BGC0001288: maklamicin biosynthetic gene cluster from Micromonospora sp. GMKU326
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Location: 1 - 149,333 nt. (total: 149,333 nt).
This entry is originally from NCBI GenBank LC021382.1.

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core biosynthetic genes
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001288
Short description maklamicin biosynthetic gene cluster from Micromonospora sp. GMKU326
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
LC021382.1
via
Compounds
  • maklamicin
Species Micromonospora sp. GMKU326 [taxonomy]
References
Chemical products information
maklamicin Evidence:
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C32H44O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAQ25475.1
 199 - 867 (-) polyketide synthesis cyclase
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    • BAQ25476.1
    		 924 - 2147 (-) cytochrome P450
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      • BAQ25477.1
      		 2144 - 2464 (-) antibiotic biosynthesis monooxygenase
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        • BAQ25478.1
        		 2461 - 4740 (-) monooxygenase
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          • BAQ25479.1
          		 4886 - 5875 (-) dTDP-glucose 4,6-dehydratase
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            • BAQ25480.1
            		 6131 - 7006 (+) glucose-1-phosphate thymidylyltransferase
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              • BAQ25481.1
              		 7272 - 28907 (+) type I polyketide synthase
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                • BAQ25482.1
                		 28904 - 40777 (+) type I polyketide synthase
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                  • BAQ25483.1
                  • makA4
                  		 40808 - 44146 (+) type I polyketide synthase
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                    • BAQ25484.1
                    • makC1
                    		 44143 - 45651 (+) FAD-dependent oxidoreductase
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                      • BAQ25485.1
                      • makR1
                      		 45940 - 47490 (-) two-component system sensor kinase
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                        • BAQ25486.1
                        • makR2
                        		 47487 - 48215 (-) two-component system response regulator
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                          • BAQ25487.1
                          • makT1
                          		 48268 - 49095 (-) ABC transporter permease
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                            • BAQ25488.1
                            • makT2
                            		 49095 - 50015 (-) multidrug ABC transporter ATP-binding protein
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                              • BAQ25489.1
                              		 50087 - 51472 (-) sodium:proton exchanger
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                                • BAQ25490.1
                                		 51469 - 52506 (-) 3-oxoacyl-ACP synthase
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                                  • BAQ25491.1
                                  • makT3
                                  		 52644 - 54131 (-) multidrug MFS (major facilitator superfamily) transporter
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                                    • BAQ25492.1
                                    		 54172 - 54927 (-) hypothetical protein
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                                      • BAQ25493.1
                                      		 54924 - 56231 (-) hypothetical protein
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                                        • BAQ25494.1
                                        		 56228 - 57316 (-) ATPase AAA
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                                          • BAQ25495.1
                                          		 57517 - 57753 (-) hypothetical protein
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                                            • BAQ25496.1
                                            		 57844 - 59052 (-) glycosyltransferase
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                                              • BAQ25497.1
                                              		 59328 - 59885 (+) hypothetical protein
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                                                • BAQ25498.1
                                                • makA5
                                                		 59882 - 60688 (+) type II thioesterase
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                                                  • BAQ25499.1
                                                  • makC2
                                                  		 60709 - 61899 (-) cytochrome P450
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                                                    • BAQ25500.1
                                                    • makR3
                                                    		 61937 - 62767 (-) SARP family transcriptional regulator
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                                                      • BAQ25501.1
                                                      • makB1
                                                      		 63147 - 64175 (+) ketoacyl-ACP synthase
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                                                        • BAQ25502.1
                                                        • makB2
                                                        		 64176 - 66059 (+) glyceryl-S-ACP synthase
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                                                          • BAQ25503.1
                                                          • makB3
                                                          		 66056 - 66283 (+) acyl carrier protein
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                                                            • BAQ25504.1
                                                            • makB4
                                                            		 66280 - 67104 (+) acyltransferase
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                                                              • BAQ25505.1
                                                              • makB5
                                                              		 67101 - 68189 (+) dehydratase
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                                                                • BAQ25506.1
                                                                		 68260 - 69300 (+) 3-oxoacyl-ACP synthase
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                                                                  • BAQ25507.1
                                                                  		 69342 - 74747 (+) type I polyketide synthase
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                                                                    • BAQ25508.1
                                                                    		 74813 - 75073 (+) acyl carrier protein
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                                                                      • BAQ25509.1
                                                                      		 75085 - 76425 (+) FADH2-dependent halogenase
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                                                                        • BAQ25510.1
                                                                        • makC3
                                                                        		 76485 - 77666 (-) cytochrome P450
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                                                                          • BAQ25511.1
                                                                          • makA1
                                                                          		 77855 - 107695 (+) type I polyketide synthase
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                                                                            • BAQ25512.1
                                                                            • makA2
                                                                            		 107708 - 130003 (+) type I polyketide synthase
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                                                                              • BAQ25513.1
                                                                              • makA3
                                                                              		 130030 - 141753 (+) type I polyketide synthase
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                                                                                • BAQ25514.1
                                                                                • makR4
                                                                                		 141845 - 142477 (+) TetR family transcriptional regulator
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                                                                                  • BAQ25515.1
                                                                                  		 143184 - 143483 (-) hypothetical protein
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                                                                                    • BAQ25516.1
                                                                                    • makA6
                                                                                    		 143595 - 144314 (-) 4'-phosphopantetheinyl transferase
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                                                                                      • BAQ25517.1
                                                                                      • makA7
                                                                                      		 144311 - 145162 (-) metallophosphoesterase
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                                                                                        • BAQ25518.1
                                                                                        • makD1
                                                                                        		 145240 - 146631 (-) acyl-CoA synthetase
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                                                                                          • BAQ25519.1
                                                                                          		 146689 - 146973 (-) hypothetical protein
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                                                                                            • BAQ25520.1
                                                                                            • makD2
                                                                                            		 147367 - 148791 (+) propionyl-CoA carboxylase
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                                                                                              Biosynthesis information
                                                                                              Annotation changelog

                                                                                              Entry version: 4

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2022-10-07
                                                                                              Update chemical activity to schema version 2.11
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                              Entry version: 3

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2022-09-15
                                                                                              Updated bioactivity data
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                              Entry version: 2

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2019-10-16
                                                                                              Migrated from v1.4
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              2019-10-16
                                                                                              Updated compound(s) information (NPAtlas curation)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                              Entry version: 1

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2015-12-24
                                                                                              Submitted
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              Detailed domain annotation
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