BGC0001251 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001251 (Epichloe festucae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	1	15,433	High	epichloenin A	NRPS:Type I

BGC0001251 - Region 1 - NRPS

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Location: 1 - 15,433 nt. (total: 15,433 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 15,434
Label		BGC0001251

Tailoring functions

Ligases: ligase

sidN: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001251.4	0.97	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.94	NRPS	epichloenin A	Epichloe festucae
BGC0001833.4	0.60	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001561.4	0.40	NRPS	curacomycin	Streptomyces curacoi
BGC0000355.5	0.40	NRPS	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0001211.5	0.40	NRPS	albachelin	Amycolatopsis alba DSM 44262
BGC0001806.4	0.40	NRPS	tolaasin A	Pseudomonas tolaasii
BGC0002272.2	0.39	NRPS	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0002606.2	0.38	NRPS, PKS	ochratoxin A	Aspergillus niger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001251.4	0.97	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.94	NRPS	epichloenin A	Epichloe festucae
BGC0001833.4	0.60	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001561.4	0.40	NRPS	curacomycin	Streptomyces curacoi
BGC0000355.5	0.40	NRPS	fumiquinazoline A, fumiquinazoline C, fumiquinazoline D	Aspergillus fumigatus Af293
BGC0001211.5	0.40	NRPS	albachelin	Amycolatopsis alba DSM 44262
BGC0001806.4	0.40	NRPS	tolaasin A	Pseudomonas tolaasii
BGC0002272.2	0.39	NRPS	asterrelenin, epi-aszonalenin A	Aspergillus terreus NIH2624
BGC0002606.2	0.38	NRPS, PKS	ochratoxin A	Aspergillus niger

Similar known clusters from MIBiG 4.0

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 15433:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gln - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

sidN: Gly - Gln - X

Search NORINE for peptide: strict or relaxed

AMP-binding (236..657): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLLMWCAITK
Nearest Stachelhaus code(s):: Gly DLLMWCAITK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1348..1760): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DACSTGVINK
Nearest Stachelhaus code(s):: Gln DACSTGVINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2462..2869): X

nrpys: E-ahmohOrn

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVGGGGVIGK
Nearest Stachelhaus code(s):: E-ahmohOrn DVGGGGVIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor