LOCUS       BGC0001273              5301 bp    DNA     linear   PLN 23-SEP-2009
DEFINITION  Aspergillus ochraceus clone 2 MSAS-type polyketide synthase gene,
            complete cds.
ACCESSION   BGC0001273
VERSION     BGC0001273
KEYWORDS    .
SOURCE      Aspergillus ochraceus
  ORGANISM  Aspergillus ochraceus
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Circumdati.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 00:20:29
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..5301
                     /clone="2"
                     /db_xref="taxon:40380"
                     /mol_type="genomic DNA"
                     /organism="Aspergillus ochraceus"
                     /strain="NRRL 3174"
     mRNA            <1..>5301
                     /product="MSAS-type polyketide synthase"
     protocluster    1..5301
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[0:5301]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..5301
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..5301
                     /SMILES="C([*])C(-O)"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..5301
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001273"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..5301
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             1..5301
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (30-455). E-value:
                     1.6e-163. Score: 536.4. Matches aSDomain:
                     nrpspksdomains_AAS98200.1_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (566-859). E-value: 5.9e-73.
                     Score: 237.6. Matches aSDomain:
                     nrpspksdomains_AAS98200.1_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (920-1052). E-value: 6.3e-14.
                     Score: 44.5. Matches aSDomain:
                     nrpspksdomains_AAS98200.1_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (1400-1592). E-value: 1.8e-57.
                     Score: 186.1. Matches aSDomain:
                     nrpspksdomains_AAS98200.1_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (1684-1763). E-value: 2.2e-18.
                     Score: 58.3. Matches aSDomain:
                     nrpspksdomains_AAS98200.1_PKS_PP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 250.1; E-value:
                     6.6e-76)"
                     /gene_kind="biosynthetic"
                     /product="MSAS-type polyketide synthase"
                     /protein_id="AAS98200.1"
                     /sec_met_domain="PP-binding (E-value: 3.9e-18, bitscore:
                     52.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 2.8e-165, bitscore:
                     536.4, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.1e-74, bitscore: 237.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3e-52, bitscore:
                     163.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MPFLDPSSSSSERDKSTSGTEYSTRDESRGVAVVGMACRAPGGIN
                     DPDQLWKSLLDKLDASGEVPSSRWESYRNRNPRFESALDGTTNRGYFVENIEEFDCQFF
                     GISPKEAEQMDPQQRISLEVAWQAIENAGISAQKLNGTDAGVFWGINTDDYSRLILEDL
                     ADVEAWMGLGTGFTGVPNRISYHLNINGPSVSVDAACASSLVAVHNGVQAILEGESTVV
                     IAGGVHAMCGPALTRVMDKAGVLAPDGRCRSFDDSACGYGRGEGAGAVVLKSLPEAIND
