BGC0001254 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001254 (Alternaria alternata)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	7,794	High	ACT-Toxin II	PKS

BGC0001254 - Region 1 - T1PKS

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Location: 1 - 7,794 nt. (total: 7,794 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 7,795
Label		BGC0001254

Tailoring functions

Ligases: synthase

ACTTS3: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001254.3	0.98	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.75	PKS	FR901512	fungal sp. No.14919
BGC0001400.3	0.70	PKS	citreoviridin	Aspergillus terreus NIH2624
BGC0001268.4	0.68	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001998.2	0.66	PKS	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001254.3	0.98	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.75	PKS	FR901512	fungal sp. No.14919
BGC0001400.3	0.70	PKS	citreoviridin	Aspergillus terreus NIH2624
BGC0001268.4	0.68	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001998.2	0.66	PKS	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 7794:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ACTTS3: pk

PKS_AT (548..865): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 66.7%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 72.3
Methoxymalonyl-CoA: 60.6
Benzoyl-CoA: 55.2
Ethylmalonyl-CoA: 39.5
Isobutyryl-CoA: 39.3
Malonyl-CoA: 28.6
Propionyl-CoA: 20.0
fatty_acid: 16.8
Acetyl-CoA: 14.7
3-Methylbutyryl-CoA: 14.7
trans-1,2-CPDA: 12.2
2-Methylbutyryl-CoA: 10.5
inactive: 0.0
CHC-CoA: 0.0

Link to PARAS substrate predictor