggg
      421 ccggagaccg agtgcttccg gatggtggga aacctgccct tcggggccag caccgaaatc
      481 ctgcgcacgt gccttggcta cggccctgac cgcttcctgg aaggcgtctt cctggtgcag
      541 ttggagttcg cccgcaagcg cgccggagca tggggcggaa acctcttcaa cgcgcagtgg
      601 agcccctggt tcaccttcca catggggcat gagtttccac gccactgctt ccgtccagtt
      661 cccaagaccg acaccgcgac gctcttcgtg gacccgcgaa gggatccgct cctgccctgg
      721 cgggagcgag tcgcctatca ggaactggtc tctgcggtgt tcaacactgg tcaactgacg
      781 gtcggcgagg ctgcccaacg ggtgaacgtg cggaagcctg cggactggct ccggcgtgct
      841 gaggtattcc ccgaaacccg ggtgaaggac cttgatgccg aggactggtc ggcgctgttc
      901 gccacacatc aacccggtcg gccgcgcact ggggcaggcg gtcggccttc agccggtcgt
      961 cgccagggag gccgtagagg catgccaccc cctgggggtg ggccaaggca ccagcgcaga
     1021 aggtgatacc agctggttgg gggagccgcc gccgggaacg gtgccggcgg agggattgat
     1081 gatcggcctc gacatccgct tcaactctcc gacggcacct tgcgcccgtg ctggcaaacc
     1141 tgttcatgcc ctgcgtgttc gacatgtggc cggccgcacg gatgacgaag accggcggcg
     1201 taccgagatg acggagaccg gagactctcg tacgggcaca cgaacttacg tttctcgggt
     1261 acacatgttc ctctcgcgcg gagcctgcag acgagacggg gcagcggtga cgggccggta
     1321 agtccgcgcc gactgctgct tacgccttct ggcctgccga tcgtgcagcg cagcctccca
     1381 acgtggtgcc cacgtagcgg ccaactccgc cattgaaccg ccgagattca caagcgtgat
     1441 gcccgtgagg acagggtggg gcatggcgca cgggcgggac tccttcgtcg tgcacgcgag
     1501 gaaccgtgcg gccgcccatg acgtcacgtc ctggcctcgc tcacagcctc gttactccca
     1561 agagccgtac gacacctcgg agaaaagggc cggggcggct ccgtgcccga cgcgcgcggt
     1621 ctggatgggg ttgcccttca tacagaaggt cacgctgtgc atcgcccact cctcggcacc
     1681 cgcgacgcgc tggcacgagc gccagaagtc cagtgtccgg ccgtggtagc ggggcgcccg
     1741 caagggctcg accagccgcc cgccgcgtac ccgccaggcg agttcgcacg agaagtggaa
     1801 gcggtcccgg tcgtcgtcga tggagaagga ctggttgccg ctgatgagga gtccgtcacc
     1861 catgtcggag aggaggtcac ccagggaccc cgaccccggt tggagattga tgttggtcat
     1921 gcgcaccaga ggcaggcctg ctccctcggt acgcgcgctg cccggtgcgg acggcaaccc
     1981 ggccgcggcc gtgctggtgg tactgctcag cagcccgacc agcagacccc ggtcgatcag
     2041 gggcgtcacg gccgtcgggg tgccctcgtc gtcccacggc atgctgccga caccgcgtcc
     2101 ggagacggga tccgcgacaa cggtcacctg gtccgacgca taggcgaggt gccccacgtc
     2161 cgtgaggccg acgaacgatc caccggcgta gtccagttcc cagcccagga tccgatccag
     2221 ctccagcgga tggccgatgg attcgtggat ctgaagggtg agctggctgg agtcgatcac
     2281 cgcgggaccg gtgccggaag ggcacggttt cgcccgggac agcagtaccg cctcgcgcgc
     2341 cgcgcgctcg gcgcctccgg gcaggtccaa cccatggaca tgctcccagc cgcccatgtc
     2401 gtggcggccg gtacggtctg ggtagctacg ggtggccggg ccggaggggc cgtcggccgc
     2461 cgcggtcaac cagcctcccg tctgggtgga ctccaggtgg tgccggtctc cgtcgctcga
     2521 cagcagcatg ctctcgcggc ggtaggcgct ggccctgaca acggcgtggg tgcagcccgc
     2581 gaccgcgagg gcccgggcgc gggcctcgcg cagcggctcg gcccgttccc ccggggacag
     2641 cgaaaagggg tctatggcca ccgggctacg gtagacgcgc tcctggggat ttccgggcgc
     2701 gggtcgctgc gccgggcgaa ccgagcggcc cgcgcccgag gcgcgggcca gttccgctgc
     2761 gcgttcggtc aggtcgagga cgctgtgccg gtccagcaaa ggtccgtcgg cgacgcccac
     2821 ggccccgtcc cggtggactc gtacggcgat ctcgaaccgg tcagaccgcg cgtgccccgg
     2881 cgcggagtcc gctcccacca ccgtgtcctc gaccgtcgta cgaaccagct ggactaccgt
     2941 acggtccgca ccgagccgcg ccgccgtgct gaaggcggca ccggcgaggg gctccgcccc
     3001 cttcatgccg acgctgccgc tcggtacacc gagacgtggt accggctgga cgcgtcgaag
     3061 cgcctgcgct cgaagtccgc gtggcgctcg accagttcga gcccggccac gttcgccatg
     3121 aggtccagct ccgccgggta ggcgtagcgc aggcggtacg ggaagagacg aatgccgccg
     3181 ccttcgctga gcacgatgtg atgggcgctg agcgtctggg ccagcgggtc atgcttgctc
     3241 gcctccaggt ggacggccgt gtcttccagc tcgaccgtac cgaaggtgtt accggtcgcc
     3301 agccgctggc ccgccgggtt cagacactgc acgacgaacg tgccgcccgg ctccagcagt
     3361 tcccgggcct ggcgcatgca gtcgatctgc tcgtcctggc ccagcaggca gaaaagggtg
     3421 ttgaacgccg cgaagacgac ggagtaacgc tgctcgccca ggtcgagctt ggcaaagttg
     3481 cccagcacgg gcacgacaag gttgccgttc gggtgcgccg cggccttctc ccgcagcttg
     3541 tccagcatgg gctcggagga ctccacaccg tgcacctcca cgccgaggtc ggccagcgga
     3601 aaggccaccc ggcccgtgcc cacgccgagt tcgagcaccg ggcgggcggc cgccagggcg
     3661 gcgacgaaca gggcggcctc cctgccgtcc ggcggcgggc cggcgtcccc cggccactcg
     3721 tcgtagacgt ccgcgatctg gtcgccgtac gttgtctcgt cgtagttcct catctgtgcc
