LOCUS       BGC0001237             21550 bp    DNA     linear   BCT 20-OCT-2015
DEFINITION  Salinispora pacifica DSM 45543 thiolactomycin biosynthesis gene
            cluster, complete sequence.
ACCESSION   BGC0001237
VERSION     BGC0001237
KEYWORDS    .
SOURCE      Salinispora pacifica DSM 45543 = CNS-863
  ORGANISM  Salinispora pacifica DSM 45543 = CNS-863
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Salinispora.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:11:21
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 21550
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..21550
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[2794:9775]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2795..9775
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     gene            complement(1..2811)
                     /gene="tlmI"
     CDS             complement(1..2811)
                     /NRPS_PKS="Domain: AMP-binding (44-447). E-value: 5.1e-93.
                     Score: 303.7. Matches aSDomain:
                     nrpspksdomains_tlmI_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (609-662). E-value: 2.5e-18. Score:
                     57.9. Matches aSDomain: nrpspksdomains_tlmI_PCP.1"
                     /NRPS_PKS="Domain: Thioesterase (686-926). E-value:
                     5.9e-29. Score: 94.0. Matches aSDomain:
                     nrpspksdomains_tlmI_Thioesterase.1"
                     /codon_start=1
                     /gene="tlmI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     328.3; E-value: 1.1e-99)"
                     /gene_kind="biosynthetic"
                     /note="NRPS, A-PCP-TE domains"
                     /product="TlmI"
                     /protein_id="ALJ49909.1"
                     /sec_met_domain="AMP-binding (E-value: 2e-103, bitscore:
                     335.4, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.4e-16, bitscore:
                     50.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSVPESAWTVPAWTGTAAALPAVATDPDPVAALPSDSLLHLAFL
                     DRAAETPDAVAVVAADRTLTYAELANESARLAGLLAARGLGCEALVAVVMEKGWEQVVA
                     CLGVLRAGAAYVPVDPQWPARRLADVLGAAGITEALTQPNLVETVAWPEGVAATAVAAP
                     AADLSAGPAPAAPAVDIAPGDLAYVIYTSGSTGMPKGVMIEHGPAVNTVRDVNRELGCA
                     PEDRVLALSALNFDLSVYDLFGPLSAGGAVVLPAPGDAREPGAWLRLATAAGVTLWNSV
                     PALMAMFTEYVRTAPPAPLPPLRAVLMSGDWIPVGLPGEIRELFPEARQWSLGGATEAS
                     IWSIWHPITPADAELASIPYGRSMSGQHVYVGDGMMRPRPCWVPGEILIAGVGLARGYL
                     GDAERTARSFVTDPATSARRYRTGDWGRLLPSGEIEFLGREDMQVKVGGHRIELGDVEA
                     ALLACPGVRGAVADVRGGRHRTRLTAQVLLEPGAGHSAEDVRALLAERVPSYLVPTSVT
                     VRDEFPLTPNGKVDRKALAALAARTDEAAAEHVVEHPADADEELLLGIWRGFFTDPAPR
                     PGQDVAGGAGDVATDRPADGAGHRPPPSSCGTHLSVTDNFFELGGDSLRAVRLMSVLRR
                     ETGVELPVSALFGAPTVRTLARRLREARETATRDGFDRPVVVPVRTTGDAVPLVFAHPV
                     GGDVLCYSELARELGADQPFYALQSPDHDGRAPGFAELVTHYAQAVLDEVPGRRYRLGG
                     WSMGAVLALELARELTARGCVVDLVAAVDVLETPQDLARAEISRDRLLGWLARDLAGLT
                     GGVRPVPPGPFETLEELYEAVRGAGILPADIAPAEFASLYGRFEANAQALCGYRPGGPL
                     TGTAVHFLQAEAGGGPAAAEGWRPLCAGGFTLTEVPGDHYTVLKGPGARTVATHLRALL
                     TTPTPA"
     misc_feature    1..21396
                     /note="thiolactomycin biosynthesis gene cluster"
     source          1..21550
                     /db_xref="taxon:999542"
                     /isolation_source="marine sediment"
                     /mol_type="genomic DNA"
                     /organism="Salinispora pacifica DSM 45543 = CNS-863"
                     /strain="CNS-863"
     protocluster    1..21550
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[0:2811]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      1..2811
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="2"
     cand_cluster    1..21550
                     /SMILES="C(C)=CNC(CS)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="interleaved"
                     /product="T1PKS"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..21550
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001237"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21550
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        complement(34..753)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmI_Thioesterase.1"
                     /evalue="5.90E-29"
                     /label="tlmI_Thioesterase.1"
                     /locus_tag="tlmI"
                     /protein_end="926"
                     /protein_start="686"
                     /score="94.0"
                     /tool="antismash"
                     /translation="PLVFAHPVGGDVLCYSELARELGADQPFYALQSPDHDGRAPGFAE
                     LVTHYAQAVLDEVPGRRYRLGGWSMGAVLALELARELTARGCVVDLVAAVDVLETPQDL
                     ARAEISRDRLLGWLARDLAGLTGGVRPVPPGPFETLEELYEAVRGAGILPADIAPAEFA
                     SLYGRFEANAQALCGYRPGGPLTGTAVHFLQAEAGGGPAAAEGWRPLCAGGFTLTEVPG
                     DHYTVLKGPGARTVATHL"
     aSModule        complement(34..2679)
                     /complete
                     /domains="nrpspksdomains_tlmI_AMP-binding.1"
                     /domains="nrpspksdomains_tlmI_PCP.1"
                     /domains="nrpspksdomains_tlmI_Thioesterase.1"
                     /final_module
                     /locus_tags="tlmI"
                     /monomer_pairings="Cys -> Cys"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(508..579)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmI_0006"
                     /evalue="4.00E-10"
                     /label="NRPS-te1"
                     /locus_tag="tlmI"
                     /protein_end="768"
                     /protein_start="744"
                     /score="32.1"
                     /tool="antismash"
                     /translation="PGRRYRLGGWSMGAVLALELAREL"
     aSDomain        complement(826..984)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmI_PCP.1"
                     /evalue="2.50E-18"
                     /label="tlmI_PCP.1"
                     /locus_tag="tlmI"
                     /protein_end="662"
                     /protein_start="609"
                     /score="57.9"
                     /tool="antismash"
                     /translation="LSVTDNFFELGGDSLRAVRLMSVLRRETGVELPVSALFGAPTVRT
                     LARRLREA"
     CDS_motif       complement(1441..1506)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmI_0005"
                     /evalue="2.20E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="tlmI"
                     /protein_end="457"
                     /protein_start="435"
                     /score="29.5"
                     /tool="antismash"
                     /translation="FLGREDMQVKVGGHRIELGDVE"
     aSDomain        complement(1471..2679)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmI_AMP-binding.1"
                     /evalue="5.10E-93"
                     /label="tlmI_AMP-binding.1"
                     /locus_tag="tlmI"
                     /protein_end="447"
                     /protein_start="44"
                     /score="303.7"
                     /specificity="substrate consensus: Cys"
                     /tool="antismash"
                     /translation="LDRAAETPDAVAVVAADRTLTYAELANESARLAGLLAARGLGCEA
                     LVAVVMEKGWEQVVACLGVLRAGAAYVPVDPQWPARRLADVLGAAGITEALTQPNLVET
                     VAWPEGVAATAVAAPAADLSAGPAPAAPAVDIAPGDLAYVIYTSGSTGMPKGVMIEHGP
                     AVNTVRDVNRELGCAPEDRVLALSALNFDLSVYDLFGPLSAGGAVVLPAPGDAREPGAW
                     LRLATAAGVTLWNSVPALMAMFTEYVRTAPPAPLPPLRAVLMSGDWIPVGLPGEIRELF
                     PEARQWSLGGATEASIWSIWHPITPADAELASIPYGRSMSGQHVYVGDGMMRPRPCWVP
                     GEILIAGVGLARGYLGDAERTARSFVTDPATSARRYRTGDWGRLLPSGEIEFLGREDMQ
                     VKVG"
     CDS_motif       complement(1585..1674)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmI_0004"
                     /evalue="8.00E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="tlmI"
                     /protein_end="409"
                     /protein_start="379"
                     /score="43.7"
                     /tool="antismash"
                     /translation="PCWVPGEILIAGVGLARGYLGDAERTARSF"
     CDS_motif       complement(2053..2076)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmI_0003"
                     /evalue="6.20E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="tlmI"
                     /protein_end="253"
                     /protein_start="245"
                     /score="-1.7"
                     /tool="antismash"
                     /translation="LSAGGAVV"
     CDS_motif       complement(2197..2256)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmI_0002"
                     /evalue="2.30E-11"
                     /label="NRPS-A_a3"
                     /locus_tag="tlmI"
                     /protein_end="205"
                     /protein_start="185"
                     /score="35.3"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGMPKGVMIEH"
     CDS_motif       complement(2455..2496)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmI_0001"
                     /evalue="2.00E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="tlmI"
                     /protein_end="119"
                     /protein_start="105"
                     /score="17.7"
                     /tool="antismash"
                     /translation="LGVLRAGAAYVPVD"
     gene            complement(2795..9775)
                     /gene="tlmH"
     CDS             complement(2795..9775)
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (5-422). E-value:
                     1.2e-162. Score: 533.5. Matches aSDomain:
                     nrpspksdomains_tlmH_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (530-825). E-value: 1.9e-95.
                     Score: 311.5. Matches aSDomain:
                     nrpspksdomains_tlmH_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (911-1072). E-value: 7.4e-47.
                     Score: 151.6. Matches aSDomain:
                     nrpspksdomains_tlmH_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (1394-1574). E-value: 6.9e-58.
