LOCUS       BGC0001260             15276 bp    DNA     linear   PLN 14-FEB-2013
DEFINITION  Chaunopycnis alba ORF1, terK, terC, terB, terQ, terM, terP, terF,
            ORF2, ORF3 genes for indoleamine 2,3-dioxygenase, cytochrome P450
            monooxygenase, prenyl transferase, terpene cyclase, cytochrome P450
            monooxygenase, FAD-dependent monooxygenase, cytochrome P450
            monooxygenase, aromatic prenyl transferase, flavin-binding
            monooxygenase, heat shock protein, complete cds.
ACCESSION   BGC0001260
VERSION     BGC0001260
KEYWORDS    .
SOURCE      Tolypocladium album
  ORGANISM  Tolypocladium album
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Hypocreomycetidae; Hypocreales;
            Ophiocordycipitaceae; Tolypocladium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 00:18:26
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15276
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(join(1..440,498..526,581..1031,1093..1224,
                     1282..1372,1422..1490,1549..1674,1728..1970))
                     /codon_start=1
                     /gene="terK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 127.6; E-value: 1.1e-38)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase"
                     /protein_id="BAM84045.1"
                     /sec_met_domain="p450 (E-value: 8.2e-35, bitscore: 109.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MNDYNVTGTTLGDAFAKLPPNWGQLTGALLFLAACTWIYLPAFDG
                     VPAPFAGYRSPLEPAIVAKTRYAFAASDIISEGYAKWKSSMYKISRHGGDVVVLSRKYI
                     DELQNAPHERLSSIKGLIKNFGGQYSGIDLLDESDIGTRALQTKITPNLTKFSDDMRDE
                     LEYALGRDMPDCEDWTLVPLQPILLKLLGRITSRVLIGLPICRDEKWLDAASQHAHNVT
                     ITQIVMKAVHPIFRPFLNLVLPTVWRYKSAVRRGKAILAPEVQRRRNLEDNDPDYVKPN
                     DLLQAMMDLSTPGGKDSQPEDLAHRHLLITLVAGHSTAAAGSHALMDLVSRPQLLEELR
                     DEVLQVLQENGGNWGKQSLSKLWKMDSFFRESQRQNPPSLLGFHRIVQDPAGITLHDGV
                     HVPYGTHLCIAPHSVSSDPAVIPNPDVFDGLRYYEQRRQKPDESMKHQHATADKNHLHF
                     GYGTWSCPGRFLASDELKMTLSALLLRYDFKYPDGSSRPTNKHIDEFPYVDPETPLLMR
                     RRHQGGTGV"
     cand_cluster    1..15276
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="indole"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..15276
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001260"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..15276
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="terpene"
                     /product="indole"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..14381
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[3316:4381]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3317..4381
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..14381
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     gene            complement(1..1970)
                     /gene="terK"
     gene            complement(3317..4381)
                     /gene="terC"
     CDS             complement(join(3317..3638,3690..4381))
                     /codon_start=1
                     /gene="terC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 101.2; E-value:
                     9.1e-31)"
                     /gene_kind="biosynthetic"
                     /product="prenyl transferase"
                     /protein_id="BAM84046.1"
                     /sec_met_domain="fung_ggpps2 (E-value: 9.8e-105, bitscore:
                     338.0, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDWLGNRVSVGNIALLAIGASMGFIAKTSTLSKPEAPNTVQQYGY
                     CKKLSSEKRNQAAGCPYEYLVSIYGRHHFESLVKEFNPLLKQEDPVKYDLVLEIMDAVH
