BGC0001289 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001289 (Paenibacillus ehimensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lanthipeptide-class-i	1	10,643	penisin	ribosomal:RiPP	100%

BGC0001289 - Region 1 - lanthipeptide-class-i

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Location: 1 - 10,643 nt. (total: 10,643 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-i: ((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03604))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 10,644
Label		BGC0001289

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001289	1.00	RiPP	penisin	Paenibacillus ehimensis
BGC0002576	0.33	RiPP	mechercharmycin	Thermoactinomyces sp.
BGC0002640	0.31	RiPP	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000538	0.23	RiPP	nisin Z	Lactococcus lactis
BGC0000542	0.23	RiPP	paenicidin B	Paenibacillus terrae
BGC0000541	0.22	RiPP	paenicidin A	Paenibacillus polymyxa
BGC0000556	0.22	RiPP	streptin	Streptococcus pyogenes
BGC0000560	0.20	RiPP	subtilomycin	Bacillus subtilis
BGC0000515	0.19	RiPP	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000506	0.19	RiPP	entianin	Bacillus subtilis subsp. spizizenii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001289	1.00	RiPP	penisin	Paenibacillus ehimensis
BGC0002576	0.66	RiPP	mechercharmycin	Thermoactinomyces sp.
BGC0002640	0.64	RiPP	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000538	0.56	RiPP	nisin Z	Lactococcus lactis
BGC0000542	0.56	RiPP	paenicidin B	Paenibacillus terrae
BGC0000541	0.56	RiPP	paenicidin A	Paenibacillus polymyxa
BGC0000556	0.55	RiPP	streptin	Streptococcus pyogenes
BGC0000560	0.52	RiPP	subtilomycin	Bacillus subtilis
BGC0000515	0.51	RiPP	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000506	0.51	RiPP	entianin	Bacillus subtilis subsp. spizizenii

Similar known gene clusters from MIBiG 4.0

Lanthipeptide predictions

Lanthipeptide(s) for penB

penA1

Leader:

MANNNFDLDVQVKSVNSVNAN

Core:

FGLYTSQCYSSQCYSSKCYSDSCYSSDCYTGRHMCGYTHGYSC

Core with dehydrations:

FGLYDhbDhaQCysYDhaDhaQCysYDhaDhaKCysYDhaDDhaCysYDhaDhaDCysYDhbGRHMCysGYDhbHGYDhaCys

antiSMASH-DB 4.0 matches for penA1

69.8% NZ_CP058561.1: Lanthipeptides: HYG85_RS07250_lanthipeptide

GLYTSQCYSSQCYSSKCYSDSCYSSDCYTGRHMCGYTHGYSC

GLYTS CY+S CY+S CY+ +CYSSDCYTG++MCGYTH SC

GLYTSTCYTSSCYTSTCYTSTCYSSDCYTGQNMCGYTHTSSC

65.1% NZ_CP058649.1: Lanthipeptides: HZI73_RS04950_lanthipeptide

LYTSQCYSSQCYSSKCYSDSCYSSDCYTGRHMCGYTHGYSC

LYTS CY+S CY+S CY+ +CY+SDCYTG++MCGYTH SC

LYTSDCYTSSCYTSSCYTSTCYTSDCYTGQNMCGYTHTSSC

16.3% NZ_CP040409.1and 4 others:

NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptideNZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptideNZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide

Lanthipeptides: FE336_RS08590_lanthipeptide

CYTGRHMCG

CY+GRH CG

CYSGRHSCG

with 3 more sequence matches

16.0% NZ_QSIO01000003.1: Lanthipeptides: DW820_RS07290_lanthipeptide

FGLYTSQCYSSQCYSSKCYSDSC

F T C++S Y+++ S SC

FTPTTPACFASIIYTARASSASC

14.0% NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: C3B71_RS16245_lanthipeptide

