BGC0001228: retimycin A biosynthetic gene cluster from Salinispora arenicola CNT005
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Location: 180,856 - 218,636 nt. (total: 37,781 nt).
This entry is originally from NCBI GenBank NZ_KI911494.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0001228
Short description retimycin A biosynthetic gene cluster from Salinispora arenicola CNT005
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
Loci NCBI GenBank: NZ_KI911494.1
Compounds
  • retimycin A
Species Salinispora arenicola CNT005 [taxonomy]
References
Chemical products information
retimycin A
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C55H66N10O15S2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • B110_RS0125630
  • WP_028678139.1
 182322 - 183044 (-) histidine phosphatase family protein
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  • B110_RS27155
  • WP_051419349.1
 183219 - 183653 (-) hypothetical protein
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  • B110_RS28510
  • WP_080679158.1
 184088 - 184825 (+) hypothetical protein
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  • B110_RS27160
 184619 - 184825 (+) hypothetical protein
Derived by automated computational analysis using gene prediction method: Protein Homology.
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  • B110_RS0125650
  • WP_028678141.1
 184822 - 185253 (+) Imm1 family immunity protein
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  • B110_RS27165
 185361 - 185897 (+) hypothetical protein
Derived by automated computational analysis using gene prediction method: Protein Homology.
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  • B110_RS28515
 185361 - >186434 (+) hypothetical protein
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  • B110_RS28520
 186401 - 187004 (-) hypothetical protein
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  • B110_RS27170
  • WP_051419342.1
 186994 - 187785 (-) PIG-L family deacetylase
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  • B110_RS0125665
  • WP_051419343.1
 187798 - 188262 (-) VOC family protein
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  • B110_RS27175
  • WP_080679149.1
 188259 - 189044 (-) TioE family transcriptional regulator
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  • B110_RS0125675
  • WP_028678143.1
 189158 - 190141 (+) daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein
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  • B110_RS0125680
  • WP_051419344.1
 190138 - 190959 (+) ABC transporter permease
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  • B110_RS27180
  • WP_155254690.1
 191070 - 192449 (+) DoxX family protein
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  • B110_RS0125690
  • WP_028678145.1
 192474 - 193442 (+) FAD-dependent oxidoreductase
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  • B110_RS0125695
  • WP_080679159.1
 193493 - 194272 (-) transposase family protein
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  • B110_RS27185
 194580 - 196213 (-) IS1634 family transposase
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  • B110_RS27190
  • WP_051419346.1
 196325 - 196732 (-) Signal transduction response regulator, C-terminal
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  • B110_RS0125710
  • WP_028678147.1
 196880 - 197092 (-) MbtH-like protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • B110_RS0125715
  • WP_028678148.1
 197126 - 206506 (-) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
Sequence-based prediction
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  • B110_RS0125720
  • WP_080679150.1
 206516 - 214249 (-) non-ribosomal peptide synthetase
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  • B110_RS0125725
  • WP_028678150.1
 214459 - 216834 (+) Excinuclease ATPase subunit
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  • B110_RS27195
  • WP_080679151.1
 216889 - 217623 (-) alpha/beta fold hydrolase
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NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactonization
Thioesterase genes
  • B110_RS0125715 (Unknown)
  • B110_RS27195 (Unknown)
NRP-synthases
Gene Modules
B110_RS0125720
Module 1
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
Module 2
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
B110_RS0125715
Module 3
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Module 4
Specificity: Norcoronamic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Modification domains: Methylation
Annotation changelog
MIBiG version Submitter Notes
1.2
  • Hidden contributor (ID: I3D2K5SU7JJDS2LEEQM3W3SO, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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Modifications to original record
  • B110_RS27160 was added
  • B110_RS27165 was added