LOCUS       BGC0001227             12144 bp    DNA     linear   BCT 06-NOV-2018
DEFINITION  Streptomyces collinus Tu 365 chromosome, complete genome.
ACCESSION   BGC0001227
VERSION     BGC0001227
KEYWORDS    .
SOURCE      Streptomyces collinus Tu 365
  ORGANISM  Streptomyces collinus Tu 365
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     Genome was manually curated based on annotation generated by the
            NCBI Prokaryotic Genomes Automatic Annotation Pipeline Group.
            Information about the Pipeline can be found here:
            http://www.ncbi.nlm.nih.gov/genomes/static/Pipeline.html.
            Bacteria available from Dr. Wolfgang Wohlleben
            (wolfgang.wohlleben@biotech.uni-tuebingen.de).
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-08 00:07:20
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 697068
            Orig. end    :: 709212
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..1020)
                     /locus_tag="B446_02720"
     CDS             complement(1..1020)
                     /codon_start=1
                     /locus_tag="B446_02720"
                     /note="COG4638 Phenylpropionate dioxygenase and related
                     ring-hydroxylating dioxygenases, large terminal subunit"
                     /product="iron-sulfur protein"
                     /protein_id="AGS67376.1"
                     /transl_table=11
                     /translation="MTPAGPPGRGRLPLRLRRAPVAWERQRPTWREARPALIADALKRA
                     QARPSGNWYVVGASRDLRADRPLARTVEGHEVVLWRDRSGDLVAGPGVCPHLGAPLRDS
                     PVRCGTLVCHWHGLALDGAPFAGWEPWPAHDDGVLLWARLDAVGGEEPTPLPPVPVRPD
                     PGRALVAVYTGSGRCEPEDVVANRLDPWHGAWFHPYSFVDLTVVDTPRPTDGRSAPDAF
                     TVDVSFKVAGRLVVPVRTEFTAPGPRTVVMRITDGEGEGSVVETHATPLGTDATGTPRT
                     AVVEAVVAASGRPGFALARRAGPLLAPLVRQAAGRLWRDDLAYAERRWSLRSTGRFPG"
     subregion       1..12144
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Terpene"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12144
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1017..2033)
                     /locus_tag="B446_02725"
     CDS             complement(1017..2033)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /locus_tag="B446_02725"
                     /note="COG1562 Phytoene/squalene synthetase"
                     /product="phytoene synthase"
                     /protein_id="AGS67377.1"
                     /sec_met_domain="phytoene_synt (E-value: 4.9e-114,
                     bitscore: 369.6, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARELDAAGITDPRLRDAYTHCRRLNARHGRTYFLATRLLPPGR
                     RPAVHALYGFARHADDIVDVCDGDLRRLADDGTQRRAAALDRLADDLAHGLAGGTGAAP
                     VTVALADTSRRYGIEHRHFTDFLGSMRSDLTVTEYADYGALRAYMHGSAAVIGLQMVPV
                     LGTVVPREEAAPYAAELGVAFQLTNFLRDVGEDLDRGRIYVPQDLLAAHGVDRDLLRHC
                     RDTGRTDPRVVAALRAFEALTRAAYDRAAPGVPLLDPVTRPCIRTAFVLYRGILDAVAG
                     DGWAVLHRRAVVPRRRRVLTAADGLLRVAAARLATRRRSPDTPGTTAPSSARTKEAM"
     gene            complement(2030..3532)
                     /locus_tag="B446_02730"
     CDS             complement(2030..3532)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 462.9; E-value: 2.5e-140)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="B446_02730"
                     /note="COG1233 Phytoene dehydrogenase and related proteins"