                     FALILVDDISDDSYQRKNQPTAHLIYGASETANRAYLVLTGVINRALRERPVLGAELLK
                     ALEDILQGQDLSLVWRRDGLKSFQYQGDESIAAYKNMASLKTGTLFVLLGRLLNDGGNE
                     LDDLLSRFGWFAQLQNDCKNIYSAEYATNKGAVAEDLRNGELSYPIVIALNDNSTSRVM
                     ERALASHAEADVEEALQALQSKPVRDACMRALQQASVGLEKLVLLWGRREKMQAGS"
     protocluster    3860..15276
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[13859:15275]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      13860..15275
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
     cand_cluster    3860..15276
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="2"
                     /tool="antismash"
     gene            4731..5524
                     /gene="terB"
     CDS             join(4731..5248,5317..5524)
                     /codon_start=1
                     /gene="terB"
                     /product="terpene cyclase"
                     /protein_id="BAM84047.1"
                     /transl_table=1
                     /translation="MDGFTDSQAPPAYEEVKWLADTLVAFMGIGWLINYGAMIRHSYQG
                     RTYCMGIIPLCNNIGWELVYTLVHPSSNRVELAVFAAGVTLNVIIMFAATRSAKTEWQH
                     SPLVANHTPLIFLGGTFVCFAGHVALAAEIGPALAYSWGAVICQLVLSIGGVCQLLQRN
                     TTRGTSVTLWLSRFLGSCCTVGFAFLRWRYWPEAFAWLAGPLVLWSLATFVLADITYGV
                     CLYLISQTETSSTKRSKLK"
     gene            complement(6377..8419)
                     /gene="terQ"
     CDS             complement(join(6377..6852,6916..7093,7154..7273,
                     7322..7430,7475..7905,7958..8100,8157..8250,8303..8419))
                     /codon_start=1
                     /gene="terQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 109.6; E-value: 3.1e-33)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase"
                     /protein_id="BAM84048.1"
                     /sec_met_domain="p450 (E-value: 2.1e-39, bitscore: 124.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MLIDRLAGAVPAHAWPTITVAGAVMVVVLLMRYLDYDKKVEVPVI
                     GPGGRFTKWLGAIRNVWYAREAIHEVANGQHGKLGFQIPTMTRMDVFICDRALTREYYS
                     LDEDHMSFRAVMSEEFQFKWLLPGQHHDVHRIPNSVIAKALSWQRTRASKADDPFFREF
                     SAEFLYGFQEEMRAFTGCGNKSRLPFFSHAGDHTSGNSGWIAAPCFPLALKVIARLTTK
                     SLFGEPLCRNPKFLDMCCEFGDAVPRDAMILRCFPDFIRPLLARFLAAPRGVKELQTVV
                     LNEITSRRNSREKNPMKDLLDFSINWIDEHSADGWEDWHIADMMTNTVFAALHTSSQLV
                     THTLFELATRPEYVVPLREEIRQCFALYGNGTKAAIDAMHKMDSFIKETQRCNPLDASA
                     LARLVLKPYTFSNGLHVPKGSFIFTPNSPLFEDEQFYEDAKRFDGLRFARMRDDPKRKS
                     DSPMTATSEYSMHFGIGRHACPGRYMVSDEVKLVMVHLLLHYDFAMANFGPRPKNMAFG
                     KFILPDMQAKVWLRKSKDAGNTARVDPGAPDGVASEPS"
     gene            complement(8699..10276)
                     /gene="terM"
     CDS             complement(join(8699..9199,9252..9622,9675..9934,
                     9987..10276))
                     /codon_start=1
                     /gene="terM"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 232; E-value: 2.2e-70)"
                     /gene_kind="other"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="BAM84049.1"
                     /transl_table=1
                     /translation="MSENFKVLIIGGSVAGLTLALCLEKLDISYEILEQGEDISPQVGA
                     SIGIMPNGSPVLDQLGVFDDVERVIEPLEFARIRYPDGFFFQSQYPAIIADHFGYPISF
                     LERQKFLQILYSKIRYKERVHTGQKAVRIESHESHVVVRTADKQYSGHLVVGADGVHSI
                     VRSEIWRLSEPGAITDEEKTALRVEYACVYGISSGVRGVTDGVQLSLLDHGVTIHVFNG
                     KAGKVFWFVIIKIDKRYSYTDMPRFSTQDAREICESLKSKLLDTSVSFGDLWAKCDIFM
                     MTPLEEGHFQTWHRGRLVCVGDAVRKLTPNIGQGANMAIEDIAVLANALFRANVRDGLP
