LOCUS       BGC0001295             18154 bp    DNA     linear   BCT 31-AUG-2015
DEFINITION  Streptomyces cremeus cremeomycin biosynthetic gene cluster, complete
            sequence.
ACCESSION   BGC0001295
VERSION     BGC0001295
KEYWORDS    .
SOURCE      Streptomyces cremeus
  ORGANISM  Streptomyces cremeus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 15:16:26
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..1098
                     /gene="creA"
     CDS             1..1098
                     /codon_start=1
                     /gene="creA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /note="oxidoreductase"
                     /product="CreA"
                     /protein_id="ALA99198.1"
                     /sec_met_domain="PF00881 (E-value: 6.1e-20, bitscore: 61.8,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIRRRAQLICRWVPEGLEVGVPGRRQWVRLSPELREILERAGEG
                     VGTDELAAAFGEENAPQLRAALDKLTAIGLLVPADSEVRPAPLWERWGGVAERFHVEGR
                     DADYLVESPRRGEVAGEIVAEGGMPDAFKEYPGRPVVPLPRRPLPLHGTVDDVFAARRT
                     HRLFTEDPVGIDQLSTLLFHGFGPHRFLDGGPFGVQQARVSSSAGGRHEVEAYLVAHNV
                     TGVAPGLYHYSAARHVLELLDADVRREQVEELTYRQEASYRGAFTIFTTAVANRLAWKY
                     RHPRAYRLWMYDAGHYGQTFALAATALGLGPFQTVAFEDSAVERLLGVDPDEEFAVYLL
                     AAGVPREAGPLLPSDFAHPRPAALR"
     source          1..18154
                     /db_xref="taxon:66881"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces cremeus"
                     /strain="NRRL 3241"
                     /type_material="type strain of Streptomyces cremeus"
     misc_feature    1..18154
                     /note="cremeomycin biosynthetic gene cluster"
     subregion       1..18154
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001295"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..18154
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1191..2390
                     /gene="creB"
     CDS             1191..2390
                     /codon_start=1
                     /gene="creB"
                     /note="cupin protein"
                     /product="CreB"
                     /protein_id="ALA99199.1"
                     /transl_table=11
                     /translation="MALKRCVAVTPHEFRKAVFGNHHLHTRAEELAEGFTDLFSPDALE
                     DLLSGGMRLSSLRLVRDGVECPVDTGAVPESGDAPGAPPFPHTDAIRAGLAAGQTLIVR
                     SLHRFHAPLRRFAHALSAELGHPVKINAFLTPPGSQGVDLHFDIQDVLVLQVAGEKRWV
                     LRTRPVRDPLPAQAWFDIPEHRRAELRAASEPLDDLTLRPGDTLYLPRGTMHSPVALDT
                     LSIHLTVAVTRLTRHDLLAELVRRAAEDEWLRAGVEPDDWAEDPEQARAFLGRAVERLG
                     EFARGDDPRELLWDVRRKAFREQTPEPVPVLPGGPAAGHRLREGVHFRLRGESADGVEL
                     LVGPRRVRLPRPVAPVLETLRYDPALDGSRLVAELGEEVARKVTAALVAMGLLVPVPPA
                     "
     gene            2411..3814
                     /gene="creC"
     CDS             2411..3814
                     /codon_start=1
                     /gene="creC"
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 219.2; E-value: 1.5e-66)"
                     /gene_kind="transport"
                     /note="major facilitator superfamily protein"
                     /product="CreC"
                     /protein_id="ALA99200.1"
                     /transl_table=11
                     /translation="MTEDTARPDRTAADGSGGVPGTAGGTPHADGGPPAASGTGGGASG
                     TADGASGASGAPGADAGKLRHHPRFLRLWASQATGAVGDQVLPVALSLYVLERGGGASG
                     VGLVLGGRAVALVLCLLIGGVIADRLRRTRILIGADCFRAVLLLAAGLLLTRLPLGALP
                     VITALVGAGEALSRPASRSLVPNLLPAALLERGNALVSAVQRGSAVLGAMLGVTAVALI
                     GTRTALLVVSGVFALGALVVARIPDERRDAKGRASVLAEAAEGLRAIRRRPWVMAMMGT
                     VCLHLFAGSATALTLLPIVAREELGGDFAYGVVLSAMGIGALPAIVLAGRWRPASRGTV