                     /product="phytoene desaturase"
                     /protein_id="AGS67378.1"
                     /transl_table=11
                     /translation="MVVGAGLAGLSTTLHLLGAGRRVTVVERDPRPGGRAGRLELGGYL
                     IDTGPTVLTMPDIADEAFAAVGTSLRDRVDLIPLHPAYRARFADGSTLDVHTDAAAMEA
                     EIERFAGGAEAARYHRLRHWLGELYRTERGRFLDADFDSPFQLLTPDLLRLAALGGFGR
                     WEARIARHLRDERLRRVFSFQALYAGVPPERALAAYAVIAFMDTIAGVYFPRGGMYALP
                     RAMAEAAAEAGAEFRYGQRVTGLERTGDRVSAVLTADARIPCDAVVLTPDLPVTYRLLG
                     RAPRRPTRLRHAPSAVVLHAGCDRTWPELAHHTLSFGHAWRGTFRQLTRTGELMSDPSL
                     LITRPTATDPGLAPPGRHLHYVLAPCPNTDIGPGAVDWSGLAPRYRDSLLRELDRRGLT
                     GIASAIETECLVTPADWSGLGHAAGTPFSAAHTFGQTGPFRPRNLVRGTANAVLAGCGT
                     TPGVGVPPVLLSGKLAAARITGPRKRAAATGRTIPTTRGARR"
     gene            complement(3565..4836)
                     /locus_tag="B446_02735"
     CDS             complement(3565..4836)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 213.8; E-value:
                     4.7e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="B446_02735"
                     /note="COG0142 Geranylgeranyl pyrophosphate synthase"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="AGS67379.1"
                     /transl_table=11
                     /translation="MRSTQVLGRLTAAAPRTPPAPAGSGAPRKPDGVADARTVDADVPG
                     AVGRELRDLLTGRLADCRALDPVFADDIAERVAGFTRRGGRRFRSRLVWWSLRACGGRD
                     AVQVRAALRTAAALELIQTCALVHDDLMDQAPTRRGAPALHADVTAQYADTASRSAAHR
                     LGASGALLAGDLALAWADDELARLLLEPGLPRDTARRLNEVWRTLRTEMVAGQYLDVQG
                     QATSALTLGRALRAACLKSALYTVERPLELGAVLAGADTATTWTLCLAGRSAGLAFQLR
                     DDLDDVFADPATTGKLSGGDVREGKPTYLLAVARARATAAGDQAALGVLEHAVGRADLT
                     GRELADVRDVLESTGARALVETKIGRLARQSLRHLAEATLEPGPADRLRALLAEITGTP
                     RPEPGPDGPPLTPAPAAARSEAAR"
     gene            5083..6279
                     /locus_tag="B446_02740"
     CDS             5083..6279
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /locus_tag="B446_02740"
                     /product="lycopene cyclase"
                     /protein_id="AGS67380.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 5.1e-99, bitscore:
                     321.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVESDVAVVGAGAAGLSLALRLARPPAGARPVTAVVLAAPPGPY
                     RAPRRTWCYWEAGEGPYDGALTASWQRLRVHAGDGRPVTAAIGPWRYKMLGSDAFEELA
                     GRALRVSPWVTTVEAVVESVAAVPGGAVVRARRADGGEVTVRARWVFDSRPPALLPPAR
                     TTLLQHFRGWFVRTRRPVFDPATVELMDFRTPQPGHGLSFGYVLPTGPHEALVEYTEFS
                     RRVLDTDAYDRALRDYTGRVLRIGEHEVTACEQGVIPMTDARFPRQAGASVFRIGAAAG
                     ATRPATGYTFSAVQRQAGAVAAALHAGRRPLPPRPHSARSRLMDAALLYALDHGRVDGP
                     AFFTRLFTRVSAPRLLRFLDGRTSLPEDLSIGLHVPVTAMLGAVLALPFAPRRSAPTS"
     gene            6491..7225
                     /locus_tag="B446_02745"
     CDS             6491..7225
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 76.9; E-value:
                     2.8e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="B446_02745"
                     /note="COG2226 Methylase involved in ubiquinone/menaquinone
                     biosynthesis"
                     /product="methyltransferase"
                     /protein_id="AGS67381.1"
                     /transl_table=11
                     /translation="MPVLRDADLASAFNHAARSYDTLVAANPGYHAHLRRSARRLGLAR
                     GGPAPRVLDLGCGTGASTAALAAVLPGADITAVDASAGMLRRAAGRPWPRPVRFVHAPV
                     EGLAEAGVRGPFDAVFAAYLLRNTADPDAVLAGAYRMLAPGGRLALHEYTLSGRPAHRA
                     VWNAVCGGLVLPVATLLGDGPLYRHLWRSVVDFDTAGQFAHRVRRAGFERVRVLPLPGW
                     QTGITHTVVARRPAAGPDGAGR"
     gene            7222..8856
                     /locus_tag="B446_02750"
     CDS             7222..8856
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 54; E-value: 2.5e-16)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="B446_02750"
                     /note="COG3349 Uncharacterized conserved protein"
                     /product="beta-carotene desaturase/methylase"
                     /protein_id="AGS67382.1"
                     /transl_table=11
                     /translation="MTGPGRGSGSGTRAPLPGRDRLARLLPAPPGVAWAEGSTAPRAAV
                     VGGGIAGLTAATALAERGVQVTLYERDAQLGGRLAGWRTRLADGSPATMSRGFHAFFRQ
                     YYNLRSLLRRTDPALTGLTPLPDYPLRHGSGRRDSFRHVPRTPPWSALGFVALSESFSV
                     RDLPRIRPRAALPLLDVRVPDVYERLDHVSAYDLLDAIRFPTAARHLAFEVFSRSFFAD
                     PRGLSAAEMALMFHVYFLGSSEGLLFDVPSEPFPQALWDPLAARLDRLGAQVRTATAVD
                     EVAVTPTGGFSVTAAGGAEPYDAVVLALDPAGLRSLVARSAGLGDAQWRERMARLRNAP
                     PFLVSRLWLDRPVRADRPGFLGTSGYGALDNVSVLSAWEGEAARWAAGSGGSVLELHAY
                     ALPQDADRETVGKELLGELHRLYPETRQARVVDARHDWRADCPLFPVGGHTDRPTVGTS
                     VPGLVVAGDTVRTGLPVALMERAATSGFLAANTLLGRWGLRGHDLWTVPGRGRSAGLRW
                     AARRFGAAYGHGGRGNSGRGGAEATGP"
     gene            8897..9736
                     /locus_tag="B446_02755"
     CDS             8897..9736
                     /codon_start=1
                     /locus_tag="B446_02755"
                     /note="COG2220 Predicted Zn-dependent hydrolases of the
                     beta-lactamase fold"
                     /product="hypothetical protein"
                     /protein_id="AGS67383.1"
                     /transl_table=11
                     /translation="MAAFEDAVAIHFVGNATVLLRYGALTLLTDPNFLHRGERAHLGYG
                     LVSRRVTEPALDVADLPRLDGVVLSHLHGDHWDRRARAGLPRSVPVVTTPHAARRLRTL
                     QGFRRAGGLRTWESCTLRRDDAQVRITALPGRHSLLAPLRALLPPVMGSMLEFGPAGGP
                     VRVRLYVSGDTLLYDGLEEIARRFPDADLAVLHLGGTRLPGGFVVTMDGLQGAELARRL
                     DYRRVLPVHYDDYTVFRSPLQDFLTAAAGLGLGERIVHCPRGGHAEVVAGGDRPTVR"
     gene            9843..10559
                     /locus_tag="B446_02760"
     CDS             9843..10559
                     /codon_start=1
                     /locus_tag="B446_02760"
                     /note="COG0640 Predicted transcriptional regulators"
                     /product="transcriptional regulator"
                     /protein_id="AGS67384.1"
                     /transl_table=11
                     /translation="MEDIDAIAALQDPVRRRLYEYVVARGREVGRNEAAEATGVARTLA
                     AHHLDRLTEAGLLESGSRRLTGRSGPGAGRPAKVYTRARAERAVSLPARDYRTAAELLA
                     EAAEQAGLDTELTTAARRRGEALRGPAAPCGSLEQAMEALAARGYEPHLETGGGTAGTD
                     DTEGTGDGAGSGTPVVRMRNCPFHAVAERFPPLVCGMNLALLEGLLGADGAVRARMDAR
                     PGGCCVVVEPSKNKSR"
     gene            10586..11170
                     /locus_tag="B446_02765"
     CDS             10586..11170