                     DDRQIDDVLSQLSATRLPATKTTCKQSEFLTRLQAGDGIWRRLAARYIFPALHDIPAAS
                     SARVLKGGQRLDFVDPPQRARPELDRWAWVKDLRGYVPRPHVLYLICGALLAWWASGLV
                     WHFPSKLDTTILSHV"
     gene            11017..12798
                     /gene="terP"
     CDS             join(11017..11220,11271..11481,11568..12248,12302..12549,
                     12637..12798)
                     /codon_start=1
                     /gene="terP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 114.8; E-value: 8e-35)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase"
                     /protein_id="BAM84050.1"
                     /sec_met_domain="p450 (E-value: 8.3e-39, bitscore: 122.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MPSLLLSLLLLQVPIICAWLLVRFIIDLTGKNGTIPTIRRWPALF
                     PEFLDRLSYNDNAAQLVEEGYRKYKDRPFRLLKMDMDLVVIPLKYATELRAITSDKLDP
                     LTASFDDNAGELTGILLGSELHSDAIHRRLTPGLRIPSTKYCRILTVCAFPERVGYLTD
                     VIGNWTPVIPYELVLRLSTRAAARVFVGETICRDEVFLETCSSFSRNTFDTIATFRNLG
                     KTIGFMLGILTPSVRKAREQGAYVQKLLGSEVERRRACPDEKHDDFLQWCIDLARTEQE
                     AKPEALATRTIGILSMAVVHTTAMATTHMLFDLLADSKLRETLKKEQEDVLPSGWDGID
                     QNSMLKMRLLDSLMRESQRINPVGEFTFRRVVRKPITLSDGYQLRRGQQIAISARRINM
                     DGATLEDAQTFCPSRWAQETQGASFSHSSSSNLHFGLGRYACPGRFFASYMIKAITSRI
                     LLEYDFKLESGREGYRPPNSIQGDKILPNRDAVVLFRRREVSI"
     gene            13860..15275
                     /gene="terF"
     CDS             join(13860..14560,14623..15093,15146..15275)
                     /codon_start=1
                     /gene="terF"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /product="aromatic prenyl transferase"
                     /protein_id="BAM84051.1"
                     /sec_met_domain="dmat (E-value: 9.8e-114, bitscore: 369.5,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTIDKKPVTAPESDSKSAAGRKYWTQLCTPILSSLLKSSGSYSAE
                     EQETHIQNLSDYVIPNLGPRPSEAHTKSFLTQSGSPFQPSVNFSSKKTQVRYCWELLGP
                     QGGSDSDPLAVEAAQDILSQLCKAFGYSTRWSDTWLSAFAPTLEEAKSVREMLPKWIAT
                     FTGGAELPALKRVPFVFVAFDLDGAKTSMKAYYNPKGKEIATGKPASDLTWKVLRSLTP
                     ALSSTAIDLVEKFLAERPVFSAVELVGIDLVDEAGLSDARVKLYVHTENNSFNTVRDYI
                     TLGGRLQDETTLKGLAILKDIWHLMLQEPDGTDDDYNKPVNDSTMLCQRAYFSFEMRPG
                     RELPEVKTYLPTWNYVRTDLETIQNYEEVFRRCGFEWGKESKYKELFERAFGPANHDRP
                     KPVHCDASYLYSEKKGIYQTLYFSPPLKDGEEYE"
ORIGIN
        1 ctacacgcca gttccacctt gatgtcgccg tctcatgagc aacggggtct ccgggtccac
       61 atacggaaac tcgtcaatgt gtttgttcgt gggccgtgag ctaccgtcag ggtacttgaa
      121 gtcgtagcgc agcagcagcg ccgagagcgt cattttcagc tcgtctgagg cgagaaagcg
      181 gcccggacac gaccatgtgc catacccaaa gtggaggtgg ttcttgtcgg cggtggcgtg
      241 ctggtgcttc atcgactcat caggtttctg acggcgctgc tcatagtacc gcagcccatc
      301 gaagacatcg gggttgggga taacggccgg atcgctcgaa acagagtgag gcgcaatgca
      361 gaggtgcgtg ccgtagggga cgtggactcc gtcgtgcagt gtgatgccgg cagggtcctg
      421 gacgatacgg tgaaagccca ctgagatatt actcgcgtca gtattcgggg cattggcgat
      481 tgatcgggac gactcacata gactgggcgg gttttgtctt tgagatctaa gaacaatgtc
      541 agcggatggg acgtagtaga tgcgtggtga agagactgac tccctgaaga agctgtccat
      601 cttccatagc ttgcttagcg attgtttgcc ccaattgcct ccattttctt gaagcacctg
      661 aagcacctcg tcacgcagct cttcgagaag ctgtggcctt gatacaaggt ccatgagtgc
      721 atgggagcct gccgcggcgg tactgtgtcc agcgactaag gttatgagga ggtgtcgatg
      781 cgctaagtcc tctggctggc tgtctttgcc acccggagtg gacaaatcca tcatagcctg
      841 taggaggtca tttggtttca cgtagtcagg gtcattatcc tcgagatttc gtctgcgttg
      901 gacttcaggt gctaaaattg ctttaccgcg gcgaacggcc gatttgtacc tccacactgt
      961 tgggagcacc agattgagga aaggtcgaaa gatcggatga accgccttca taacaatttg
     1021 cgtgattgtc actgtctcga agtcagcctc ttcttttctt ccatggcgac tctcgctgcg
     1081 agactcgttt accattgtgt gcatgttggg aagctgcgtc tagccatttc tcatcgcgac
     1141 aaatgggaag tccaataagt actcggctcg tgatgcgtcc tagaagcttc agaagaatag
     1201 gttgaagagg gaccaatgtc cagtctgaga acctgtgttt gcgccgtgag ccgatacatg
     1261 ggctgctagg aacagaaata ccttcacaat cgggcatatc acggcccaac gcgtattcaa
     1321 gctcatctct catatcatct gaaaacttcg tcaaatttgg cgtgattttc gtcttgatct
     1381 cgataagtga tgcactctca agcctgaaat gtacttctta cctgaagcgc acgagttcca
     1441 atatcacttt cgtcgaggag atcgatcccg ctgtactggc cgccgaagtt ctaagcagag
     1501 ataattaatg tttgagatca gagatagtca agccaagcag gctcttgcct tgatcaatcc
     1561 cttgatcgag ctgagtctct catgaggagc gttctgcagc tcgtcgatat atttgcgtga
     1621 cagaacgacc acgtcgccgc catgccgcga aattttatac atggagcttt tccactgtac
     1681 agtattagct tgaacaatgc ctcgatcgtt gggcaaaata tggctacttt ggcatatccc
     1741 tcgctgatga tatcagacgc tgcaaatgcg taccgcgttt tagcgacaat ggcgggttct
     1801 aacggcgatc gatacccggc aaatggagca ggaacgccgt caaaggctgg taggtaaatc
     1861 caggtgcatg ccgcaaggaa gagaagagcg ccggttagct ggccccaatt tggggggagt
     1921 ttggcaaatg catcgcccag ggtggttccc gtcacgttgt agtcgttcat gtttggtgtg
     1981 ttcactgtga tggctcgacc tgtggtgtat tgcggataac tcggagtatc ttgaagttct
     2041 gtaactgggg aggttttctg ggtttaatac ctttggtcgg acagtcctgc cacagctcat
     2101 tggggaatac gggtgcagct gcatatgcta agcgggggta ccacatcagc tggagcccta
     2161 cgtagtacat gtaggaaagc cttgggcata tttagtgctc atttctcgag acaggcaaca
     2221 taaattgctc ccagccattt ttctctgctg tcggtccatg accttaatcc tcaaatgatc
     2281 aagatgtctt cagcatggca aatgagcatt cttcaggcat tcttcgctct tgtcggcatg
     2341 acttggaagc tgaaagaggg ctatccaatc tttgaggttc taaatttgcc acgtctggtc
     2401 gaatcattcc gcaatgaggg cggctggcaa gggctttgca catgggtaga agtttttggg
     2461 ggcatctcga tgcaatcttt gcagcacgat tggccttggt tctcacttca tctgttcctg
     2521 tacatcggtc agctggtacc attcgttatt ttggtcatga atgagacgct ggctgcagga
     2581 gcatcgacat cactcaagta agttattttg ctcgtctcat cttgccacgc tacgacgaac
     2641 tgacagaaac tggaaaggac cattgcgatg ctcggcagcc tatccagctt cgtcggcttc
     2701 tcaacggcta tgcccatcat ctcgctctgg atactacata accatcaaca gaaaagactt
     2761 tccgaggcgc aacacagaaa cgagaggctt atattgaggt ctgtgtttgt attctcagcg
     2821 attacacacg ttggcgcatt tttggtggca ttcaccgcaa catgggcacc ctcaattctg
     2881 ccgtctcgtg ctgccagtgc actccatata atgaatagct tggttggcgt acctgattct
     2941 acaccggcgg gcgtttcaag ctcgggtatc cggcaagcgc gattaaggca gatcaacgag
     3001 atgactggta cctcgagcgg attcttcatg acagtgggac tattttgcca tgcgctcgag
     3061 ttcaagagcc aacagttgac tgcaaagact atggtgtgga tgttcttcgt gagcttgatc
     3121 gcgggcccgg ccgccggtgg cgcggccgtc ctactgctca gaaactcggt tgcaagagaa
     3181 tctcatgaca aagataaata gatagcctct agagatagct caaaaatcag ttgaaatgca
     3241 cggttcttgg ccgttgtgtg ctttcccctc cccagagcat ctactttaca tcgaccaggc
     3301 agcttcaatc gctgtcttaa gaccctgcct gcatcttctc gcgccgtccc caaagcaata
     3361 ccagcttttc caatcctacg ctagcttgct gaagcgctct catgcaagca tccctcacgg
     3421 gctttgactg cagagcctgt aaagcttctt cgacgtccgc ttcagcatgg cttgcaagtg
     3481 cccgctccat cacccgactg gtgctgttgt cattaagagc gatgacgatg ggatacgaca
     3541 gttctccgtt gcgcaaatct tcagcaacag cgcctttgtt agttgcgtat tcggctgagt
     3601 atatgttctt gcagtcattc tgcagctggg cgaaccatct gcgtcgagac attagcactc
     3661 gtttgaccaa agctcgaaga gaagcttacc caaatcgact cagtaagtca tccagctcat
     3721 tccctccgtc gttcagcagc ctccccagaa ggacaaacaa ggtacccgtt ttcagcgagg
     3781 ccatgttctt gtaagcggca atgctctcgt caccttggta ttggaaggac ttcaagccat
     3841 cccgacgcca tacgagggac aggtcttgac cctggaggat gtcctccaaa gctttgagca
     3901 gctccgcccc gagaaccggg cgctcacgca aagctctatt gatgactccc gtcagcacca
     3961 aataggctct gttggccgtt tcagaggctc cgtagatcag gtgcgcagtt ggctgattct
     4021 tgcgctggta gctatcatct gatatgtcgt ccaccagtat taaagcaaaa tggactgcat
     4081 ccatgatttc caggaccaaa tcatacttga ccggatcttc ctgtttcagc aagggattga
     4141 actctttgac aagggactcg aaatggtgcc gcccgtagat gctgacaagg tattcgtaag
     4201 ggcaccctgc cgcctggttg cgcttctctg aggagagctt cttgcaatac ccatattgct
     4261 gaacggtgtt cggtgcttca ggttttgaaa gggtagaggt tttggcaatg aagcccatcg
     4321 acgcgccaat tgcaagcaag gcaatgttgc cgacactgac tcgattccct aaccaatcca
     4381 ttgtgtcttg acgaatgaat tatgttcgct aataatggta gtgtcggtga agtgtgatct
     4441 gggatctggg ttcacggcac gcagggacgg gaagaactct cgtctgatat aaggttggcg
     4501 gctacaggcc catgtacgca tgtgtcatcg cagatctaga ttcatctgac actcgctaca
     4561 agcactaccc aaagtacttt agtgggttgc aatgcacttc ggtccccatc aggaccgtca
     4621 gcagacgagc tcagccccta cggatataaa agcatgacaa aatccggcat cgtgcctgct
     4681 ggacaagata attcctcaga cgacgcaacc ttcatcagca tcaatacatc atggacggct
     4741 tcaccgattc gcaggctcca cctgcgtatg aagaggtcaa gtggctggct gacactctag
     4801 ttgccttcat gggcatcggt tggctcatca actatggcgc catgatcagg cattcttacc
     4861 aaggacggac gtattgcatg ggtatcatcc cgctctgcaa caacatcggc tgggaacttg
     4921 tgtatacgct agtacacccc tcatcaaaca gggtagagct ggctgtcttt gcagcaggcg
     4981 tcacgctgaa cgtcatcatc atgttcgccg cgactcgttc cgcgaagacg gagtggcagc
     5041 attcaccctt ggtcgcgaat cacacgcccc tcatcttcct tggaggaaca ttcgtctgct
     5101 tcgccggcca cgtcgcactg gctgccgaaa ttggacctgc gttggcttat tcgtgggggg
     5161 ctgtcatatg ccagctcgtg ctgagcattg gtggggtttg ccaactgctg cagagaaaca
     5221 ccacacgagg gacgtcggta actttgtggt acgtgacaac cctgtctcag cctcgcattg
     5281 gataccacgt cgacgccaca atctaacgtc ttccaggctg agccgattcc tcggctcgtg
     5341 ttgcaccgtc ggatttgcct tcttgcggtg gaggtactgg ccagaagcgt tcgcgtggct
     5401 tgcaggcccg ctcgtccttt ggagtctcgc gacgttcgtg ctggccgata tcacgtacgg
     5461 ggtctgcttg tatctgatat cccagactga gacaagctcg acaaagcggt ccaagctgaa
     5521 gtgacgctat tgatgtcttc tgcaccgccg gcacagctca gcgcgacact gagacccgct
     5581 ggccccgccg ctccgccctc accggtatgc gaagcaagat gagtcggaaa agaggacatt
     5641 gcgcctgaga gagagatggc tcggttgttg cctagatttg tcagttccaa tgattcgtta
     5701 gctcatatga atctatggcg catgcatcat tagcctcacg catctgcatc tgatagcgac
     5761 tgcattcata cctccacccc cggcgtcgcc aagatctccg tcccgtctgg gcccaacggg
     5821 cggttcgacg aaaagaaccc tgaatttgaa tgacacatac tgctctcttg gctcggtacc
     5881 agtaaatgca tacagggcag gctttcagcg gcccggtccg ggtccggtcc ccggttagga
     5941 cagcgcatga aacatcggct acggcgaatg aagcgaaaac ggaaagagat tccacctcag
     6001 gtccctcgaa ttgtccaatt aaaagattta ctgtaacggt gactgacgca atatcaccga
     6061 ctcgccgcga ctcgccgcta tcaacgggtg gcagtatgcc acagcggctg ctgtggagaa
     6121 cggagactag gtaatgccgt atgtagatct tgatttcggt ggagcattcc agatccttgt
     6181 gacggcaact gtgcttctct tcgagaacaa cgctttcttt tggcttgcac ggctaatcta
     6241 ccgcgcaatt actactctgt atacaattct ctatgcaaac gactcctaat tatgcacccc
     6301 cagataacaa acagacaaac caatgggtca cgtcattttg ctgaatttcg cattgagggt
     6361 ggtgattgct acgagtctat gacggctcag atgcgacgcc gtcgggcgct cccgggtcaa
     6421 cacgggctgt gtttccagca tcctttgact ttctcagcca gacctttgct tgcatgtcag
     6481 ggagtatgaa tttgccgaac gccatgtttt ttggtcgagg gccaaaattt gccatggcaa
     6541 aatcgtagtg caacaggagg tgcaccatga ccagcttgac ctcgtctgaa accatgtatc
     6601 ggcccgggca ggcgtggcgt ccaatgccaa agtgcatgct gtactcactg gttgccgtca