                     Score: 187.4. Matches aSDomain:
                     nrpspksdomains_tlmH_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (1749-1817). E-value: 4e-26. Score:
                     83.0. Matches aSDomain: nrpspksdomains_tlmH_ACP.1"
                     /NRPS_PKS="Domain: Heterocyclization (1889-2188). E-value:
                     4.9e-78. Score: 254.4. Matches aSDomain:
                     nrpspksdomains_tlmH_Heterocyclization.1"
                     /codon_start=1
                     /gene="tlmH"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 277.2; E-value:
                     4e-84)"
                     /gene_kind="biosynthetic"
                     /note="Type I PKS, KS-AT-DH-KR-ACP-C domains"
                     /product="TlmH"
                     /protein_id="ALJ49910.1"
                     /sec_met_domain="mod_KS (E-value: 5.6e-189, bitscore:
                     617.7, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 3.5e-96, bitscore: 311.5,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 5.6e-59, bitscore:
                     188.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.2e-17, bitscore:
                     53.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 2.4e-42, bitscore:
                     134.4, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARDDIAVIGMACRYPGGVDTPEALWDLVAGGRDAVGAFPDNRGW
                     DTEDLYDPAYVREGGFLHGADRFDAAFFGIRAAEAKAMDPQQRNLLEVAWEAIERAGIV
                     PSTLKGSRTGVFVGVMPNEYGMPLWRWQDETAGFMGTGTSPSVASGRISYLLGLEGPAL
                     TIDTACSSSGVAIHTAVRSLRSGETELALAGGCTVLAGPGMFADYAKKQALSPDARCRT
                     FSDAANGTVWAEGAGVLVLEPLSKARRLGRRILGVIKGTAVNQDGASNGLTAPSGKAQT
                     KVIEQALADAGLASQDVQLVEAHGTATRLGDPIEVNAIHATYGAGERDEPVWLGSLKSN
                     IGHSMAAAGVGGVIKCLKAMRAGEMPRTMHVEGPLNSLVNWSGSVEVLRENRPWPLRAG
                     VRRCAVSSFGVSGTNSHVILESWQEPAADPADGGSEPVPADRPEVLTLSAKTPTALAAY
                     AEALASMLDATTQPLPAVAQALRTRREGYEYRAAALGTDRAELAAALRAFAAGQEDVPV
                     VRGEARRIRRPVFVFPGQGSQWPGMAAGLLAGSEVFRLRVEECAAAFKPHVDYDLMAVL
                     WGEETSVDLERTDVIQPLLFCTMLGLTALWQSVGVEPAAVVGHSQGEVAAACLSGALSL
                     EDAALIVACRSRVLEDSRGGMAAVAASAEETATLIAEAGADLVIAAINGPSFVVVSGDD
                     EPGLARLLDLCEERGRYARRVPAKCASHSPVMEELREEIFAGLDGVAPVPSTVPMFSTV
                     DRARLRGDELDAGYWFRNLRGQVRFAETIVEMVSYGFDAFVEISPHPVLTGSLEAILQE
                     AGSTAPVSTTLKRDQGTRERFLAAAAEAYVQGHALDWSRLLPAPPAAAVAAVELPTYPL
                     ERERFWLHTEGVGRMTPAAAPAGTAAVPRAAGPSSVADGSHPFLRSVVETADGTVLLTG
                     RLSVRSHPWLMDHRVEDTALLPGTAFMELLLTAGREVGCERLEEMVVSDPLLLPMGGTA
                     VDVQVAVAPVDAQGARAATVHSRTAADSGWVRNAEGLLGAARPGTETVDLAAVPGASAL
                     PSAETLYPRLRGLGYGYGEAFQGVRSGEHLGTEWVRSRVELPEAALVNHSGFAAHPALT
                     DAALHAAVACGLLGEPEPGRIAVPFVFSGVRTAAAAGAVACEALAYRVGPDAMALTLAA
                     ADGTVLLEVERMVVRGLALDGTGAVPVDLDRAGLYETSWQEPAGEAPGDVRLCVVGGDE
                     GPLPAALRDANREGISVATLDEAIMIVSSIPGTWQIVMGCPAPRNATVEQVHVSAERTL
                     AALQTWLRAETLPDTAVLTFVTQDSVAVPGDETFSLGDSAVWGVVRSAQTEYPGQFRVV
                     DTDSAASGSTEGLLGALRRTEPQLAVRGGRVLMPQLAPHACASTPRPEVGDGTVVLTGG
                     TGTLGREVARHLVTAGGVRSLALLSRSGEGAPGIADFRAELGALGADVRVFAADVADAH
                     DVRRVLAQIRSRGPIGGVVHAAGLLDDSILANMTPEQLHRVLRSKVDSAWHLDAATRDD
                     DLRFFVLFSSLYGVLGGPGQANYAGANTFLDQFAAWRSAQGRATRAVAWGLWAEATGMT
                     GHLDESDLLRLRRNGIAPFETAAGLALFDAAVAGIAPALVGARLALPDETGPGAGDVPF
                     LLNQLAGAAGGTGSGPVVRAAVPLPAEAGVRTAAPGATAAPGRTATLGAAGAPVRTAAP
                     LRGTGPATPAVAAAARAVAGTADAAEQPGAAAVAVLTSRDASADQRLVAAVGLVKECVA
                     GLLGLKAERVDAQRSFYEMGVDSLTSMELRVRLGKILGIRLGATAVFDHPTPEALAQHV
                     VDLFGPPGPSGGGGGTGPQRTPGGPGNDGASAAEAAADAHSGTRAAGPQDRTGSVGAEP
                     ADPAGAPRRPARPDSPPFPLTKLQEAYLAGRGGDFELGDVPTVLCIEVDLTGFDVRAAE
                     RAFRQLVDRHEMLRAVFDVAGAQRVLGEVPDFRIPVEDIRALGPDERAARLAAIHEEVT
                     THTFDTTRWPLVLVWATRVDESVTRLHVAVDVLVSDGASSTLLFNEWARLYRDPQAPLP
                     ATGPSFAHHVARAAAYQASPEIEPSRAYWQQRAASLPPAPLLPYAVPLCDVGRPAFGNR
                     FIRVEAPQWQRFKKNAAAAGLTASGAVLAAYCHVLARWSKVPDFTLTVLVSQRSTFAEE
                     DLSTVVGNFSSTMLLEVHVDEAAPFREVAAGIQRRLLQDMEHVAYTGLDVLRDLSRLDG
                     QAGQARLPVVFNSTIGAVASAPGAPRTAGPVGALCLLGDSGTPVWSGVRTPQVVLDHQA
                     FEEDGALVLNWDVVEEVFPEGVVDAMLAAYEGLIRELCA"
     CDS_motif       complement(2879..2947)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0018"
                     /evalue="6.80E-06"
                     /label="Cy7"
                     /locus_tag="tlmH"
                     /protein_end="2299"
                     /protein_start="2276"
                     /score="19.0"
                     /tool="antismash"
                     /translation="RTPQVVLDHQAFEEDGALVLNWD"
     CDS_motif       complement(3107..3154)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0017"
                     /evalue="8.70E-04"
                     /label="afterCy5"
                     /locus_tag="tlmH"
                     /protein_end="2223"
                     /protein_start="2207"
                     /score="12.3"
                     /tool="antismash"
                     /translation="DMEHVAYTGLDVLRDL"
     aSDomain        complement(3212..4108)
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmH_Heterocyclization.1"
                     /evalue="4.90E-78"
                     /label="tlmH_Heterocyclization.1"
                     /locus_tag="tlmH"
                     /protein_end="2188"
                     /protein_start="1889"
                     /score="254.4"
                     /tool="antismash"
                     /translation="PPFPLTKLQEAYLAGRGGDFELGDVPTVLCIEVDLTGFDVRAAER
                     AFRQLVDRHEMLRAVFDVAGAQRVLGEVPDFRIPVEDIRALGPDERAARLAAIHEEVTT
                     HTFDTTRWPLVLVWATRVDESVTRLHVAVDVLVSDGASSTLLFNEWARLYRDPQAPLPA
                     TGPSFAHHVARAAAYQASPEIEPSRAYWQQRAASLPPAPLLPYAVPLCDVGRPAFGNRF
                     IRVEAPQWQRFKKNAAAAGLTASGAVLAAYCHVLARWSKVPDFTLTVLVSQRSTFAEED
                     LSTVVGNFSSTMLLEVHV"
     CDS_motif       complement(3215..3268)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0016"
                     /evalue="7.70E-05"
                     /label="Cy5"
                     /locus_tag="tlmH"
                     /protein_end="2187"
                     /protein_start="2169"
                     /score="15.2"
                     /tool="antismash"
                     /translation="DLSTVVGNFSSTMLLEVH"
     CDS_motif       complement(3329..3388)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0015"
                     /evalue="3.80E-08"
                     /label="Cy4"
                     /locus_tag="tlmH"
                     /protein_end="2149"
                     /protein_start="2129"
                     /score="26.0"
                     /tool="antismash"
                     /translation="GLTASGAVLAAYCHVLARWS"
     CDS_motif       complement(3647..3700)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0014"
                     /evalue="1.20E-03"
                     /label="C3_LCL_132-143"
                     /locus_tag="tlmH"
                     /protein_end="2043"
                     /protein_start="2025"
                     /score="11.7"
                     /tool="antismash"
                     /translation="VSDGASSTLLFNEWARLY"
     CDS_motif       complement(3926..4006)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0013"
                     /evalue="6.60E-09"
                     /label="C2_LCL_024-062"
                     /locus_tag="tlmH"
                     /protein_end="1950"
                     /protein_start="1923"
                     /score="28.2"
                     /tool="antismash"
                     /translation="LTGFDVRAAERAFRQLVDRHEMLRAVF"
     aSDomain        complement(4325..4528)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmH_ACP.1"
                     /evalue="4.00E-26"
                     /label="tlmH_ACP.1"
                     /locus_tag="tlmH"
                     /protein_end="1817"
                     /protein_start="1749"
                     /score="83.0"
                     /tool="antismash"
                     /translation="LVKECVAGLLGLKAERVDAQRSFYEMGVDSLTSMELRVRLGKILG
                     IRLGATAVFDHPTPEALAQHVVD"
     aSModule        complement(4325..9760)
                     /complete
                     /domains="nrpspksdomains_tlmH_PKS_KS.1"
                     /domains="nrpspksdomains_tlmH_PKS_AT.1"
                     /domains="nrpspksdomains_tlmH_PKS_DH.1"
                     /domains="nrpspksdomains_tlmH_PKS_KR.1"
                     /domains="nrpspksdomains_tlmH_ACP.1"
                     /locus_tags="tlmH"
                     /monomer_pairings="mmal -> Me-ccmal"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(5054..5593)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmH_PKS_KR.1"
                     /evalue="6.90E-58"
                     /label="tlmH_PKS_KR.1"
                     /locus_tag="tlmH"
                     /protein_end="1574"
                     /protein_start="1394"
                     /score="187.4"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="GTVVLTGGTGTLGREVARHLVTAGGVRSLALLSRSGEGAPGIADF
                     RAELGALGADVRVFAADVADAHDVRRVLAQIRSRGPIGGVVHAAGLLDDSILANMTPEQ
                     LHRVLRSKVDSAWHLDAATRDDDLRFFVLFSSLYGVLGGPGQANYAGANTFLDQFAAWR
                     SAQGRATRAVAWGLWAE"
     CDS_motif       complement(5105..5212)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0012"
                     /evalue="6.30E-19"
                     /label="PKSI-KR_m4"
                     /locus_tag="tlmH"
                     /protein_end="1557"
                     /protein_start="1521"
                     /score="60.6"
                     /tool="antismash"
                     /translation="LRFFVLFSSLYGVLGGPGQANYAGANTFLDQFAAWR"
     CDS_motif       complement(5489..5590)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0011"
                     /evalue="2.30E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="tlmH"
                     /protein_end="1429"
                     /protein_start="1395"
                     /score="26.6"
                     /tool="antismash"
                     /translation="TVVLTGGTGTLGREVARHLVTAGGVRSLALLSRS"
     aSDomain        complement(6560..7042)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmH_PKS_DH.1"