                     SVVALTGYALVPLSLAAPFPLPAVVVCFALGGFVVELYFVYWVSALQRAFPDAVLGKVF
                     ALDQLGAYALLPVGYALVGPLVALLGTTVTLVAGGVVVALSSLLCLLVPGVKRFEDPVP
                     PPAPAARAA"
     gene            complement(4420..5850)
                     /gene="creD"
     CDS             complement(4420..5850)
                     /codon_start=1
                     /gene="creD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 208.8; E-value: 2.5e-63)"
                     /gene_kind="biosynthetic-additional"
                     /note="3-carboxy-cis,cis-muconate cycloisomerase"
                     /product="CreD"
                     /protein_id="ALA99201.1"
                     /transl_table=11
                     /translation="MTRPPAPPPGAPGADELLDCGLLSPVRAGTPVEALVCDSAWLQAM
                     LDAEAALTRAQARTGFLPAAAAEAITAAARADRIDLLAVARGARETANPVVGLVAALTA
                     AVRRDDPAAAEYVHRGSTSQDVLDTGAMLVARRALRLIGDDLDRAADALAALAADHRDT
                     PMAGRTLALHAVPTTFGLKAAGWLELVSEAAGRVARLRDGLPFSLGGAAGTLAGYFGDR
                     TDRGDPAVLLDRLLDAYAAETGLARPVLPWHVLRTPVADLAAVLAFTAGALGKIAVDVQ
                     SLARTEVAEVAEPAVEGRGASSAMPHKRNPVLSTLIRSAALQVPALATGLTQCLVSEDE
                     RSAGAWHAEWQPLRECLRLTGGAARTAVELAAGLEVDAARMRANLDLTDGRIVSESVAV
                     ALTPLLGRQAAKELLTRAAFTAGHEGRTLGEVLGELPELDGVLPKERWEALLDPARATG
                     VAGALVDGALARRRPPAR"
     gene            complement(5847..7847)
                     /gene="creE"
     CDS             complement(5847..7847)
                     /codon_start=1
                     /gene="creE"
                     /note="oxidoreductase"
                     /product="CreE"
                     /protein_id="ALA99202.1"
                     /transl_table=11
                     /translation="MSVRRLTVCIVGAGPRGLSVLERFCAHERKSASHPAVTVHVVDPA
                     RPGAGRVWRTGQPRQLLMNTVASQVTVFTDGSVDMAGPVEAGPSLHEWARELAALTPVE
                     ELLGGHDDATLAEARALGADSYPTRAFYGCYLEEMFRRVVCGAPAHLEVRVHRSTAVSL
                     ADETPGSGGAQSLLLADGTRLAGLDAVVLALGHVRAEEPGAPDPRAAALGLAHFPPANP
                     ADLDLSGIAPGTPVLLRGLGLNFFDHMALFTLGRGGAFSRRPHGLRYHPSGLEPRLYAG
                     SRRGVPYHARGENEKGVDGRHTPLLLTPERIAELTGRHREGPGLSFLRTLWPLIAREVE
                     CVYYGTLLASRGRAAERDAFVTAYLAGGDDTDRGGVLERFGIGPADRWCWERTASPHPR
                     HGFTGPDGHRRWLLEHLAQDVRRARAGNVSDPHKAALDVLRDLRNEIRLVVDHGGLDGL
                     SHRDDLDGWYTGLNAFLSIGPPASRIEEMAALIEAGVLDVVGPGLEVDIDEADAAFVAR
                     SPLVPGRPVRAHVLIEARLPVTDLRRTADPLLRDLLRSGQCRSYRIPAGRAPEGYETGG
                     LEVTRRPYRLVDALGRAHPRRFAFGVPTEAVHWVTAAGARPGVNSVTLGDADAIAHAVA
                     SLTPAAAPRLPAYEDPGVRCPSDDRLTEVTA"
     gene            complement(7991..9094)
                     /gene="creH"
     CDS             complement(7991..9094)
                     /codon_start=1
                     /gene="creH"
                     /note="3,4-AHBA synthase"
                     /product="CreH"
                     /protein_id="ALA99203.1"
                     /transl_table=11
                     /translation="MKLSWIDIRTIGSAKDAVVQEALHAGVHGILSDRVEDLAPLPPSV
                     KRVLFPQGQALPEDFGAADVVIVDPAKHGEPAELALLHPDVEFGRFTEIVDAETLEEAC
                     ASGRQEKWSVLLFRDPTKIPLEIVIAAAARATGSLITVAQDVEEAEIIFGVLELGSDGV
                     LMAPARVGDATALRQAAETGVPDLELVELEVTATAHVGMGERACVDTATYFRKDEGILV
                     GSHSKGMILCVSETHPLPYMPTRPFRVNAGAIHSYTLAKDERTNYLSELKAGSKITAVD
                     IHGKTRLVTVGRVKIETRPLLSIDAVGRDGRTANLILQDDWHVRVLGPGGTVLNSTELK
                     PGDKVLGYLPVADRHVGYPIEEFCLEK"
     gene            complement(9091..9906)
                     /gene="creI"
     CDS             complement(9091..9906)