     3781 ttctcgtctc gtgcgtctcg tcgtcgaccg ccgcggggtg cggcgggcgg gatgcgggag
     3841 ggatgcgggg gaacaggcgc ccttgccatg gctctcgtgt cggtcatcgg tggtcgtcgc
     3901 ggggcaggac cggtgtcgtg tccgccgccc ggagcagggc ctcgatgagc gcctgtgccg
     3961 gttcctcggc cgaactggac agggcgcaca ccgaggcgct gtcctcgccg accgcccagg
     4021 tcagcgacca cggtgcgccg agccaggcgc cgggcaggac gaaatggccc gtgcagtcgt
     4081 ccggttcgtg ccaggcgggc agccgcggaa ggaccgtcac catcgcgtgc cagtccgccc
     4141 gctgtccgtc cggggaaacg atgaagctgt tctcacccca gctcgcggcc gcctctctgc
     4201 gggcggcgta cggcacgtcc cggcactcgt gctcgtaggc cagggcctgg tcgacgagcg
     4261 cggagcggtc cgtgccgctc agccgggcac cgatgaccgc caggttctcg cccggttcca
     4321 tcccaggggc ccaggggcac aggatcgtgc tggtccagtt gccccccacg gggggcgggg
     4381 cagcacggcg cagatcgacg gtgatgttca ggccgagagt ggtgcagcgg ccgcgggcgg
     4441 tggtcaccgc accggcgatc gccgcgccgg acagccaggc cgccaaggcg cccttggtac
     4501 tgccggtctc ctcgcgcaac cgccgccact gagcgccgag ggtggccgtg gccagggacc
     4561 ggtgcttcca gtgcgcgggc aggatcgcgg ggaatccatc gtccgccgcg gcggagtcgt
     4621 ccgtgcgggc gggcggcggg gcggtgccga tcgcgtcgcg tcgtacgcgc agggccgtgt
     4681 ccgcagtcag ggcggtcggc tccgccgggg ccggatcgcg gcccgggtcg gtcatcagca
     4741 accgccccat cgtggcgccg tcgatggtga cgtggtggaa gctgaacacc agccaccagc
     4801 gctgggggcc ctggatgacg tgcacccgca tcagcggccg gtcggtcggc aactgccgcc
     4861 gggtgatctc cgcgaggacg gcatcgggcc actcctcgtc cgtggtccac tcatccacat
     4921 gggcgccggc gtcgaacggc accggctcga aatacggctc cgccgcgtcc tggggcgccc
     4981 tgcggagcac cgcccccagt cggcccagat acggggcgag ccgggagagc gtcttgcgga
     5041 ccgcggacgc gtcggcctgt ccccggtagg tgtggaccac gccgatcaca ccggggaagt
     5101 ccgggcgctc gatcagcagg aagtcgtagt cctgggcgga caaggccaga tccgctgccg
     5161 tcagaccgcc ggaatgggtg gttggatcaa gatgcacgtc tgaactacct gacactggag
     5221 gaatcatgag cggacgggct gcggttctct tcgaccggga cggtgtcctt gtgcaggccc
     5281 tggtacggga cggacggccg tacccgcccc gctccctgcg ggagttacgg ctcgacgagg
     5341 acgcgcagga cgtggtgcgc cgcctgaccg aggcggggtg gggggtcgcc gtggtgacca
     5401 atcagccgga tgtgccgcga gggctgatga ccgaggagac ggtgcaccgc atcaacaggg
     5461 cggtcgctgc tggtctgggc ttgtccgaga gttgtttctt cacctgcttt cacgacgatg
     5521 actcggggtg cgagtgccgc aagcccggcc ccgcattgct ggtcgaggct gcgcggagcc
     5581 tcggcgccga cctcgcgcgc tgcacggtcg tgggggaccg ctggcgggac atcggcgccg
     5641 cgcacagggc gggctgtggt gcggtgtgga tagaccgcgg ttaccgcgag caggccccgc
     5701 agcctcccta cgacagggtg acctcgacgg ccgcggccgt ggacctcgtc ctgggcgggc
     5761 ggctccgcgc ggaatccggc tgacgtccac ggcggtggtc agcttccgga gacctgacgc
     5821 ataccgaggt actgccagcc cgcggcgcgc agcacttcgg gggagagcgc cacgcacccg
     5881 tcggccacca ggcgttcggc gggggcgagg cgggaccagt ccgtgtcggc cagttccggc
     5941 agcgcagagc cgatcagcag ggcgtcggcg cccttgacac acgcggccag cgatccggca
     6001 cgctcgacgg ccagatcgcc gggcagctct tcggccaggg ggtcgtacgc ggacaccacc
     6061 gcgccctcgg cgaggagctg gtgcacgagg cgcagaggca gcgagtcccg cagggtcctc
     6121 gtcgtcggct tgtacgtcag tccggcgacg gcgacccgcc gtccggccag acctccgtag
     6181 tgggcgcgca acaggtcgac agcgaagtac gcgtgccgtt ggttcgcact gagcaccgag
     6241 tcgaacagct ccgcccggcc gtgctcggtg cccaggcggc gcagggcgac caggtcccgc
     6301 tgcagggtgc tgccggagaa ggcagcgccg ggcagcagcg gagcccgggg tgagatccgc
     6361 gggtcggttt tgagcagtct ggccaccacg gtggggtcgg ctcccagccg gaaaccgatc
     6421 caggcgagct cgttggcgaa ggcgacgcac agcccgaggt aggcgttggt ggcgtgcttg
     6481 accaattcgg cctcggtcag ggagacgttg gccgactcga cggcggggaa cagcgccgcg
     6541 gccagccggg ccgcggtgtc gtcctcggct ccgatcacca ggcgcggtgg ctcgaggaag
     6601 tccgccagcg cctcgcccag ccggaggttc tccggcacgt ggacgatccg gaggtcgggc
     6661 cgcccggcga gcaggccgcc gcgccacctg gtgtgggtgc cggcgggcac ctggctgagc
     6721 accaccagta cggccccgcg cgggccgtac tcggcgaacg cggcgacggc ggcgtccaac
     6781 cggtcatcgg ccaccccgcc ctcggcgtct accgcactgt cgtacgtcag cagacacagc
     6841 gtcgagcggg cccagtccgc tatgtctccg gtgatccgca gccgctgctc gcgcagcccc
     6901 gcggcgagtg cgtcaccgac gccgggctcg ccggtgggtg cctgtgcgcg gccggcgccc
     6961 cggcgcagcc cgtcgtccgg gtcgtagccc acgacctggt ggccacggct cagcagtccc
     7021 gcggcgacgg tggtgcccag gtgccacagt ccgcacaccg agatctccgc cggcagggcc
     7081 gcggcgccgc cctggtcgtc cgaggtcacg gctgtgtcca gccgcgctcg gccagcagcc