                     /codon_start=1
                     /locus_tag="B446_02765"
                     /product="hypothetical protein"
                     /protein_id="AGS67385.1"
                     /transl_table=11
                     /translation="MAMTAATHALHLAQLNVAALTHPLDDPRTAPFVELLDPVNAAADA
                     APGFVWRLVEEGAADATALRPMGENVIVNLSVWETREALWEFTYRSGHLEVMRRRREWF
                     ERHVEAHMVLWWVPAGHLPTVGEALERLADLRAHGPSPRAFTFASAYTAAEAARHGHAP
                     HEVSSPAPPPADHTWTVPLATPIASVDPVVS"
     gene            complement(11074..12144)
                     /locus_tag="B446_02770"
     CDS             complement(11074..12144)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173:WD-40
                     repeat-containing protein (Score: 73.6; E-value: 2.3e-22)"
                     /gene_kind="other"
                     /locus_tag="B446_02770"
                     /note="COG2319 FOG: WD40 repeat"
                     /product="putative regulatory protein"
                     /protein_id="AGS67386.1"
                     /transl_table=11
                     /translation="MVIILVAGAAFTAGWSLPIPWPGQDRRPSPDPITARADIKRTFGV
                     GAGPVAGIAYSPDGSRLAAATSDGGVVVRDALNGREESRRYTPEYTGAVTGLTFSTDGR
                     TVAVSTSSGYVLLWPVSGARAESAALEPPAGRGSAVTGTAFSHDAHTLAVANSQGVVRL
                     WDVRDPRHPHVVATPARRHSVTDVAFDRADRSLAVGSIDGTIQLWDVRDPRRPEVLDTL
                     HSGQSVTSVGYSPDGSVLAAGRSDGTTRFWDVHDPAAPRPYTQARSWAAPGDIGSITGL
                     TFTDGSRLAASTAGGYVQVWNLRSHRSPSLLRPSSRSQAFTSLSYDTTGSTLAIGVANG
                     TVQVWSAGGGAGDETS"
ORIGIN
        1 tcagccaggg aagcggccgg tggagcgcag ggaccagcgg cgctcggcgt aggccaggtc
       61 gtcgcgccag aggcgccccg cggcctgccg gaccagcggg gccagcagcg ggccggcccg
      121 gcgcgcgagg gcgaaccccg ggcgtccgga ggcggccacg acggcttcga ccacggcggt
      181 gcgcggggtg cccgtcgcgt cggtgcccag gggtgtcgcg tgggtctcca cgaccgagcc
      241 ctcgccctcg ccgtcggtga tccgcatgac gaccgtgcgc ggtccgggtg cggtgaactc
      301 cgtgcgtacg ggcacgacga gccgtccggc gaccttgaag gagacgtcga ccgtgaaggc
      361 gtccggcgcc gaacgcccgt ccgtcgggcg gggggtgtcg acgacggtga ggtcgacgaa
      421 ggagtacggg tggaaccagg cgccgtgcca ggggtcgagg cggttggcca ccacgtcctc
      481 cggctcgcac cgcccgctcc cggtgtagac ggcgaccagc gcccggccgg ggtcgggccg
      541 gaccggcacc ggtggcaggg gggtgggttc ctccccgccc acggcgtcca ggcgtgccca
      601 gagcagcact ccgtcgtcgt gcgcgggcca cggctcccag ccggcgaacg gggcgccgtc
      661 cagggccagt ccgtgccagt ggcacaccag cgtgccgcag cgcaccgggc tgtcgcgcag
      721 cggcgcgccc aggtgggggc agacgccggg cccggcgacc aggtcgccgc tccggtcgcg
      781 ccagagcacc acctcgtgtc cctccacggt acgggccagg ggccggtcgg cgcgcaggtc
      841 gcgggaggcg ccgacgacat accagttgcc gctgggccgg gcctgcgccc gcttgagggc
      901 gtcggcgatc agtgcgggcc gcgcctcgcg ccaggtgggg cgctggcgtt cccaggcgac
      961 gggggcgcgg cgcaggcgca ggggcagacg gccgcgcccg gggggaccgg cgggtgtcac
     1021 atggcctcct tggtgcgggc ggacgacgga gcggtggtgc cgggggtgtc cggcgaccgg
     1081 cggcgggtgg cgaggcgggc cgccgcgacg cggagcaggc cgtcggcggc ggtgaggacg
     1141 cggcggcggc gcggcacgac cgcgcggcgg tgcagcaccg cccagccgtc gccggcgacg
     1201 gcgtccagga tgccgcggta gaggacgaac gccgtgcgga tgcacggccg ggtgacgggg
     1261 tcgagcaggg gcacgccggg ggccgcgcgg tcgtaggcgg cgcgggtgag ggcctcgaag
     1321 gcgcggagcg cggcgacgac gcgggggtcg gtgcggccgg tgtcccggca gtggcgcagc
     1381 aggtcgcggt cgacgccgtg cgcggcgagc aggtcctggg ggacgtagat ccggccgcgg
