BGC0001245 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001245 (Lasiodiplodia theobromae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	30,072	High	lasiodiplodin	PKS

BGC0001245 - Region 1 - T1PKS

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Location: 1 - 30,072 nt. (total: 30,072 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 30,073
Label		BGC0001245

Tailoring functions

Transferases: methyltransferase sulfotransferase

lasG: glutathione S-transferase

smcogs: SMCOG1193: glutathione S-transferase

lasM: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: protease

AHV78248.1: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Ligases: synthase

lasS1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

lasS2: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001245.3	1.00	PKS	lasiodiplodin	Lasiodiplodia theobromae
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001245.3	1.00	PKS	lasiodiplodin	Lasiodiplodia theobromae
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 30072:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: lasS1 + lasS2

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

lasS1: pk

PKS_AT (565..880): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 92.2
Malonyl-CoA: 83.2
Methoxymalonyl-CoA: 82.6
Ethylmalonyl-CoA: 61.2
Isobutyryl-CoA: 57.1
Benzoyl-CoA: 39.7
Propionyl-CoA: 26.3
inactive: 23.4
trans-1,2-CPDA: 21.3
Acetyl-CoA: 20.8
CHC-CoA: 19.1
2-Methylbutyryl-CoA: 16.7
3-Methylbutyryl-CoA: 12.8
fatty_acid: 10.7

lasS2: mal

PKS_AT (886..1182): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 104.6
inactive: 70.3
Methoxymalonyl-CoA: 61.8
Methylmalonyl-CoA: 53.9
Isobutyryl-CoA: 36.8
trans-1,2-CPDA: 28.7
Benzoyl-CoA: 24.5
Acetyl-CoA: 24.2
Propionyl-CoA: 23.0
Ethylmalonyl-CoA: 20.0
fatty_acid: 17.9
CHC-CoA: 17.1
3-Methylbutyryl-CoA: 15.4
2-Methylbutyryl-CoA: 14.5

Link to PARAS substrate predictor