LOCUS       BGC0001276              7588 bp    DNA     linear   PLN 09-SEP-2006
DEFINITION  Aspergillus terreus atX gene for 6-methylsalicylic acid synthase,
            complete cds.
ACCESSION   BGC0001276
VERSION     BGC0001276
KEYWORDS    .
SOURCE      Aspergillus terreus
  ORGANISM  Aspergillus terreus
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Circumdati.
COMMENT     On Sep 8, 2006 this sequence version replaced D85860.1.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 15:13:59
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7588
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..7588
                     /db_xref="taxon:33178"
                     /mol_type="genomic DNA"
                     /organism="Aspergillus terreus"
                     /strain="IMI 16043"
     subregion       1..7588
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..7588
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     regulatory      864..868
                     /regulatory_class="CAAT_signal"
     regulatory      925..929
                     /regulatory_class="TATA_box"
     gene            join(1102..1224,1287..6575)
                     /gene="atX"
     CDS             join(1102..1224,1287..6575)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (46-471). E-value:
                     3.2e-163. Score: 535.4. Matches aSDomain:
                     nrpspksdomains_atX_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (582-873). E-value: 1.3e-70.
                     Score: 230.0. Matches aSDomain:
                     nrpspksdomains_atX_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (939-1071). E-value: 2.7e-16.
                     Score: 52.2. Matches aSDomain: nrpspksdomains_atX_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (1433-1628). E-value: 6.3e-58.
                     Score: 187.6. Matches aSDomain:
                     nrpspksdomains_atX_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (1730-1795). E-value: 8.6e-20.
                     Score: 62.7. Matches aSDomain: nrpspksdomains_atX_ACP.1"
                     /codon_start=1
                     /gene="atX"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 118.9; E-value:
                     3.7e-36)"
                     /gene_kind="biosynthetic"
                     /product="6-methylsalicylic acid synthase"
                     /protein_id="BAA20102.2"
                     /sec_met_domain="PKS_KS (E-value: 5.7e-165, bitscore:
                     535.4, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 2.2e-72, bitscore: 230.0,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3.9e-57, bitscore:
                     179.2, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.9e-16, bitscore:
                     45.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVHGDEVLSVDSGISTPPSTGGGFRRPLETPGTEIGNLNLNPQN
                     EVAVVGMACRLAGGNHSPEELWQSILNRKDASGEIPSMRWEPYYRRDIRNPKILDQTTK
                     RGYFLDHIENFDAAFFGVSPKEAEQMDPQQRLSLEVTWEALEDAGIPPQSLSGSETAVF
                     MGVNSDDYSKLLLEDIPNVEAWMGIGTAYCGVPNRISYHLNLMGPSTAVDAACASSLVA
                     IHHGRQAILQGESEVAIVGGVNALCGPGLTRVLDKAGATSTEGRCLSFDEDAKGYGRGE
