BGC0001250 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001250 (Epichloe festucae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	14,073	epichloenin A	NRPS:Type I	100%

BGC0001250 - Region 1 - NRPS

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Location: 1 - 14,073 nt. (total: 14,073 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,074
Label		BGC0001250

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001250	1.00	NRP	epichloenin A	Epichloe festucae
BGC0001251	0.87	NRP	epichloenin A	Epichloe festucae
BGC0001527	0.21	Other	basidioferrin	Gelatoporia subvermispora
BGC0001833	0.20	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286	0.20	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001767	0.12	NRP	salinichelins	Salinispora pacifica CNY331
BGC0001211	0.12	NRP	albachelin	Amycolatopsis alba DSM 44262
BGC0001561	0.10	NRP	curacomycin	Streptomyces curacoi
BGC0002272	0.08	NRP	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0000355	0.08	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001250	1.00	NRP	epichloenin A	Epichloe festucae
BGC0001251	0.96	NRP	epichloenin A	Epichloe festucae
BGC0001527	0.53	Other	basidioferrin	Gelatoporia subvermispora
BGC0001833	0.52	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286	0.52	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001767	0.39	NRP	salinichelins	Salinispora pacifica CNY331
BGC0001211	0.39	NRP	albachelin	Amycolatopsis alba DSM 44262
BGC0001561	0.35	NRP	curacomycin	Streptomyces curacoi
BGC0002272	0.32	NRP	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0000355	0.32	NRP	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 14073:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gln - X)

Direct lookup in NORINE database: strict or relaxed

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NRPS/PKS substrate predictions

sidN

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AMP-binding (236..657): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLLMWCAITK
Nearest Stachelhaus code(s):: Gly DLLMWCAITK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1348..1760): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DACSTGVINK
Nearest Stachelhaus code(s):: Gln DACSTGVINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2462..2869): X

nrpys: E-ahmohOrn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVGGGGVIGK
Nearest Stachelhaus code(s):: E-ahmohOrn DVGGGGVIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)