BGC0001257 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001257 (Nodulisporium sp. ATCC74245)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	7,549	High	1,3,6,8-tetrahydroxynaphthalene	PKS

BGC0001257 - Region 1 - T1PKS

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Location: 1 - 7,549 nt. (total: 7,549 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 7,550
Label		BGC0001257

Tailoring functions

Ligases: synthase

pks1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001257.3	1.00	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.83	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.81	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175.3	0.78	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.78	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001284.4	0.77	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001906.2	0.75	PKS	2-acetyl-1,3,6,8-tetrahydroxynaphthalene, 1,3,6,8-tetrahydroxynaphthalene	Daldinia eschscholzii IFB-TL01
BGC0002161.2	0.70	PKS	scytalone, T3HN	Pestalotiopsis fici W106-1
BGC0000156.5	0.66	PKS	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001257.3	1.00	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.83	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.81	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002175.3	0.78	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.78	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001284.4	0.77	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001906.2	0.75	PKS	2-acetyl-1,3,6,8-tetrahydroxynaphthalene, 1,3,6,8-tetrahydroxynaphthalene	Daldinia eschscholzii IFB-TL01
BGC0002161.2	0.70	PKS	scytalone, T3HN	Pestalotiopsis fici W106-1
BGC0000156.5	0.66	PKS	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 7549:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

pks1: mal

PKS_AT (912..1212): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 62.5%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 125.2
inactive: 70.5
Methoxymalonyl-CoA: 50.3
Methylmalonyl-CoA: 49.6
Ethylmalonyl-CoA: 25.0
2-Methylbutyryl-CoA: 23.3
CHC-CoA: 22.0
Propionyl-CoA: 18.6
Isobutyryl-CoA: 18.6
fatty_acid: 13.9
Benzoyl-CoA: 12.4
3-Methylbutyryl-CoA: 11.6
trans-1,2-CPDA: 10.0
Acetyl-CoA: 8.6

Link to PARAS substrate predictor