Lanthipeptides: C3B71_RS16245_lanthipeptide

CYSDSCYSSDCYTGRHMCGYTHGYSC

++D ++D GR +C G

LHTDRHSAADTRPGRRLCAGRQGQPA

14.0% NZ_CP093291.1and 3 others:

NZ_FMJG01000030.1 Lassopeptides: CCY63_RS29280_lassopeptideNZ_NUML01000016.1 Lassopeptides: COD66_RS30535_lassopeptideNZ_NUVR01000001.1 Lassopeptides: COI88_RS29825_lassopeptide

Lassopeptides: MN093_RS00440_lassopeptide

KCYSDSCYSSDCYTGRH

+ Y D Y+ + TG H

EGYHDEAYNGEPATGPH

penA2

Leader:

MANNVFDLDVEVKSVNSVNQNIGLFTS

Core:

TCFSSQCFSSKCFTDTCFSSNCFTGRHQCGYTHGSC

Core with dehydrations:

DhbCysFDhaDhaQCysFDhaDhaKCysFDhbDDhbCysFDhaDhaNCysFDhbGRHQCysGYDhbHGDhaCys

antiSMASH-DB 4.0 matches for penA2

47.6% NZ_CP058561.1: Lanthipeptides: HYG85_RS07250_lanthipeptide

TCFSSQCFSSKCFTDTCFSSNCFTGRHQCGYTHGS

TC++S C++S C+T TC+SS+C+TG++ CGYTH S

TCYTSSCYTSTCYTSTCYSSDCYTGQNMCGYTHTS

43.9% NZ_CP058649.1: Lanthipeptides: HZI73_RS04950_lanthipeptide

CFSSQCFSSKCFTDTCFSSNCFTGRHQCGYTHGS

C++S C++S C+T TC++S+C+TG++ CGYTH S

CYTSSCYTSSCYTSTCYTSDCYTGQNMCGYTHTS

22.2% NZ_FNGF01000002.1and 1 other:

NZ_FNGF01000002.1 Lanthipeptides: BLS99_RS09575_lanthipeptide

Lanthipeptides: BLS99_RS09575_lanthipeptide

SSQCFSSKCFTDTCFSSNC

+ C +S C T TCF+ +C

TDNCATSPCATATCFTVSC

with 3 more sequence matches

17.2% NZ_RJUP01000016.1: Lanthipeptides: allorf_085018_085254_lanthipeptide

TCFSSQCFSSKCFTDTCFSSNC

C S C S+ C +D C S NC

ACGSDICMSTVCDSDWCLSFNC

16.7% NZ_CP040409.1and 4 others:

Lanthipeptides: FE336_RS08590_lanthipeptide

NCFTGRHQCG

C++GRH CG

RCYSGRHSCG

13.9% NZ_JADPCZ010000011.1and 1 other:

NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide

Lanthipeptides: I4W03_RS06785_lanthipeptide

NCFTGRHQCG

+C++G+H CG

HCYSGKHSCG

MIBiG 3.1 matches for penA2

13.9% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

SSNCFTGRHQCGYTHGSC

++N F+ + G G C

TTNTFSLSNALGNNGGWC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

penA1 - Class I

Cleavage pHMM score: 3.10

RODEO score: 24

Monoisotopic mass: 4646.8 Da

Molecular weight: 4650.0 Da

Number of bridges: 7

Alternative weights: (assuming N unmodified Ser/Thr residues); 4668.0 Da N = 1; 4686.1 Da N = 2; 4704.1 Da N = 3; 4722.1 Da N = 4; 4740.1 Da N = 5; 4758.1 Da N = 6

penA2 - Class I

Cleavage pHMM score: 1.80

RODEO score: 24

Monoisotopic mass: 3750.5 Da

Molecular weight: 3753.1 Da

Number of bridges: 7

Alternative weights: (assuming N unmodified Ser/Thr residues); 3771.1 Da N = 1; 3789.2 Da N = 2; 3807.2 Da N = 3; 3825.2 Da N = 4; 3843.2 Da N = 5