BGC0001257 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001257 (Nodulisporium sp. ATCC74245)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	7,549	1,3,6,8-tetrahydroxynaphthalene	PKS	100%

BGC0001257 - Region 1 - T1PKS

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Location: 1 - 7,549 nt. (total: 7,549 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 7,550
Label		BGC0001257

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001257	1.00	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154	0.45	Polyketide	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001906	0.45	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0001258	0.42	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175	0.36	Polyketide	YWA1	Aspergillus oryzae RIB40
BGC0000107	0.36	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001284	0.35	Polyketide	alternariol	Parastagonospora nodorum SN15
BGC0002161	0.33	Polyketide	scytalone, T3HN	Pestalotiopsis fici W106-1
BGC0001583	0.29	Polyketide	emodin	Escovopsis weberi
BGC0000156	0.28	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001257	1.00	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154	0.76	Polyketide	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001906	0.75	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0001258	0.73	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175	0.69	Polyketide	YWA1	Aspergillus oryzae RIB40
BGC0000107	0.69	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001284	0.68	Polyketide	alternariol	Parastagonospora nodorum SN15
BGC0002161	0.66	Polyketide	scytalone, T3HN	Pestalotiopsis fici W106-1
BGC0001583	0.63	Polyketide	emodin	Escovopsis weberi
BGC0000156	0.62	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 7549:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

pks1

PKS_AT (912..1212): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 62.5%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 125.2
inactive: 70.5
Methoxymalonyl-CoA: 50.3
Methylmalonyl-CoA: 49.6
Ethylmalonyl-CoA: 25.0
2-Methylbutyryl-CoA: 23.3
CHC-CoA: 22.0
Propionyl-CoA: 18.6
Isobutyryl-CoA: 18.6
fatty_acid: 13.9
Benzoyl-CoA: 12.4
3-Methylbutyryl-CoA: 11.6
trans-1,2-CPDA: 10.0
Acetyl-CoA: 8.6