                     /codon_start=1
                     /gene="creI"
                     /note="aldolase"
                     /product="creI"
                     /protein_id="ALA99204.1"
                     /transl_table=11
                     /translation="MARLAGHGDGNLLLVPLDHSVSDGPIASVEGFHQLVRDVVAGGAD
                     GLVVHKGRARLLDPLLFSTCSLLVHLSASTAHGPDVDAKVLVGDVEDAVRLGADAVSVH
                     VNIGSDTESAQLSDLGTVAAACDRWGMPLLAMIYPRGPRLTRPPSPELVAHVVNVAADL
                     GADLVKTVFVGPVERMAEVVAASPLPVLVAGGADQRQSLAEFAGTAMAAGCRGLAVGRR
                     VFASASPRQTVRELSAIVHGRPADAEAVGFPAPVAHSSSTPSSALAGAL"
     gene            10341..11204
                     /gene="creF"
     CDS             10341..11204
                     /codon_start=1
                     /gene="creF"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     268.9; E-value: 1.9e-81)"
                     /gene_kind="regulatory"
                     /note="SARP family regulator"
                     /product="CreF"
                     /protein_id="ALA99205.1"
                     /transl_table=11
                     /translation="MEDALYTSTFSPGQTLNTGIGAAGSPDRGLRCGVLGPLYIGIGES
                     AESAPVAPKIRTVLATLAVSADFVVPVSVLMREIWGENPPASGLRTLQTYILNCRKTLA
                     KLTGLSLAETAQEILVTRPGGYSYKSAAGTLDWQDFRRLSDLGRRAVEAGEDDRAIHLL
                     DGALSLWRGSVFADVPEGPVLETRRRLFDEWRLGAMETLAEARLRTGLHQLAIADLAAL
                     TSEFPLHEGLHGQYMRALALVGRRALALEVFSLLRARLVEEIGIEPGRDLQDLQLAILN
                     SHSGGT"
     gene            complement(11179..11928)
                     /gene="creG"
     CDS             complement(11179..11928)
                     /codon_start=1
                     /gene="creG"
                     /note="regulatory protein"
                     /product="CreG"
                     /protein_id="ALA99206.1"
                     /transl_table=11
                     /translation="MSVHGYRTPSRANLPRPAAPRSCEEPPGSAVEAVPVDLLLPAGHG
                     RSGRGAAGPVAGAGQGDGRPVVVHRGTMRVIVGAAVLYAARARGARTVDVRFFDGSLEE
                     ALTMAAESALALPAVTTPAQRAAEAARLLRAHPQWSDRAVAAAAGVSPKTVAAHRARLR
                     GTAAAPQKRIGLDGRARPLSSAEGRALAGRLLLDAPGASLREIASRAGISPATVRDVRE
                     RLKRGENPVPPGCAPSAAQVRSRPSGS"
     gene            complement(12024..12530)
                     /gene="creJ"
     CDS             complement(12024..12530)
                     /codon_start=1
                     /gene="creJ"
                     /note="BadM/Rrf2 transcriptional repressor"
                     /product="CreJ"
                     /protein_id="ALA99207.1"
                     /transl_table=11
                     /translation="MSEIARVLVMKLSNGVEWGLHCCVSISQSDGPVSAARLAELHGVP
                     PSYLAKHLQALSRAGIVRSTPGPVGGYAFTRPAAEVSVLQVVQAVDGPEPAFRCTEIRR
                     RGPLALSPERCEKPCAVSRAMATAETAWREALAGISVADLAGRIDQDSSGTAMRDLRSW
                     LAGAP"
     gene            12598..13893
                     /gene="creK"
     CDS             12598..13893
                     /codon_start=1
                     /gene="creK"
                     /gene_functions="transport (smcogs) SMCOG1137:Major
                     facilitator superfamily MFS 1 (Score: 71.7; E-value:
                     7.6e-22)"
                     /gene_kind="transport"
                     /note="Major facilitator superfamily protein"
                     /product="CreK"
                     /protein_id="ALA99208.1"
                     /transl_table=11
                     /translation="MADTDDRLRLGGPQAPGAGDRTAADARPGPAPAADARVALGLAAL
                     ALFVAAANLRPAIAAVSPLVDRIRTDLDLSATGVALLTTVPTLAMGACAPLAASIGRRW
                     GLQRGVLAGLFVVGLATAVRGLGEAAWLQLCAAAVVGAGIAVAQTLLPAVVKTRFAARA