                     /evalue="7.40E-47"
                     /label="tlmH_PKS_DH.1"
                     /locus_tag="tlmH"
                     /protein_end="1072"
                     /protein_start="911"
                     /score="151.6"
                     /tool="antismash"
                     /translation="HPFLRSVVETADGTVLLTGRLSVRSHPWLMDHRVEDTALLPGTAF
                     MELLLTAGREVGCERLEEMVVSDPLLLPMGGTAVDVQVAVAPVDAQGARAATVHSRTAA
                     DSGWVRNAEGLLGAARPGTETVDLAAVPGASALPSAETLYPRLRGLGYGYGEAFQGV"
     CDS_motif       complement(6887..6961)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0010"
                     /evalue="3.40E-09"
                     /label="PKSI-DH_m2"
                     /locus_tag="tlmH"
                     /protein_end="963"
                     /protein_start="938"
                     /score="29.2"
                     /tool="antismash"
                     /translation="WLMDHRVEDTALLPGTAFMELLLTA"
     aSDomain        complement(7301..8185)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmH_PKS_AT.1"
                     /evalue="1.90E-95"
                     /label="tlmH_PKS_AT.1"
                     /locus_tag="tlmH"
                     /protein_end="825"
                     /protein_start="530"
                     /score="311.5"
                     /specificity="substrate consensus: mmal"
                     /specificity="PKS signature: Methylmalonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFPGQGSQWPGMAAGLLAGSEVFRLRVEECAAAFKPHVDYDLMAV
                     LWGEETSVDLERTDVIQPLLFCTMLGLTALWQSVGVEPAAVVGHSQGEVAAACLSGALS
                     LEDAALIVACRSRVLEDSRGGMAAVAASAEETATLIAEAGADLVIAAINGPSFVVVSGD
                     DEPGLARLLDLCEERGRYARRVPAKCASHSPVMEELREEIFAGLDGVAPVPSTVPMFST
                     VDRARLRGDELDAGYWFRNLRGQVRFAETIVEMVSYGFDAFVEISPHPVLTGSLEAILQ
                     EAGSTAPVSTTLKR"
     CDS_motif       complement(7370..7399)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0009"
                     /evalue="6.60E-03"
                     /label="PKSI-AT-mM_m9"
                     /locus_tag="tlmH"
                     /protein_end="802"
                     /protein_start="792"
                     /score="9.3"
                     /tool="antismash"
                     /translation="FVEISPHPVL"
     CDS_motif       complement(7442..7489)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0008"
                     /evalue="9.10E-05"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="tlmH"
                     /protein_end="778"
                     /protein_start="762"
                     /score="14.7"
                     /tool="antismash"
                     /translation="LDAGYWFRNLRGQVRF"
     CDS_motif       complement(7700..7738)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0007"
                     /evalue="3.80E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="tlmH"
                     /protein_end="692"
                     /protein_start="679"
                     /score="13.7"
                     /tool="antismash"
                     /translation="AAINGPSFVVVSG"
     CDS_motif       complement(7838..7948)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0006"
                     /evalue="2.70E-17"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="tlmH"
                     /protein_end="646"
                     /protein_start="609"
                     /score="54.6"
                     /tool="antismash"
                     /translation="GVEPAAVVGHSQGEVAAACLSGALSLEDAALIVACRS"
     CDS_motif       complement(7952..8023)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0005"
                     /evalue="6.20E-06"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="tlmH"
                     /protein_end="608"
                     /protein_start="584"
                     /score="19.1"
                     /tool="antismash"
                     /translation="LERTDVIQPLLFCTMLGLTALWQS"
     CDS_motif       complement(8135..8191)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0004"
                     /evalue="7.00E-09"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="tlmH"
                     /protein_end="547"
                     /protein_start="528"
                     /score="27.4"
                     /tool="antismash"
                     /translation="VFVFPGQGSQWPGMAAGLL"
     aSDomain        complement(8510..9760)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmH_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="1.20E-162"
                     /label="tlmH_PKS_KS.1"
                     /locus_tag="tlmH"
                     /protein_end="422"
                     /protein_start="5"
                     /score="533.5"
                     /tool="antismash"
                     /translation="IAVIGMACRYPGGVDTPEALWDLVAGGRDAVGAFPDNRGWDTEDL
                     YDPAYVREGGFLHGADRFDAAFFGIRAAEAKAMDPQQRNLLEVAWEAIERAGIVPSTLK
                     GSRTGVFVGVMPNEYGMPLWRWQDETAGFMGTGTSPSVASGRISYLLGLEGPALTIDTA
                     CSSSGVAIHTAVRSLRSGETELALAGGCTVLAGPGMFADYAKKQALSPDARCRTFSDAA
                     NGTVWAEGAGVLVLEPLSKARRLGRRILGVIKGTAVNQDGASNGLTAPSGKAQTKVIEQ
                     ALADAGLASQDVQLVEAHGTATRLGDPIEVNAIHATYGAGERDEPVWLGSLKSNIGHSM
                     AAAGVGGVIKCLKAMRAGEMPRTMHVEGPLNSLVNWSGSVEVLRENRPWPLRAGVRRCA
                     VSSFGVSGTNSHVILESW"
     CDS_motif       complement(8693..8755)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0003"
                     /evalue="1.20E+00"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="tlmH"
                     /protein_end="361"
                     /protein_start="340"
                     /score="2.3"
                     /tool="antismash"
                     /translation="IGHSMAAAGVGGVIKCLKAMR"
     CDS_motif       complement(8831..8875)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0002"
                     /evalue="2.80E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="tlmH"
                     /protein_end="315"
                     /protein_start="300"
                     /score="10.4"
                     /tool="antismash"
                     /translation="VEAHGTATRLGDPIE"
     CDS_motif       complement(9251..9298)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmH_0001"
                     /evalue="2.30E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="tlmH"
                     /protein_end="175"
                     /protein_start="159"
                     /score="16.6"
                     /tool="antismash"
                     /translation="GPALTIDTACSSSGVA"
     gene            complement(9783..12002)
                     /gene="tlmG"
     CDS             complement(9783..12002)
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (13-424). E-value:
                     5.8e-148. Score: 485.1. Matches aSDomain:
                     nrpspksdomains_tlmG_PKS_KS.1"
                     /NRPS_PKS="Domain: ACP (665-733). E-value: 1.1e-19. Score:
                     62.3. Matches aSDomain: nrpspksdomains_tlmG_ACP.1"
                     /codon_start=1
                     /gene="tlmG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 238.1; E-value:
                     3e-72)"
                     /gene_kind="biosynthetic-additional"
                     /note="KS-ACP domains"
                     /product="TlmG"
                     /protein_id="ALJ49911.1"
                     /sec_met_domain="PKS_KS (E-value: 1e-148, bitscore: 485.1,
                     seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.3e-15, bitscore:
                     45.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQHTSGGGAMTPVAVIGMSCRFPGAAGPARFWRNLAAGTESVGP
                     VPADRRPAGGTAVAARGGFVEAVDAFDAAFFGASQREAQYMDPQQRLLLELAWECLEDA
                     GRPAADLRDCGWGVFVGAAADDFRADYLTGGALDRFGHTGTARCMLANRISHHFGLRGP
                     SEVVDTGQSSSLTALHRAVSSLWLGECEAALVGGVQLNLLHEVTEQIGLWGGLSPDGRC
                     HTFDGRANGYVRGEGGGCVLLKPLPAALRDGDHVYAVVRGSAVANDGGRGGLAVPSREA
                     QYEAVTRALRVAGARPEDLAYVELHGTGTPVGDPVEARALGAAAGRARPAGNPLPVGSV
                     KTNIGHLESAAGIAGFIKACLVLEHGALPASLNFEAPGPALDPAGLGLRVVNAYEERDF
                     GADELVGVSSFGMGGTNVHVVLGAAPAPAADPVPDPDEDADSGAVWCLSGRSQEAVRDL
                     AYALLAELDRHPAGGPEAGFRAVAATLARRTHWEHRAAVVGADWTHFREGLAKVAAGHG
                     FAVPSDWATAGGPDGAGPVRAAGDYVHAGRVPEISAPSAQRKLPRPVPGLPTYPFQRDR
                     FPLPARAASHAAPGTGAATPATAPAAPAAPAAPAATTAPAATAAPAATAAASAAVPGPA
                     SDAGHAGTAYARSWAAASDAGDRLWATQVLLERELAAVLGGSVPDLDPEVSLTDLGVDS
                     MTLLEFLDRLIEATGLTLSETVVFDHPTISEMAARVNQEMGSRHG"
     aSDomain        complement(9804..10007)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmG_ACP.1"
                     /evalue="1.10E-19"
                     /label="tlmG_ACP.1"
                     /locus_tag="tlmG"
                     /protein_end="733"
                     /protein_start="665"
                     /score="62.3"
                     /tool="antismash"
                     /translation="LERELAAVLGGSVPDLDPEVSLTDLGVDSMTLLEFLDRLIEATGL
                     TLSETVVFDHPTISEMAARVNQE"
     aSModule        complement(9804..11963)
                     /domains="nrpspksdomains_tlmG_PKS_KS.1"
                     /domains="nrpspksdomains_tlmG_ACP.1"
                     /incomplete
                     /locus_tags="tlmG"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(10731..11963)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmG_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="5.80E-148"
                     /label="tlmG_PKS_KS.1"
                     /locus_tag="tlmG"
                     /protein_end="424"
                     /protein_start="13"
                     /score="485.1"
                     /tool="antismash"
                     /translation="VAVIGMSCRFPGAAGPARFWRNLAAGTESVGPVPADRRPAGGTAV
                     AARGGFVEAVDAFDAAFFGASQREAQYMDPQQRLLLELAWECLEDAGRPAADLRDCGWG
                     VFVGAAADDFRADYLTGGALDRFGHTGTARCMLANRISHHFGLRGPSEVVDTGQSSSLT
                     ALHRAVSSLWLGECEAALVGGVQLNLLHEVTEQIGLWGGLSPDGRCHTFDGRANGYVRG
                     EGGGCVLLKPLPAALRDGDHVYAVVRGSAVANDGGRGGLAVPSREAQYEAVTRALRVAG
                     ARPEDLAYVELHGTGTPVGDPVEARALGAAAGRARPAGNPLPVGSVKTNIGHLESAAGI
                     AGFIKACLVLEHGALPASLNFEAPGPALDPAGLGLRVVNAYEERDFGADELVGVSSFGM
                     GGTNVHVVLGAA"
     CDS_motif       complement(10947..10991)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmG_0004"
