BGC0001287: chaxamycin A biosynthetic gene cluster from Streptomyces leeuwenhoekii
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Location: 1,211,049 - 1,289,829 nt. (total: 78,781 nt).
This entry is originally from NCBI GenBank LN831790.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001287
Short description chaxamycin A biosynthetic gene cluster from Streptomyces leeuwenhoekii
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: LN831790.1
Compounds
  • chaxamycin A
  • chaxamycin B
  • chaxamycin C
  • chaxamycin D
Species Streptomyces leeuwenhoekii [taxonomy]
References
Chemical products information
chaxamycin A
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C35H45N1O10
Chemical database entries
NPAtlas
PubCHEM
chaxamycin B
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C35H45N1O9
Chemical database entries
NPAtlas
PubCHEM
chaxamycin C
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C35H45N1O11
Chemical database entries
NPAtlas
PubCHEM
chaxamycin D
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C36H45N1O12
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CQR60473.1
  • cxmJ
 1211049 - 1211555 (+) RifJ homologue, AminoDHQ dehydratase, AHBA biosynthesis
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  • CQR60474.1
  • cxmZ
 1211584 - 1212324 (-) Transcriptional regulator, atypical response regulator
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  • CQR60475.1
  • cxmY
 1212932 - 1214233 (+) LuxR Family Transcriptional Regulator, possible activator; no Rif homologue
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  • CQR60476.1
  • cxmR2
 1214242 - 1214403 (-) RifR homologue; Type II thioesterase, probably non-functional
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  • CQR60477.1
  • cxmR
 1214471 - 1214728 (-) RifR homologue; Type II thioesterase, probably non-functional
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  • CQR60478.1
  • cxm24
 1215239 - 1216306 (+) Methyltransferase SAM-dependent; not homolog to rifamycin Orf14
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  • CQR60479.1
  • cxm23
 1216434 - 1217690 (+) Rif-orf5 homologue; Cytochrome P450
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  • CQR60480.1
  • cxm22
 1217819 - 1219000 (+) Rif-orf4 homologue; Cytochrome P450
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  • CQR60481.1
  • cxm21
 1219014 - 1219205 (+) Ferredoxin 4Fe-4S single cluster domain; no Rif homologue
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  • CQR60482.1
  • cxm20
 1219269 - 1220477 (-) Rif-orf20 homologue; O-Acyltransferase
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  • CQR60483.1
  • cxm19
 1220780 - 1222381 (+) Rif-orf19 homologue. FDA dependent-monooxygenase; Naphthalene ring formation; 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase
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  • CQR60484.1
  • cxm18
 1222473 - 1223360 (+) Rif-orf11 homologue, Flavin-dependent oxidoreductase
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  • CQR60485.1
  • cxmN
 1223440 - 1224363 (-) RifN homologue, kanosamine kinase, AHBA biosynthesis
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  • CQR60486.1
  • cxmM
 1224368 - 1225066 (-) RifM homologue, phosphoglycolate phosphatase, AHBA biosynthesis
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  • CQR60487.1
  • cxmL
 1225100 - 1226176 (-) RifL homologue, oxidoreductase, AHBA biosynthesis
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  • CQR60488.1
  • cxmK
 1226173 - 1227333 (-) RifK homologue, 3-amino-5-hydroxy benzoic acid (AHBA) synthase
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  • CQR60489.1
  • cxmI
 1227514 - 1228320 (-) RifI homologue, Aminoquinate dehydrogenase, AHBA biosynthesis
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  • CQR60490.1
  • cxmH
 1228390 - 1229610 (-) RifH homologue, AminoDAHP synthase, AHBA biosynthesis
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  • CQR60491.1
  • cxmG
 1229607 - 1230713 (-) RifG homologue, AminoDHQ synthase, AHBA biosynthesis
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  • CQR60492.1
  • cxmF
 1230710 - 1231519 (-) RifF homologue, amide synthase, release of polyketide from PKS and ciclysation
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  • CQR60493.1
  • cxmE
 1231564 - 1242030 (-) Polyketide synthase, type I, modules: 9 and 10
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  • CQR60494.1
  • cxmD
 1242103 - 1247424 (-) Polyketide synthase, type I, module 8
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  • CQR60495.1
  • cxmC
 1247482 - 1252944 (-) Polyketide synthase, type I, module 7
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  • CQR60496.1
  • cxmB
 1252955 - 1269046 (-) Polyketide synthase, type I, modules: 4, 5 and 6
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  • CQR60497.1
  • cxmA
 1269077 - 1285927 (-) Polyketide synthase, type I, modules: loading, 1, 2 and 3
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  • CQR60498.1
  • cxm4
 1285991 - 1287184 (-) Rif-orf0(cero) homologue, Cytochrome P450
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  • CQR60499.1
  • cxmT
 1287486 - 1288457 (-) RifT homologue; NAD-dependent oxydoreductase
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  • CQR60500.1
  • cxmS
 1288454 - 1289437 (-) RifS homologue; NAD-dependent oxydoreductase
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  • CQR60501.1
  • sle_10390__cxm1
 1289413 - 1289829 (-) Hypothetical Protein
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Annotation changelog
MIBiG version Submitter Notes
1.2
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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