                     GDHILAVIKGSAVAHNGRSNGIMAPDSKSQQRVALKALRAAGVDPMTVQFVEAHATSTS
                     LGDPTEISAIAEVYGKLRPTNDPCYVGSIKPNIGHLEAGAGVMGFIKAVLALQHGVIPP
                     QTNLQTLNSKIDWKNAGLRVVKEKTKWPATEGRRRAAVCSYGYGGAVTHAILEEAPPLP
                     ELVEPEIPVVNETGPRVLLVSALQEQRLPAAAESLRDWLSQHPQPPSLDSISKTLAARR
                     THHDIRAAAIVDDTASAVGALDNLAKKSNAVWTVQGRVLKSAPTRDVVWVFSGHGAQWQ
                     SMGKEVLKNEVFLNALKPLDAIVRNEIGSSPIEWLQLGDFASSDRVQILTFLMQIGISA
                     ILQSQGIVPNAVIGHSVGEIAASVVAGALSPEEGTLLVTRRSVLYRQVIGQGAMALVRR
                     PFEQVSRELEGNDKVTVAIDSSPSSCVIAGTKDAVKEIQKSYNKQEIENFTVKTDIAFH
                     SPMLDQLANPLSVALRDAIWPKQPSIKLYSTTLSDARSQNPRGVKYWIDNMISPVRLTS
                     AVQAAKEDGFRVFLEVSSHPLVAHSIEETLVDSDAGEHVVIPTLRRDQPAEKSVLRAIG
                     RLHCSGVDIDWENQISGPWVHGVPTAPWVHRPFWRKPSAAALALHNIRGHSLLGQKVTV
                     AGSETVLYTTTLSKEAKPFPGSHPVMGTEIIPAAVLLNSFLQATRGFALQNVNLIAPLE
                     TESQRLVQVVIQGDNVKILSQIVQKEGLLDNPWTTHTTAEIVPRSEATEAAVDDTIKSH
                     RPGKELSKSFTMDYLTGTGVDGMGFPWAVLEHWGDTQEMMVRVEVDPDNERLQWETSSW
                     APFLDAATSIAATIFHDRAKLRMTAGLGAIEILKVQDPPRVGWIRVQRNDGSDCTCNVD
                     ILDEEGEHFVRINTMRFAELESSSDQNDGVSKLVHRVAWPPARLTEEPLDIQEIVLVTS
                     DEDAKTVYTKEVPRHVGLTHISTPDELVRRGADIAYRKELVVVYVPGQVSSSQDIPNLV
                     ERFLAELLAVAKHLIQSGVPSKLFVHTTNAFQGKTPTALAHGPLLGTSRLIFSEHPDIW
                     GAHIDDEYRAVPLSTMKYIQGSDVIRVLDGVARTAKLRDLPLDRRTQPVSQMLPRPEGT
                     YLITGGLGDLGLATAEFFADHGARRIVLLSRRQLPPRRLWGSLTGADQAVAARINELEK
                     RGLCVFVLSIDIGSSNAAETLIQTLDQLGLPTVQGVVHAAGVLEDQLILNTTEEAFHRV
                     LSPKVTGTLALHQAFPPSTLDFFVLFGSCGHLVGFPGQGAYAPANAFLDSIATHRRNLG
                     DNAVSFLWSSWTDMGLGNGNDLLVSEIENKGITEISRQEAFEAWLHLARYDIDHGVVVR
                     ALPIEEGQGIVNPLLTDIAVYRRSTNSGPKSGEPAAATRTSSIPSSGPELKAYLDENIR
                     ATVGEVLHLPPSDVDPTVALADMGMDSVMTTVLRRQLQKAFSINVPPTLIWNHPTVGHM
                     VGWFAEKLAA"
     aSDomain        91..1365
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAS98200.1_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="1.60E-163"
                     /label="AAS98200.1_PKS_KS.1"
                     /locus_tag="AAS98200.1"
                     /protein_end="455"
                     /protein_start="30"
                     /score="536.4"
                     /tool="antismash"
                     /translation="VAVVGMACRAPGGINDPDQLWKSLLDKLDASGEVPSSRWESYRNR
                     NPRFESALDGTTNRGYFVENIEEFDCQFFGISPKEAEQMDPQQRISLEVAWQAIENAGI
                     SAQKLNGTDAGVFWGINTDDYSRLILEDLADVEAWMGLGTGFTGVPNRISYHLNINGPS
                     VSVDAACASSLVAVHNGVQAILEGESTVVIAGGVHAMCGPALTRVMDKAGVLAPDGRCR
                     SFDDSACGYGRGEGAGAVVLKSLPEAINDGDHILAVIKGSAVAHNGRSNGIMAPDSKSQ
                     QRVALKALRAAGVDPMTVQFVEAHATSTSLGDPTEISAIAEVYGKLRPTNDPCYVGSIK
                     PNIGHLEAGAGVMGFIKAVLALQHGVIPPQTNLQTLNSKIDWKNAGLRVVKEKTKWPAT
                     EGRRRAAVCSYGYGGAVTHAILEEAP"
     aSModule        91..5289
                     /complete
                     /domains="nrpspksdomains_AAS98200.1_PKS_KS.1"
                     /domains="nrpspksdomains_AAS98200.1_PKS_AT.1"