                     /evalue="1.40E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="tlmG"
                     /protein_end="352"
                     /protein_start="337"
                     /score="13.9"
                     /tool="antismash"
                     /translation="GSVKTNIGHLESAAG"
     CDS_motif       complement(11052..11099)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmG_0003"
                     /evalue="1.50E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="tlmG"
                     /protein_end="317"
                     /protein_start="301"
                     /score="13.7"
                     /tool="antismash"
                     /translation="YVELHGTGTPVGDPVE"
     CDS_motif       complement(11292..11330)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmG_0002"
                     /evalue="2.80E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="tlmG"
                     /protein_end="237"
                     /protein_start="224"
                     /score="13.9"
                     /tool="antismash"
                     /translation="FDGRANGYVRGEG"
     CDS_motif       complement(11472..11519)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmG_0001"
                     /evalue="3.00E-03"
                     /label="PKSI-KS_m3"
                     /locus_tag="tlmG"
                     /protein_end="177"
                     /protein_start="161"
                     /score="10.4"
                     /tool="antismash"
                     /translation="GPSEVVDTGQSSSLTA"
     gene            complement(11999..13267)
                     /gene="tlmF"
     CDS             complement(11999..13267)
                     /codon_start=1
                     /gene="tlmF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 360.9; E-value:
                     1.3e-109)"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="TlmF"
                     /protein_id="ALJ49912.1"
                     /sec_met_domain="p450 (E-value: 2.3e-23, bitscore: 72.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGASGDRTGQCPIALDHDFYADPHPAYRVIKENGNKPTPIVLKT
                     GMAYLPPGLEAWLVTAYEDVEFVLRDPRFRKSIDEAMPLFAAQSGGTAAARGSLLYNNM
                     ANNDPPVHTRLRKPLNAMFTSRSVAGRRDVVRSAALETLEKVAGSQTFDLVKDFAFPFS
                     ISVISRTLGVPDADRGTFHGWVQTITGDAPPEILRRDAGLMVEYLRGLIRGRRESAGNG
                     TDDVLTLLATSLAEDEAVAQAYALLAAGYETTANLIVTGFLTLAAHPEQLRRLWSDPGL
                     VPDAVEEMLRHQSPFNLSLYRYVTEPVELNGVRIPRGAIVFLAFAAANRDECRFTEPDS
                     FDITQPHRDHLAFGGGIHNCIGKHLARMEAQVAFETLIERCPGLAVHTPDEEFDWKASP
                     TFRGLRTLRVGPGPAPGGWEREQ"
     gene            complement(13298..14518)
                     /gene="tlmE"
     CDS             complement(13298..14518)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (62-403). E-value:
                     1.6e-47. Score: 154.2. Matches aSDomain:
                     nrpspksdomains_tlmE_PKS_KS.1"
                     /codon_start=1
                     /gene="tlmE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FabF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 352.7; E-value:
                     4.7e-107)"
                     /gene_kind="biosynthetic-additional"
                     /note="similar to FabB/F"
                     /product="TlmE"
                     /protein_id="ALJ49913.1"
                     /sec_met_domain="FabF (E-value: 7.6e-149, bitscore: 485.2,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQNAIEVWATGLGAMTPLGVDLPTTWAAMQSGENGIGALEESWAE
                     ALPVRIAARLTADPAAAMPRTEARKLDRSEQMALVTAREAWADAGSPRPDPERLAVVIG
                     TGIGGVTSLLVQNHVLETSGPRRVSPHAVPMLMANGPAAWVSMDLGAQAGAHAPVSACA
                     SGAEAIALGLDLIRSGRADIVVAGGVEASVHPLPLTAFAQMMALSTQNDDPAHACRPFD
                     TKRGGFVLGEGAALVVLERADHARARGIASPHGTVLGAGISSSATHITASDVAGQVRAM
                     RMSLRDADVAAERIGHVHAHATSTPQGDVAEARAIAEAIGTHPVVNATKSMTGHLLGAS
                     GALGAIAALLALRDGRVPPVRNLEELDPDVELDVVRGAPRTGSWECALANSFGFGGHNV
                     SLVLGRP"
     aSDomain        complement(13310..14332)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmE_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.60E-47"
                     /label="tlmE_PKS_KS.1"
                     /locus_tag="tlmE"
                     /protein_end="403"
                     /protein_start="62"
                     /score="154.2"
                     /tool="antismash"
                     /translation="MPRTEARKLDRSEQMALVTAREAWADAGSPRPDPERLAVVIGTGI
                     GGVTSLLVQNHVLETSGPRRVSPHAVPMLMANGPAAWVSMDLGAQAGAHAPVSACASGA
                     EAIALGLDLIRSGRADIVVAGGVEASVHPLPLTAFAQMMALSTQNDDPAHACRPFDTKR
                     GGFVLGEGAALVVLERADHARARGIASPHGTVLGAGISSSATHITASDVAGQVRAMRMS
                     LRDADVAAERIGHVHAHATSTPQGDVAEARAIAEAIGTHPVVNATKSMTGHLLGASGAL
                     GAIAALLALRDGRVPPVRNLEELDPDVELDVVRGAPRTGSWECALANSFGFGGHNVSLV
                     L"
     gene            14888..17434
                     /gene="tlmD"
     CDS             14888..17434
                     /codon_start=1
                     /gene="tlmD"
                     /gene_functions="regulatory (smcogs) SMCOG1149:LuxR family
                     transcriptional regulator (Score: 628.6; E-value:
                     3.6e-190)"
                     /gene_kind="regulatory"
                     /note="LuxR family transcriptional regulator"
                     /product="TlmD"
                     /protein_id="ALJ49914.1"
                     /transl_table=11
                     /translation="MGTADGHRAREVLEDLFARAREGQGRAVLVTGAAGMGKTTLVHEL
                     QNHALSSGARVLTAIASRAERDLPMGVVGQLAAAAHPASPAAAGADPGTGATLQAVDAF
                     HRLMLGLAERDPLVITVDDAHEMDAASRHCLLYLVRRVGASRILLVLGERADTSQPGST
                     LTSEFVRNPHCALVQLGRLSVAGTESVLAALPGARPAAESAPLWQRASGGSPLLLQALL
                     DDRADGAAAEPAAGQAFALAVRHLLDQLDPATARTAHGLAVLGDDATAADLDRLLDLPA
                     GTAARAMATTDALGLTEEGRYRVAAARATALAELRPEERAALHRAAARLLYQHRAATSE
                     VARHLVVGGPVDESWGLAVLRDTAQQALRTNDPVRALTCLRVAHDACPDPREQAQVRAE
                     LVQAEWEVDPAAVRVHLPCLVKDHRAGLLEHRQSIRLIAHLLWHGRPEEADALFADLDP
                     VEGRLPGDCRAQLETMRVWFAHSYPVLGARYRAHTLLDEAALSRSVGAVDPQADGALLL
                     HALMSEGPTGKVLETAERLLQGMVLHDPPVAPTIAALATYMHAARLDRAADWCDLLLRE
                     ADRRTPVIRAILAAASAAVESRLGNFEVARQRADLALTLVGPTAWGIALGVPLAAKVLA
                     CTAQGDREGAAECFRVPVLDVMFQTLPGLHYLQARGRYHLSVGRYHAALGDFHACRDLM
                     AAWNLDVSASLSWRAYAAEALIELDSPAQARELLAEELAQQGDGSGGNPWLKERSLQLL
                     DRLGSPRPAGSAATAPGRGGPEESGPEELSKAEQRVALLASQGCTNREIAARLFVTGST
                     VEQHLTRAYHKLGVRGRADLPAVLGRVPAGRRGSDS"
     gene            complement(17796..18314)
                     /gene="tlmC"
     CDS             complement(17796..18314)
                     /codon_start=1
                     /gene="tlmC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095:3-hydroxybutyryl-CoA dehydrogenase (Score: 70;
                     E-value: 3.3e-21)"
                     /gene_kind="biosynthetic-additional"
                     /note="3-hydroxybutyryl-CoA dehydrogenase"
                     /product="TlmC"
                     /protein_id="ALJ49915.1"
                     /transl_table=11
                     /translation="MPLNSSVVGVVGLGSVGLPLLALLHTAGHEVIGVDQEADVLARAE
                     RWMKARAAVGEGPAGGYTLTNDTVALVGADVVVEAVPEDLAGKTEVLRRLHAVCLDGAV
                     LVSTSASLSLPQLAIASGRPARTLGLRMLRPPAPGGTVELLCTAMSSDDAVAALEALLD
                     GIGLAAAAP"
     gene            complement(18357..19700)
                     /gene="tlmB"
     CDS             complement(18357..19700)
                     /NRPS_PKS="Domain: PKS_ER (52-413). E-value: 8.2e-25.
                     Score: 79.4. Matches aSDomain:
                     nrpspksdomains_tlmB_PKS_ER.1"
                     /codon_start=1
                     /gene="tlmB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 331.1; E-value: 1.1e-100)"
                     /gene_kind="biosynthetic-additional"
                     /note="crotonyl-CoA carboxylase/reductase"
                     /product="TlmB"
                     /protein_id="ALJ49916.1"
                     /sec_met_domain="ADH_N (E-value: 3e-10, bitscore: 29.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 3.1e-34, bitscore:
                     107.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEIVSAILSDDVAAGDIAALSIPESYRGSVVRKEDVGMFEGLAT
                     ADKDPRKSLHVQDVPTPEPGPGEALVAVMASSVNYNTVWSSIFEPLPTFGFLERYGRLS
                     ELTKRHDLPYHVLGSDLAGVVLRTGPGVNRWKAGDRVVAHCLSVELESADGHDDTMLDP
                     EQRIWGFETNFGGLAEIALVKSNQLMPKPAHLSWEEAASPGLVNSTAYRQLVSRNGAGM
                     KQGDNVLIWGASGGLGSYATQFALAGGATPICVVSSPEKAEICRKIGADAVIDRNAEGY
                     RFWKDEQTQDPREWKRFGSKIRELTGGEDIDIVFEHPGRETFGASVYVTRKGGTITTCA
                     STSGYMHQYDNRYLWMSLKRIIGSHFANYREAWEANRLVAKGKIHPTLSKTYSLEETGQ
                     AAYDVHRNLHQGKVGVLCLSPEEGLGVRDHDMRAEHLDAINRFRATGR"
     aSDomain        complement(18462..19544)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmB_PKS_ER.1"
                     /evalue="8.20E-25"
                     /label="tlmB_PKS_ER.1"
                     /locus_tag="tlmB"
                     /protein_end="413"
                     /protein_start="52"
                     /score="79.4"
                     /tool="antismash"
                     /translation="SLHVQDVPTPEPGPGEALVAVMASSVNYNTVWSSIFEPLPTFGFL
                     ERYGRLSELTKRHDLPYHVLGSDLAGVVLRTGPGVNRWKAGDRVVAHCLSVELESADGH
                     DDTMLDPEQRIWGFETNFGGLAEIALVKSNQLMPKPAHLSWEEAASPGLVNSTAYRQLV
                     SRNGAGMKQGDNVLIWGASGGLGSYATQFALAGGATPICVVSSPEKAEICRKIGADAVI
                     DRNAEGYRFWKDEQTQDPREWKRFGSKIRELTGGEDIDIVFEHPGRETFGASVYVTRKG
                     GTITTCASTSGYMHQYDNRYLWMSLKRIIGSHFANYREAWEANRLVAKGKIHPTLSKTY
                     SLEETGQAAYDVHRNLHQGKV"
     CDS_motif       complement(18966..19028)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmB_0001"
                     /evalue="1.80E-03"
                     /label="PKSI-ER_m5"
                     /locus_tag="tlmB"
                     /protein_end="245"
                     /protein_start="224"
                     /score="11.1"
                     /tool="antismash"
                     /translation="GDNVLIWGASGGLGSYATQFA"
     gene            19853..20653
                     /gene="tlmA"
     CDS             19853..20653
                     /NRPS_PKS="Domain: Thioesterase (34-256). E-value: 1.3e-55.