                     GAAVVILKRLSTAIRDGDHIRAIIKGSAVAQDGKTNGIMAPNAKAQELVAWNALRTAGV
                     DPLTVGYVEAHATSTPLGDPTEVSAVSAVYGKGRPEGNPCFIGSVKPNVGHLEAGAGAV
                     GFIKAVMAVEKATFPPQTNLKRLNSRIDWDQAGVKVVQETLEWPGNEDDVRRAGVCSYG
                     YGGTVSHAIIEEFAQQLQRPTTNTTDEEPLPRILLLSAPQERRLALQARTQASWIAAEG
                     RNRTLESIATTLSTRRGHHDYRAAIIAENHDDAVQKLSDIVNGKAAEWTTSSRVLDASC
                     SKDVVWVFSGHGAQWTAMATDLLKDIVFYQTISRLDPIVEREMGFSALHSLASGDFESS
                     IKVQVLTYLVQVGLAAILRSKGLEPQAVIGHSVGEIAASVAAGCLTAEEGALIVTRRAN
                     LYRRVMGAGAMVLVNIPFADMEKELQGRTDLVAAIDSSPSSCVVSGATEAVLALVEDLK
                     SRGVNAFRVKTDIPFHHPMLDQLSEPLREAMEGSLSPRKPRVRLYSTSAEDPRSMVARD
                     IHYWTSNMVNPVRLTAAVQAAVDDGLRLFLEVSSHPIVSHSVRETMLDLGVEDFTVTNT
                     MARNKPADKTILSSIAQLHCRGAVVNWKKQLPGPWALDVPLTTWDHKPFWRHIHTGPIS
                     ASTLHDVDKHTLLGQRVPVAGETTMVFTTQMDDQTKPFPGSHPLHGSEIVPAAALVNTF
                     LHATRATTLSNITLRVPVAISQPRDIQVVVSQNQIKICSRLTQKADSGADEGSWLTHTT
                     GQWEAGGSKNPPAQLDIAAIKARLANNKLADNFSIDYLDKVGVSAMGFPWAVTEHYGTL
                     QEMIARVDVAPDVPATSPLPWDAASWAPILDAATSVGSTLFFDQPRLRMPAHIHGVQVY
                     TTQPPPKVGYLYVEKAGDRDLAVHVSVCDELGTVLARFESMRFSEIEGTPGSNGSEESL
                     VHQLAWPPATYSEKPLTINNVVLISRDRNVADLYCGSLKDRVSSITVLDAAADLLSLSQ
                     DPSSVLQAKDTAVVYVPGPLHSADSIPTAAHSFLMELLLLVKIIVNGSLPTKVFVLTDR
                     VCESESATALAQSPIHGVSRIIASEHPDQWGGLIDVETPGQFPLETMKYVQEADNIRIS
                     DGIPRIARLRPLPRDKLLPPSKQTSLLPRPEGTYLITGGLGALGLEVAQFLVEKGARRL
                     ILVSRRALPPRREWADILADPSSSLAPALETIQALETQGATVHTLAVDISSPDAAPQLA
                     VAIDALSLPPVRGVVHAAGVLDSQLVLSATSDSVERVLAPKITGALVLGTVFPPKALDF
                     FMLFSSCGQILGFPGQASYASGNAFLDAFATSRRHQGDNAVAVQWTSWRSLGMAASTDF
                     INAELASKGITDITRDEGFRAWMHISKYDIDQAAVLRSLAFEADEPLPTPILTDIAVRK
                     AGSASSADAPSAAPKETNEMPESIPERRTWLDERIRDCVARVLQLGSSDEVDSKAALSD
                     LGVDSVMTVSLRGQLQKTLGVKVPPTLTWSCPTVSHLVGWFLEKMGN"
     intron          1225..1286
     aSDomain        1302..2576
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_atX_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.20E-163"
                     /label="atX_PKS_KS.1"
                     /locus_tag="atX"
                     /protein_end="471"
                     /protein_start="46"
                     /score="535.4"
                     /tool="antismash"
                     /translation="VAVVGMACRLAGGNHSPEELWQSILNRKDASGEIPSMRWEPYYRR
                     DIRNPKILDQTTKRGYFLDHIENFDAAFFGVSPKEAEQMDPQQRLSLEVTWEALEDAGI
                     PPQSLSGSETAVFMGVNSDDYSKLLLEDIPNVEAWMGIGTAYCGVPNRISYHLNLMGPS
                     TAVDAACASSLVAIHHGRQAILQGESEVAIVGGVNALCGPGLTRVLDKAGATSTEGRCL
                     SFDEDAKGYGRGEGAAVVILKRLSTAIRDGDHIRAIIKGSAVAQDGKTNGIMAPNAKAQ
                     ELVAWNALRTAGVDPLTVGYVEAHATSTPLGDPTEVSAVSAVYGKGRPEGNPCFIGSVK
                     PNVGHLEAGAGAVGFIKAVMAVEKATFPPQTNLKRLNSRIDWDQAGVKVVQETLEWPGN
                     EDDVRRAGVCSYGYGGTVSHAIIEEF"
     aSModule        1302..6548