     6661 tagggctatc agacttgcgt ttggggtcat cacgcatccg ggcgaagcgc aggccatcga
     6721 agcgtttcgc atcctcgtag aactgctcgt cttcaaacag cggggagttg ggtgtaaaga
     6781 tgaaactacc ctttggaacg tgcaagccat tggagaaggt gtagggcttc agaacgagcc
     6841 tcgcgagggc agctgcgcca tgtaagcgag atgtgcgaag caccatttgc agatgagaca
     6901 ttgtgataaa cgtacatgca tcgagtgggt tacatctctg agtttctttg atgaaactgt
     6961 ccatcttgtg catggcatcg atagcagctt tagttccgtt tccatacagc gcaaagcatt
     7021 gtcgtatctc ttcgcggaga ggtacgacat attcgggacg cgtcgcgagc tcaaagagcg
     7081 tatgagttac cagcttgctc ttgcgtcagt gacctcaaaa ttgatcagat ggatgagcaa
     7141 tgcgggagca cacctgactt gacgtatgta aggcagcaaa aactgtgttt gtcatcatgt
     7201 ctgcgatgtg ccaatcttcc cacccatctg cgctgtgctc gtcgatccag ttgatcgaga
     7261 aatcgaggag atcctacttt catttagata gtgaacacag tgacagtctc ttgaaactca
     7321 ctttcatggg gttcttctcc ctcgagtttc ttcgcgacgt aatctcgttg agtacgaccg
     7381 tttgtaactc tttcacacct cgaggggctg ccaggaacct tgcaagaaga ctgcgaactt
     7441 agccaagacc tcacatgaga gacgtctcac ttacggtctg atgaaatccg ggaaacaacg
     7501 caagatcatg gcgtctcgtg gcactgcgtc gccaaactcg cagcacatat cgagaaattt
     7561 gggattcctg catagaggct ccccaaagag ggacttggtt gtaaggcgag caatcacctt
     7621 caacgctagc gggaaacaag gggccgcgat ccagccagag tttccggagg tatgatcacc
     7681 ggcgtgtgag aagaatggta agcgagactt atttccgcat ccagtgaaag cgcgcatctc
     7741 ttcttgaaag ccgtagagaa attcagcgga aaattctctg aagaaggggt catctgcctt
     7801 gctggctcga gttctctgcc aactcaacgc cttcgctatg acggagttcg gtatcctgtg
     7861 aacgtcatga tgttggccag gtagcagcca cttgaattga aactcctgag tcttgtcagc
     7921 gcgtctctcc gtagtgccgg gactatggcg ggagtacttc ggacatcaca gccctgaagg
     7981 acatgtgatc ttcatcaaga gagtaatatt ctctcgtcaa tgccctatcg caaatgaaga
     8041 cgtccattcg cgtcatggta ggtatctgaa accccaactt tccatgctgt ccatttgcaa
     8101 ctgtgagcgc aagtcatgtg gcatatcaga agtgcagtat cttgccttgg cgtaaccttc
     8161 gtgaatagcc tcgcgggcat accagacatt gcgaattgcg cccagccatt tggtgaagcg
     8221 gccgccaggg ccaataacgg ggacttcgac ctagcgctct aatcagctca gtacgctcat
     8281 cgacttcata gaaaaagcga acttttttgt cgtagtcaag gtagcgcatc agcaggacga
     8341 ccaccatcac cgctccagcg accgtgattg taggccacgc atgggctggc acagcgccgg
     8401 caaggcggtc gatcaacatg acagtggctg gtgaatgggt gcaaggtttt ggggatccca
     8461 cgaagcaagt aactcagacg gaatcgcgtt gaggtgtcag gctcttgtcc agcccaacac
     8521 atgtactata aagatgatat cgtttgatgg cgacgttgca ctagtgactg gtgggccgtc
     8581 gattgcaagc ttacgagtaa agtcccatac attcagctgc actggggcac gtcggtgata
     8641 atgcatggtc gcagtgatga agccggtctg aagtgattga gaaaggtgca tgatcaactt
     8701 agacatgtga tagtatcgtg gtgtccagct tcgatgggaa gtgccacacc aaacccgacg
     8761 cccaccatgc aagcaaagcc ccacagatga gatacagtac atgaggtcta ggcacgtatc
     8821 ccctcagatc cttgacccag gcccatcggt ccagctccgg tcgtgctctc tgtgggggat
     8881 ccacaaaatc cagccgctgc ccccctttga gcaccctggc tgaggaggct gcggggatat
     8941 catgcagggc agggaatatg tacctggcgg caaggcgcct ccatatgccg tcgccagcct
     9001 gcaggcgggt caggaattct gactgcttgc aggttgtctt tgtggcgggc aggcgggtcg
     9061 cgctgagctg gctcaacacg tcgtctatct gacgatcgtc gggcaggccg tcgcgcacat
     9121 ttgccctgaa gagcgcattg gccaacaccg caatgtcttc gatagccatg ttggctccct
     9181 ggccaatgtt tggtgtcaac tgggggattt gtcaactcat tgcccaaata ggttgccaag
     9241 atgacgccta ccttgcgcac ggcgtccccg acacatacta ggcggcctcg gtgccacgtc
     9301 tggaaatgac cctcctccag cggtgtcatc atgaaaatgt cacacttagc ccacaaatcc
     9361 ccgaatgata cgctcgtgtc aaggagcttc gacttgaggc tttcacagat ctctcgggca
     9421 tcctgagtac tgaaccgcgg catgtcggtg taagagtatc gtttatcgat cttgatgatg
     9481 acgaaccaga agactttgcc ggccttgcca ttgaagacgt ggattgtgac gccatggtcc
