BGC0001289 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001289 (Paenibacillus ehimensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-i	1	10,643	High	penisin	ribosomal:RiPP

BGC0001289 - Region 1 - lanthipeptide-class-i

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Location: 1 - 10,643 nt. (total: 10,643 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 10,644
Label		BGC0001289

Tailoring functions

Lyases: cyclase dehydratase

penB: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

penC: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001289.5	1.00	ribosomal	penisin	Paenibacillus ehimensis
BGC0002576.2	0.76	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000542.3	0.56	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.56	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000515.4	0.51	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000506.4	0.51	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000559.4	0.50	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000544.4	0.47	ribosomal	planosporicin	Planomonospora alba
BGC0000540.5	0.46	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001289.5	1.00	ribosomal	penisin	Paenibacillus ehimensis
BGC0002576.2	0.76	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000542.3	0.56	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.56	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000515.4	0.51	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000506.4	0.51	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000559.4	0.50	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000544.4	0.47	ribosomal	planosporicin	Planomonospora alba
BGC0000540.5	0.46	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF

Similar known clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for penB

penA1

Leader:

MANNNFDLDVQVKSVNSVNAN

Core:

FGLYTSQCYSSQCYSSKCYSDSCYSSDCYTGRHMCGYTHGYSC

Core with dehydrations:

FGLYDhbDhaQCysYDhaDhaQCysYDhaDhaKCysYDhaDDhaCysYDhaDhaDCysYDhbGRHMCysGYDhbHGYDhaCys

antiSMASH-DB 4.0 matches for penA1

69.8%

NZ_CP058561.1:

Lanthipeptides: HYG85_RS07250_lanthipeptide

GLYTSQCYSSQCYSSKCYSDSCYSSDCYTGRHMCGYTHGYSC

GLYTS CY+S CY+S CY+ +CYSSDCYTG++MCGYTH SC

GLYTSTCYTSSCYTSTCYTSTCYSSDCYTGQNMCGYTHTSSC

65.1%

NZ_CP058649.1:

Lanthipeptides: HZI73_RS04950_lanthipeptide

LYTSQCYSSQCYSSKCYSDSCYSSDCYTGRHMCGYTHGYSC

LYTS CY+S CY+S CY+ +CY+SDCYTG++MCGYTH SC

LYTSDCYTSSCYTSSCYTSTCYTSDCYTGQNMCGYTHTSSC

16.3%

NZ_CP040409.1and 4 others:

NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptideNZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptideNZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide

Lanthipeptides: FE336_RS08590_lanthipeptide

CYTGRHMCG

CY+GRH CG

CYSGRHSCG

with 3 more sequence matches

16.0%

NZ_QSIO01000003.1:

Lanthipeptides: DW820_RS07290_lanthipeptide

FGLYTSQCYSSQCYSSKCYSDSC

F T C++S Y+++ S SC

FTPTTPACFASIIYTARASSASC

14.0%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: C3B71_RS16245_lanthipeptide

Lanthipeptides: C3B71_RS16245_lanthipeptide

CYSDSCYSSDCYTGRHMCGYTHGYSC

++D ++D GR +C G

LHTDRHSAADTRPGRRLCAGRQGQPA

14.0%

NZ_CP093291.1and 3 others:

NZ_FMJG01000030.1 Lassopeptides: CCY63_RS29280_lassopeptideNZ_NUML01000016.1 Lassopeptides: COD66_RS30535_lassopeptideNZ_NUVR01000001.1 Lassopeptides: COI88_RS29825_lassopeptide

Lassopeptides: MN093_RS00440_lassopeptide

KCYSDSCYSSDCYTGRH

+ Y D Y+ + TG H

EGYHDEAYNGEPATGPH

penA2

Leader:

MANNVFDLDVEVKSVNSVNQNIGLFTS

Core:

TCFSSQCFSSKCFTDTCFSSNCFTGRHQCGYTHGSC

Core with dehydrations:

DhbCysFDhaDhaQCysFDhaDhaKCysFDhbDDhbCysFDhaDhaNCysFDhbGRHQCysGYDhbHGDhaCys

antiSMASH-DB 4.0 matches for penA2

47.6%

NZ_CP058561.1:

Lanthipeptides: HYG85_RS07250_lanthipeptide

TCFSSQCFSSKCFTDTCFSSNCFTGRHQCGYTHGS

TC++S C++S C+T TC+SS+C+TG++ CGYTH S

TCYTSSCYTSTCYTSTCYSSDCYTGQNMCGYTHTS

43.9%

NZ_CP058649.1:

Lanthipeptides: HZI73_RS04950_lanthipeptide

CFSSQCFSSKCFTDTCFSSNCFTGRHQCGYTHGS

C++S C++S C+T TC++S+C+TG++ CGYTH S

CYTSSCYTSSCYTSTCYTSDCYTGQNMCGYTHTS

22.2%

NZ_FNGF01000002.1and 1 other:

NZ_FNGF01000002.1 Lanthipeptides: BLS99_RS09575_lanthipeptide

Lanthipeptides: BLS99_RS09575_lanthipeptide

SSQCFSSKCFTDTCFSSNC

+ C +S C T TCF+ +C

TDNCATSPCATATCFTVSC

with 3 more sequence matches

17.2%

NZ_RJUP01000016.1:

Lanthipeptides: allorf_085018_085254_lanthipeptide

TCFSSQCFSSKCFTDTCFSSNC

C S C S+ C +D C S NC

ACGSDICMSTVCDSDWCLSFNC

16.7%

NZ_CP040409.1and 4 others:

Lanthipeptides: FE336_RS08590_lanthipeptide

NCFTGRHQCG

C++GRH CG

RCYSGRHSCG

13.9%

NZ_JADPCZ010000011.1and 1 other:

NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide

Lanthipeptides: I4W03_RS06785_lanthipeptide

NCFTGRHQCG

+C++G+H CG

HCYSGKHSCG

MIBiG 4.0 matches for penA2

13.9%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

SSNCFTGRHQCGYTHGSC

++N F+ + G G C

TTNTFSLSNALGNNGGWC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

penA1 - Class I

Cleavage pHMM score: 3.10

RODEO score: 24

Monoisotopic mass: 4646.8 Da

Molecular weight: 4650.0 Da

Number of bridges: 7

Alternative weights: (assuming N unmodified Ser/Thr residues); 4668.0 Da N = 1; 4686.1 Da N = 2; 4704.1 Da N = 3; 4722.1 Da N = 4; 4740.1 Da N = 5; 4758.1 Da N = 6

penA2 - Class I

Cleavage pHMM score: 1.80

RODEO score: 24

Monoisotopic mass: 3750.5 Da

Molecular weight: 3753.1 Da

Number of bridges: 7

Alternative weights: (assuming N unmodified Ser/Thr residues); 3771.1 Da N = 1; 3789.2 Da N = 2; 3807.2 Da N = 3; 3825.2 Da N = 4; 3843.2 Da N = 5