                     /complete
                     /domains="nrpspksdomains_atX_PKS_KS.1"
                     /domains="nrpspksdomains_atX_PKS_AT.1"
                     /domains="nrpspksdomains_atX_PKS_DH.1"
                     /domains="nrpspksdomains_atX_PKS_KR.1"
                     /domains="nrpspksdomains_atX_ACP.1"
                     /iterative
                     /locus_tags="atX"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       1782..1829
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_atX_0001"
                     /evalue="8.60E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="atX"
                     /protein_end="222"
                     /protein_start="206"
                     /score="14.9"
                     /tool="antismash"
                     /translation="GPSTAVDAACASSLVA"
     CDS_motif       1971..2009
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_atX_0002"
                     /evalue="1.20E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="atX"
                     /protein_end="282"
                     /protein_start="269"
                     /score="12.0"
                     /tool="antismash"
                     /translation="FDEDAKGYGRGEG"
     CDS_motif       2202..2249
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_atX_0003"
                     /evalue="5.30E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="atX"
                     /protein_end="362"
                     /protein_start="346"
                     /score="9.6"
                     /tool="antismash"
                     /translation="YVEAHATSTPLGDPTE"
     CDS_motif       2310..2354
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_atX_0004"
                     /evalue="6.00E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="atX"
                     /protein_end="397"
                     /protein_start="382"
                     /score="9.5"
                     /tool="antismash"
                     /translation="GSVKPNVGHLEAGAG"
     CDS_motif       2904..2960
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_atX_0005"
                     /evalue="4.80E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="atX"
                     /protein_end="599"
                     /protein_start="580"
                     /score="15.9"
                     /tool="antismash"
                     /translation="VWVFSGHGAQWTAMATDLL"
     aSDomain        2910..3782
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_atX_PKS_AT.1"
                     /evalue="1.30E-70"
                     /label="atX_PKS_AT.1"
                     /locus_tag="atX"
                     /protein_end="873"
                     /protein_start="582"
                     /score="230.0"
                     /tool="antismash"
                     /translation="VFSGHGAQWTAMATDLLKDIVFYQTISRLDPIVEREMGFSALHSL
                     ASGDFESSIKVQVLTYLVQVGLAAILRSKGLEPQAVIGHSVGEIAASVAAGCLTAEEGA
                     LIVTRRANLYRRVMGAGAMVLVNIPFADMEKELQGRTDLVAAIDSSPSSCVVSGATEAV
                     LALVEDLKSRGVNAFRVKTDIPFHHPMLDQLSEPLREAMEGSLSPRKPRVRLYSTSAED
                     PRSMVARDIHYWTSNMVNPVRLTAAVQAAVDDGLRLFLEVSSHPIVSHSVRETMLDLGV
