BGC0001245 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001245 (Lasiodiplodia theobromae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	26,273	hypothemycin	Polyketide	40%

BGC0001245 - Region 1 - T1PKS

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Location: 1 - 26,273 nt. (total: 26,273 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 26,274
Label		BGC0001245

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001245.1	0.67	Polyketide	lasiodiplodin	Lasiodiplodia theobromae
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001858.1	0.29	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001068.1	0.25	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000046.1	0.24	Polyketide	depudecin	Alternaria brassicicola
BGC0000056.1	0.23	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000041.1	0.23	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000003.1	0.22	Polyketide	AF-toxin	Alternaria alternata
BGC0001998.1	0.22	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0001124.1	0.22	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001245.1	0.87	Polyketide	lasiodiplodin	Lasiodiplodia theobromae
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001858.1	0.63	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000046.1	0.57	Polyketide	depudecin	Alternaria brassicicola
BGC0000056.1	0.56	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000041.1	0.56	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000003.1	0.55	Polyketide	AF-toxin	Alternaria alternata
BGC0001998.1	0.55	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0001124.1	0.55	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 26273:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (pk)
Non-colinear ordering:: lasS2 + lasS1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

lasS1

PKS_AT (565..880): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 92.2
Malonyl-CoA: 83.2
Methoxymalonyl-CoA: 82.6
Ethylmalonyl-CoA: 61.2
Isobutyryl-CoA: 57.1
Benzoyl-CoA: 39.7
Propionyl-CoA: 26.3
inactive: 23.4
trans-1,2-CPDA: 21.3
Acetyl-CoA: 20.8
CHC-CoA: 19.1
2-Methylbutyryl-CoA: 16.7
3-Methylbutyryl-CoA: 12.8
fatty_acid: 10.7

lasS2

PKS_AT (886..1182): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 104.6
inactive: 70.3
Methoxymalonyl-CoA: 61.8
Methylmalonyl-CoA: 53.9
Isobutyryl-CoA: 36.8
trans-1,2-CPDA: 28.7
Benzoyl-CoA: 24.5
Acetyl-CoA: 24.2
Propionyl-CoA: 23.0
Ethylmalonyl-CoA: 20.0
fatty_acid: 17.9
CHC-CoA: 17.1
3-Methylbutyryl-CoA: 15.4
2-Methylbutyryl-CoA: 14.5