                     Score: 181.2. Matches aSDomain:
                     nrpspksdomains_tlmA_Thioesterase.1"
                     /codon_start=1
                     /gene="tlmA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 263.8; E-value: 1.7e-80)"
                     /gene_kind="biosynthetic-additional"
                     /note="Type II thioesterase"
                     /product="TlmA"
                     /protein_id="ALJ49917.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.5e-14, bitscore:
                     43.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMESPDHGDGPGDADGADGGSWIRGFHPVPDPAARLVCFPHAGGS
                     ASFFFPLSRELAQRGVEVLPVQYPGRQDRRAEPNIPDLAVMADRVAEALAPRLDRPFAL
                     FGHSMGATLAYEVARRAQEAGRPPAALFVSGRRAPHRVVDDGLHLLSDRELVEDIMALD
                     GTESGMFGDPELLELVLPAIRSDYRAAETYRFVPGPRLDCPVHALTGFSDPRVSVGELR
                     HWAGHTDGPFELQVFPGGHFYLTDHAETITTGIAERLAAATSAA"
     aSDomain        19955..20620
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlmA_Thioesterase.1"
                     /evalue="1.30E-55"
                     /label="tlmA_Thioesterase.1"
                     /locus_tag="tlmA"
                     /protein_end="256"
                     /protein_start="34"
                     /score="181.2"
                     /tool="antismash"
                     /translation="RLVCFPHAGGSASFFFPLSRELAQRGVEVLPVQYPGRQDRRAEPN
                     IPDLAVMADRVAEALAPRLDRPFALFGHSMGATLAYEVARRAQEAGRPPAALFVSGRRA
                     PHRVVDDGLHLLSDRELVEDIMALDGTESGMFGDPELLELVLPAIRSDYRAAETYRFVP
                     GPRLDCPVHALTGFSDPRVSVGELRHWAGHTDGPFELQVFPGGHFYLTDHAETITTGIA
                     "
     CDS_motif       20147..20212
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlmA_0001"
                     /evalue="4.40E-09"
                     /label="NRPS-te1"
                     /locus_tag="tlmA"
                     /protein_end="120"
                     /protein_start="98"
                     /score="28.8"
                     /tool="antismash"
                     /translation="DRPFALFGHSMGATLAYEVARR"
     gene            complement(20956..21396)
                     /gene="tlmJ"
     CDS             complement(20956..21396)
                     /codon_start=1
                     /gene="tlmJ"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     102.9; E-value: 2.8e-31)"
                     /gene_kind="regulatory"
                     /note="transcriptional regulator"
                     /product="TlmJ"
                     /protein_id="ALJ49918.1"
                     /transl_table=11
                     /translation="MVTPQAEKIRCLLALLCVRSGTVVSRQSLPHALWSGTPPRTARTV
                     LQVYVSKLRKFLDEHGDLAGHLVTKPHGYVFELEPERLDLRRFDALSDGEPAAGALPGE
                     RPGPAPEKELRRLRQRRARCGPALADLRGLPAFAALGRALDE"
     misc_feature    complement(21259..21261)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 tcaggcgggg gtgggggtcg tcaggagggc gcggaggtgg gtggcgaccg ttcgggcgcc
       61 ggggcccttc aggacggtgt agtggtcgcc ggggacctcg gtgagcgtga aaccgcccgc
      121 gcacagcggg cgccagccct cggcggccgc cggaccgccg cccgcctcgg cctgcaggaa
      181 gtgcaccgcc gtgccggtga ggggcccgcc gggacgatag ccacacagcg cctgcgcgtt
      241 cgcctcgaag cgcccgtaca gggacgcgaa ctccgccggc gcgatgtccg ccggcaggat
      301 cccggcgccg cgcacggcct cgtacagctc ctccagggtc tcgaacgggc ccggcgggac
      361 cggccggacg ccgccggtca ggcccgcgag gtcgcgggcc agccagccga gcagccggtc
      421 gcggctgatc tcggcgcggg ccaggtcctg gggggtctcc aggacgtcga cggccgccac
      481 caggtccacc acgcagcccc gcgcggtcag ttcccgggcc agctccagtg ccagcaccgc
      541 ccccatcgac cagccgccca gccggtaccg acggcccggc acctcgtcca ggacggcctg
      601 cgcgtaatgg gtgaccagct cggcgaagcc gggcgcccgg ccgtcgtggt cgggcgactg
      661 gagggcgtag aacggctggt ccgcgccgag ctcgcgggcc agctccgagt agcacagcac
      721 gtcgccgccc accgggtggg cgaagaccag cggaaccgcg tcacccgtgg tgcgcacggg
      781 gacgacgacc ggccggtcga agccgtcccg ggtggccgtt tcgcgggcct cgcgcagccg
      841 gcgggccagg gtccgcacgg tgggcgcgcc gaagagggcg gacaccggca gttccacacc
      901 ggtctcccgg cgcaggacgg acatcaggcg taccgcgcgc agcgaatcgc cgcccagctc
      961 gaagaagttg tccgtgacgg acaggtgcgt gccgcaggac gacggcgggg gccggtggcc
     1021 ggcaccgtcg gcgggccggt ccgtggccac gtcgccggca ccgcccgcga cgtcctgccc
     1081 tgggcgcggg gccgggtccg tgaagaagcc gcgccagatg ccgaggagca gctcctcatc
     1141 ggcatccgcg ggatgctcga ccacgtgctc ggcggcagcc tcgtcggtgc gggcggcgag
     1201 ggcggcgagg gccttgcggt cgaccttgcc gttcggggtc agcgggaact cgtcccggac
     1261 cgtgacggac gtgggcacca ggtacgacgg cacccgctcg gccagcagcg cccgcacgtc
     1321 ctcggccgag tgaccggcgc cgggctccag cagcacctgg gcggtgagcc gggtgcggtg
     1381 ccggccaccc cggacgtcgg ccaccgcgcc ccgcacaccc gggcaggcca gcaacgcggc
     1441 ctcgacgtcg ccgagttcga ttcggtggcc gccgaccttg acctgcatgt cctcgcgccc
     1501 caggaactcg atctcgccgc tgggcaggag gcgcccccag tcgccggtcc ggtagcggcg
     1561 ggcgctggtg gccggatcgg tgacgaagct gcgcgcggtg cgctcggcgt cgccgaggta
     1621 gccgcgggcc aggccgacgc cggcgatgag gatctcaccg ggcacccagc agggccgggg
     1681 ccgcatcatc ccgtcgccga cgtacacgtg ctggccgctc atcgaccggc cgtacgggat
     1741 cgaggcgagt tcggcgtccg cgggcgtgat ggggtgccag atggaccaga tggaggcctc
     1801 ggtggcgccg ccgagggacc actggcgggc ctcggggaac agctcccgga tctcaccggg
     1861 caggccgacc gggatccagt cgccgctcat cagcaccgcg cgcagcggcg gcaggggcgc
     1921 cggcggggca gtgcggacgt actcggtgaa catggccatc agggccggca cgctgttcca
     1981 gagggtgacc ccggccgcgg tcgcgagccg cagccaggcg ccgggctcgc gggcgtcgcc
     2041 gggtgcgggc agcaccaccg cgccgccggc cgacaggggg ccgaagaggt cgtagacgga
     2101 gaggtcgaag ttgagcgccg acagggccag cacccggtcc tcgggcgcgc agcccagctc
     2161 acggttgacg tcccggaccg tgttgaccgc cggcccgtgt tcgatcatca cgcccttggg
     2221 catgccggtg gagccggagg tgtagatgac gtacgcgagg tcgccgggtg cgatgtccac
     2281 ggccggcgcc gcgggggcgg ggccggccga aaggtccgcg gcgggggccg cgaccgcggt
     2341 ggccgcgacg ccctcgggcc aggccacagt ctcgacgagg ttgggctggg tgagtgcctc
     2401 ggtgatgccg gcggcaccga gcacgtcggc cagccggcgg gccggccact gcgggtccac
     2461 ggggacgtac gcggcgccgg cgcgcaggac gccgaggcag gccacgacct gctcccagcc
     2521 cttctccatc accacggcga cgagcgcttc gcagcccagg ccgcgggccg cgagcaggcc
     2581 ggctagccgg gcggactcgt tggccagctc ggcatacgtc agggtccggt cggcggccac
     2641 gacggccacg gcgtccgggg tctcggcggc ccggtcgagg aaggccaggt gaagcaggga
     2701 gtcggaaggg agggcggcga ccgggtcggg gtcggtggcc accgccggga gggcggcggc
     2761 ggtcccggtc cacgcgggca ccgtccaggc ggactcaggc acagagttca cggatcagtc
     2821 cttcgtaagc ggcgagcatg gcgtccacga cgccctcggg aaacacctct tcgaccacgt
     2881 cccagttgag gacgagcgct ccgtcctcct cgaacgcctg gtggtccagg acgacctggg
     2941 gcgtgcggac cccgctccat accggggtgc ccgagtcgcc gaggaggcac agggcgccca
     3001 ccgggccggc cgtgcgcggg gcgccgggtg cggacgcgac ggcgccgatg gtgctgttga
     3061 acacgacggg caaccgggcc tggccggcct gcccgtccag ccggctcagg tcacgcagga
     3121 cgtcgaggcc ggtgtaggcg acgtgctcca tgtcctgcag cagccggcgc tggatgcccg
     3181 cggcgacctc gcggaacggg gccgcctcgt cgacgtggac ctccagcagc atggtggagg
     3241 agaagttacc gacgaccgtg gacaggtcct cctcggcgaa ggtggagcgc tgggagacca
     3301 ggaccgtgag ggtgaagtcc gggaccttgg accagcgggc cagcacgtgg cagtacgcgg
     3361 cgaggacggc gccggaggcg gtcaggccgg cggccgccgc gttcttcttg aagcgctgcc
     3421 actgcggcgc ctcgacccga atgaaccggt tgccgaaggc cggccggccg acgtcgcaca
     3481 gcggcacggc gtacggcagg agcggcgcgg gtggcaggct cgccgcgcgc tgctgccagt
     3541 aggcgcggct gggctcgatc tccggggagg cctggtacgc ggcggcccgc gccacgtgat
     3601 gggcgaacga ggggccggtc gcgggcagcg gagcctgcgg gtcgcggtag aggcgggccc
