BGC0001275 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001275 (Glarea lozoyensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	9,951	High	6-methylsalicyclic acid	PKS

BGC0001275 - Region 1 - T1PKS

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Location: 1 - 9,951 nt. (total: 9,951 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 9,952
Label		BGC0001275

Tailoring functions

Ligases: synthase

pks2: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001275.3	1.00	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.79	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.79	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.70	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000056.3	0.67	PKS	esperamicin	Actinomadura verrucosospora
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002229.2	0.64	PKS	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001275.3	1.00	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.79	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.79	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.70	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000056.3	0.67	PKS	esperamicin	Actinomadura verrucosospora
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002229.2	0.64	PKS	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 9951:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

pks2: pk

PKS_AT (572..865): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 66.7%; CE-Malonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 103.9
Ethylmalonyl-CoA: 88.7
Methoxymalonyl-CoA: 80.5
Isobutyryl-CoA: 60.1
Malonyl-CoA: 60.0
Acetyl-CoA: 48.2
2-Methylbutyryl-CoA: 47.7
Propionyl-CoA: 47.5
Benzoyl-CoA: 32.7
trans-1,2-CPDA: 27.1
3-Methylbutyryl-CoA: 25.5
fatty_acid: 24.8
CHC-CoA: 24.1
inactive: 0.0

Link to PARAS substrate predictor