     7141 gacgggcgca ctcgcggacg gccgcggcgc agccgtgctc ggcggtccag ccgaggccgc
     7201 cgagcttgct caggtcgtac tcgaccacgg ggacgtcacc cggccatccg cgcgagccgc
     7261 cctcgtaggt gatctgcacg tcctgcaggc ccatttcgtc gatgatgacg gacgcgatct
     7321 cgtcgaccgt gacggtgccc gggttgccga ggttgagcac gtggaagccc tcgccgagct
     7381 tctcgctggt ggtcaggatg ccctcgacgc actcctcgac caggaagtag ttcttgcgct
     7441 gcttcccgtc gccgaggatg tgcagccggg agctgtcctc ggtgagtttg acgatgaagt
     7501 cgtagatcac gccgtggttc atccgaccgc ccacgacgtt gccgaagcgg aaggcgtgtg
     7561 cggtgaagcc gtacaggtgg cagaaggcgc tcagcagcgc ctcggcggac agcttgcccg
     7621 cgccgtacag cgagatcggc gcgtacgggc cggcgtgctc gggcgtgggc agcacggtgg
     7681 gctcgccgta gacggtggag ctggaggaga agagcacctt gcgcgggccg acctcgcgca
     7741 tcgcctcgag cacggagagc gtgccgttgg cgcactggcg caggtcgaag gacgagtcgc
     7801 tcaggccctt gcgcatgtcc acgctggagg ccaggtgcac cacgacgtcg cggtccgtca
     7861 tcccggcctc ggacatcgcg gcggtgagtt cgggggtgtc gaggatgtcg gcctcgacga
     7921 aggtgagccg cgggtccttc agcagcggct cgatccactc ggtggtgctg ttgctgaggt
     7981 cgtcgtaggc gatgacggag gtggtgtgtg cgtccgacaa cagccgctcg acgaagtgac
     8041 tgccgatgaa gcccgctccg ccggtcacga agtagcgcgt cacttggcgt cctcctggat
     8101 gagctggcgc acaccgacgc acagcgcgtg gtggatgagg acgtgcaggg actcgatgag
     8161 gggagtggcc accggctcgg tgaagtgcgg cacgttgatg tgcgcgtcgg cgacgtcgcc
     8221 ggccgctccg ccgtcgaagc cggtgaccgc aatgaccgag ctgccgcggc tcttggcgag
     8281 ctcggcgacc ttgccgaggt tggaggagac cgccgaagcg tcggtggcgc gcgaaccgcc
     8341 gtgcacggag aaggagatga gggtcgcctt gtcgtccagc cacggctcgg cctgctcggt
     8401 gtagaccgtg tcgaagccct cgtcgttggt ccaggcggag aacgcggaag cgttgtcgtt
     8461 caggcacagg gtgcgcagcc gcggacagcc ggggacgatg gtcagcttgg ccaggtcggc
     8521 ggcgaagtgc gaagcggtcg acgccgagcc gccgttgccg caggatatga cggtgccgcc
     8581 ctgctgccag gtacggaaga tgagccgcgc ggcgctctcg atgtccccgc tgtctaacgc
     8641 cgtggtgtgc tcgatcgcgt cgacgagcag gttcttgacg gaattcactg ttgatgctcc
     8701 ttggtcggtg cgttacgtgc tggtgcgggc gatggtctcg gcgatggccg ccggggtgtt
     8761 gaagttggcg agggtcagtt cttcgggcgg cagggggacc caccggctct cgatcgcggc
     8821 ctgtatctcc tccagcgcca ggctgtcgag cagctggctg ctgaacagct cggtgtcagg
     8881 cgtgagttcg gtgtccgcgc tgggcagcag ggggcgcagc agctcaagga cgtcgaccag
     8941 cagcgacggc gcaggggcgg cgctgccgtc cgcgccggtg gcgggccggg cccagctcag
     9001 accgtccgca ccctggtagg cggcttccac gatccgcacc gccgccgcgc cgtcctcggc
     9061 cgagctgagg tccccggggt tgtccaccaa ccggaggaag tactcccact cctgctgcca
     9121 cgaccggtcg ccaccgcgga actcggtgcg ggccgcggag aacggcccgt ccgtacggtc
     9181 ccacacagtc agcgtctggg tgccgtacga accggccagg ccctggacct ccgcggtcgc
     9241 ccgctccccg ccgagctcca gacggaagag gttgacccac tgtgtgaggg tggagtggat
     9301 ggtggacatg gcaccgccgt ggtggcgcag cagcaccatc gcgtcgtctt ccaggggggc
     9361 catggcgggc cagacagcgg tgttgcgcac ggcagtggtg gactccacgt cgccgagcag
     9421 ggtacgcagc agatcgacgg cgtggatacc ctgctccatg agctgcccgc cggcgacctg
     9481 tgcggggtcg gcccgccatt cgttctcgta gccgtcgcgt ccgccgatgc cgtacgcgaa
     9541 gcgggcccac aggacgcggc ccatcctccc ttgtgtgacg agccgacgca gctcggcgag
     9601 cgccgggtgg tggcggtggt tgaacccgca ggccagcgcc ttgccgtggg tgcgagcggc
     9661 ctggagcatg cgctcggctt cggcgccggt gcgcgcgaac ggcttctcgc acagcacgtg
     9721 tttgtgggct tccagtgccg cgatgctcat ctcggcgtgc aggtggggcg gggtgcagac
     9781 caggacgatg tcgatgtcgg cggcgccgac cagcgcgtgc cagtccttct cggcgcggat
     9841 accgtgctcg gcggcgaacg cttctcctgc ggcggcgtcg tgcccggcga ccgccacaac
     9901 gttcgccccg gccaccgcga tacgccgcct ggcctgcaga ccggtgccga taatcccgac
     9961 gcgcggtggg gcgtcgtggc gggtggggga tgtcatgcgt cactccttgg gtgccgacgg
    10021 ggtcagcggg gctgccaggc gcgtgagggg cgggtgcgca acgcctcgac ggcgggcagg
    10081 aatcggtccg ggcggcggcc gaggaacacc ttgacccagt cgggggcgta ggggatctgg
    10141 gcactggcca gaagcacgcc ggtgtcggca aacaggcgtt gccggaagtc ctcctggctc
    10201 cacccgccgg gcacctcgaa caggacgaag ggcgagcccc cgtggcagtg gcgggtggtg
    10261 ttcgagacct cggccaacgc gtccagcagg gcgtcaccgt tgctgcggat ggcctcccgg
    10321 cgctcgtcgg cccacttacg gctctcgggg ttgttgagcc acccggcgaa cgcggcctgt
    10381 tctcgggcgt ggcccgggta ctcccggaac ccgcgccagc ggtgggcgaa ctcgtcgatc
    10441 acatcgggca tcgcggtgac gctgcccacg gcccagccgt tgcaggcgaa ctgcttgccg
