Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001228.1:
Cluster 1NRP137781

BGC0001228, retimycin biosynthetic gene cluster from Salinispora arenicola. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Retimycin A
SMILES string: Copy to clipboard
Molecular formula: C55H66N10O15S2
Exact molecular mass: 1171.4151 Da ([M+H]+)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP
Cyclic depsipeptide (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
rtmO (WP_028678149.1)
Module 1
A specificity: Threonine
Evidence for specificity: Structure-based inference
AA is epimerized
C domain subtype: Starter
Module 2
A specificity: Alanine
Evidence for specificity: Structure-based inference
C domain subtype: Other
rtmP (WP_028678148.1)
Module 3
A specificity: Cysteine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation
Module 4
A specificity: Norcoronamic acid
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation

Gene cluster description

retimycin (BGC0001228). Gene Cluster 1. Biosynthetic class = NRP. GenBank NZ_KI911494, positions 196325-234105. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Max Cruesemann (University of Bonn)

Literature references

1. Duncan KR et al. (2015) Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species. Chem Biol 22(4):460-471. doi: 10.1016/j.chembiol.2015.03.010. Epub