                     /domains="nrpspksdomains_AAS98200.1_PKS_DH.1"
                     /domains="nrpspksdomains_AAS98200.1_PKS_KR.1"
                     /domains="nrpspksdomains_AAS98200.1_PKS_PP.1"
                     /iterative
                     /locus_tags="AAS98200.1"
                     /monomer_pairings="pk -> pk"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       571..618
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AAS98200.1_0001"
                     /evalue="2.40E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="AAS98200.1"
                     /protein_end="206"
                     /protein_start="190"
                     /score="16.5"
                     /tool="antismash"
                     /translation="GPSVSVDAACASSLVA"
     CDS_motif       760..798
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AAS98200.1_0002"
                     /evalue="9.10E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="AAS98200.1"
                     /protein_end="266"
                     /protein_start="253"
                     /score="9.5"
                     /tool="antismash"
                     /translation="FDDSACGYGRGEG"
     CDS_motif       1099..1143
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AAS98200.1_0003"
                     /evalue="6.00E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="AAS98200.1"
                     /protein_end="381"
                     /protein_start="366"
                     /score="9.5"
                     /tool="antismash"
                     /translation="GSIKPNIGHLEAGAG"
     CDS_motif       1693..1749
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AAS98200.1_0004"
                     /evalue="7.80E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="AAS98200.1"
                     /protein_end="583"
                     /protein_start="564"
                     /score="15.3"
                     /tool="antismash"
                     /translation="VWVFSGHGAQWQSMGKEVL"
     aSDomain        1699..2577
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAS98200.1_PKS_AT.1"
                     /evalue="5.90E-73"
                     /label="AAS98200.1_PKS_AT.1"
                     /locus_tag="AAS98200.1"
                     /protein_end="859"
                     /protein_start="566"
                     /score="237.6"
                     /specificity="consensus: pk"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFSGHGAQWQSMGKEVLKNEVFLNALKPLDAIVRNEIGSSPIEWL
                     QLGDFASSDRVQILTFLMQIGISAILQSQGIVPNAVIGHSVGEIAASVVAGALSPEEGT
                     LLVTRRSVLYRQVIGQGAMALVRRPFEQVSRELEGNDKVTVAIDSSPSSCVIAGTKDAV
                     KEIQKSYNKQEIENFTVKTDIAFHSPMLDQLANPLSVALRDAIWPKQPSIKLYSTTLSD
                     ARSQNPRGVKYWIDNMISPVRLTSAVQAAKEDGFRVFLEVSSHPLVAHSIEETLVDSDA
                     GEHVVIPTLRRD"
     CDS_motif       1921..2031
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AAS98200.1_0005"
                     /evalue="7.80E-16"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="AAS98200.1"
                     /protein_end="677"
                     /protein_start="640"
                     /score="50.1"
                     /tool="antismash"
                     /translation="GIVPNAVIGHSVGEIAASVVAGALSPEEGTLLVTRRS"