    10501 agtgtgcgga catggatcag ccgctcctcg aagccgccgt ccagggccag gcgcaccgtg
    10561 ctggtgggct gggtgccggc cgcggtcatg ccgtggtagg cgttgtcgac caggacccac
    10621 atgcccaggg tgtcggcgag gctcagcgcg tagcggacga actccggcgt ccagttgccg
    10681 ccggtcgcgt agtgctgggg gttgaggacg agcaccgtgg gccgcagtcc cttggcgcgg
    10741 gtctgctcca ccgcccggtc caggtcgccc ggctcagggc cggtgggcga agtgaacggg
    10801 acgtggtagc cgatgggttc gtaaccgaca tcgtgtgcga acagccggta gtcccagccg
    10861 ggccggggga cgagcgcggc catcgggcct tcgggctccc gggccttgat cgtgcgcagc
    10921 aggtcgtaca tggcggggcc ggtgccagtc atggtcgccg tggtgagcag gcggcgccga
    10981 cgcggccagt tctcgtcgtc ggcgaaccac cgttccatcg cttggcgcag ctccggcagg
    11041 ccgtggtgcg agagcacgta gctgtccagt ggttcgtccc aagcctcccg caggcactgg
    11101 cgcagcccct cgggagcgcc ttcgaggggg tcggcgaggt ggagggcgta ggccggggtg
    11161 ccctcagggt ggtcagcgag ccatttcagc tcagggttac ggccggtgga aaccgcgtca
    11221 atcgctattc gacgcagcgt ggaccagtca tcaacggcag ctaagtcgga cactcgctac
    11281 gcccccaata cctgagttat aaacgccgca atgacaaacg atgctaggtg cagtcgaatc
    11341 ttttcgtcaa gcattgctgc gcgttccttc gaggcgcggt agtctgtggt gcatgcagcg
    11401 gaagattctc actgtgcacg cccacccgga tgatgaggtc tcgcgcggcg gtgccaccat
    11461 tgcccattac acggcacaag gtgtccaggc cgttctggtg acttgtacag atggcgccgc
    11521 cggggaaata ctcaaccccg acttcggtgc ccttccccag ggccggacgc tggctgccca
    11581 gcgagccgag gagctggccg ccagcgcccg cgccctgggg tactcaaccg tgcactcgct
    11641 gggcttcgcc gactccggtt tcgacggcac tgcaggcggc accgacgcgt tcgtcaaggc
    11701 gtcgaccgat gccgcggcag agcgcctagc cgctttgata gaaaaggaga aaccccaggt
    11761 catagtaggt tacggtacca accacgcacg ggatccgcac cctgatcaca tccgcgccaa
    11821 ccaggtgctg acccggtgtg tggagctgct gggcgagcgg gacggatccc gggtgcccga
    11881 cgtcttccac gtggccttct cgcggcgtcg gcaccgggtc ctccacgagg cgtgcgggac
    11941 tgcgggcgtg ccgagcccct atgccccggg gctgcgcgaa cccgacacga gcttcgacga
    12001 cgcggaaata aataccgtta tctcgctgag cgaaacagca attgagcgac gactgtccgc
    12061 tctacgctgc cacaagacgc agatagccgc taattcaggc tggttcgcac tctctgcttc
    12121 cgagctttac caggcgtttc cctacgatga atacattcgc gtagccgccc caccgggcgg
    12181 gcgcccgtgc gacgacttgt tcgtggcttc ttcgtgatcg tccggtcaga gttccttgag
    12241 caatcgccgc gcgtattcga cgtccacctc ggcggctttt tcaagggcac tgaacagtgc
    12301 actgaggttc tgccggtcca accgccggta cagcttctgg ccactgcgcc aggccagccg
    12361 ccaggcctcg tcggggcgca ggcccccgac ggccccggcc agaccgagcc cctcgaccag
    12421 ccgcagcgtt ccggctctgg cgtacgccgc gaaggccagt tcgtcagtga gggcgaggaa
    12481 gaggtagcgg cccaaggcca catcccgggc gtgctcggtg gacaggtcat tgcgggcggc
    12541 cagcggacag agatagtccc agccacgcag ccgctcgacc agcaggggca cgctctgcgg
    12601 gccgttcgcc cagacgatcc gtccggccgg agtctccgtc tcgccgcact cggcggccag
    12661 atacgtgcgc aggccggcag ccaactcctg gcgggccagc gtgtccagct gtgcggcacg
    12721 ttcggccgac ggacggatgc gcaggctcag cacccgtccg gccacatggt gcggatccgg
    12781 gtccggatag gaggcggcca gcaggtcctg ctcggacatc gcgtacctgc cgcgccacca
    12841 ggagtgtccc tcgatcagct gccaactgcc gtcgggggcc acgccgtcgg gcaccaccac
    12901 gtgcggcagc atccccggac tgtgtgcgga gtcgagccac gggcacgcgc ggtcctccat
    12961 gaacagcagc gttccgccct cggcgcggtc cgcatgcagt gtcgacagca gctcttcgcg
    13021 cgggacatga cggctggtca cttcgccacc ggtcatcctg gccagcaggg cgggccagcc
    13081 ctcgccctgg gcgctgaagg tcacctgtgt gcggtccagt aatggctgag ggaaggtgcc
    13141 gacctcccgg accagcatcc gcgacgccca gtgcgcaccg atcacctggc gggccaggtc
    13201 gaccccgacc ctccgggcca cgttggccgc gcaccccacc tcgcagtgcg gtgcgtgcag
    13261 tgtctgatca accgaaccct tggattgggc catgaatacc tccactgtcc gtaactcgct
    13321 gtcaacgctg ctggccgata cggccgcggc cactcccggg gcgacggccc tgcgggagcc
    13381 cggcggcgac accacctacc gcgacctggc cgccctggcc ggcggcatcc agaccgccct
    13441 cgccgaggcc ggggtgcggc ccggcgaccg ggtcgccgta ctggccccgc agaccgcggc
    13501 ggccgtagcg gcggtgcacg ccgtcctgtc cgcgggcgct gcctatgtgc cgctggatcc
    13561 cgcctcgccg cccgcccgtt gggcggcggt gtgcggcatg agcacgcccc gtgccgtcgt
    13621 gggcaccagg gacgcgctgg ccaagctcac cgccgagctg ccgcacctgg ccaccgtcga
    13681 tctggaagcc ccctggcccg aggccccgct ggccccggtg gaacgggagg ccgctgacct
    13741 cggcgccgtc ctgccgacgt cgggctcgac cggagtgccc aagggcgtgg ccatcagccg
    13801 ggaggccctg ctggcctttg cctcctggat ggtggacacc ttcgaggtag gcgccgatga