                     EDFTVTNTMA"
     CDS_motif       3132..3248
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_atX_0006"
                     /evalue="1.60E-15"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="atX"
                     /protein_end="695"
                     /protein_start="656"
                     /score="49.1"
                     /tool="antismash"
                     /translation="GLEPQAVIGHSVGEIAASVAAGCLTAEEGALIVTRRANL"
     aSDomain        3981..4376
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_atX_PKS_DH.1"
                     /evalue="2.70E-16"
                     /label="atX_PKS_DH.1"
                     /locus_tag="atX"
                     /protein_end="1071"
                     /protein_start="939"
                     /score="52.2"
                     /tool="antismash"
                     /translation="HTLLGQRVPVAGETTMVFTTQMDDQTKPFPGSHPLHGSEIVPAAA
                     LVNTFLHATRATTLSNITLRVPVAISQPRDIQVVVSQNQIKICSRLTQKADSGADEGSW
                     LTHTTGQWEAGGSKNPPAQLDIAAIKAR"
     aSDomain        5463..6047
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_atX_PKS_KR.1"
                     /evalue="6.30E-58"
                     /label="atX_PKS_KR.1"
                     /locus_tag="atX"
                     /protein_end="1628"
                     /protein_start="1433"
                     /score="187.6"
                     /tool="antismash"
                     /translation="GTYLITGGLGALGLEVAQFLVEKGARRLILVSRRALPPRREWADI
                     LADPSSSLAPALETIQALETQGATVHTLAVDISSPDAAPQLAVAIDALSLPPVRGVVHA
                     AGVLDSQLVLSATSDSVERVLAPKITGALVLGTVFPPKALDFFMLFSSCGQILGFPGQA
                     SYASGNAFLDAFATSRRHQGDNAVAVQWTSWR"
     CDS_motif       5466..5564
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_atX_0007"
                     /evalue="3.80E-17"
                     /label="PKSI-KR_m1"
                     /locus_tag="atX"
                     /protein_end="1467"
                     /protein_start="1434"
                     /score="54.8"
                     /tool="antismash"
                     /translation="TYLITGGLGALGLEVAQFLVEKGARRLILVSRR"
     CDS_motif       5892..6002
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_atX_0008"
                     /evalue="5.10E-19"
                     /label="PKSI-KR_m4"
                     /locus_tag="atX"
                     /protein_end="1613"
                     /protein_start="1576"
                     /score="60.8"
                     /tool="antismash"
                     /translation="LDFFMLFSSCGQILGFPGQASYASGNAFLDAFATSRR"
     aSDomain        6354..6548
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_atX_ACP.1"
                     /evalue="8.60E-20"
                     /label="atX_ACP.1"
                     /locus_tag="atX"
                     /protein_end="1795"
                     /protein_start="1730"
                     /score="62.7"
                     /tool="antismash"
                     /translation="RIRDCVARVLQLGSSDEVDSKAALSDLGVDSVMTVSLRGQLQKTL
                     GVKVPPTLTWSCPTVSHLVG"
ORIGIN
        1 tatctcttcc cttaatgatc ggatgtctaa aaggagcagt ggatttcgag atctaatcta