     CDS_motif       2131..2169
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AAS98200.1_0006"
                     /evalue="9.90E+01"
                     /label="PKSI-KS_m3"
                     /locus_tag="AAS98200.1"
                     /protein_end="723"
                     /protein_start="710"
                     /score="-3.9"
                     /tool="antismash"
                     /translation="VAIDSSPSSCVIA"
     aSDomain        2761..3156
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAS98200.1_PKS_DH.1"
                     /evalue="6.30E-14"
                     /label="AAS98200.1_PKS_DH.1"
                     /locus_tag="AAS98200.1"
                     /protein_end="1052"
                     /protein_start="920"
                     /score="44.5"
                     /tool="antismash"
                     /translation="HSLLGQKVTVAGSETVLYTTTLSKEAKPFPGSHPVMGTEIIPAAV
                     LLNSFLQATRGFALQNVNLIAPLETESQRLVQVVIQGDNVKILSQIVQKEGLLDNPWTT
                     HTTAEIVPRSEATEAAVDDTIKSHRPGK"
     aSDomain        4201..4776
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAS98200.1_PKS_KR.1"
                     /evalue="1.80E-57"
                     /label="AAS98200.1_PKS_KR.1"
                     /locus_tag="AAS98200.1"
                     /protein_end="1592"
                     /protein_start="1400"
                     /score="186.1"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="GTYLITGGLGDLGLATAEFFADHGARRIVLLSRRQLPPRRLWGSL
                     TGADQAVAARINELEKRGLCVFVLSIDIGSSNAAETLIQTLDQLGLPTVQGVVHAAGVL
                     EDQLILNTTEEAFHRVLSPKVTGTLALHQAFPPSTLDFFVLFGSCGHLVGFPGQGAYAP
                     ANAFLDSIATHRRNLGDNAVSFLWSSWTD"
     CDS_motif       4204..4302
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AAS98200.1_0007"
                     /evalue="3.00E-17"
                     /label="PKSI-KR_m1"
                     /locus_tag="AAS98200.1"
                     /protein_end="1434"
                     /protein_start="1401"
                     /score="55.1"
                     /tool="antismash"
                     /translation="TYLITGGLGDLGLATAEFFADHGARRIVLLSRR"
     CDS_motif       4618..4728
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AAS98200.1_0008"
                     /evalue="4.00E-19"
                     /label="PKSI-KR_m4"
                     /locus_tag="AAS98200.1"
                     /protein_end="1576"
                     /protein_start="1539"
                     /score="61.2"
                     /tool="antismash"
                     /translation="LDFFVLFGSCGHLVGFPGQGAYAPANAFLDSIATHRR"
     aSDomain        5053..5289
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAS98200.1_PKS_PP.1"
                     /evalue="2.20E-18"
                     /label="AAS98200.1_PKS_PP.1"
                     /locus_tag="AAS98200.1"
                     /protein_end="1763"
                     /protein_start="1684"
                     /score="58.3"
                     /tool="antismash"
                     /translation="GPELKAYLDENIRATVGEVLHLPPSDVDPTVALADMGMDSVMTTV
                     LRRQLQKAFSINVPPTLIWNHPTVGHMVGWFAEK"
ORIGIN
        1 atgcctttct tggatccgtc ctcgtcgagc tccgagcggg ataagagcac ctcgggcaca
       61 gaatacagca ctcgagatga atcgagaggc gttgccgtag tgggcatggc ctgccgcgcc
