BGC0001246 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001246 (Sarocladium zeae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	28,428	High	trans-resorcylide	PKS

BGC0001246 - Region 1 - T1PKS

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Location: 1 - 28,428 nt. (total: 28,428 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,429
Label		BGC0001246

Tailoring functions

Ligases: synthase

resS1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

resS2: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001246.3	1.00	PKS	trans-resorcylide	Sarocladium zeae
BGC0000045.3	0.69	PKS	dehydrocurvularin	Aspergillus terreus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001246.3	1.00	PKS	trans-resorcylide	Sarocladium zeae
BGC0000045.3	0.69	PKS	dehydrocurvularin	Aspergillus terreus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 28428:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: resS1 + resS2

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

resS1: pk

PKS_AT (555..871): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Ethylmalonyl-CoA: 70.8%; Methylmalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 99.8
Methoxymalonyl-CoA: 86.4
Malonyl-CoA: 78.3
Ethylmalonyl-CoA: 64.9
Isobutyryl-CoA: 54.2
Benzoyl-CoA: 37.1
Propionyl-CoA: 31.5
2-Methylbutyryl-CoA: 28.2
trans-1,2-CPDA: 22.0
CHC-CoA: 19.6
inactive: 12.5
fatty_acid: 10.1
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

resS2: mal

PKS_AT (955..1267): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 58.3%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 97.1
Methoxymalonyl-CoA: 59.4
inactive: 59.1
Methylmalonyl-CoA: 58.3
Isobutyryl-CoA: 47.8
Propionyl-CoA: 37.9
Benzoyl-CoA: 32.2
CHC-CoA: 21.8
2-Methylbutyryl-CoA: 20.8
Acetyl-CoA: 19.6
3-Methylbutyryl-CoA: 19.2
trans-1,2-CPDA: 18.1
Ethylmalonyl-CoA: 18.1
fatty_acid: 12.5

Link to PARAS substrate predictor