       61 cacccatcgg actactcaaa ggagtcatac tatggagcac acgtagcgcg atagagacgt
      121 agataagatg gagagggcgg ggataaattc tagacctgca gattgtgagc cccaattacc
      181 caaaaaggca aaagaccctg cacattgacc taagcggatg atagttatgc tccgtgaata
      241 tacggaatag tagaatctga caagcagatt ggcaccccca gctctaccaa taacgatgga
      301 acgggcatac cacgacacac gcaagagtct gtcgctaagg ggagctactg cacggtgtcc
      361 cttggtctca aagcgctagg ggaaacggcg cgaaacagat ccacagttcc cacagtgaca
      421 gactgtcttc ggctatcatt ccctaaccgc gaatgaggac ccataatgag accaccattc
      481 caagaatacc aagaatacca aggatgccaa ttctcaccat cgcagacgcc gagacttcca
      541 gacgtgcttg atgcgacttc gcgacgtttt agcgccagaa gccatcacag attaatcatt
      601 cctttaccta aaggggttct gcggtgcagg gctccgagag acaggcgcca attcctggcg
      661 ctagtctcct atctgcacgt cccgggaaga ttccgtagga ctggatgccc gaattgttcg
      721 cgggatgcaa gtgttgacga agatccacca agacttgttt gcacatggca ggtgcactgg
      781 agattctgat tcgaaacact atccaccata cctcgcgtgg tactgctgaa gatggtgatc
      841 aagcgaatca agacagaagg agtcaaatcc ctcgcgatat tcagaaaact gtagtaatat
      901 cagtgaatca tatactgtac cgagtataag atgtagagcg acgccgaaga ttttgcggac
      961 tttcaatcaa agaaattccc taccatacca tctctcctct tcaggcgtta taggattctc
     1021 tcctctatca gttgatgctc cattgacaaa atcttttacc ggcttctctc gcatagacag
     1081 caaatatcag caagagcagc catggaggta catggagatg aagtgttgtc agtcgactct
     1141 ggcatctcaa ctccgccctc gacaggaggt ggatttcgga ggccactaga gactcccgga
     1201 acagaaatcg ggaatctcaa tcttgtgggt cttgctagct cccccaccgt tctatgcact
     1261 gtatctgacc tctgggaacc attcagaacc ctcagaatga ggttgccgtt gttggaatgg
     1321 cctgccggct tgccgggggc aatcattctc cggaagaact gtggcagtcc attctaaaca
     1381 ggaaggatgc ctctggcgag atcccaagca tgcgctggga gccgtactac cgtcgggaca
     1441 ttcgcaaccc caagatccta gatcaaacga caaagcgcgg ctacttcttg gaccacatcg
     1501 agaattttga tgccgcgttc tttggcgttt cccccaaaga ggccgagcag atggaccccc
     1561 agcagcggtt gtcactcgag gtgacttggg aggccctgga agacgcagga atcccaccgc
     1621 agagtttgtc cggctcagaa acagccgtgt ttatgggggt caattcggat gattattcca
     1681 agctcttact ggaagatatt ccgaacgtgg aggcctggat gggcatcggc actgcgtact
     1741 gcggagtccc gaaccgcatc tcctaccacc tgaacctcat ggggcccagc actgccgttg
     1801 atgccgcctg tgcctcctct ctcgttgcca tccatcacgg acgacaggcc atcctacaag
     1861 gcgagagcga agtcgctatt gtcggaggag tcaacgctct ctgcgggcca ggactgactc
     1921 gcgtactcga taaggcagga gcgacctcca cggaaggtcg ctgtctctct ttcgacgaag
     1981 atgcgaaggg ctacggccgt ggtgaaggag ctgcggtggt gatcttgaaa cggctgtcca
     2041 ccgccatccg ggacggagac cacattcgcg ccatcatcaa gggtagtgcc gtagcacagg
     2101 atggcaaaac caacggcatc atggctccca acgccaaggc acaagagctt gtggcatgga
     2161 atgctcttcg gacagccgga gtcgaccctc tgacggttgg gtatgtggaa gctcacgcaa
     2221 cgtcaacccc tcttggcgat cctaccgagg tcagcgccgt ctcagcagtc tacggcaaag
     2281 gcagaccgga agggaatcct tgcttcattg gctctgtcaa acccaacgtg ggccatttgg
     2341 aagcgggcgc tggcgccgtc ggtttcatca aagcagtcat ggcagttgaa aaggccactt
     2401 tccccccaca aaccaacctg aagagactca attctcgcat tgactgggac caagccggag
     2461 tgaaggtcgt ccaggagaca ctggaatggc ctggcaatga ggatgacgtc cgccgagccg
     2521 gtgtttgctc ttacggatat ggcggtacgg tctcccatgc aatcatcgag gagtttgcgc