     1441 tcgaggtcct cgccgacgtc ccgcaggaag ttggtcaact ggaaggcgac gccgagttcg
     1501 gcggcgtagg gtgcggcctc ctcccggggg acgacggtgc cgaggacggg gaccatctgg
     1561 aggccgatga cggccgccga gccgtgcatg taggcgcgca gggcgccgta gtcggcgtac
     1621 tcggtgacgg tcaggtcgct gcgcatggag ccgaggaagt cggtgaagtg gcggtgctcg
     1681 atgccgtagc ggcggctggt gtcggcgagg gcgacggtga ccggcgcggc gccggtgccg
     1741 ccggcgaggc cgtgggcgag gtcgtcggcc agccggtcga gggcggcggc ccgccgctgc
     1801 gtcccgtcgt cggcgagccg gcgcaggtcg ccgtcgcaga cgtcgacgat gtcgtccgcg
     1861 tggcgggcga agccgtacag ggcgtgcacg gcggggcgcc gtccgggcgg gagcagccgg
     1921 gtggcgagga agtaggtgcg gccgtggcgg gcgttgagcc ggcggcagtg ggtgtaggcg
     1981 tcacgcagcc gcgggtccgt gatgccggcg gcgtccagtt cgcgggccgt catcgccggg
     2041 ctcctcgcgt cgtcgggatg gtccggccgg tggcggcggc ccgcttgcgc ggcccggtga
     2101 tgcgggcggc cgccagcttt cccgagagca ggacgggggg cacgccgacg ccgggggtgg
     2161 tgccgcaccc ggcgaggacg gcgttggcgg tgccgcgcac caggttgcgc gggcggaacg
     2221 ggccggtctg gccgaaggtg tgcgcggcgg agaacggggt ccccgccgcg tgtccgagtc
     2281 cgctccagtc ggcgggggtg accaggcatt cggtctcgat ggccgaggcg atgccggtca
     2341 ggcccctgcg gtccagttcg cgcagcaggc tgtcgcggta acggggggcc aggccggacc
     2401 agtcgacggc gccggggccg atgtcggtgt tggggcaggg ggcgaggacg tagtgcaggt
     2461 ggcggccggg cggggcgagg ccggggtcgg tggcggtggg ccgggtgatc aggagcgagg
     2521 ggtcgctcat gagctcgccg gtgcgggtga gctggcggaa ggtgccgcgc caggcgtggc
     2581 cgaaggacag ggtgtggtgg gccagttcgg gccaggtgcg gtcgcagccg gcgtgcagga
     2641 cgacggcgga cggggcgtgc cgcaggcggg tggggcggcg tggggcgcgg cccagcaggc
     2701 ggtacgtcac cggcaggtcg ggggtgagga cgacggcgtc gcaggggatg cgcgcgtcgg
     2761 cggtgaggac ggccgagacc cggtcgccgg tccgttccag gccggtcacc cgctgcccgt
     2821 accggaactc cgcccccgcc tcggcggcgg cctcggccat cgcgcggggc agcgcgtaca
     2881 tgccaccgcg cgggaagtac accccggcga tggtgtccat gaaggcgatc acggcgtagg
     2941 cggccagggc ccgttccggc gggacgccgg cgtagagggc ctggaaggag aagacgcggc
     3001 gcagccgctc gtcgcgcagg tggcgggcga tgcgcgcctc ccagcggccg aagccgccga
     3061 gggcggcgag ccgcagcagg tcgggggtga ggagctggaa cggggagtcg aagtcggcgt
     3121 cgaggaagcg gccgcgctcg gtgcggtaca gctcgcccag ccagtgccgc agccggtggt
     3181 agcgggccgc ttcggcgcct ccggcgaacc gttcgatctc cgcctccatg gccgccgcgt
     3241 cggtgtgcac gtcgagggtg ctgccgtcgg cgaagcgcgc ccggtaggcg gggtgcagcg
     3301 ggatgaggtc gacgcggtcg cgcagcgagg tgccgacggc ggcgaacgcc tcgtcggcga
     3361 tgtccggcat ggtgagcacg gtggggccgg tgtcgatgag gtagccgccg agttcgaggc
     3421 gtccggcccg gccgcccggc cgcgggtcgc gttcgacgac ggtcacccgg cggcccgcgc
     3481 cgagcaggtg cagggtggtg gagaggccgg ccagcccggc gccgacgacc acgacgtgat
     3541 cggtgggtcc cgttaccgtc ctggtcaccg ggccgcctcc gatcgcgccg cggcgggtgc
     3601 gggggtgagc ggggggccgt cgggtcctgg ttccggccgg ggggtgccgg tgatctcggc
     3661 cagcagggcg cgcagccggt cggcgggacc gggttcgagg gtggcctcgg cgaggtggcg
     3721 cagggactgc cgggccagcc gcccgatctt cgtctccacc agggcgcggg cgccggtgct
     3781 ttcgagcacg tcccggacgt cggccagttc acggcctgtc aggtccgccc ggccgaccgc
     3841 gtgttcgagc acgccgagcg ccgcctggtc gccggcggcg gtggcccggg cccgggccac
     3901 cgccagcagg taggtgggct tgccctcgcg cacgtcgccg ccgctcagtt tgccggtggt
     3961 ggcggggtcg gcgaagacgt cgtcgagatc gtccctgagc tggaaggcca gtcctgccga
     4021 gcgtccggcg aggcacagcg tccaggtggt ggcggtgtcg gcgccggcga gcaccgcgcc