    13861 cgtgatagcc gggttctcgc cgctgcactt cgacgtttcg gtgttcagcc tgttcggtgc
    13921 tgctctgacc ggtgccgcac tggcccccgc cccgccccaa cttgctggat ttccacatga
    13981 gttggcgtcc tgggccgatg atgcggggat cacggtgtgg tactcggtcc cctacccgct
    14041 ggcccggctc ggcaccctgg acgccgtcgt cctcgaacag cgtctgggac gactgcggtg
    14101 tgtctgcttc gccggcgagg tcttcccgca ccgccagctc gccaccctga tgagcaagat
    14161 gccctgggtt cgctacacca acctctacgg cccgaccgag acgaatgtgt gcacgttcga
    14221 gcaggtcctc gcaccgccgg acgaggccat cgccatcggc agccccgcct gcggtgccga
    14281 atgctgggtg gagcgggacg gcgagcgggt cgataccgag ggcgcggtcg gcgaactgat
    14341 cgtggccgga ccgaccgtgg ccgacggcta ctgggggaac gaggacgaga ccgcgcgccg
    14401 tttccgcttc ggccgggagt accggtccgg gcgggcgtac gccaccggcg accaggtacg
    14461 catcctcccg gacgggcggt acgcctatct ggggcgacag gaccacatgg tcaagattcg
    14521 cgggcagcgg ctcgaactgg aagaggtgga gagcgtgttg ggtacggcgg acggggtgac
    14581 cggctgctgt gtcgtcgcag tcacaccacc cggtcgtcct gccctgctct gtgccgccgt
    14641 ggtcggcgat cagcttgatc atgccgcgct gcgctcccac tgccgcggcc ggctgccgag
    14701 ctgggcgatc ccccagcgtt tcctcgaggt gcccgcgatc ccgctgacct cgacgggcaa
    14761 gacggaccgc caggaagtgc gccggagggt gatggccgag ctggtgtagc ggtacgtcac
    14821 gctgtgcgca ccccgtcctc gctgacgcgc acggcgaccc tgcgcaggcc ctccgaggcg
    14881 agggcgctgc tgacccgatc ggcgtgcgcg gcggggacgg ccaccagcag atggccgccc
    14941 ccgcccgcgc cgacgacctt ggcgcccagt gcaccgtgcg caagcagagt ctcgtaccag
    15001 cggtcgatct gcgggctggt caccgcgctg ttgaaccgcc gtttggcctg ccagtgctgg
    15061 tccagcagcg cgccaacccg gtcgatgtcg ccgctggtca gcgcggagtg gaaggcgtcc
    15121 accatgttct gaatcgtgcc catgcccgat ccgtggcggg acttgagggc cctggtatgg
    15181 gccgcaagcg gggcgccggc tgcgcgggtg atcggggtgc gcagcaacag cagttcactg
    15241 tccagcaggg tgtcgacggc cttgcgcagc tccggcagct cggtcgtcgt ggcgttaccg
    15301 ccgcggtcga tccgcagttc cagcgccccg ccgcaggccg ccgtccaatg gtcctgctgg
    15361 cccacgggga aaccgcactt ctcccgctcc agatggaagg ccagccgggc cgcctcgtct
    15421 gtggtgaccg gtttgccgat gtgttgggcc aaggcgctgg tcagggccac catgaacgca
    15481 ccggagccgc ccaggccgct gcccggcagc acatcggact gaacggtgag ctcgactccg
    15541 tcggtgatgc cgaagtgccg cagcgcggcc cggaccaggg ggttggccac cgaatcggca
    15601 tgcggggcgt gctcctgggc gccgaacgcg gagaaccgca accccgaggg tgctccgttc
    15661 accgtgaccg tcactgtgag atccagcgtg acggccagca gccgacagcc gaactcctcg
    15721 tagtgctcgg gcagatccgt accgccgcct gcaagggaca gacgcagcgg agcggtggtc
    15781 gtgatcatat cgtctccgcg aatcgaagat atttttcgta acgcgcggcc gtgccgatgt
    15841 ccacgaccgg atcctgcacc gggatggccg cgagctcgcc atcgcgcgca agtgagccgt
    15901 agaactcctg ctcatcacgg cccggatgac ggtccagggt ccgtttctcc agtgccagca
    15961 gcccccggtc gcagtcggtc gctccagcgg gaccgggctt cttggcgtac gccgccacct
    16021 tcccaccgcg tatccggacg ttggcctctg ccgcagtggg cgcgggtccc acggccatgg
    16081 ctgcctggca cccactggag cgggcctgct ctgcgaacca ccgcgggtcg atcgtcggca
    16141 gtacatcgca gtaggtgagc aggaacgcat ccggcaggtc ggctgcgtgg cgcagcgccc
    16201 cgatgggacc gagcggctcg ggctcgggac tgtggatcac ccgcagtccg agctggctgc
    16261 cgtcgccgat ctcgtcccgc acctggtcgg ccttgtgtcc ggtgcagagc acgacctcga
    16321 cgatgccgcc gcggtcgcgg aaggcacaga ggagtccggt caggaaaggc ttgccgccca
    16381 cggggagcag ggccttgggc gttgacctgg tgtggtgcag catccggctg ccgaggcctc
    16441 cggcaagcac gaccaatggc ggtgttccgg gcagcgcaac cacgacgtct cagctcctcg
    16501 tgccctcgtg tgccttgcgg acggccgtca cgacacgctc caccgcgccg tcgtccatag
    16561 cggggaagat gggcagggac agcagccggc ccgcagctgc gtccgccacc gggaaccgct
    16621 gtccgtcgcg caccacgttt tccgcatacc agctgaagtg atgcagaggg acgaagtgga
    16681 cgctggtgcc gacgcccagt tcgtgcagct cgtcacggaa cgcgtcacga tccgcctgca
    16741 tgttctccag gcgcaactgc acggggaaga ggtaccagga gctgaggttg tcggcggtgt
    16801 ccggggcggg cagcctcagg ttgggcaggc cgtccagctc gcgcagatac gtttcggcga
    16861 tcgtggttcg cgcggcgtgc agccggtccg ccttggccag ctggacccgg cccagcgccg
    16921 cctgcacatc ggacatattg tatttgaagc cgggccggtc cacgtcgtag gcggcgcgtg
    16981 cgcccggccg gtagcggttg acagcgcccc ggctcagccc gtgaaggctc cacacccgtg
    17041 cctcctcggc gatgcgggag tcgtcggtgc acagcattcc gccctcggct gtggtgatcg
    17101 gcttggtggc gaagaacgag aaggccgata cgtcgccgac ctgcccggca cggtacgggc
    17161 cgtcgctggc cggaagggtg tgcgcggcgt cctccagcag cgcgatgcca tgttggtcgc
    17221 acagctcacg cagcggaccg ggtgaggcca tccgcccggt gaagtgcacc ggtacgacgg
