BGC0001228: retimycin A biosynthetic gene cluster from Salinispora arenicola CNT005
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Location: 177,126 - 234,249 nt. (total: 57,124 nt).
This entry is originally from NCBI GenBank NZ_KI911494.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC
MIBiG accession BGC0001228
Short description retimycin A biosynthetic gene cluster from Salinispora arenicola CNT005
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_KI911494.1
180856 - 218636
via
Compounds
  • retimycin A
Species Salinispora arenicola CNT005 [taxonomy]
References
Chemical products information
retimycin A Evidence: NMR, Mass spectrometry
Copy SMILES
C55H66N10O15S2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • B110_RS0125625
  • WP_028678138.1
 180847 - 181620 (-) hypothetical protein
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    • B110_RS0125630
    • WP_028678139.1
    		 182322 - 183044 (-) histidine phosphatase family protein
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      • B110_RS27155
      • WP_051419349.1
      		 183219 - 183653 (-) hypothetical protein
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        • B110_RS28510
        • WP_080679158.1
        		 184088 - 184825 (+) SCP1.201-like deaminase
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          • B110_RS27160
          		 184619 - 184825 (+) hypothetical protein
            Derived by automated computational analysis using gene prediction method: Protein Homology.
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            • B110_RS0125650
            • WP_028678141.1
            		 184822 - 185253 (+) Imm1 family immunity protein
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              • B110_RS27165
              		 185361 - 185897 (+) hypothetical protein
                Derived by automated computational analysis using gene prediction method: Protein Homology.
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                • B110_RS28515
                		 185361 - >186434 (+) hypothetical protein
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                  • B110_RS28520
                  		 186401 - 187004 (-) hypothetical protein
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                    • B110_RS27170
                    • WP_051419342.1
                    		 186994 - 187785 (-) PIG-L family deacetylase
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                      • B110_RS0125665
                      • WP_051419343.1
                      		 187798 - 188262 (-) VOC family protein
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                        • B110_RS27175
                        • WP_080679149.1
                        		 188259 - 189044 (-) TioE family transcriptional regulator
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                          • B110_RS0125675
                          • WP_028678143.1
                          		 189158 - 190141 (+) daunorubicin resistance protein DrrA family ABC transporter ATP-binding protein
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                            • B110_RS0125680
                            • WP_051419344.1
                            		 190138 - 190959 (+) ABC transporter permease
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                              • B110_RS27180
                              • WP_155254690.1
                              		 191070 - 192449 (+) DoxX family protein
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                                • B110_RS0125690
                                • WP_028678145.1
                                		 192474 - 193442 (+) FAD-dependent oxidoreductase
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                                  • B110_RS0125695
                                  • WP_080679159.1
                                  		 193493 - 194272 (-) transposase family protein
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                                    • B110_RS27185
                                    		 194580 - 196213 (-) IS1634 family transposase
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                                      • B110_RS27190
                                      • WP_051419346.1
                                      		 196325 - 196732 (-) Signal transduction response regulator, C-terminal
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                                        • B110_RS0125710
                                        • WP_028678147.1
                                        		 196880 - 197092 (-) MbtH-like protein
                                        • Scaffold biosynthesis
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                                        • B110_RS0125715
                                        • WP_028678148.1
                                        		 197126 - 206506 (-) non-ribosomal peptide synthetase
                                        • Scaffold biosynthesis
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                                        • B110_RS0125720
                                        • WP_080679150.1
                                        		 206516 - 214249 (-) non-ribosomal peptide synthetase
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                                          • B110_RS0125725
                                          • WP_028678150.1
                                          		 214459 - 216834 (+) Excinuclease ATPase subunit
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                                            • B110_RS27195
                                            • WP_080679151.1
                                            		 216889 - 217623 (-) alpha/beta fold hydrolase
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                                              • B110_RS27200
                                              • WP_155254692.1
                                              		 217642 - 219627 (-) KedN5 family methylcobalamin-dependent radical SAM C-methyltransferase
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                                                Biosynthesis information

                                                Biosynthetic modules

                                                Name
                                                1
                                                Type
                                                nrps-type1
                                                Genes
                                                B110_RS0125720
                                                Substrates
                                                threonine (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (Starter), adenylation, epimerase
                                                Name
                                                2
                                                Type
                                                nrps-type1
                                                Genes
                                                B110_RS0125720
                                                Substrates
                                                alanine (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation, adenylation
                                                Name
                                                3
                                                Type
                                                nrps-type1
                                                Genes
                                                B110_RS0125715
                                                Substrates
                                                cysteine (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (LCL), adenylation, methyltransferase
                                                Name
                                                4
                                                Type
                                                nrps-type1
                                                Genes
                                                B110_RS0125715
                                                Substrates
                                                Norcoronamic acid (evidence: Structure-based inference)
                                                Integrated Monomers
                                                Domains
                                                condensation (LCL), adenylation, methyltransferase
                                                Annotation changelog

                                                Entry version: 4

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Corrected NRP module activity
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Corrected gene identifiers
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Changed amino acid substrates to lower case
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Migrated from v1.4
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2015-12-24
                                                Submitted
                                                • (ID: I3D2K5SU7JJDS2LEEQM3W3SO)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                Detailed domain annotation
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                                                Modifications to original record
                                                • B110_RS27160 was added
                                                • B110_RS27165 was added