      121 ccgggtggaa taaatgaccc cgaccagctt tggaagtctc tgttagacaa gctggacgcc
      181 agcggggagg ttccttcctc tcggtgggag tcgtatcgca acaggaaccc tcgcttcgag
      241 agcgcactcg acggaaccac aaaccgcggt tatttcgtcg agaacattga ggagtttgac
      301 tgccagttct ttggaatctc ccccaaggag gcagagcaaa tggatcccca acaacggatc
      361 tctctcgaag tggcatggca ggcgatcgaa aatgccggca tttccgcgca aaagctcaat
      421 ggcactgacg cgggagtctt ctggggcatc aataccgatg attattcacg actcatcctg
      481 gaggatctcg ctgatgttga ggcgtggatg ggccttggga ctggattcac cggtgttccc
      541 aatcgcattt cataccactt gaacataaat ggcccgagtg tctcggttga cgccgcatgc
      601 gcctcttctc ttgtggcagt gcacaatggt gttcaagcta tcctcgaggg tgagtcaacc
      661 gttgtgatcg ccggtggtgt acatgccatg tgtggccctg ctctcacccg ggtgatggac
      721 aaggcgggag ttttggcacc cgatggacgt tgtcgctcct tcgacgacag tgcttgtggg
      781 tacgggcgtg gagagggtgc aggggcggtt gtcctgaaat ctcttcccga ggccatcaac
      841 gatggagacc acatccttgc ggtgatcaag ggaagcgctg tcgcacacaa tggtcgatca
      901 aacggaatta tggcccccga ctccaaatcc cagcaacgag tggctttgaa ggcccttcgg
      961 gccgccggcg ttgacccgat gaccgttcaa ttcgttgaag cccatgccac atcgacatct
     1021 ctcggggacc caacagagat ttctgcgatt gcggaggtgt atggcaaact aagaccgacc
     1081 aatgatccct gctacgtggg ctcgatcaag ccaaatattg gtcacttgga ggcaggtgct
     1141 ggtgttatgg gattcatcaa agcagtcctg gcccttcagc acggagttat acctcctcaa
     1201 acgaacctac aaaccttgaa cagtaagatc gactggaaga atgccggcct gcgtgttgtg
     1261 aaagagaaga cgaagtggcc ggcaactgag gggaggcgac gtgcggcagt ttgttcttat
     1321 ggttacggag gagccgtcac tcatgccatt cttgaggagg ctcccccact cccggaattg
     1381 gtcgagcctg agattcctgt tgtcaatgag actggcccac gagtgttgct ggtgtctgcc
     1441 ctccaagaac agcgattgcc ggcagctgcg gaatcactga gagactggct aagccaacac
     1501 ccccagcctc ctagcttgga ttctatttcc aagaccctag ctgcgagacg tacccaccat
     1561 gacattcgag cggctgcgat agtggatgac actgccagcg ccgtgggtgc tttggataat
     1621 ctggccaaaa agtcaaatgc agtttggacc gttcaaggcc gagtgctcaa gtcagctcca
     1681 acaagagacg ttgtctgggt cttctctgga cacggagcgc agtggcaaag catgggaaag
     1741 gaggtcctga aaaatgaggt cttcctaaac gcactcaagc ccctagatgc cattgtacgc
     1801 aatgaaatcg gctcatctcc gattgaatgg ctccagttgg gcgattttgc gtcgtccgat
     1861 cgtgttcaga tcttgacctt cctgatgcaa atcggcatca gtgcaatctt gcagagccaa
     1921 gggatcgtcc caaatgctgt tattggtcac tctgttggag aaattgcagc ttccgttgtg
     1981 gcaggggcac tctctccaga agagggtaca cttctcgtca cgcgcagatc tgtcctgtat
     2041 cgacaggtca ttggccaagg cgcgatggcc ctggtacgcc ggcctttcga gcaggtctct
     2101 cgagagcttg aaggtaatga caaggtgaca gtggctatcg actcatctcc ttcctcgtgt
     2161 gtcatcgccg ggaccaaaga tgctgtcaag gagattcaga agtcctacaa caagcaggaa
     2221 atagagaact tcaccgtcaa gaccgatatt gcgtttcatt caccgatgtt agaccagctt
     2281 gcaaaccctc tgtccgtcgc tcttcgagat gccatttggc ccaaacagcc gtccatcaag
     2341 ctctattcca caacattgtc ggacgcacga agtcaaaatc cccgaggcgt caagtactgg
     2401 attgataata tgattagtcc agtccgattg acatctgccg tgcaggccgc caaagaggat
     2461 ggctttagag tcttcttaga agtctcaagc catccactcg tcgcgcattc tattgaagaa
     2521 acgcttgtgg acagtgacgc tggggagcat gtggtgatac ccacccttcg ccgcgaccag
     2581 cccgccgaga aaagtgttct tcgtgccata ggccgcctgc attgtagcgg cgttgatatt
     2641 gactgggaga atcaaatatc cggaccttgg gtgcatggtg taccaactgc accgtgggtg
