BGC0001288: maklamicin biosynthetic gene cluster from Micromonospora sp. GMKU326
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Location: 1 - 149,333 nt. (total: 149,333 nt).
This entry is originally from NCBI GenBank LC021382.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
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Gene details
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001288
Short description maklamicin biosynthetic gene cluster from Micromonospora sp. GMKU326
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: LC021382.1
Compounds
  • maklamicin
Species Micromonospora sp. GMKU326 [taxonomy]
References
Chemical products information
maklamicin
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C32H44O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAQ25475.1
 199 - 867 (-) polyketide synthesis cyclase
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  • BAQ25476.1
 924 - 2147 (-) cytochrome P450
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  • BAQ25477.1
 2144 - 2464 (-) antibiotic biosynthesis monooxygenase
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  • BAQ25478.1
 2461 - 4740 (-) monooxygenase
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  • BAQ25479.1
 4886 - 5875 (-) dTDP-glucose 4,6-dehydratase
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  • BAQ25480.1
 6131 - 7006 (+) glucose-1-phosphate thymidylyltransferase
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  • BAQ25481.1
 7272 - 28907 (+) type I polyketide synthase
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  • BAQ25482.1
 28904 - 40777 (+) type I polyketide synthase
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  • BAQ25483.1
  • makA4
 40808 - 44146 (+) type I polyketide synthase
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  • BAQ25484.1
  • makC1
 44143 - 45651 (+) FAD-dependent oxidoreductase
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  • BAQ25485.1
  • makR1
 45940 - 47490 (-) two-component system sensor kinase
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  • BAQ25486.1
  • makR2
 47487 - 48215 (-) two-component system response regulator
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  • BAQ25487.1
  • makT1
 48268 - 49095 (-) ABC transporter permease
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  • BAQ25488.1
  • makT2
 49095 - 50015 (-) multidrug ABC transporter ATP-binding protein
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  • BAQ25489.1
 50087 - 51472 (-) sodium:proton exchanger
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  • BAQ25490.1
 51469 - 52506 (-) 3-oxoacyl-ACP synthase
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  • BAQ25491.1
  • makT3
 52644 - 54131 (-) multidrug MFS (major facilitator superfamily) transporter
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  • BAQ25492.1
 54172 - 54927 (-) hypothetical protein
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  • BAQ25493.1
 54924 - 56231 (-) hypothetical protein
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  • BAQ25494.1
 56228 - 57316 (-) ATPase AAA
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  • BAQ25495.1
 57517 - 57753 (-) hypothetical protein
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  • BAQ25496.1
 57844 - 59052 (-) glycosyltransferase
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  • BAQ25497.1
 59328 - 59885 (+) hypothetical protein
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  • BAQ25498.1
  • makA5
 59882 - 60688 (+) type II thioesterase
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  • BAQ25499.1
  • makC2
 60709 - 61899 (-) cytochrome P450
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  • BAQ25500.1
  • makR3
 61937 - 62767 (-) SARP family transcriptional regulator
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  • BAQ25501.1
  • makB1
 63147 - 64175 (+) ketoacyl-ACP synthase
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  • BAQ25502.1
  • makB2
 64176 - 66059 (+) glyceryl-S-ACP synthase
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  • BAQ25503.1
  • makB3
 66056 - 66283 (+) acyl carrier protein
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  • BAQ25504.1
  • makB4
 66280 - 67104 (+) acyltransferase
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  • BAQ25505.1
  • makB5
 67101 - 68189 (+) dehydratase
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  • BAQ25506.1
 68260 - 69300 (+) 3-oxoacyl-ACP synthase
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  • BAQ25507.1
 69342 - 74747 (+) type I polyketide synthase
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  • BAQ25508.1
 74813 - 75073 (+) acyl carrier protein
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  • BAQ25509.1
 75085 - 76425 (+) FADH2-dependent halogenase
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  • BAQ25510.1
  • makC3
 76485 - 77666 (-) cytochrome P450
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  • BAQ25511.1
  • makA1
 77855 - 107695 (+) type I polyketide synthase
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  • BAQ25512.1
  • makA2
 107708 - 130003 (+) type I polyketide synthase
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  • BAQ25513.1
  • makA3
 130030 - 141753 (+) type I polyketide synthase
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  • BAQ25514.1
  • makR4
 141845 - 142477 (+) TetR family transcriptional regulator
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  • BAQ25515.1
 143184 - 143483 (-) hypothetical protein
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  • BAQ25516.1
  • makA6
 143595 - 144314 (-) 4'-phosphopantetheinyl transferase
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  • BAQ25517.1
  • makA7
 144311 - 145162 (-) metallophosphoesterase
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  • BAQ25518.1
  • makD1
 145240 - 146631 (-) acyl-CoA synthetase
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  • BAQ25519.1
 146689 - 146973 (-) hypothetical protein
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  • BAQ25520.1
  • makD2
 147367 - 148791 (+) propionyl-CoA carboxylase
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Annotation changelog
MIBiG version Submitter Notes
1.2
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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