BGC0001276 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001276 (Aspergillus terreus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	7,588	High	6-methylsalicyclic acid	PKS

BGC0001276 - Region 1 - T1PKS

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Location: 1 - 7,588 nt. (total: 7,588 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 7,589
Label		BGC0001276

Tailoring functions

Ligases: synthase

atX: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	1.00	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000160.3	0.71	PKS	terreic acid	Aspergillus terreus NIH2624
BGC0001275.3	0.70	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.70	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.69	PKS	asperlactone	Aspergillus ochraceus
BGC0000056.3	0.68	PKS	esperamicin	Actinomadura verrucosospora
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001276.3	1.00	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0000160.3	0.71	PKS	terreic acid	Aspergillus terreus NIH2624
BGC0001275.3	0.70	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.70	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.69	PKS	asperlactone	Aspergillus ochraceus
BGC0000056.3	0.68	PKS	esperamicin	Actinomadura verrucosospora
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 7588:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

atX: pk

PKS_AT (582..873): pk

ATSignature: Malonyl-CoA, Acetyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Acetyl-CoA: 66.7%; CE-Malonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 110.5
Ethylmalonyl-CoA: 86.5
Methoxymalonyl-CoA: 85.5
Malonyl-CoA: 76.1
Isobutyryl-CoA: 75.9
Acetyl-CoA: 70.9
2-Methylbutyryl-CoA: 59.8
Propionyl-CoA: 53.6
trans-1,2-CPDA: 42.0
Benzoyl-CoA: 37.9
3-Methylbutyryl-CoA: 33.4
fatty_acid: 31.6
CHC-CoA: 28.6
inactive: 12.9

Link to PARAS substrate predictor