    17281 ccttggtccg cttgccgatc agcttttcca cctgctcggg gtcgagcgtc aggtgcaccg
    17341 gctcgacatc ggcgagcacg ggcgtggcgc cggcgtgcac cacggcggcg gctgtcgcgg
    17401 tgaacgtgat ggtgggcacg atgacctcgt cgccggggcc gatgcccagg gccagcagcg
    17461 ccaggtgcag cgcggcggtg caggagttca gcgcgaccgc gtggcgcgtg ccgacgtaat
    17521 tcgcgaactc cttctcgaag gagtcggcct ccacaccggt ggacacccag ccactgcgca
    17581 gcacccgcgt gaccgcatcg atctcggcct cgtccagcgt cggctcggca aaggggacgt
    17641 agtcgctcac ttggtaccca tcttcatacc agcgtcggag ttgaactgct ggacggtcat
    17701 acgggagtag tggtggtcga gccagcgttc cagcagggcc ggcggcactg tgacgacatc
    17761 ggccccggcg ctcagcgctt tggtgatgtc gccggctgcc cggacactgc cgatgagcaa
    17821 ctgggtgggc aggccgtact ggcgcagcag gcgagcggcg tcggccacca cggcctccgg
    17881 tgagcctcct tcgtcggcca cccggcccca cagcaggctc gcgtaccgcg cgcctgcctt
    17941 ggccgcggcc agcacctggg cgaggctcag acacgcggtc gcgttgactg ccacgccctg
    18001 ccgggtgagc gtggtcatca cgtcgaggtt cggccggcca tccgggcgga tgacgggcac
    18061 cttgatgacg atgttctcgc ctaacgtccg gtatcccagg gcctgctgga ccatttcctc
    18121 gtgcgtctca ccggcgacct gtacggatac gtcgcccggt gcgacccgct gggcgagctc
    18181 acgtacgatc tcgcgggcgt tgcggacacc ggccttgcgt agcagggtcg ggttggtggt
    18241 gacgccgtcc acgatgccgt gaggcagcca ctgtgcgacc gcttccatat cagtggtgtc
    18301 caggaagatc ttcatgggaa ctccagattc gagggagcaa gagggagagg ccgagccaac
    18361 ggagaggtgg gcggcgtggc ttacggcacc agccgcaggt ccgcgcagtg caccgctggg
    18421 cagcgcacca cgcagccgcc ccaggtgacc ggcacggtac gggccgggcc cagcccgcct
    18481 gtgatgcggc gcaggagatc ggggacactg atggtgaagc gcaccgtccc gacgttggca
    18541 cggggggcgc cgttctccac caccgagcag tagtcccggg tggagccggt gaccgtgccg
    18601 gtctccgcag acacgacact gatgtactgc acccgctcga tgcgcaggta ggggccgatg
    18661 ggcgcggtgg tcggcgggca ctccagggtc agtgccgcgg ggtaggcgcg cagcccgtcc
    18721 accgagcggg ccgcgcggcc gttggagatc tggccgaggg cggcggcgcc gcggtggtcg
    18781 gtcgcgtacc cggtgatacg gccgtcgcgc agaagcgaca gcggggcggc gggagtgccc
    18841 tcgatgtcga gggtccagcc gccgagcgcg gccggcgtgt cggtgatgtc gacacctgcc
    18901 gctgccacct gctgccccat acagcggcgg tggaactccc gcgcggtatg cgggtcttgt
    18961 acggccaggc cgacactggc gtactcggcg aggagttcgg ccagcgcgag gggctccagc
    19021 accacttgcg tgggcagtgg cccttcgtgt tggggcagcg gcttgccggc cagcgccagt
    19081 cctctgacat cgagttcgtc gggcgaaccg gagacagcgc gggtacggcg tacaccgtca
    19141 cggaccgtcg tgacgatgac gttgcgccgc gccatggtgc ccatgccggt gcgctcgcga
    19201 tcgtccacgg tggcggtggc gccatagacg tcctcgacac ggccgtagat gccgggcccc
    19261 agggacgcca gttcacgcag tagccccatc cgctcccgag tgccgatacg cgaggccgcg
    19321 gcgacgacat cggcgcactc ctccgccaac tgcccggcct ccttgaggca ctcctgcgag
    19381 ccgaccaccc ggtaccgggt gcgttcggag ccggccgacc gctcggcata ctcgacaacg
    19441 tcgtgctcga cgtggctggt cagcgcggag tcggcgaacc tcagggttgc ggaccgcaca
    19501 tgacgcagtg tccggacgtc ggcagaggcg gcgttcaccg cggcactaca gtggccttcg
    19561 gatgaattca caggtcgctc cagcggctca cggccgagga gaccaggtca cggatgttcg
    19621 ccaggaagtc gcagtgctcg cgcacgacgt cggcggcggt ttcgcgcatc cgggtgcgct
    19681 cctcacccgt catggcctga gccgtccgca gcgcctcggc gaccgccgtg ccggtacggg
    19741 cggtcaggat gccggcccgt ccgccgtcga cgagttcggg gaggttaccc gtgtcggcgg
    19801 cgatcaccac tgcgccggac cggcgggtga cccacatcgc ttccatgggc gagacagcgc
    19861 cgggctcggc ttcgccgagg aacgcggcag ccagtgttcg ttcggactgc agcaacgcgg
    19921 agatggtctc gaagggctgg tcggcaagga acaccgcctg cacgcccagc cgttcagcat
    19981 actgctggag atccggggcc ggacggcggt tggcgatcac ggggaccacg ccgggcacat
    20041 cggcggccgc ttcgagcagc aggtggtagc ccttgtcgag gtcgggggcg ctgttccggc
    20101 cccacatcac cgctagtcgg ccctcgtcgg gcaggccgag gggggccagc cgcttggcca
    20161 ccgtgttctt gtcgagaagc gtgaacagcg ggtcgtccag cggaattccg ctgcggttgg
    20221 gaagcaagga gcgccgcggt atcgcgtagg tccgctcgta cagccgcgcc gtgtagtcgg
    20281 aaatgtaggc caccgtgacg ttcggtgtct gacgcgtcca gaaggcgacg tcaccgtcgg
    20341 cggcgatttc tgcggggctg ggaggaagcg ccgtctcgtg ggtggccaga ccgaaggtgt
    20401 ggacgtgcag gatgcgttcg gccagggggc cacccaacct ctgtaccatc cccgcaacct
    20461 gagcaaaggc gctggtgccg gaaatcgcga tgacgccgtc atagcgttcg gcggtttcca
    20521 ggactaactg ggcgccggcc gcggataacg cgtggaagaa acggtcgccg ccccactgct
    20581 caatcccgtc gctgtcgctg acgagccgga cggcgcggcc tccgcgctcc gcaaggtgag
