BGC0001254 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001254 (Alternaria alternata)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	7,794	ACT-Toxin II	PKS	100%

BGC0001254 - Region 1 - T1PKS

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Location: 1 - 7,794 nt. (total: 7,794 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 7,795
Label		BGC0001254

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001254	1.00	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002192	0.32	Polyketide	FR901512	fungal sp. No.14919
BGC0001400	0.31	Polyketide	citreoviridin	Aspergillus terreus NIH2624
BGC0002745	0.26	Polyketide	verrucosidin	Penicillium polonicum
BGC0002258	0.26	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus
BGC0001998	0.25	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0000064	0.23	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0001268	0.23	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0002139	0.21	Polyketide	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400
BGC0002191	0.21	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001254	1.00	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002192	0.65	Polyketide	FR901512	fungal sp. No.14919
BGC0001400	0.64	Polyketide	citreoviridin	Aspergillus terreus NIH2624
BGC0002745	0.59	Polyketide	verrucosidin	Penicillium polonicum
BGC0002258	0.59	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus
BGC0001998	0.58	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0000064	0.57	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0001268	0.57	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0002139	0.54	Polyketide	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400
BGC0002191	0.53	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 7794:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ACTTS3

PKS_AT (548..865): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 72.3
Methoxymalonyl-CoA: 60.6
Benzoyl-CoA: 55.2
Ethylmalonyl-CoA: 39.5
Isobutyryl-CoA: 39.3
Malonyl-CoA: 28.6
Propionyl-CoA: 20.0
fatty_acid: 16.8
Acetyl-CoA: 14.7
3-Methylbutyryl-CoA: 14.7
trans-1,2-CPDA: 12.2
2-Methylbutyryl-CoA: 10.5
inactive: 0.0
CHC-CoA: 0.0