BGC0001283: Bisenarsan biosynthetic gene cluster from Streptomyces lividans 1326
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Location: 1,069,037 - 1,117,180 nt. (total: 48,144 nt).
This entry is originally from NCBI GenBank NZ_CM001889.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001283
Short description Bisenarsan biosynthetic gene cluster from Streptomyces lividans 1326
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The actual structures of these products are still subject to further investigation and will be discussed in detail in a future publication. "
Biosynthetic class(es)
  • PKS (Type I)
Loci
NZ_CM001889.1
1080808 - 1113162
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • Bisenarsan
Species Streptomyces lividans 1326 [taxonomy]
References
Chemical products information
Bisenarsan Evidence: NMR [1]
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C15H28As1O3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SLI_RS05000
  • WP_016325491.1
  • arsB
 1079702 - 1080808 (-) ACR3 family arsenite efflux transporter
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    • SLI_RS05005
    • WP_016325492.1
    		 1080805 - 1081113 (-) metalloregulator ArsR/SmtB family transcription factor
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      • SLI_RS05010
      • WP_016325493.1
      		 1081206 - 1081619 (+) arsenate reductase ArsC
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        • SLI_RS05015
        • WP_016325494.1
        • trxB
        		 1081616 - 1082608 (+) thioredoxin-disulfide reductase
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          • SLI_RS05020
          • WP_016325495.1
          		 1082697 - 1083119 (-) cobalamin B12-binding domain-containing protein
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            • SLI_RS05025
            • WP_016325496.1
            		 1083162 - 1084757 (-) methylmalonyl-CoA mutase family protein
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              • SLI_RS05030
              • WP_016325497.1
              		 1084813 - 1085088 (-) DUF5988 family protein
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                • SLI_RS05035
                • WP_042799404.1
                		 1085582 - 1085935 (-) metalloregulator ArsR/SmtB family transcription factor
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                  • SLI_RS05040
                  • WP_042799405.1
                  		 1086020 - 1086799 (+) SDR family NAD(P)-dependent oxidoreductase
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                    • SLI_RS05045
                    • WP_016325500.1
                    		 1086860 - 1088341 (-) NAD(P)-binding domain-containing protein
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                      • SLI_RS41050
                      • WP_016325501.1
                      		 1088377 - 1088538 (-) hypothetical protein
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                        • SLI_RS05050
                        • WP_042799407.1
                        		 1089037 - 1096113 (+) type I polyketide synthase
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                          • SLI_RS05055
                          • WP_007445820.1
                          		 1096140 - 1097180 (+) ketoacyl-ACP synthase III family protein
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                            • SLI_RS05060
                            • WP_016325503.1
                            		 1097289 - 1097960 (+) VTT domain-containing protein
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                              • SLI_RS05065
                              • WP_016325504.1
                              • aepY
                              		 1097957 - 1099060 (+) phosphonopyruvate decarboxylase
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                                • SLI_RS05070
                                • WP_016325505.1
                                		 1099136 - 1099537 (-) metalloregulator ArsR/SmtB family transcription factor
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                                  • SLI_RS05075
                                  • WP_016325506.1
                                  		 1099606 - 1101171 (-) MFS transporter
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                                    • SLI_RS05080
                                    • WP_042799411.1
                                    		 1101916 - 1102638 (+) CTP synthase
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                                      • SLI_RS05085
                                      • WP_016325508.1
                                      		 1102749 - 1105271 (+) molybdopterin-dependent oxidoreductase
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                                        • SLI_RS05090
                                        • WP_016325509.1
                                        • aroA
                                        		 1105327 - 1106649 (+) 3-phosphoshikimate 1-carboxyvinyltransferase
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                                          • SLI_RS05095
                                          • WP_016325510.1
                                          • gpmI
                                          		 1106646 - 1108181 (+) 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
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                                            • SLI_RS05100
                                            • WP_016325511.1
                                            		 1108178 - 1108537 (+) hypothetical protein
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                                              • SLI_RS05105
                                              • WP_016325512.1
                                              		 1108858 - 1109730 (+) phosphate ABC transporter substrate-binding protein
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                                                • SLI_RS05110
                                                • WP_016325513.1
                                                • pstC
                                                		 1109734 - 1111545 (+) phosphate ABC transporter permease subunit PstC
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                                                  • SLI_RS05115
                                                  • WP_042799412.1
                                                  		 1111533 - 1112222 (+) ATP-binding cassette domain-containing protein
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                                                    • SLI_RS05120
                                                    • WP_042799413.1
                                                    		 1112344 - 1112685 (-) metalloregulator ArsR/SmtB family transcription factor
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                                                      • SLI_RS05125
                                                      • WP_007445854.1
                                                      		 1112803 - 1113162 (-) metalloregulator ArsR/SmtB family transcription factor
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                                                        Biosynthesis information

                                                        No biosynthesis information available for this record.

                                                        Annotation changelog

                                                        Entry version: 3

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2024-05-28
                                                        MIBiG v4 annotathon
                                                        • (ID: VN4WQJSSFIJHEVCKX4HDODAG)
                                                        • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2019-10-16
                                                        Migrated from v1.4
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2015-12-24
                                                        Submitted
                                                        • (ID: YFQE6LBJ4VCTUO2RYKJB5QD7)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        Tailoring functions
                                                        Tailoring enzymes detected in this region
                                                        Oxidoreductases: dehydrogenase electron transfer oxidase reductase
                                                        SLI_RS05015: alkyl hydroperoxide reductase subunit
                                                        smcogs
                                                        SMCOG1176: alkyl hydroperoxide reductase subunit
                                                        SLI_RS05040: short-chain dehydrogenase/reductase SDR
                                                        smcogs
                                                        SMCOG1001: short-chain dehydrogenase/reductase SDR
                                                        SLI_RS05065: pyruvate oxidase/decarboxylase
                                                        smcogs
                                                        SMCOG1055: pyruvate oxidase/decarboxylase
                                                        SLI_RS05085: flavodoxin
                                                        smcogs
                                                        SMCOG1134: flavodoxin
                                                        Ligases: synthase
                                                        SLI_RS05050: Beta-ketoacyl synthase
                                                        smcogs
                                                        SMCOG1093: Beta-ketoacyl synthase
                                                        SLI_RS05055: 3-oxoacyl-(acyl carrier protein) synthase III
                                                        smcogs
                                                        SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III
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                                                        Detailed domain annotation
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