    20641 tgacgacgcg ctgccagcgc tgggcgtcgt atccggcggc gttttctcga tagaatggtt
    20701 caccgagaat gaagtcaatc tcgtagtcgt gcgccagcca ctcagcacga atggaatcct
    20761 gcgccctgag aagattttcg acgtaccggg ccactccccc ctgggagacc tgcccgccct
    20821 ccagcatgag ccatacgacg gctattcgcc gctgcttcga agccgcttca gccatgagaa
    20881 tcctctactt tctcaacccc ggctcacagg agaactttga gtttcttgac aaggagctgg
    20941 atgtgtggat ccgaggtcac ggattcaagc ggcagccgct ggctgaccgc ggcgacgaac
    21001 tgttcggctg tgagcgtcag ctgggcggtt tcgtcactga cggagatggt gcccgtgccg
    21061 tcgtgcacgt caagggagac gggaacccgg cgctcttcga ctgcgaagca ggaaaaggcg
    21121 aaacgccagg ccaaacgctc ggcgcggtcc tctgcaggaa ccggcactcc catgtcgtcg
    21181 ctgtgggtgg cgtactcgga ggctatgtgc cagcactgga gcccgaccgc gtacgggccg
    21241 tagctggtgc tcagttgggc gtcgggcgcc atggcccgcc attgggcgtg gacgtcggta
    21301 tgccgctcga tccactcgtc gagtacctga tgatgagtca gagggcggcg taacgccaca
    21361 tgaaggacgt tgtacgcctc gtcgtcatcg ccccaatcgc cccatgagcg caatgattcg
    21421 atttcattgc gcaggcagtg ctggttgtag agctccccgc tcgccagatg ggcgacaacg
    21481 tcatgaacgt cccactcggt acaccgggta ctgcgggacc agagcccatc gtcagcaccg
    21541 gtcagccatg ccctgagccg gtcggtctct cgatccaggg ctgagatgcc ggaacccagt
    21601 cggcgtaacc cttccatctg ccactcaaag gagtaaatct cttgcccagc taacaaagcg
    21661 ctcttctttc agtagcgata cggcatgtat cgatgcgcag gctcaacgtg tatcagagcg
    21721 caacatgagg cgtcaacagt tgcactaggt aatgcgcggt aaagcgccta ggtccaggcc
    21781 tggtgcggga aagcaggcga gaagtttgat aaacgtgtga tgcgtcacac gatactaggt
    21841 tgcgcaggtc gatggggcgt gggtagcctg cgacgaagat cactattgat ctcgctgtac
    21901 gacttggctt gtttatcacc tcggccagtc ggaggagttg cgcagcggcg cgtgctcgat
    21961 ttttagttat cgcgagttaa tgcagcgaac acttcttagc cgcctcatag acgctcacga
    22021 atgggcacgc gcaccgtgat tttccgggca gggggagtta aacgtgaagc gacgtggcat
    22081 ggttccgtgg ccggcggaat ctgcggccgc ctaccggtcg gcgggctact ggctggacaa
    22141 gtccctcggc aatcacctgt gggactgggc cgaccgctac ggtgaccgca cggccctggt
    22201 tgacggtgag cgacggctga gctatcgagc actcgccata cgcgtggact cgctggctga
    22261 gaacctgctg gggctggggc tgcgcccggg tcagaacgtc ctggtgcagt tgccgaactg
    22321 ctggcagttc atggtcaccg tcatggcgtg cgtacgcatc ggtatcgcgc cggtactggc
    22381 cctgcccgcg caccggcggc gcgaactggc ccatgtggcc accgagtcgg aggccaccgc
    22441 cgtcgtggtg ccgacgtcct ggaaggactt cgactacgag ggcctggcgc acgaagtcgc
    22501 ggccaggtgc cccggcagtc cgcaggtcct cgtcctcggc gagccgggcc gcgagggcag
    22561 cgtcgcactc gacccgctca tcggcaccgt cgacgactcc ggtcccctcc gcgccgaaga
    22621 tgtggccgct cgccgccgtc acctggacgc cgtggacgtc gatcccgagg acgttgccct
    22681 gctgctgctg tccgggggaa ccaccggcct gcccaagctc atcggccgga cccacaacga
    22741 ctacgagtac aacgcccggc gcagcggtga ggtctgcggg ttcggcggtg acacggtcta
    22801 tctggcggtc ctgccggttg cccacaactt cccgctcgcc tgtccgggtg tgctgggcac
    22861 ctggggggtc ggcgggcggg tggtcatggc accgtcggca cggcctgagg tcgccttccc
    22921 gctgatcgcc cgtgagcggg tgaacaccac cgccgtggtg cccgccgtag cacaacgctg
    22981 gctacaggcg gccggcacgg ggcccgcgga tctgacgagt ctgcgctcgc tccaggtcgg
    23041 gggggctcgg ctcgccccgg agatcgcccg gcgagtgccc gccgaactgg gctgcgcctt
    23101 ggtgcaggtc ttcgggatgg ccgaaggcct gctgaactac acccggcccg acgacccgcc
    23161 cgaggtcgtc gccaccaccc agggccgacc catcagtccg cacgacgaga tcctgatcgt
    23221 ggacgagaac gatgttccgg tggcgcaggg ggagagcggc gcactgctga cccgggggcc
    23281 gtacacaccg cccggttact tccggggcgg gccgcacaac aagcgcgcgt tcactcctga
    23341 cggctggtat cgcaccggcg atgttgtgcg tctccatccc ggcggcaatc tggtcgttgc
    23401 tgggcggtcc aaggacctca tcaaccgcgg cggtgaaaag atctccgcgg aggaggtgga
    23461 ggacatcgcc tattccatgc ctcaggtggt cgaagccgct gcgatcgctg ttcccgacga
    23521 tgaactcggg gagcgcatct gcctatgcgt ggtgctgaaa gaaaatgaaa cccttgcgat
    23581 gactgatgta gtggagacgt tctcccgcac gtcgatcgct cgctacaagt tccctgagca
    23641 cttgagaatt ctgccgagtc ttccgcacac gccagtcggc aagatcgaca aaaaggcgct
    23701 gcgtgcggag ttcatgacct tatgaggctc gccagaggga tcgaaaaaga ggatgtcttg
    23761 cccactaagt acatataccg ccacaggcgg gaagtcccga tcgtcagtga tccgctggcc
    23821 gtaatggccc ggctggtcca agccagcgcc tcggaaacgc atctgctcta cgagagcgaa
    23881 aaggtctggt cgttcagcag cggagtcctc gctgagatcc gcctgaggcg cagcggcatc
    23941 acgtaccggt gcgccgacga cagtcgtgaa ctgccctggc cggacgatcc gctcaagacc