     4081 gagttccagg ggccgttcga cggtgtagag ggcgctcttg aggcaggcgg cgcgcagcgc
     4141 gcggcccagg gtgagggcgg aggtggcctg gccctggacg tcgaggtact ggccggcgac
     4201 catctcggtg cgcagggtgc gccagacctc gttcagccgg cgcgcggtgt cccgcgggag
     4261 gccgggctcc agcagcagcc gggcgagttc gtcgtccgcc caggcgagcg cgaggtctcc
     4321 ggcgagcagc gcgccggacg cgccgagccg gtgggccgcg gaccgtgacg ccgtgtcggc
     4381 gtactgagcc gtcacgtcgg cgtgcagcgc cggtgcgccg cggcgggtgg gcgcctggtc
     4441 catcaggtcg tcgtggacca gggcgcaggt ctggatgagt tcgagcgcgg cggccgtacg
     4501 cagcgccgcg cggacctgga cggcgtcccg gccgccgcag gcgcgcagcg accaccacac
     4561 gagccgggag cggaaccggc ggccgccgcg ccgggtgaag ccggcgaccc gctcggcgat
     4621 gtcgtcggcg aacaccgggt cgagtgcgcg gcagtcggcg aggcggccgg tgagcaggtc
     4681 ccgcagctcc ctgccgacgg cgccgggcac gtcggcgtcg acggtgcgcg cgtcggccac
     4741 gccgtcgggc ttccggggcg cgccggatcc ggccggcgcg ggcggcgtac ggggtgccgc
     4801 tgccgtgagg cggccgagca cctgggtgga acgcatcgtg gatcctctcg ccgtccggag
     4861 agccgggctg cgcgccccgg gctcgcctgt cctgtctcgt gtcactcgtg tctcgtctct
     4921 tgtcgtcaca cattccgcgc ggatcaccgc accggatgcg ccattcggtg gacatgccgg
     4981 cgccgggggc gggcggcggc acgacacgcc cacggctgca tccgccgggg cggtgcggcg
     5041 ggaagactgg tcggatcaaa cgggccgggg aagggagcca ccgtggaggt ggagtcggac
     5101 gtcgcggtgg tcggcgcggg ggccgccggg ctgtcgctcg ccctgcggct ggcccggccg
     5161 cccgcgggag cgcgcccggt gacggcggtg gtgctggcgg caccgccggg cccgtaccgc
     5221 gcgccgcgcc gtacctggtg ctactgggag gcgggcgaag ggccgtacga cggggcgctc
     5281 acggcttcct ggcagcggct gcgggtgcac gcgggcgacg ggcggccggt gaccgccgcg
     5341 atcgggccct ggcggtacaa gatgctgggc tcggacgcgt tcgaggaact ggccggccgg
     5401 gcgctgcggg tgagcccgtg ggtgacgacg gtcgaggcgg tcgtcgagag cgtggcggcc
     5461 gtgccgggcg gtgccgtggt gcgggcccgc cgggccgacg gcggcgaggt gaccgtgcgc
     5521 gcccgctggg tgttcgactc gcgtccgccg gccctgctgc cgccggcccg cacgacgctg
     5581 ctgcagcact tccgcggctg gttcgtgcgc acccggcggc cggtgttcga ccccgcgacc
     5641 gtggagttga tggacttccg caccccgcag ccggggcacg ggctgtcgtt cggctacgtc
     5701 ctgccgaccg gcccgcacga agcgctggtg gagtacacgg agttctcccg gcgcgtgctg
     5761 gacacggacg cgtacgaccg tgcgctgcgg gactacaccg gccgggtcct gcggatcggg
     5821 gagcacgagg tcaccgcgtg cgagcagggc gtgatcccga tgacggacgc gcgtttcccc
     5881 cggcaggccg gggcgtccgt gttccggatc ggggcagcgg ccggtgccac ccggcccgcg
     5941 acgggctaca cgttcagcgc ggtgcagcgc caggcgggcg ccgtcgcggc cgcgctgcac
     6001 gcgggccgcc gtccgcttcc gccgcgcccg cactcggcgc gctcccggct gatggacgcc
     6061 gcgctgctgt acgccctgga ccacggccgg gtcgacggcc cggccttctt cacccgcctg
     6121 ttcacccgag tctccgcgcc tcggctgctg cgtttcctgg acggtcgcac cagcctgccg
     6181 gaggacctgt ccatcggcct gcacgtgccc gtcaccgcga tgctcggcgc ggtcctcgcc
     6241 ctgcctttcg ccccgcgccg aagtgccccg acctcgtgaa ctccgccccg gaaagccccg
     6301 cccgcgcgac cgcgccccgg aaagccccgc ccgtacgacc cgcgccctga agagccccgc
     6361 ccgcacggcc cacggcccga agagcccccg accgcacgac ccacgctccg aagagctccg
     6421 accgcacgcc ccacgaccgg actgccccga tcgcaccacc cacgccccga cgacctctta
     6481 cggagatggc atgcccgtgc tgcgtgacgc cgacctggcc agcgcgttca accacgccgc
     6541 ccgcagttac gacacgctgg tggcggccaa tccgggctac cacgcccatc tgcgccgctc
     6601 cgcccggcgg ctcggcctgg cccgtggcgg tccggccccg cgcgtgctcg acctcgggtg
     6661 cggcacgggt gcctcgacgg cggcgctggc cgccgtgctg ccgggcgcgg acatcaccgc
     6721 cgtcgacgcg tcggccggca tgctgcggcg tgcggcgggg cggccgtggc cacggccggt