     2581 aacagctcca acggccgact accaacacaa ccgatgaaga gcctctgcct cggattcttc
     2641 tgctgtcggc acctcaagag agacgccttg ctttgcaggc acggacacag gcctcctgga
     2701 ttgccgcgga gggcagaaat agaaccctgg agtcgatcgc aaccaccttg agcactcgtc
     2761 gtgggcacca tgactaccgg gctgccatca tcgcagagaa ccatgatgac gctgtgcaga
     2821 aactgtctga cattgtcaat ggtaaagcag ccgaatggac gacgtcgagt cgtgttctcg
     2881 atgccagttg ctccaaggac gtggtgtggg ttttctccgg tcatggcgca caatggactg
     2941 caatggctac ggatctcctc aaagacattg tgttctatca aacaatcagc cgtctggacc
     3001 cgattgtgga gcgcgaaatg ggcttctcgg cattgcattc ccttgcaagt ggcgatttcg
     3061 aatcgtccat caaggtgcaa gtgctcacct atctcgtaca ggtgggactg gctgccatct
     3121 tgcgctcgaa gggactggag ccccaggctg tcatcggtca ttcagttggc gaaattgccg
     3181 cctcagtcgc ggccggctgt ctgactgcag aagaaggcgc cctgattgtc acccgcagag
     3241 caaacctcta tcggcgtgtg atgggcgcgg gcgcaatggt tctcgtcaac attccattcg
     3301 ccgacatgga gaaagagctt caaggccgga cggacctggt ggccgccatt gactcctcgc
     3361 cgtcttcatg tgttgtttcc ggtgccactg aagctgtcct ggcgctcgtg gaagacctca
     3421 agtctcgtgg tgtcaacgct ttccgggtca agacggatat tcccttccac cacccgatgc
     3481 tggatcagct gtccgagcca ttgcgagagg ccatggaagg gtccctgtcg ccacgcaagc
     3541 ccagagtccg tctttactcg acgtcggcag aagacccacg cagtatggtt gctcgggata
     3601 tccattactg gaccagcaac atggtcaacc cggtccggtt gacggccgca gtgcaggcag
     3661 cagtggacga tggcctgcga ctgttccttg aagtctcttc tcatcccatt gtgtctcact
     3721 ccgtccgaga gaccatgttg gacctgggtg tggaggactt caccgtgacc aacaccatgg
     3781 ctcgcaataa gcctgccgac aagactattc tgtccagcat tgcccagctt cactgtcggg
     3841 gcgccgtcgt caattggaag aagcagctgc cgggcccttg ggcgctggat gtgcccttga
     3901 cgacgtggga ccacaagccc ttctggcggc atattcacac tggccctatc agtgcctcga
     3961 ctttgcatga tgtggacaaa cacacgctgt tgggtcagcg cgttcccgtt gcgggagaaa
     4021 cgactatggt gttcaccacc caaatggatg accagaccaa gcctttccca ggaagccatc
     4081 cactgcacgg ctctgagatt gttccggctg ctgcccttgt caacactttc ttgcatgcca
     4141 ccagggctac caccctttcc aacattactc ttcgcgtccc agtggccatc agccagccgc
     4201 gcgacatcca ggtggtggtg tcacagaatc aaatcaagat ctgctcccgt ctcactcaga
     4261 aggcggattc tggggcagac gaaggttcct ggctgacaca cactacgggt cagtgggaag
     4321 ctggtggaag caagaacccc ccggcgcaac tcgatattgc tgctatcaag gctcgtctcg
     4381 ctaataacaa gttggcggac aacttctcca tcgactattt ggacaaggtt ggcgtttcgg
     4441 ccatgggctt cccttgggca gttacagagc actacggcac cctgcaggag atgatcgctc
     4501 gcgttgatgt cgcgccagac gtccccgcga ccagtccact cccctgggat gctgcctctt
     4561 gggccccgat cctcgatgcg gccacctcag tgggatccac gctctttttc gatcagcctc
     4621 gcctgcgcat gccggctcac attcacgggg ttcaagtcta caccacgcag ccgcctccca
     4681 aggtgggtta cctgtacgtg gaaaaggctg gcgatcggga tctggcggtg catgtcagtg
     4741 tctgcgacga gctcggaacc gtcttagctc gattcgaatc catgcgcttt tccgagatcg
     4801 aaggcacgcc gggcagtaac ggcagcgagg agagtcttgt ccaccagctc gcatggcctc
     4861 ccgccaccta cagcgagaag ccgctgacaa tcaacaatgt cgtcctcatt tcccgggata
     4921 ggaacgtcgc agatctctac tgtgggtctt tgaaagatcg tgtgtcatct atcacggtgc
     4981 tggatgctgc tgccgacctg ctttcccttt cgcaggatcc cagcagtgtc ttgcaagcaa
     5041 aggatacagc ggtggtgtac gtgcccggtc ccctccacag cgcggattct atcccgactg