     9541 aggagactca actgaacgcc gtcggtaacg cctcgaactc cggaggagat tccatagaca
     9601 caagcgtact caacgcgcag ggctggcggc gtcagactcc atgtccacat gcggcgtcga
     9661 tgaacaccac ttaccggtct tttcttcatc cgtgatagct ccaggctcag aaagcctcca
     9721 gatctcggat cgcacgatgc tgtggactcc atcggctcca actactaagt gtccagagta
     9781 ctgtttgtcg gcagttctca cgactacgtg agattcgtgg ctctcaattc gcacggcctt
     9841 ttggcccgtg tggactcgct ccttataacg gatcttgctg tacagaattt ggaggaactt
     9901 ttggcgctca aggaatgata tcgggtaccc aaagctaatt gtgttctctg tgagcttcat
     9961 cgtaccgaat tgcacattac acttactggt ctgctattat ggccggatat tggctttgga
    10021 agaagaaacc gtccggataa cgtatccgtg cgaactcaag aggctcaatc acacgttcca
    10081 cgtcgtcaaa tacgccgagc tggtccagaa caggggagcc atttggcatt atgccaatgg
    10141 atgctccgac ctgagggctt atgtcttcgc cttgttcaag tatctcatag gagatgtcca
    10201 gcttttccag gcaaagggcg agcgtgaggc ctgccacaga cccgccaatg atcaagactt
    10261 tgaagttttc cgacatgatg accagggttg aacagcgttt cgatggtagt gacgggaaat
    10321 accgatgtct gaacgacgag actaagatac tcaaaacgac ggatccaaag tgcagtgatc
    10381 agttacgcag aggggtcaat taagtatttt gcacatgtaa cttcactgca tggaccgtta
    10441 tgttgtgctg cttgacgggt aacacaggaa ttgagaatca tacgtgtggt catgagcttt
    10501 gagctcgagc agaaatgtta gatcagctgt cttggatgtt ttggtcaatg acacggcagg
    10561 cctttggaag gggaacagcc gaggaggctg cctccttgtt gttcagcctg ccaatgacct
    10621 gtacggtgga gctgatttga gccgctggtc cactgcactg catgatgcac gtcgaacagc
    10681 agggggtgtg taggaatcgt gcccacctca ccgcggagta ctccgtattg cctccgcttc
    10741 tgcaggtcga tgcgtcgggc tgcatctgca cgatgtcgac gttgagcgga aaggttgcgc
    10801 aaagccttta cggggcacac cctggggcct gcctgacagg gctagactct cgacttcatg
    10861 tcacgtaact ccaccggctt cgccgtcagg tcttagtgcc tgtgaaagct gcttttactt
    10921 gtcgccgccg atatctggca gtgctcgaca aaattacgag cgttgtactc tgcgcgttgg
    10981 caatcttcaa cctcttgtct ttgttcaaac agcatcatgc ctagcctctt gctgagtttg
    11041 ttgctgttgc aagtaccaat catttgtgcc tggttgttag tacgcttcat catcgatttg
    11101 accggcaaga acggaaccat acctacgatc agacgatggc cagcactgtt cccagagttt
    11161 ctggaccgac tgtcctacaa tgacaacgcc gctcagttag ttgaagaggg gtatcggaag
    11221 gtgagttgtt tacttctcct actgtggttt caatatctga ttagtcgcag tataaggacc
    11281 gaccattcag gctgctgaag atggatatgg atcttgtcgt catcccgtta aaatatgcaa
    11341 ctgaactgcg tgccataaca agtgacaagc tggaccctct aaccgcaagc tttgatgaca
    11401 atgccggcga gctcacagga attctgcttg gcagtgagct ccattccgat gccatacacc
    11461 ggcgtttgac accggggctg cgtaggtgtg agacactcaa caaacacagc caaaattctg
    11521 acattctcta tagctcgaat tattccagta ataatggacg agctgaggca taccttcgac
    11581 caagtattgc cgcattctga cggtatgcgc tttcccagag agagttggat atctcactga
    11641 cgttataggc aactggactc cggtcatccc atacgagctg gttcttcgtc tctccacgcg
    11701 cgctgcggcc agagtcttcg tcggcgagac catttgtcga gacgaagttt ttctcgagac
    11761 ctgttcttcc ttcagccgga acacttttga caccattgcc acctttcgca atctcggcaa
    11821 gaccattggc tttatgctcg gaatcctgac gcccagcgtc aggaaagcgc gcgaacaagg
    11881 agcctacgtc cagaagctcc tggggtcaga ggtagagaga aggcgagcct gtcccgacga
    11941 gaagcacgac gacttcctcc agtggtgcat agatctggca cgaaccgagc aggaagcaaa
    12001 gccggaggcc ttagcgacgc gaacgattgg aatcttgagc atggccgtcg ttcacacaac
    12061 cgctatggct acgacccaca tgctttttga cctgctcgcc gattccaagc tgcgggagac
    12121 gctcaaaaaa gagcaagagg atgtcttacc atcaggttgg gacggcatcg atcagaattc
    12181 gatgcttaaa atgaggcttt tagacagcct catgagagaa tcgcaacgga tcaatccagt
    12241 gggtgaatgt gagtccctgt cgccgcccca gccgcttgga atagagctaa acatcgcata
    12301 gtcaccttca ggcgcgtcgt caggaaaccg attacactgt ccgatggcta tcagttgcga
    12361 cgaggccagc agattgccat ctcggcaaga cgtatcaaca tggacggcgc cactttagaa