    24001 gtggagaagc ttctcgcgga acttcctgtg gaggactggc gtgcctacgg atggggcggt
    24061 ttcgagctcg cgtacgtgaa tgcgggactc accgaactcg tccgggacga gcagctgctg
    24121 cacctggtcg tgccgcgcac cgaggtccgt ctggacagtg gccgagcgct gctgcgcagc
    24181 gtcgaccaag agcacttaca gaccctgtcg gagctgctcg ccaagccggc cgagctgccg
    24241 gtccaccgca ccaggccggt tgacgtggag acggctcttg ccgaggagta ccgtgccagt
    24301 gtgggcaacg cggtcgagga gatccgcagc acgaagctcc agaaggtcat tctgtcgcgg
    24361 cgggtgcccg tcgactattc cgtcgatctg ctcggcacgt acatcgaggg acgcaaggcg
    24421 aacaccccgg cccgctcttt cctcataggc ttcccggaga tgaaggctgc tggattcagc
    24481 ccggagatcg tggctgaggt cagcgccgac ggccgggtca cttcccagcc actggccggg
    24541 acccgcgcgc tcaccggcga cgccgagacg gaccgggcca gccgcgaagt cctcctcaac
    24601 gacgtcaagg aagtcttcga acacgcgatc tcggtgaagg tctcctgtgc cgagatgaca
    24661 gacgtctgca ggccgggctc agtcgtcgtg gacgacttca tgacgatcaa ggaacgcgga
    24721 acggtccagc acctggcctc cagtgtttcg ggtcaactcg ccgacggact gagtgcctgg
    24781 agcgcattca gggcgctctt cccggcggtc accgcttccg gggttcccaa gcgagacgcc
    24841 tacgagagca tcagccgtaa cgagcaagaa ccgcggggac tttacagcgg caccgtgatg
    24901 acggtggaca gttcgggcgc catggattcc gctctggtat tgcgcaccat cttcaccgag
    24961 tccgggcact cctggctgca ggcgggtgcg ggcatcgtcg aacactccaa gccggaacgc
    25021 gagttccgcg aaacctgcga gaagctgctg agcgcagctc tgcacgtcgt acccgcacag
    25081 aaccagtaaa tccgtccacc gtcggcgaca gatatgggcc cgacggaatc ggccggcagg
    25141 tcaggtcacc cgtacctcga accccatgaa gacgcccggt acatcgcacc ccgggcggga
    25201 cacgcaccga gagctaggga aaatcatggc aatcagcaag gaccagcacc aggaaatcct
    25261 gtcgcacctc atcttcggga cactgagggc gcaggttttc cgcgccgcag gtcagctcaa
    25321 gctcgccgac cacctggcga aggggccgtt gaccagcgtc gaactcgccg agcaggctca
    25381 gctgaacgag ccggggctgc gccgtctgct gctggcgctg gagaagatgg atgtcgtcac
    25441 tctcctcgag ggcgagaagt acgagctcac gtccttgggc cagcgtctgc gcgaggacgt
    25501 gccggactcg gtccgcgacc tcgtcctgtg ctacaacggc gaggccacct ggcactgctg
    25561 gagcgacctg gcggacatcg tgcgcacggg tgtgaacacg ttcgagcgcg tcgacaacaa
    25621 gaactatttc gagtacctca aggagcgccc ggaggagtac gcgttgttca acggcgcgat
    25681 ggcggacgac tcccgcaact ccgccgagag catcgccagc ggtttcgact tctcccgctt
    25741 cgagaccgtg atggacgtcg gtggcggcaa cggcaccctc atctccaaca tcgccgccgc
    25801 ccacaagagc gtccagggca tcgtctttga tctgccgacc gcggtggaca gcgcccagaa
    25861 gcacttcaag agcaatggtg tcgcggaccg ctgccgtgcc atcggcggcg atgtcttcgc
    25921 cgaggtgccc ggcggtgccg acgcgtacgt gatgaagagc ttcctgcacg actgggacga
    25981 cgagcacgtc accaccatcc tcaccaacat ccgcaaggtc atcaaggcgg aaggccgggt
    26041 gctgatcgtc gagccgctgc tgccggacaa tgcgcacgat gtgccgtcgt tcttcggcat
    26101 cgtcacctcc gacctggatc tgctggcagc cacccagggc aagatccgta ccacggagga
    26161 cttccgggag ctgctccgcg cgaccggctt cgagctgacc gatgtcacgc cgctgggttc
    26221 ctacgagttc tccacccacg accactacaa cgtgcttgag gccactccgt gctgaccgcg
    26281 gtcgatcacg aacaacccat ggcgaccgtc cccgccctgg ccgccgccgc tccgggagcg
    26341 gaactggaac ccaccagcat ccggctgcgt ccggttggtg atcacgacgt actcatccag
    26401 atcgcgtacg tgggcatctg ccactcggac atccaccagg tccgggagga gtggggcgcg
    26461 gcatcgttcc ccatggtccc gggacatgag atagcgggtg tggtcaccca ggccgggtca
    26521 ggcgtcaagc ggttctccgt cggcgatcgg gtgggcgtgg gatgcttcgt ggactcgtgc
    26581 cggagctgcg tgcactgccg gcgcggcgag gagcagttct gcgagcaggg catgacctcc
    26641 acgtacaacg cggtcggccg cgacggcctg cccaactacg gcgggtacag cacgcacatc
    26701 gtcgtggacg agaactacgt gctggccatc cccgactctc tcgcgctgga cgaggccgca
    26761 cctctgctgt gcgccggaat caccatgtac gcgccgctcg tgcgctgggg cgcgggacct
    26821 ggtacacgtg tggcagtcgt gggcctggga ggactcggcc acctgggggt caagttcgcc
    26881 cgggccatgg gggccgaggt gaccgtactc agccgcgggt cgcgtaagca gcggggcgcg
    26941 ctgcggctgg gcgctgacca ctttcgggcg actgaaaaac ctgcggtctt cgaggagttg
    27001 agtggggcct tcgaccttgt cctcagtacg gtgtccgcgt cgttggagct ggactcctat
    27061 ctgggactgc tgacggttgg cggtaccctc gtccacgtgg gggtcccacc gggcccctcg
    27121 tctctcagcg tcgccgcact cgtcgacggg cgcaagaacc tgtccggatc gttcatcggc
    27181 ggtacaggcg agactcaggc gatgctcgac ttctgcgccg tgcacggtat cggtgcggag
    27241 gtggaggtca tcgacgccaa gcaggccaac gacgcatatg cacgggtggt ggacggggac
    27301 gttcgctacc gtttcgtcat cgacgtcacg acgttggggc gcgcggactc atga
//