     5101 cggcccattc cttcctcatg gaattgctcc tcctggtcaa aatcattgtc aatggctctt
     5161 tgcccaccaa ggtctttgtc cttacggacc gcgtctgcga gagtgagtct gcgacggctc
     5221 tcgctcagtc tccgatccac ggtgtctccc gcatcattgc ttcggagcac ccagatcaat
     5281 ggggcggact gattgacgtc gaaacgccgg gccagttccc actcgagacg atgaagtatg
     5341 tgcaggaggc ggacaacatc cgcatctcgg atggcatacc cagaattgct cgtctgcgcc
     5401 cgcttcctcg cgacaagctc ctaccgccta gcaagcagac ttccctgctt ccccggcccg
     5461 aaggtaccta cttaattacg ggtggactgg gcgctctggg gttggaggtc gcacagttcc
     5521 tggtggaaaa gggtgctcgt cgattgatcc tcgtttctcg gcgtgccttg cctccgcgcc
     5581 gggagtgggc agacatcctt gctgatccat cgtcctcgct ggcgccggcg ctggagacaa
     5641 tccaggccct tgagacacag ggagccactg tccacaccct cgcagtggac atttcctctc
     5701 ctgacgcagc gcctcaactg gcagtcgcca ttgatgctct gtcgctacct ccagtccgcg
     5761 gcgtggtcca cgcagcaggc gttctggaca gccagctggt cctctccgcc acgtcagact
     5821 ctgtcgagcg cgtgctggcg cccaagatca ccggagcgct ggtccttggc accgtcttcc
     5881 cccccaaggc actcgatttc ttcatgctat tctcctcatg cggacagata ctaggcttcc
     5941 caggtcaagc atcctacgcg tccggaaacg cgttccttga tgcattcgca acatcgcgcc
     6001 gacaccaagg agacaacgct gtcgccgtgc agtggaccag ctggcgctcc ctcggcatgg
     6061 cagccagtac cgacttcatc aacgctgagc tagccagcaa gggcatcact gacatcactc
     6121 gcgacgaggg gttccgcgcg tggatgcata tttccaaata tgatatcgac caggccgccg
     6181 tcttgcgcag tctggccttc gaggccgatg aacccctccc cacccctatc cttacggata
     6241 ttgccgtccg caaggctggc tccgcctcct ccgctgatgc tccctctgct gcaccgaaag
     6301 agacgaacga aatgccggaa tcgatcccgg agcgtcgtac ctggttggat gaacgaatcc
     6361 gtgattgtgt ggcccgcgtg cttcagctgg ggagcagcga tgaggttgat tccaaggccg
     6421 ctctgagtga tctgggagtc gacagcgtca tgaccgttag cttgagaggt cagctgcaga
     6481 agacgttggg ggtcaaggtg ccacccacac tgacctggag ttgcccgacg gtgtcacatc
     6541 tggtgggatg gtttttggaa aagatgggaa attgattaga gctgatggtt tctccttgtg
     6601 tgttcttcat ttgatatata tttgttgttt cgtctctggt ttcccccttt gcctgttccc
     6661 ctgaatcaat ttgccaagac tgtgatgcca actgaacctg acgagattgt atatgtcaca
     6721 tgatattaat ttgtatgagg atattagcaa tagacgagtc atgtttttgg atatatatat
     6781 actctccctg cgcgaaagga ggcaggaatg aagctggaga agaggcgatg aattggatag
     6841 gctttctgca gacgcctctg gagtagggga tgtgctaggc ctaaacgggc aggctcacgg
     6901 cctgaggctc cagcgttccc aattgtttcc ctatcaagtc aagggtgttg gggacggaga
     6961 gctttctctt gcgcaataaa gaatagtcga tttagtttct tgaacgtgca cataccgcag
     7021 cattgtagga attggctcgt caattgacat aattcggatg tatctcaaca tcatctgtag
     7081 agcatcgtgt gtgaaatata tatcatacca acttgaatac catcaagaag acataggttc
     7141 tagttactga gatagttgca ttaaacagct cgtatcaact atgcgtatgc ttcgctaaat
     7201 actgtagcat gcaaagatac cacactcact gaaagttgat ctgagatgag aactgcaaga
     7261 ggcagttttc accgagtcag gctgtcctat cttctggtgt ctagacaact tcccactgct
     7321 acgtatattc atcgactaag gtgtggacag tctagtacat tatctgtaag ctacttcagg
     7381 cagtacatgc gacgtgtgcc agagatagtc tcggatgcag tataagacat cgtggcaatg
     7441 aaaaagatca tctaaaaccg gagcttgctt ataataacct gacaggataa ccacttatat
     7501 ttgcactccg aaccccggag tgtatgctcc aatacagcag tagcccatca cctcaggaaa
     7561 cctcataaat tcacttactc aagatatc
//