     6781 gcggttcgtg cacgcgccgg tggagggact ggccgaggcg ggggtacggg gcccgttcga
     6841 cgcggtcttc gccgcctacc tgctgcgcaa caccgccgac ccggacgccg tcctggccgg
     6901 cgcgtaccgg atgctcgccc cgggcggccg gctggcgctg cacgagtaca cgctgagcgg
     6961 gcggccggcc caccgcgcgg tgtggaacgc ggtgtgcggc ggactggtgc tgccggtcgc
     7021 caccctgctc ggcgacggcc cgctctaccg gcacctgtgg cgcagcgtcg tcgacttcga
     7081 cacggcgggg cagttcgccc accgggtgcg gcgggccggc ttcgagcggg tgcgggtgct
     7141 gccgctgccg ggctggcaga cggggatcac ccacaccgtg gtcgcccgcc gcccggcggc
     7201 cggcccggac ggggcgggac gatgaccggc ccgggccgcg ggtccgggag cggcacccgg
     7261 gcgccgctcc ccggccggga ccggctggcg aggctgctgc ccgcaccgcc cggcgtcgca
     7321 tgggccgagg ggtcgaccgc cccgcgcgcg gcggtcgtcg gcggcggaat cgccggcctg
     7381 acggcggcca ccgccctggc cgaacgcggc gtccaggtca ccttgtacga acgggacgcc
     7441 cagctgggcg ggcggctggc cgggtggcgg acgcggctgg cggacggatc cccggccacg
     7501 atgagccgcg gcttccacgc cttcttccgg cagtactaca acctgcggtc cctgctgcgt
     7561 cgtaccgacc ccgccctgac cgggctgacc ccgctgcccg actacccgct gcggcacggc
     7621 agcggccgcc gggacagctt ccggcacgta ccgcgcacac ccccgtggag cgcgctcggg
     7681 ttcgtggcgc tgagcgagtc gttctccgtg cgcgacctgc cccggatccg gccgcgtgcg
     7741 gccctgccgc tgctcgacgt gcgggtcccg gacgtgtacg agcggctcga ccacgtcagc
     7801 gcctacgacc tgctggacgc gatccggttc cccacggccg cccggcacct ggcgttcgag
     7861 gtgttctcgc gcagcttctt cgccgatccg cgcgggctgt cggccgcgga gatggcgctg
     7921 atgttccacg tctacttcct cggttcgtcc gagggcctgc tgttcgatgt gccctctgag
     7981 ccgttcccgc aggccctgtg ggacccgctg gccgcgcggc tcgaccggct cggcgcacag
     8041 gtgcgcacgg ccacggccgt ggacgaggtc gccgtgacgc ccaccggggg cttctccgtg
     8101 accgcggcgg gcggggccga gccgtacgac gccgtggtcc tcgccctgga cccggcggga
     8161 ctgcgctcgc tggtggcccg ttcggccggg ctgggcgacg cgcaatggcg cgagcggatg
     8221 gcgcggctgc gcaacgcgcc gcccttcctg gtctcccgtc tgtggctgga ccggccggta
     8281 cgcgcggacc ggcccgggtt cctcggtacc agcggatacg gcgcgctgga caacgtgagc
     8341 gtgctcagcg cctgggaggg cgaggccgcc cgctgggcgg ccggctcggg cggttcggtg
     8401 ctcgaactgc acgcgtacgc cctgccccag gacgcggacc gggagaccgt gggcaaggag
     8461 ctgctcggcg aactgcaccg gttgtatccg gagacccggc aggccagggt ggtcgacgcc
     8521 cgccacgatt ggcgggccga ctgcccgctg ttcccggtag gcggccacac ggaccggccg
     8581 acggtgggca cgtccgtgcc cggcctggtc gtcgcgggcg acacggtccg caccggtctg
     8641 ccggtggccc tgatggaacg ggcggccacc agcggtttcc tcgccgccaa caccctgctc
     8701 ggccggtggg ggctgcgcgg ccacgatctg tggacggtgc ccggccgggg ccgctccgcg
     8761 ggcctgcggt gggcggcgcg gcggttcggc gcggcgtatg ggcacggcgg ccgggggaac
     8821 tcgggccggg gaggggctga ggcgacagga ccgtaggacg gtacaggcgg gctcgtcccg
     8881 ccgggcaagg actctcatgg cagccttcga ggacgcggtc gcgatccact tcgtcggcaa
     8941 cgcgacggtg ctgctgcgct acggcgcgct gaccctgctg acggacccca acttcctcca
     9001 ccgcggcgag cgggcgcacc tggggtacgg gctggtcagc cgccgggtca ccgagccggc
     9061 cctggacgtg gcggacctgc cgcgcctgga cggcgtcgtc ctgtcccatc tgcacggtga
     9121 ccactgggac cgccgggcca gggccggcct gccccggtcg gtgcccgtcg tcacgacacc
     9181 gcacgccgcg cgccgcctgc gcaccctgca ggggttccgc cgggcgggcg ggctgcgcac
     9241 ctgggagagc tgcaccctgc gacgggacga cgcgcaggta cggatcaccg ccctgcccgg
     9301 ccggcactcc ctgctggcgc cgctgcgcgc gctgctgccg ccggtcatgg gcagcatgct
     9361 ggagttcggc cccgcgggcg ggccggtgcg ggtccggctg tacgtctcgg gcgacaccct
     9421 cctgtacgac ggcctggagg agatcgcgcg gcgcttcccg gacgccgacc tggccgtgct
