BGC0001252 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001252 (Alternaria alternata)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	7,958	UNII-YC2Q1O94PT	PKS	100%

BGC0001252 - Region 1 - T1PKS

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Location: 1 - 7,958 nt. (total: 7,958 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 7,959
Label		BGC0001252

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001252	1.00	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002191	0.31	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002155	0.29	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001606	0.26	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002222	0.24	Polyketide	zopfiellin	Diffractella curvata
BGC0002224	0.23	Polyketide	zopfiellin	Diffractella curvata
BGC0002515	0.23	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002525	0.22	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002194	0.22	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002240	0.21	Polyketide	BAB, BAA	Metarhizium anisopliae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001252	1.00	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002191	0.65	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002155	0.63	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001606	0.59	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002222	0.57	Polyketide	zopfiellin	Diffractella curvata
BGC0002224	0.57	Polyketide	zopfiellin	Diffractella curvata
BGC0002515	0.56	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002525	0.55	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002194	0.55	Polyketide	epipyrone A	Epicoccum nigrum
BGC0002240	0.54	Polyketide	BAB, BAA	Metarhizium anisopliae

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 7958:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ACRTS2

PKS_AT (546..873): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 74.7
Methoxymalonyl-CoA: 73.5
Malonyl-CoA: 67.3
Isobutyryl-CoA: 55.1
Propionyl-CoA: 44.8
Benzoyl-CoA: 34.4
Ethylmalonyl-CoA: 29.3
2-Methylbutyryl-CoA: 25.4
3-Methylbutyryl-CoA: 21.4
fatty_acid: 14.6
trans-1,2-CPDA: 8.9
inactive: 8.4
CHC-CoA: 5.4
Acetyl-CoA: 1.9