    12421 gatgcgcaaa ccttctgtcc gtctcgctgg gcgcaagaaa cacagggagc atcattttcg
    12481 cacagcagct cctccaacct gcattttggt ctgggccgct acgcctgtcc cggacgcttc
    12541 tttgcttcgg tacgtatttg ctgaactgtt gtttcccagc ttcatcagcc cgattgcgac
    12601 tctgtatctc gattgctgac tagaggttgc tggcagtata tgatcaaagc tattacaagt
    12661 cggatccttc tcgaatacga cttcaaactt gaaagcggcc gagagggcta tcgtccgcca
    12721 aattccattc aaggcgacaa gatcttgccc aaccgggatg cggttgtcct cttccgtcgc
    12781 cgcgaggtta gcatttgagt gcatttagag ccagtcacgt ccaagtaggg atgtgtttca
    12841 agacgtctga atatagagtc aaaacccaca tcatgttacc taaacggcag gaactcacga
    12901 gcctcatctt attttggctg ggctgtcctg tgctattcac gggagactgg cagtacaata
    12961 cacatgaatt tcacaaggaa ggagtctacg atctgtgaca tattcagacg actgcctgcc
    13021 gcttgggtcg catcggacga ggctcctcgt aacgaggaaa atctctaaac aacaagtcat
    13081 ttgctattcg taggcttgtt cttggctgaa gctttttcca tgcaaatctt gctgccccag
    13141 accccatacg atagtcagac aggaggcatg agactcgggg cacgcctaca cagcgccccg
    13201 cacaaatcag cgttgacacc caatcgtgta ggaatcatta ccgcctcacc caaacattca
    13261 atgcatctgg cagcgcagac cgtcttggaa aaagcaaatg atctacaatc gactgcgcag
    13321 tgtcttgcca atcgccgaga tatgggcgct gtgctatatt gtttctttgg cttgcatgcc
    13381 gcagtttcag ggatcttgcc aaggattcca tcgaccgggc tgggccccca gatgcggcat
    13441 ggccgatccc atgacggttt ttatgcgctg aaagctgaaa aggacatctg ctgcgacgcg
    13501 aacgactcga tcaggcctac aaaaacttag ctgcatatgc agtctttcat tcacggcgac
    13561 cttttagccg ccaccgtgaa gtcgtcatct ccgaactatc gtttaatacg ttaaccctcc
    13621 tgtacgttgc cataacgtaa agatgtagaa cgaaatccct ggagttgcat ttatccacta
    13681 ttgacatcgc atcatctggg ccgcctcgcc gcggtcacct gcgctatcta tgcgcggggc
    13741 tcgacgcatt cttgcagccg cagcttgttg aatatgtact tgtatatcaa ggtctggtgc
    13801 ttgaacttca cgtcatactt gtccacactt cacgttctca ttcaatcctc ctttgcaaaa
    13861 tgactatcga caagaagccg gtgacagctc cagaaagcga cagcaaaagt gctgctggcc
    13921 ggaaatactg gacacagctt tgcaccccta ttctgagctc actcctaaag tcctccggat
    13981 cctactcggc tgaggaacaa gagacgcata tacagaatct gtctgactat gtcatcccga
    14041 atctcggtcc tcggccatcc gaggcacata ctaaatcttt tctgacacaa agtggttctc
    14101 ctttccagcc aagtgtaaac ttcagctcca agaagaccca agtacggtat tgctgggaac
    14161 ttctgggccc tcagggcggc agtgatagtg acccgcttgc tgtggaggct gcgcaagaca
    14221 tattatctca actctgcaag gctttcggct acagcactcg atggagcgat acatggctat
    14281 ccgcatttgc cccaacacta gaagaagcaa aatccgttcg ggagatgctt ccaaaatgga
    14341 tcgcgacctt taccggcggg gcagaattgc cggctttgaa gcgagttccc tttgtcttcg
    14401 tcgccttcga cttggacggg gccaagacgt ctatgaaggc gtattacaat cccaagggca
    14461 aggaaattgc aaccgggaag ccagcatcag acctcacttg gaaagtccta cgcagtctga
    14521 caccggcact cagctcgacg gcaatagatc tcgtcgagaa gtgagtacaa cgccgcctcg
    14581 gcagttcact tcaatcaaaa atattaattg tcgttgcaac agattcctcg ccgaacgccc
    14641 agtgttttcc gccgtggaac tcgtgggtat cgatctggtt gacgaagccg gcctatccga
    14701 tgcacgggtg aagctctacg ttcacacgga gaacaactcc ttcaacacag tccgggatta
    14761 cataactctg ggtggccgcc tgcaggacga aacaactttg aagggcttgg ccatcttgaa
    14821 ggacatttgg caccttatgc tccaagagcc cgatggcacg gatgatgact acaacaagcc
    14881 cgtcaacgat agcaccatgc tctgccagag ggcttacttt agcttcgaga tgaggcccgg
    14941 tagggaattg cccgaggtca agacctactt gccgacctgg aactacgtac gaaccgactt
    15001 ggagacgatc cagaactacg aagaggtgtt ccgcagatgc ggcttcgagt gggggaaaga
    15061 aagtaaatac aaggagctct tcgagcgcgc attgtacgtc tcgaacccta ttccgaacgc
    15121 aaagagtcac taattttatc ttcagcggac ctgcaaatca tgaccgccca aagccggttc
    15181 actgcgatgc atcgtacctg tactccgaaa agaaggggat ataccagact ctgtacttta
    15241 gcccaccact gaaagatggc gaagagtacg aatagg
//
