BGC0001293 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001293 (Streptomyces sp. NCIB 11649)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	49,740	cyclizidine	PKS	100%

BGC0001293 - Region 1 - T1PKS

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Location: 1 - 49,740 nt. (total: 49,740 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 49,741
Label		BGC0001293

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001293	1.00	Polyketide	cyclizidine	Streptomyces sp. NCIB 11649
BGC0001273	0.36	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000041	0.35	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000996	0.32	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001276	0.32	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000170	0.31	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001244	0.31	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000919	0.31	Other	phaseolotoxin	Pseudomonas syringae
BGC0002615	0.31	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre
BGC0000068	0.31	Polyketide	geldanamycin	Streptomyces hygroscopicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001293	1.00	Polyketide	cyclizidine	Streptomyces sp. NCIB 11649
BGC0001273	0.69	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000041	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000996	0.65	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001276	0.65	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000170	0.65	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001244	0.65	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0000919	0.65	Other	phaseolotoxin	Pseudomonas syringae
BGC0002615	0.64	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre
BGC0000068	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 49740:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - ccmal) + (Me-ccmal - ccmal) + (Me-redmal - ccmal) + (ccmal)
Non-colinear ordering:: cycF + cycE + cycC + cycB

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cycB

PKS_AT (556..855): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.1
inactive: 92.9
Methylmalonyl-CoA: 60.6
Methoxymalonyl-CoA: 57.1
Propionyl-CoA: 37.9
Acetyl-CoA: 37.1
Isobutyryl-CoA: 35.8
Ethylmalonyl-CoA: 35.1
Benzoyl-CoA: 26.9
fatty_acid: 19.3
CHC-CoA: 18.1
2-Methylbutyryl-CoA: 15.2
trans-1,2-CPDA: 9.7
3-Methylbutyryl-CoA: 0.0

cycC

PKS_AT (348..673): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.8
Ethylmalonyl-CoA: 183.0
Methoxymalonyl-CoA: 163.9
2-Methylbutyryl-CoA: 133.1
trans-1,2-CPDA: 104.6
Malonyl-CoA: 93.3
Propionyl-CoA: 92.7
CHC-CoA: 81.6
Isobutyryl-CoA: 56.3
Benzoyl-CoA: 37.8
Acetyl-CoA: 35.2
inactive: 28.3
fatty_acid: 26.7
3-Methylbutyryl-CoA: 24.7

PKS_AT (2468..2767): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 183.9
inactive: 97.0
Methoxymalonyl-CoA: 58.7
Methylmalonyl-CoA: 57.0
Isobutyryl-CoA: 36.9
Acetyl-CoA: 36.8
Propionyl-CoA: 35.9
Ethylmalonyl-CoA: 35.2
Benzoyl-CoA: 29.8
fatty_acid: 26.8
CHC-CoA: 18.4
2-Methylbutyryl-CoA: 12.6
trans-1,2-CPDA: 12.5
3-Methylbutyryl-CoA: 0.0

cycE

PKS_AT (578..885): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.5
Ethylmalonyl-CoA: 185.0
Methoxymalonyl-CoA: 167.4
2-Methylbutyryl-CoA: 141.4
Malonyl-CoA: 113.2
trans-1,2-CPDA: 112.3
CHC-CoA: 107.8
Propionyl-CoA: 105.2
Isobutyryl-CoA: 62.9
Benzoyl-CoA: 50.0
Acetyl-CoA: 41.6
3-Methylbutyryl-CoA: 37.1
inactive: 35.9
fatty_acid: 30.2

PKS_AT (2339..2638): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 183.9
inactive: 93.2
Methylmalonyl-CoA: 57.7
Methoxymalonyl-CoA: 57.6
Propionyl-CoA: 36.3
Isobutyryl-CoA: 34.0
Acetyl-CoA: 31.6
Ethylmalonyl-CoA: 27.1
fatty_acid: 22.1
CHC-CoA: 16.2
Benzoyl-CoA: 15.4
trans-1,2-CPDA: 14.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.4

cycF

PKS_AT (283..585): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.7
Ethylmalonyl-CoA: 183.6
Methoxymalonyl-CoA: 156.9
2-Methylbutyryl-CoA: 138.4
trans-1,2-CPDA: 134.0
Propionyl-CoA: 111.0
CHC-CoA: 87.1
Malonyl-CoA: 86.5
Isobutyryl-CoA: 47.2
fatty_acid: 32.3
3-Methylbutyryl-CoA: 30.3
Benzoyl-CoA: 29.1
Acetyl-CoA: 22.2
inactive: 19.7

PKS_AT (1308..1607): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.5
inactive: 93.9
Methylmalonyl-CoA: 59.4
Methoxymalonyl-CoA: 57.5
Acetyl-CoA: 39.7
Propionyl-CoA: 38.7
Isobutyryl-CoA: 36.5
Ethylmalonyl-CoA: 31.9
fatty_acid: 22.1
CHC-CoA: 19.7
Benzoyl-CoA: 17.7
trans-1,2-CPDA: 13.9
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.4