     9481 ccacctgggc ggcacgcggc tgcccggggg cttcgtcgtc accatggacg gcctccaggg
     9541 agccgagctg gcccggcgcc tcgactaccg ccgtgtcctg ccggtgcact acgacgacta
     9601 caccgtcttc cgctcaccgc tccaggactt cctgaccgcg gcggccgggc tcggactcgg
     9661 ggagcggatc gtgcactgcc cccgtggcgg tcacgcggag gtggtggcgg gcggtgaccg
     9721 gcccaccgtg cgctgagcgc ccccacgtgc acggctcagc cacctcctcg cccgcggcat
     9781 cgcttcgccc tccggcctgc gctgcttcta tctccgactc gcgttgttcc tagaatgggc
     9841 gggtggagga catcgacgcg atcgccgccc tgcaggaccc ggtgcggcgc cgcttgtacg
     9901 agtacgtggt ggcgcggggc cgcgaggtcg gccgcaacga ggccgccgag gcgactggcg
     9961 tggcgcgcac actcgccgcg caccatctgg accggttgac cgaggccggg ctgctggaga
    10021 gcggcagccg ccgcctgacg ggccgttcgg gccccggggc cggccggccc gccaaggtgt
    10081 acacccgggc gcgggccgag cgggccgtgt ccttgcccgc acgcgactac cgcacggccg
    10141 ccgaactcct cgccgaggcc gccgagcagg ccggcctcga caccgaactc accacggccg
    10201 cgcgccgccg gggcgaggcg ctgcgcggcc cggcggcccc ctgcggaagc ctcgaacagg
    10261 ccatggaggc actggcggcc cgcggctacg aaccgcacct ggagacgggc gggggcaccg
    10321 cgggcacgga cgacacggaa ggcaccgggg acggggccgg atcgggcaca cccgtggtcc
    10381 ggatgcgcaa ctgccccttc cacgcggtcg ccgagcgctt cccgccgctc gtctgtggca
    10441 tgaacctcgc actgctggag gggctgctcg gcgcggacgg cgccgtccgc gcccgtatgg
    10501 acgcccggcc ggggggatgc tgcgtggtgg tcgaaccttc taaaaacaaa tctcgttgac
    10561 atagaaatcc gcgccgtgct gggatgtggc catgaccgca gccacgcacg ccctccacct
    10621 cgcccagctc aacgtcgccg ccctcaccca ccccctggac gacccgcgca ccgctccgtt
    10681 cgtcgagctg ctcgacccgg tcaacgccgc cgcggacgcg gcgcccggct tcgtgtggcg
    10741 gctggtggag gagggagcgg ccgatgccac cgccctgcgc ccgatgggcg agaacgtcat
    10801 cgtcaacctg tcggtgtggg agacccggga ggccctgtgg gagttcacct accgcagcgg
    10861 tcacctggag gtgatgcggc gccgccgcga gtggttcgag cggcacgtcg aggcgcacat
    10921 ggtgctctgg tgggtccccg ccggccatct ccccaccgtc ggcgaggcgt tggagcggct
    10981 cgccgacctc agggcgcacg ggccgtcccc gcgcgcgttc accttcgcct ccgcgtacac
    11041 ggcggccgag gccgcccggc acggccacgc ccctcacgag gtctcgtcgc ccgcaccacc
    11101 gccggcggac cacacctgga ccgtgccgtt ggccaccccg atcgccagcg tggacccggt
    11161 ggtgtcgtag gacagactcg tgaaggcctg ggaccgggac gacggcctga gcaggctcgg
    11221 actgcggtgg ctgcgcaggt tccagacctg gacgtagccc cctgccgtgc tggccgcgag
    11281 gcggctgccg tcggtgaagg tcaggccggt gatggacccg atgtcgccgg gagcggccca
    11341 gctgcgcgcc tgcgtgtagg ggcgcggcgc cgccgggtcg tgcacgtccc agaacctggt
    11401 ggtcccgtcg ctccgcccgg cggcgaggac actgccgtcc gggctgtacc cgacactggt
    11461 gaccgactgg ccggagtgca gggtgtcgag cacctccgga cgccgtgggt cgcggacgtc
    11521 ccagagctgg atggtgccgt cgatgctgcc cacggccagc gaccggtcgg cgcggtcgaa
    11581 cgccacgtcg gtcaccgagt gccggcgcgc cggggtcgcc acgacgtgcg ggtggcgcgg
    11641 gtcgcgtacg tcccacagcc gcacgacgcc ctgggagttc gccacggcga gcgtgtgtgc
    11701 gtcatggctg aacgcggtgc ccgtcacggc gctcccgcgc ccggcgggcg gctccagggc
    11761 ggccgattcc gccctcgcac cgctcaccgg ccagagcagg acgtatccgc tgctcgtact
    11821 gacggcgacc gtcctgccgt ccgtactgaa agtcagcccc gtgacggcgc cggtgtactc
    11881 cggcgtgtac cgtctgctct cctcccggcc gttcagggcg tcccgtacga cgactccccc
    11941 gtccgaggtg gcggccgcca ggcgggaccc gtcggggctg tacgcgatgc cggcgacggg
    12001 cccggctccg acaccgaagg tgcgtttgat gtcggcccgc gcggtgatcg ggtccgggga
    12061 cggccgccgg tcctgaccgg gccatggaat gggcagcgac cagcccgcgg tgaatgccgc
    12121 gccggcgacg agaatgatga ccac
//