     3661 actcgttgaa gaggagcgtg ctgctcgcgc cgtccgacac caggacatcg acggccacgt
     3721 gcagccgggt gaccgactcg tccacgcggg tggcccagac caggaccagc ggccagcggg
     3781 tggtgtcgaa ggtgtgcgtg gtcacctcct cgtggatggc ggccagccgg gcggcccgct
     3841 cgtcggggcc gagcgcgcgg atgtcctcga cggggatccg gaagtccggc acctcgccga
     3901 gcacccgctg ggcgccggcg acgtcgaaga ccgcccggag catctcgtgg cggtccacga
     3961 gctgccggaa ggcccgctcg gcggcccgta cgtcgaaccc ggtgaggtcg acctcgatgc
     4021 acaggaccgt gggtacgtcg cccagctcga agtccccgcc acggcccgcg aggtaggcct
     4081 cctgcagctt ggtgagcggg aacggcggcg agtccggccg ggccggccgc cgcggtgcgc
     4141 cggccgggtc ggcgggctcg gcgcccacgg agccggtacg gtcctgcggg ccggcggccc
     4201 gggtcccgga gtgcgcgtcc gcggcggcct ccgccgcgga cgcaccatca tttcccgggc
     4261 cgcccggggt ccgctgcggg cccgtgccgc caccgccgcc ggacggtccg ggcgggccga
     4321 acaggtcgac gacgtgctgg gccagcgcct ccggcgtcgg gtggtcgaag accgcggtgg
     4381 ccccgagccg gatgcccagg atcttgccga gccggacccg cagctccatg gaggtcaggg
     4441 aatcgacgcc catctcgtag aacgagcgct gcgcgtccac ccgttcggcc ttgaggccca
     4501 gcaggccggc cacgcactcc ttgaccagcc cgaccgcggc gaccagccgc tggtcggccg
     4561 aggcgtcgcg ggaggtcagc accgcgaccg cggcggcgcc gggctgctcg gcggcgtccg
     4621 ccgtgccggc gacggcgcga gcggcggcgg ccacggccgg ggtggccggg ccggtccccc
     4681 gcagcggggc ggcggtacgt accggagcgc ccgccgctcc gagagtggcc gtacgtccgg
     4741 gagcggccgt agctcccggc gcggcggtcc ggaccccggc ctccgcgggc agcgggacgg
     4801 cggcgcggac gacgggcccg ctgccggtgc cgcccgccgc gcccgccagc tggttcagca
     4861 ggaacgggac gtcgcccgcc ccgggcccgg tctcgtccgg cagggccagc cgggcgccga
     4921 cgagggcagg cgcgatgccg gccacggcgg cgtcgaagag ggccaggccg gcggccgtct
     4981 cgaagggcgc gatgccgttg cgccgcaggc gcagcaggtc gctctcgtcg agatgtccgg
     5041 tcatgccggt ggcctcggcc cacagacccc aggccactgc gcgggtggcc cgtccctgcg
     5101 ccgatcgcca ggcggcgaac tggtccagga aggtgttggc accggcgtag ttggcctggc
     5161 cggggccgcc gagcacgccg tagagggagg agaagagcac gaagaagcgc aggtcgtcgt
     5221 cgcgcgtcgc cgcgtccagg tgccaggccg agtcgacctt gctgcgcagg acgcggtgca
     5281 gctgctccgg ggtcatgttc gcgaggatcg agtcgtcgag caggccggcg gcgtgcacga
     5341 cacccccgat cggcccgcga gaccgtatct gcgcgaggac ccggcggacg tcgtgtgcgt
     5401 cggccacgtc ggccgcgaac acccgcacgt cggcgccgag ggcaccgagc tcggcgcgga
     5461 agtccgcgat gccgggggcc ccttctccgc tgcggctgag cagggccagg gaccgtacgc
     5521 ccccggcggt gaccaggtgg cgggccacct cgcggccgag agtaccggtg ccaccggtga
     5581 gcacgacggt gccgtcgccc acctcgggcc gcggcgtgct cgcgcaggcg tgcggggcca
     5641 gctggggcat cagcacgcgg ccgccgcgga cggcgagctg cggctcggtg cgccgcaggg
     5701 cgccgagtag gccttcggtg gagccggacg ccgcggagtc ggtgtcgacc acgcggaact
     5761 ggcccgggta ctcggtctgg gcggagcgga ccacgcccca gacggcgctg tccccgaggg
     5821 aaaacgtttc gtcaccgggg acggccacgg agtcctgcgt cacgaacgtc agcaccgccg
     5881 tgtccggcag ggtctcggcc cgcagccacg tctgcagggc ggccagggtc cgctcggcgg
     5941 agacgtgcac ttgctcgacc gtggcgttcc tgggcgccgg acagcccatg acgatctgcc
     6001 aggtgcccgg gatcgacgag acgatcatga tcgcctcgtc gagggtggcc accgagatgc
     6061 cctcccggtt ggcgtcccgc agcgcggccg gcagcgggcc ctcgtccccg ccgaccacgc
     6121 acagccgtac gtccccgggc gcctcgccgg ccggctcctg ccagctcgtc tcatacagac
     6181 ccgcgcggtc gaggtcgacc gggacggcgc ccgtcccgtc gagggccagc ccgcgtacaa
     6241 ccatccgctc gacttcgagc agtacggtgc cgtcggccgc ggccagcgtc agcgccatcg
     6301 cgtcggggcc gacccgatag gccagcgcct cgcacgcgac ggcgccggcc gcagcggccg
     6361 tccggacgcc gctgaacacg aacggcaccg cgatccgccc gggctccggc tcaccgagca
     6421 gcccgcaggc tacggcggcg tgcagggcgg cgtcggtcaa cgcgggatgc gcggcgaaac
     6481 cgctgtggtt gaccagggcc gcctcgggca gctcgacccg ggaccggacc cattccgtgc
     6541 ccaggtgctc gccggagcgc acgccctgga aggcctcgcc gtagccgtag cccaggccgc
     6601 gcagccgcgg gtaaagggtc tcggccgagg gcagcgcgga ggcgccggga accgccgcca
     6661 ggtcgaccgt ctcggtgccg gggcgggcgg cgcccagcag gccctccgcg ttgcgcaccc
     6721 agccggagtc ggcggcggtg cgggagtgca cggtggcggc acgcgcgccc tgggcgtcca
     6781 cgggcgcgac ggcgacctgg acgtccacgg cggtgccacc catcggcagg agcagcgggt
     6841 cgctgacgac catctcttcc aggcgctcgc agcccacctc gcggccggcg gtcagcagca
     6901 gctccatgaa ggccgtaccg ggcagcaggg cggtgtcctc gacgcggtgg tccatcagcc
     6961 acgggtggct gcgcacggac agccggccgg tgagcagcac cgtgccgtcg gccgtctcga
     7021 cgacggagcg caggaacggg tggctgccat ccgccaccga gctcgggccg gccgcccgcg
     7081 ggacggcggc ggtgccggcc ggggcggccg ccggggtcat ccggcccacg ccctcggtat
     7141 gcagccagaa ccgctcccgc tcgagcgggt aggtgggcag ctccacggcc gccacggccg
     7201 cggcgggtgg agcgggcagc agccgggacc agtcgagcgc gtggccctgg acgtacgcct
     7261 cggcggccgc ggcgaggaac cgctcgcggg tgccctggtc gcgcttgagg gtggtggaca
     7321 ccggagcggt gctgccggcc tcctgcagga tggcttcgag ggagccggtc agtacggggt
     7381 gcgggctgat ctcgacgaag gcgtcgaagc cgtacgagac catctcgacg atcgtctcgg
     7441 cgaagcgcac ctggccgcgc aggttgcgga accagtagcc ggcgtccaac tcgtcgccac
     7501 gcagccgtgc gcggtcgacg gtggagaaca tcgggacggt ggacgggacc ggggcgaccc
     7561 cgtcgaggcc cgcgaagatc tcctcgcgca gctcctccat gaccggcgaa tgcgaggcac
     7621 acttggcggg cacccggcgg gcgtagcggc cgcgctcctc gcacaggtcg agcaggcgcg
     7681 cgaggccggg ctcgtcgtcg cctgagacca ccacgaacga ggggccgttg atggcggcga
     7741 tcaccaggtc ggcgccggcc tcggcgatca gcgtcgccgt ctcctcggcc gaggccgcca
     7801 cggcggccat accaccgcgg gagtcctcga ggacgcggct gcgacaggcc acgatcaggg
     7861 ccgcgtcctc cagggacagg gccccggaca ggcaggcggc tgcgacctcg ccctgggagt
     7921 ggccgaccac ggcggccggc tcgacgccca ccgactgcca caaggcggtc aggccgagca
     7981 tcgtgcagaa cagcagcggc tggatgacgt cggtgcgctc caggtcgacc gaggtttcct
     8041 cgccccagag cacggccatc aggtcgtagt cgacgtgggg cttgaaggcc gcggcgcact
     8101 cctcgacccg caggcggaag acctccgacc cggcgagcag cccggcggcc atgccgggcc
     8161 actgcgagcc ctggccgggg aagacgaaga cgggccggcg gatccggcgc gcctcgccgc
     8221 ggaccaccgg gacgtcctcc tggccggcgg cgaacgcgcg cagcgcggcg gcgagttccg
     8281 cgcggtcggt gccgagggcg gccgcgcggt actcgtaacc ctcgcgccgg gtccgcagcg
     8341 cctgcgcgac ggccggcagc ggctgcgtcg tggcgtccag catgctcgcc agcgcctcgg
     8401 cgtacgcggc cagggcggtc ggggtcttgg cggaaagggt caggacctcg gggcggtcgg
     8461 ccggaacggg ctcgctcccc ccgtcggccg gatccgcggc cggctcctgc cagctctcca
     8521 ggatgacgtg cgagttggtg ccgctgacgc cgaacgagga cacggcgcag cgccgcaccc
     8581 ccgcacgcag gggccagggc cggttctcgc gcaggacctc caccgaaccg gaccagttga
     8641 ccagcgagtt gaggggaccc tcaacgtgca tcgtgcgggg catctccccc gcgcgcatcg
     8701 ccttgaggca cttgatgacg ccgcccacgc cggcggcggc catggagtgg ccgatattcg
     8761 acttgaggga gccgagccag accggctcgt ctcgctcccc cgcgccgtac gtggcgtgga
     8821 tggcgttgac ctcgatgggg tcgcccagcc gggtggcggt gccgtgggcc tcgacgagct
     8881 ggacgtcctg cgaggccagg cccgcgtccg ccagcgcctg ctcgatgacc ttggtctggg
     8941 ccttgccgct gggggcggtc aggccgttgc tggcgccgtc ctggttgacg gcggtgccct
     9001 tgatgacgcc gaggatgcgg cggcccaggc gacgggcctt ggagagcggt tcgagcacca
     9061 gcacgccggc gccctcggcc cacacggtgc cgttggcggc gtcggagaag gtgcggcaac
     9121 gggcgtcggg cgacagcgcc tgcttcttgg cgtagtcggc gaacataccg gggccggcga
     9181 gtacggtgca gccgccggcc agcgccagct ccgtctcacc gctgcgcagc gagcgtacgg
     9241 cggtgtggat ggccacaccg gaggacgagc aggcggtgtc gatggtcagg gccgggccct
     9301 caaggcccag caggtaggag atgcggccgg aggcgacgct gggcgaggtg ccggtgccca
     9361 tgaagcccgc cgtctcgtcc tgccagcgcc acagcggcat gccgtactcg ttgggcatga
     9421 cgcccacgaa cacgccggta cgggagccct tgagggtcga gggcacgatg ccggcgcgct
     9481 cgatggcctc ccaggcgacc tcgagcaggt tgcgctgctg cgggtccatg gccttggcct
     9541 cggcggcccg gatgccgaag aaggcggcgt cgaagcggtc ggcgccgtgc aggaagccgc
