BGC0001290 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001290 (Aspergillus nidulans FGSC A4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,T1PKS	1	37,424	emericellamide A/emericellamide B	NRPS:Type I	100%

BGC0001290 - Region 1 - NRPS,T1PKS

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Location: 1 - 37,424 nt. (total: 37,424 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 37,425
Label		BGC0001290

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001290	1.51	NRP	emericellamide A, emericellamide B	Aspergillus nidulans FGSC A4
BGC0002191	0.64	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002259	0.61	Polyketide, NRP	beauveriolide I, beauveriolide III	Cordyceps militaris CM01
BGC0002525	0.61	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002405	0.61	Saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0002155	0.60	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001252	0.60	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002515	0.55	Polyketide	solanapyrone A	Ascochyta rabiei
BGC0002203	0.55	NRP, Polyketide, Other	beauveriolide B, beauveriolide C, beauveriolide D	Beauveria bassiana ARSEF 2860
BGC0002194	0.54	Polyketide	epipyrone A	Epicoccum nigrum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001290	1.00	NRP	emericellamide A, emericellamide B	Aspergillus nidulans FGSC A4
BGC0002259	0.69	Polyketide, NRP	beauveriolide I, beauveriolide III	Cordyceps militaris CM01
BGC0002191	0.65	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002518	0.65	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.64	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002525	0.64	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0002405	0.64	Saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0002155	0.64	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0001252	0.64	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata
BGC0002203	0.63	NRP, Polyketide, Other	beauveriolide B, beauveriolide C, beauveriolide D	Beauveria bassiana ARSEF 2860

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 37424:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (Gly - Val - Leu - Ala - Ala)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 4637 - 37424:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (Gly - Val - Leu - Ala - Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ANIA_02545

Search NORINE for peptide: strict or relaxed

AMP-binding (1002..1394): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DIQGVLAMQK
Nearest Stachelhaus code(s):: Gly DIQGVLAMQK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2535..2930): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DASQIGGIYK
Nearest Stachelhaus code(s):: Val DASQIGGIYK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3619..4018): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DIHFVGAIAK
Nearest Stachelhaus code(s):: Leu DIHFVGAIAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4731..5133): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DLLVVAGILK
Nearest Stachelhaus code(s):: Ala DLLVVAGILK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (5823..6216): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DIAILVAILK
Nearest Stachelhaus code(s):: Ala DIAILVAILK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ANIA_02547

PKS_AT (586..902): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 58.3%; inactive: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 71.8
Methylmalonyl-CoA: 65.1
Malonyl-CoA: 50.2
Isobutyryl-CoA: 45.6
Ethylmalonyl-CoA: 34.2
fatty_acid: 26.3
Propionyl-CoA: 22.5
2-Methylbutyryl-CoA: 21.2
3-Methylbutyryl-CoA: 20.9
inactive: 17.9
Benzoyl-CoA: 11.0
trans-1,2-CPDA: 10.2
Acetyl-CoA: 9.0
CHC-CoA: 0.0

ANIA_02549

AMP-binding (48..465): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLGYVGAVVK
Nearest Stachelhaus code(s):: nohBza GLGLVGAIIK (41% 8Å match)
Stachelhaus code match:: 70% (weak)