BGC0001244 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001244 (Parastagonospora nodorum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	5,358	High	(-)-Mellein	PKS

BGC0001244 - Region 1 - T1PKS

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Location: 1 - 5,358 nt. (total: 5,358 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 5,359
Label		BGC0001244

Tailoring functions

Ligases: synthase

SNOG_00477: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	1.00	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.79	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.79	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.70	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000056.3	0.68	PKS	esperamicin	Actinomadura verrucosospora
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0002229.2	0.63	PKS	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	1.00	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.79	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.79	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.70	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000056.3	0.68	PKS	esperamicin	Actinomadura verrucosospora
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0002229.2	0.63	PKS	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 5358:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SNOG_00477: pk

PKS_AT (576..867): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 90.4
Methoxymalonyl-CoA: 68.7
Ethylmalonyl-CoA: 66.3
Isobutyryl-CoA: 65.3
Malonyl-CoA: 57.6
Acetyl-CoA: 38.2
Benzoyl-CoA: 35.6
Propionyl-CoA: 34.5
fatty_acid: 29.9
3-Methylbutyryl-CoA: 28.5
trans-1,2-CPDA: 28.3
2-Methylbutyryl-CoA: 24.3
inactive: 15.8
CHC-CoA: 10.4

Link to PARAS substrate predictor