     9601 cctcgcgcac gtaggcgggg tcgtagagat cctcggtgtc ccagccgcgg ttgtcgggga
     9661 acgcgccgac ggcgtcccgg ccgccggcga ccaggtccca cagcgcctcc ggggtgtcca
     9721 caccgccggg atagcggcag gccatcccga tcacggcgat gtcgtcgcgc gccatgtcgt
     9781 tctcagccat gcctggaccc catctcctgg ttcacacgtg ccgccatttc gctgatcgtg
     9841 gggtggtcga agacgacggt ctccgagagg gtgaggccgg tcgcctcgat gagccggtcc
     9901 aggaactcca ggagggtcat ggagtccacg cccaggtccg tgagggagac ctcggggtcc
     9961 aggtcgggga cggatccgcc gagcacggcc gcgagttcgc gttcgaggag gacctgggtg
    10021 gcccagagcc ggtcacccgc gtcgctggcg gccgcccagg accgcgcgta cgccgtgccg
    10081 gcgtgcccgg cgtcggaagc agggcccggg acggccgcgg acgccgcggc agttgcggca
    10141 ggcgcggcag ttgcggcagg cgcggtagtt gcggcaggcg cggcaggcgc ggcaggcgcg
    10201 gcaggcgcgg tagccggggt ggccgcaccg gtgccggggg ccgcgtggga ggcggcccgg
    10261 gcaggcagcg ggaagcggtc ccgctggaag gggtacgtgg gcaggcccgg caccggccgg
    10321 ggcagtttcc gctgcgcgga gggggccgat atctcgggga cccggcccgc gtggacgtag
    10381 tcgccggcgg cccggacggg gccggccccg tccgggccgc ccgccgtcgc ccagtccgag
    10441 ggcacggcga atccgtggcc ggcggccacc ttcgccaggc cctcgcggaa gtgcgtccag
    10501 tcggcgccca ccaccgcggc ccggtgctcc cagtgggtgc ggcgggccag ggtggccgcg
    10561 accgcgcgga agccggcctc gggaccgccg gccggatgcc ggtcgagctc tgcgagcagg
    10621 gcgtacgcga ggtcgcggac cgcctcctgg gagcgtccgg acaggcacca cacggcaccg
    10681 ctgtcggcgt cctcgtcggg gtcgggcacc gggtccgcgg ccggggccgg ggccgcgccc
    10741 agcacgacgt ggacgttcgt gccgcccatc ccgaacgagc tgacgccgac cagctcgtcg
    10801 gcgccgaagt cccgttcctc gtaggcgttg acgacgcgca ggccgaggcc ggccgggtcg
    10861 agggcggggc cgggggcctc gaagttcagg ctcgccggca gggccccgtg ctccagcacc
    10921 aggcaggcct tgataaaccc ggcgatgccg gcggcggact ccaggtggcc gatgttggtc
    10981 ttgaccgacc cgaccggcag cgggttcccg gcgggccggg cgcggccggc ggccgcgccg
    11041 agcgcgcggg cctcgaccgg gtcccccacc ggggttccag tgccgtggag ttcgacgtac
    11101 gcgaggtcct ccggccgggc ccccgccacc cgcagggcgc gggtgacagc ctcgtactgc
    11161 gcctcccggg acggtacggc caagccgccg cggccgccgt cgttggcgac ggcgctgcca
    11221 cggacgacgg cgtagacgtg gtcgccgtcg cgcagggcgg ccggcagcgg cttgaggagg
    11281 acgcagccgc cgccctcgcc gcggacgtag ccgttggcgc ggccgtcgaa ggtgtggcag
    11341 cggccgtccg gggacagccc tccccacagc ccgatctgct cggtgacctc gtgaaggagg
    11401 ttgagctgta cgccgccgac gagcgcggcc tcgcactcgc ccagccacag gctcgacacc
    11461 gcgcggtgca gggcggtcag ggaggaggac tgaccggtgt ccaccacctc gctcgggccg
    11521 cgcagcccga agtggtggga gatccggttg gccagcatgc accgggcggt gccggtgtgg
    11581 ccgaaccggt ccagtgcgcc cccggtcagg tagtccgccc ggaagtcgtc ggcggcagcg
    11641 ccgacgaaca ccccccagcc gcagtcgcgc aggtctgcgg ccggccgtcc ggcgtcctcc
    11701 aggcactccc aggccagctc cagcagcagc cgctgctggg ggtccatgta ctgcgcctcg
    11761 cgctgggagg cgccgaagaa cgcggcgtcg aaggcgtcga ccgcctcgac gaagccgccg
    11821 cgcgcggcga cagcggtgcc gccggccggc cggcggtccg cggggacggg gcccacgctc
    11881 tccgtgccgg cggccaggtt ccgccagaag cgggccggac cggccgctcc cgggaaccgg
    11941 caggacatcc cgatgacggc gacgggggtc atggccccgc cgccggaagt gtgctgtgtc
    12001 attgctcccg ttcccagcct ccgggggccg gaccgggccc gacgcgcagg gtgcgcagcc
    12061 cacggaacgt agggctggcc ttccagtcga attcctcgtc cggcgtgtgc acggccagcc
    12121 cggggcagcg ctcgatgagc gtctcgaagg ccacctgggc ctccatccgg gcgaggtgct
    12181 tgccgatgca gttgtggatg ccgccgccga acgcgaggtg gtcgcggtgc ggctgggtga
    12241 tgtcgaagga gtcgggctcc gtgaagcggc actcgtcacg gttggcggcg gcgaaggcca
    12301 ggaagacgat cgcgccccgg gggatccgca ccccgttcag ctccaccggc tcggtcacgt
    12361 agcggtagag ggagaggttg aagggcgact ggtggcggag catctcctcc accgcgtcgg
    12421 ggaccaggcc ggggtcggac cataggcgcc gcagctgctc ggggtgggcc gcgagggtca
    12481 ggaacccggt gacgatgagg ttggccgtgg tctcgtagcc ggccgcgagc agggcgtacg
    12541 cctgggcgac ggcctcgtcc tcggccagcg aggtggccag cagggtgagc acgtcgtcgg
    12601 tgccgttgcc cgcgctttcg cgccggcccc tgatcaggcc gcgcaggtac tcgaccatca
    12661 ggccggcgtc gcgccggagg atctcggggg gcgcgtcacc cgtgatcgtc tggacccagc
    12721 cgtggaaggt gccgcggtcg gcgtcgggga cgccgagggt gcgggagatc acggagatgg
    12781 agaaaggaaa ggcaaaatcc ttgacaagat cgaaagtctg tgatcccgcc accttctcca
    12841 gggtctccag cgccgcgctg cggaccacgt cccgccgccc ggcgacggaa cgcgaggtga
    12901 acatcgcgtt gagcggcttg cgcagccggg tatgcaccgg tgggtcgttg ttcgccatgt
    12961 tgttgtagag cagcgaaccg cgggccgcgg cggtcccgcc gctctgcgcc gcgaaaagcg
    13021 gcatggcctc gtcgatgctc ttgcggaacc gcgggtcccg gaggacgaat tccacgtcct
    13081 cgtacgccgt gacaagccag gcctccaagc cgggcggcag atatgccatt ccggtcttca
    13141 ggacaatggg cgtcggtttg ttgccgttct ctttgatgac ccggtaggcc ggatgcggat
    13201 cggcgtagaa atcgtgatcg agggctatcg gacactgacc ggtccggtcg ccgctggcgc
    13261 ctgtcatctc aaccttcaag ggggtgcgtt cggacaatta cggccggccg aggacaaggg
    13321 agacgttgtg cccgccaaag ccaaaggaat tggccagcgc gcactcccag ctcccggtgc
    13381 gcggggcgcc gcggacgacg tccagttcga cgtcggggtc gagctcctcc aggttccgca
    13441 cgggcggtac gcggccgtcg cgcagcgcta gcagcgcggc gatggcgccg agcgcgccgg
    13501 aggcaccgag caggtgcccg gtcatggact tcgtcgcgtt caccacgggg tgggtgccga
    13561 tggcctcggc gatggcgcgg gcctccgcca cgtcgccctg cggggtggag gtggcgtgcg
    13621 cgtgcacgtg accgatccgc tcggcggcga cgtcggcgtc gcgcagcgac atccgcatgg
    13681 cgcggacctg cccggcgacg tcggaggcgg tgatgtgggt ggcgctggag ctgatgccgg
    13741 cgccgaggac ggtgccgtgc ggggaggcga tgccgcgggc ccgggcgtgg tcggcccgct
    13801 ccaggacgac cagggcggcg ccctcgccga ggacgaagcc accccgcttg gtgtcgaagg
    13861 gacggcaggc gtgcgccggg tcgtcgttct gcgtggacag cgccatcatc tgcgcgaacg
    13921 cggtcagcgg cagcgggtgg acgctggcct ccacaccacc ggcgacaacg atgtccgcac
    13981 ggcccgagcg gatgaggtcc aggccgaggg cgatggcctc ggcgccggag gcacaggcgc
    14041 tgaccggggc gtgcgcaccg gcctgggcgc ccaggtccat gctgacccag gcggcagggc
    14101 cgttggccat cagcatgggg acggcgtgcg gcgagacccg gcgcgggccg gaagtctcca
    14161 ggacgtggtt ctggaccagc agcgaggtca cgccgccgat gccggtgccg atgaccacgg
    14221 cgaggcgctc ggggtcgggc cgtgggctgc ccgcgtcggc ccacgcctcg cgggcggtga
    14281 ccagggccat ctgctccgag cggtccagct tgcgcgcttc ggtccggggc atggccgcgg
    14341 ccggatcggc ggtgagccgg gccgcgatgc ggacgggaag ggcttccgcc cagctttcct
    14401 caagcgctcc gattccgttc tcgccggatt gcatcgccgc ccatgtggtg ggcagatcca
    14461 cacccagcgg cgtcatggct cccaggcctg tggcccagac ctcgatcgcg ttctgcatgt
    14521 atctggacgc tagtcagcgc acgacgcggc tggcaagatt tcaattcgct cccgaccccc
    14581 cggatttccg agccgtaggg ggtcccctgt tcacccccta ttcggggccg acgaataccg
    14641 cttcccccta tagggtggtg tttcggcgga gcgctgccgg cgtgcgcgcg ggatgtccgc
    14701 gcggtggtgc aggaggtgtg caagtgatgc ctgggatgtg tcccgagtgt tcgcgggaca
    14761 catcccggga cggtctcgaa cggccccggc acccggcgtc cgggaacgct cggtgcgtct
    14821 catgttttga tctacctgag ctaggcaacg caggtcggcg gagtcggccg ttttgagggg
    14881 agcgtctgtg gggacggcag acgggcatcg ggcgcgcgag gtcctggaag acctgttcgc
    14941 gcgggcaagg gagggccagg gacgggcggt gctcgtcacc ggggcggcgg gcatgggcaa
    15001 gaccaccctc gtccacgagc tccagaacca cgcgctgagc tcgggtgcca gagtgctcac
    15061 cgccatcgcc tcgcgcgccg agcgcgacct cccgatgggc gtcgtcggcc agctggcggc
    15121 ggccgcccac cccgctagcc cggccgcggc cggcgcggac ccgggtacgg gcgcgacgct
    15181 ccaggccgtc gacgccttcc accgcctcat gctcgggctg gccgaacgtg accccctcgt
    15241 catcaccgtg gacgacgcgc acgagatgga cgccgcctcc cggcactgcc tgctgtacct
    15301 ggtccgccgg gtgggcgcct cccggatcct gctggtgctc ggcgagcggg ccgacacctc
    15361 ccagccgggc tccacgctca cctcggagtt cgtccgcaat ccgcactgcg cgctggttca
    15421 gctgggccgg ctttccgtcg ccggcaccga gtccgtgctc gccgcgcttc ccggcgcccg
    15481 gccggccgcg gagagcgcgc cgctctggca acgcgcctcg ggcggcagtc cgctgctgct
    15541 gcaggcactg ctcgacgacc gcgccgacgg cgcggcggcg gagccggccg ccggtcaggc