     2701 catcgccctt tctggcgcaa accttccgcc gcagctctcg ccttgcacaa catacgtggg
     2761 cacagtttac tgggccagaa ggttaccgtg gcaggcagcg agaccgttct ctacacgaca
     2821 actttgagca aggaggcgaa acctttcccc gggagtcatc ccgtcatggg aactgagatc
     2881 atacccgcag cggttcttct caacagcttc cttcaagcta cccgcggctt tgcattgcag
     2941 aatgtcaact tgattgcacc tctggagacc gagtctcaac gacttgtgca ggtggtgatt
     3001 caaggcgaca acgtgaaaat tttgtcgcaa attgtacaaa aagaagggct acttgataac
     3061 ccctggacga cccatacaac cgcagagatt gtcccccgat cagaagccac ggaagcggcc
     3121 gtcgatgata caatcaaatc acaccgccca ggaaaggagc ttagcaaatc attcaccatg
     3181 gactatttga caggaactgg ggttgacggc atgggattcc cttgggccgt gctagagcac
     3241 tggggtgaca ctcaagaaat gatggtgcgt gttgaagtcg acccagataa tgaacgtctt
     3301 caatgggaaa cctcttcatg ggcgccgttc ctggatgcag caacctctat tgccgccacc
     3361 atattccacg atcgggccaa actacgcatg acggccggcc tgggcgcgat tgagatattg
     3421 aaggtgcagg acccaccaag ggttggctgg attcgcgtgc agagaaatga tggcagcgac
     3481 tgcacttgca acgtcgatat cctggatgaa gagggtgaac actttgtacg aatcaacact
     3541 atgcgcttcg cagagctcga gagcagctcc gatcagaatg acggcgtctc gaagcttgtg
     3601 catcgggtgg cctggccgcc ggcaagactc accgaggaac ctcttgacat tcaagagatt
     3661 gttctagtca caagtgacga ggatgcgaaa actgtttaca ctaaggaagt tcctcgccac
     3721 gtgggcctaa ctcacatttc gactccagat gagctggtcc ggcgtggagc ggatatcgca
     3781 taccgcaaag agcttgttgt tgtctatgtc cctggtcaag tctcgtcatc tcaggacatc
     3841 cccaacttag tcgaacgttt cttggcggag ctccttgcgg tcgcaaaaca cttgatccag
     3901 tcaggcgtac caagcaagct cttcgttcac acgacaaatg cattccaggg taagacgcca
     3961 acggcgctgg ctcacggacc gctcctcggc acaagtcgcc ttattttcag cgagcacccg
     4021 gacatctggg gcgcgcacat tgatgacgag tatagagcgg tgcctctctc gactatgaaa
     4081 tacattcaag gaagcgatgt cattcgggtt ctggacggag tcgcccgaac ggcaaaactc
     4141 cgcgatcttc cactggatcg tcgcacccaa cctgtatctc agatgctgcc tcgtcccgag
     4201 ggaacatact tgatcaccgg agggcttggg gatcttggac tcgcaacagc tgagttcttc
     4261 gcagaccacg gagcgcggcg gatagtcctg ctatctcggc gtcaactacc acctcgcaga
     4321 ctgtggggca gtctcacagg cgccgatcaa gcagtcgctg cgcggataaa cgagttggaa
     4381 aagcgcggcc tttgcgtctt tgtgctttcc attgacatcg ggtctagcaa cgccgccgag
     4441 acactcatcc aaacgctaga ccaactcggc cttccaacag ttcagggcgt cgtccacgca
     4501 gccggggtgc tggaagacca gcttatcctt aacaccaccg aggaagcatt ccatcgtgtt
     4561 ctctcgccca aagtcaccgg tacattggct cttcaccagg cattccctcc cagtactctt
     4621 gacttttttg tcctattcgg ttcgtgtggt catctggttg gcttccctgg acagggcgcg
     4681 tacgcgcctg ctaacgcttt ccttgattcc attgctactc atcgtcgcaa tcttggagat
     4741 aacgcggtat cattcctgtg gagttcttgg accgatatgg gtctaggtaa tggtaacgac
     4801 ttgctggttt cggagatcga gaacaagggt atcacggaaa taagccgtca agaagccttt
     4861 gaggcctggc tacatcttgc caggtatgac attgatcacg gcgtagtggt ccgagccctg
     4921 ccaatcgagg aggggcaggg cattgtgaac ccccttctga ccgacattgc cgtttatcgt
     4981 cgttcgacaa actcaggccc caagtctgga gagcctgctg ctgcgacccg tacgtcgtct
     5041 ataccgtcgt ctgggcccga attgaaggcc tacttagatg agaacattcg cgcgactgtc
     5101 ggggaagttc ttcatcttcc tccatcagat gttgacccta cagtcgcact tgcagacatg
     5161 ggtatggatt cggtgatgac gacggtttta cgacgacagc tccagaaggc gttcagtatc
     5221 aacgtaccgc caaccttgat atggaatcac ccaacagttg gtcacatggt cgggtggttc
     5281 gcggagaaac tagctgccta g
//