    15601 gttcgcgctg gcggtgcgcc acctgctcga ccagctcgac ccggccaccg cccgcaccgc
    15661 ccatggcctg gccgtcctgg gcgacgacgc tacggccgcg gacctcgacc ggctgctgga
    15721 cctgcccgcc ggtacggccg cccgggccat ggcgaccacg gacgcactcg gcctgaccga
    15781 ggaaggccgt taccgcgtcg cggccgcgcg cgccaccgcg ctggcggagc tgcgccccga
    15841 ggagcgggcc gccctgcacc gggccgcggc ccggctgctc tatcagcacc gggccgcgac
    15901 cagcgaggtg gcccgccacc tggtcgtcgg cggtccggtc gacgagagct gggggctggc
    15961 cgtactgcgt gacacggccc agcaggccct gcgcacgaac gacccggtac gcgccctgac
    16021 ctgcctgcgg gtggcgcacg acgcgtgccc cgacccgcgc gagcaggctc aggtgcgcgc
    16081 cgaactggtg caggccgaat gggaggtgga ccccgccgcc gtccgcgtcc acctgccctg
    16141 tctcgtcaag gaccaccgcg ccgggctgct cgaacaccgg cagagcatcc gcctgatcgc
    16201 ccacctgctg tggcacggcc ggcctgagga ggcggacgcc ctgttcgccg acctggaccc
    16261 ggtggagggc cggctgccgg gggactgccg ggcgcagttg gagacgatgc gggtctggtt
    16321 cgcgcactcg tacccggtgc tcggagcccg ttaccgggcg cacacgctgc tggacgaggc
    16381 ggcgctcagc cggagcgtgg gcgccgtgga tccgcaggcc gacggggctc tgctgctgca
    16441 cgcgctgatg tccgaggggc cgaccgggaa ggtgctggag accgccgaac ggctgctcca
    16501 aggcatggtg ctgcacgatc cgccggtggc cccgaccatc gccgcgctgg ccacgtacat
    16561 gcacgccgcc cggctggacc gggccgcgga ctggtgcgac ctgctgctgc gggaggccga
    16621 ccggcgcacg ccggtgatcc gggcgattct cgccgccgcc agtgccgcgg tcgagagccg
    16681 gctcggcaac ttcgaggtgg cccgccagcg ggccgacctt gcgctgacgc tggtgggccc
    16741 gaccgcctgg ggcatcgccc tcggcgtgcc attggccgcc aaggtgctgg cctgcacggc
    16801 ccagggcgac cgggaggggg ccgccgagtg cttccgggtg ccggtgctcg acgtgatgtt
    16861 tcagacccta cccggattgc actacctgca ggcgcggggc cgctaccacc tctcggtggg
    16921 ccgctaccac gcggcgctcg gcgacttcca cgcctgccgc gacctgatgg cggcgtggaa
    16981 cctggacgtc tcggcgtccc tgtcgtggcg ggcgtacgcc gccgaggcac tgatcgagct
    17041 cgacagcccg gcgcaggccc gggagctgct ggcggaggag ctggcccagc agggcgacgg
    17101 cagcggcggc aacccgtggc tgaaggaacg ttcgctgcag ctgctcgacc ggctgggcag
    17161 cccccggccg gccgggtccg ccgcgaccgc cccaggccgg ggcgggccgg aggagagcgg
    17221 tcccgaggag ctgagcaagg cggagcagcg ggtggcgctg ctggcctcgc agggttgcac
    17281 gaaccgggag atcgcggccc ggctgttcgt cacggggagc accgtcgagc agcacctgac
    17341 ccgcgcctac cacaagttgg gggtgcgggg ccgggccgat ctgcccgcgg tgctgggccg
    17401 ggtgccggcc ggcagaaggg gctccgactc ttaggcgagt ccgagcgtgg cgcgcccgac
    17461 ggaagccctg gccgcccttg cggccgaggc agccgcgggc cgccagctgt tccagcagcg
    17521 gcggggtgta gccgccttcg gggaactccc cgtccaggcg ccgcagggcg gcccgggaga
    17581 cgtcgagccc gatggtgtcg agcagggcga acggccccat cgggtggccc aggccctgtt
    17641 cgaaggcggc gtcgatccgc tcgatgtcga cgtcgtgacc gtcccgtccg tcgagcaggc
    17701 cgagggcggc gcgcttgtcc tgcgggccga agccggaccg cgcggttgag gtaggcgtac
    17761 atcatcgcgc tcgcggccgc gcccggccgc gccccttacg gggcggccgc cgccaggccg
    17821 atcccgtcga gcagggcctc cagcgcggcg acggcgtcgt cgctactcat ggcggtgcac
    17881 agcaactcga cggtgccgcc gggggccggc ggccgcagca tgcgcagccc cagcgtgcgg
    17941 gccggccggc cggacgcgat cgccagctgc ggcaacgaca gcgaggccga ggtgctcacc
    18001 aggacggcgc cgtccaggca gacggcgtgc agccggcgaa ggacctcggt cttgccggcc
    18061 aggtcctccg gcacggcctc gacgaccacg tcggccccga ccagggcgac cgtgtcgttc
    18121 gtgagcgtgt agccaccggc cggaccctca ccgacggccg ctcgggcctt catccaccgc
    18181 tccgcgcggg ccagtacgtc ggcttcctgg tcgacaccga tgacctcgtg accggcggtg
    18241 tgcagcaggg cgagcagggg caggccgacg gagccgagcc cgacgacgcc gacgacggat
    18301 gagttgagcg gcatgacctc gctgtgttcc ttttctgcgg tggggtgcgg tcgggctcag
    18361 cggccggtgg cccggaagcg gttgatggcg tcgaggtgtt cggcgcgcat gtcgtggtcg
    18421 cgcacgccca ggccctcctc gggcgagagg cacagcacgc cgaccttgcc ctggtggagg
    18481 ttgcggtgga cgtcgtacgc cgcctggccc gtctcctcca gggagtaggt cttggagagg
    18541 gtggggtgaa tcttgccctt ggcgacgagg cggttggcct cccaggcctc gcggtagttg
    18601 gcgaagtggg agccgatgat gcgcttgagc gacatccaca ggtaccggtt gtcgtactgg
    18661 tgcatgtagc cggaggtgga ggcgcaggtg gtgatcgtgc cgcccttgcg ggtgacgtag
    18721 accgaggcgc cgaacgtctc gcggcccggg tgctcgaaga cgatgtcgat gtcctcgccg
    18781 ccggtcagct cgcggatctt ggagccgaag cgcttccact cgcgcgggtc ctgggtctgc
    18841 tcgtccttcc agaacctgta gccctcggcg ttgcggtcga tgaccgcatc ggcgcctatc
    18901 ttgcggcaga tctcggcctt ttcgggggag gagaccacgc agatgggggt ggcgccgccg
    18961 gccagggcga actgggtggc gtaggagccc aggccgccgc tggcgcccca gatcagaacg
    19021 ttgtcgcctt gcttcatgcc ggcgccgttg cgcgagacca gctggcggta ggcggtggag
    19081 ttcaccaggc cgggggaggc ggcctcctcc cagctgaggt gggccggctt gggcatcagc
    19141 tggttggact tgaccagcgc gatctccgcg agaccgccga agttcgtctc gaagccccag
    19201 atccgctgct cggggtcgag catcgtgtcg tcgtggccgt cggcggactc cagctccacc
    19261 gacaggcagt gggccacgac gcggtcgccg gctttccagc ggttgacgcc cggtccggtg
    19321 cgcaggacga cgcccgcaag gtcggagccg aggacgtggt acggcaggtc gtggcgcttg
    19381 gtgagttcgc tgagtcggcc gtagcgctcc aggaatccga acgtcggcag cggctcgaag
    19441 atcgaagacc agacggtgtt gtagttgacc gaggaggcca tgacggccac cagggcctcg
    19501 cccggacccg gctccggtgt cgggacgtcc tgcacgtgca aggacttgcg cgggtccttg
    19561 tccgccgtcg ccaggccctc gaacatgccg acgtcttctt ttcttacgac gctcccccgg
    19621 tagctctcgg ggatcgacag agcggcgata tcgccggccg cgacgtcgtc ggaaaggatg
    19681 gcgctgacta tttctttcac ggggtcaggg taggaagcgg gcccccagcc ggaaacccca
    19741 attcccgtgc tggacccccc agaaaagccg gtaggggggt tgtccgccgg aaagccgttc
    19801 cgccattctc aattcggcgt accagcaaga acagatatga gggaaagtgg aaatgatgga
    19861 gagtcccgac cacggtgacg gtcccggcga cgccgacggc gccgacggcg gttcctggat
    19921 ccgcgggttc cacccggtcc ccgaccccgc cgcccggctc gtctgcttcc cgcacgccgg
    19981 cggctccgcc agcttcttct tcccgctctc gcgcgagctc gcgcagcggg gcgtcgaggt
    20041 gctgccggtg cagtaccccg gacggcagga ccggcgggcc gaacccaaca tccccgacct
    20101 ggcggtgatg gccgaccggg tggccgaggc cctcgccccc cgtttggacc ggccgttcgc
    20161 gctgttcggg cacagcatgg gcgccaccct cgcctacgag gtggcccgcc gggcgcagga
    20221 ggccggccgg ccgcccgccg cgctcttcgt ctcggggcgc cgggccccgc accgggtcgt
    20281 cgacgacggg ctgcacctgc tctcggaccg ggagctggtc gaggacatca tggccctgga
    20341 cggcacggag tcggggatgt tcggcgatcc ggagctgctg gagctggtcc tgccggccat
    20401 ccgcagcgac taccgggccg cggagacgta ccggttcgtc ccgggaccgc ggttggactg
    20461 cccggtgcac gcgctgaccg ggttctccga cccacgcgta tcggtcggcg aactgcgcca
    20521 ctgggccggg cacaccgacg gtccgttcga gctccaggtc ttcccgggcg gccacttcta
    20581 cctcacggac cacgccgaga cgatcaccac gggcatcgcc gagcggctgg ccgccgcgac
    20641 gtccgccgcc tgacgggcgg ccccgggcca gggcaggtcg aggagcgggt cccgccgcag
    20701 gatcgagcgg tggagcatcc ggatcgggtc gcccggctcc atcccgagct cggccaccag
    20761 cgtaccgcgg atgcggcggt aggcctccaa cgcctccggc acccggccgc tgcggcagag
    20821 cgagagcatc agctgcgcgt ggagcgcctc ccacatgggg tgctcgtcgg cgagttcgta
    20881 cagctccgcg atggcggcct ggtgcccgcc cagccgcagc cgcaggtcaa agccccgctc
    20941 cagggcgccc agccgctact cgtcgagggc gcgccccagc gcggcgaagg cgggcagccc
    21001 gcgcaggtcg gccagggccg ggccacagcg cgcacgcctc tggcgcagcc ggcgcagttc
    21061 cttctcgggc gccgggcccg ggcgctcgcc cggcagggcg cccgcggccg gttccccgtc
    21121 ggacagcgcg tcgaaccggc gcaggtccag ccgctccggc tccagctcga agacgtaccc
    21181 gtgcggcttg gtgaccagat ggccggccag atcgccgtgc tcgtcgagga acttgcgcag
    21241 cttggacacg tacacctgta acacggtgcg ggccgtacgg ggcggggtgc ccgaccacag
    21301 cgcgtggggc agggactgcc tggagacgac cgttcccgac ctcacgcaca agagcgccag
    21361 cagacagcgg atcttctccg cctgcggcgt caccacccgt ccgccggctt cgacctcgac
    21421 ccctcgaccg gttccgggac cctgaatagc acgtcacatt cccccttttc gccgtgtcga
    21481 ctccacctga gaactggctc tggcacatat tttttgattg ttcttggtga cggctgacga
    21541 gttagtcagg
//