                     GLVTGIYTAGLGLGGAVAAGASAPLAQALGSWPGALASWAVLAVIGIVMWTAARRSLGL
                     EHVAGPKGPATSGLPWRSSLAWRITALSAANSALYYCELAWIAPLLHDSGGVSEANAGV
                     MLTVMISIQVVAMLGVPALLGERADKRTGLAATSVLTAIGFLGFAFSPGTGAWIWILAM
                     GIGHGGLFTLVLTLPVSASRDAVQAGRFSAMAFFVGYGCAAVGPVLVGGLRDITGDYRL
                     AFGLLAVITFLMLLPIARLSPRRIEQDQQKAL"
     misc_feature    12619..12621
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14139..15323
                     /gene="creL"
     CDS             14139..15323
                     /codon_start=1
                     /gene="creL"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 298.6; E-value: 1.2e-90)"
                     /gene_kind="other"
                     /note="flavin-dependent monooxygenase"
                     /product="CreL"
                     /protein_id="ALA99209.1"
                     /transl_table=11
                     /translation="MVDRDIRIAVVGAGVAGLTVAALLRDRGVDCRVFERAPRLVAVGA
                     GIQLSPNGVRVLHGLGLRDSLAATGVRARAIETRSWADGAPIARTPLGDRCEELYGAPY
                     YLIHRADLHRCLTSLLPASAVELGRACARVEERPDAVRLHFTDGTMADADLVIGADGVH
                     SVVRRSVVRDAPRYAGYAVHRGLVPASVVPSFRDDPRVMFWLGPGRHVTYYPVAGGRTV
                     HFSAVGVSPEESPGGGPEDLGAAFGHWHEEVRRVVTSASSVTRWGLYDRDIPDRYATGR
                     VVLLGDAAHPTLPYLSQGANQALEDVTTLVGCLDARPGAPQEAVRQYESLRLPRTAEVH
                     RRARRLAEEFHLPDGPECTDRDQRMRATQDPTHLAWLYGRTAGLPDASDLAPRP"
     gene            15399..17060
                     /gene="creM"
     CDS             15399..17060
                     /NRPS_PKS="Domain: AMP-binding (43-451). E-value: 5.6e-44.
                     Score: 142.2. Matches aSDomain:
                     nrpspksdomains_creM_AMP-binding.1"
                     /codon_start=1
                     /gene="creM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     146.7; E-value: 1.3e-44)"
                     /gene_kind="biosynthetic-additional"
                     /note="long-chain fatty acid CoA ligase"
                     /product="CreM"
                     /protein_id="ALA99210.1"
                     /sec_met_domain="AMP-binding (E-value: 2.3e-41, bitscore:
                     131.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHALLRRVTRGNGFYIGDLFHAAAGHDATTPVTLDQPLQYAPELG
                     TRFTVGQLAEQTDELAARLWAAGVRPTERVALYKKDNFDIALHACAAARIGAVPALLSP
                     ALEAPVVRTLLDRLDGPWLLTDATTLAGPLGTVLAPASVRAVLLTTGTPAEGALPAAGA
                     TGPAREGDAPPPAPVVRLADHRGAPKRPPVFLHPRQPSLITHSSGTTGVPKLAVHCPEA
                     GWHRLVPQKVVSWPIRGKEKAALCMTFVHSRFYQGLAMFLSHGNPMLIAVDPDPSRIGP
                     LFARERPGYIETHPNTYVDWEALADAPGEPLAGVRVFGATFDAMHPRTIQRMLGASRRT
                     RPLFVQFYGQSEIGPMAGRWYTRRSAARMNGRCVGLPLPGFISLRVVDDAGKRLRGGRT
                     GHLEVRSRTRILTYLGEDQRYAEQLHDGWWRVGDMGRRDRWGLLHLLDREVDRIGDLES
                     SLAVEDLLMSRLEELREVVLVPGADGEPVPVVATVDESPLDAARWQRATSDLPTMAPVR
                     QFRFEDLPRTSTRKIQKPELARLIQGVRATDQGVGA"
     aSDomain        15528..16751
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_creM_AMP-binding.1"
                     /evalue="5.60E-44"
                     /label="creM_AMP-binding.1"
                     /locus_tag="creM"
                     /protein_end="451"
                     /protein_start="43"
                     /score="142.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LGTRFTVGQLAEQTDELAARLWAAGVRPTERVALYKKDNFDIALH
                     ACAAARIGAVPALLSPALEAPVVRTLLDRLDGPWLLTDATTLAGPLGTVLAPASVRAVL
                     LTTGTPAEGALPAAGATGPAREGDAPPPAPVVRLADHRGAPKRPPVFLHPRQPSLITHS
                     SGTTGVPKLAVHCPEAGWHRLVPQKVVSWPIRGKEKAALCMTFVHSRFYQGLAMFLSHG
                     NPMLIAVDPDPSRIGPLFARERPGYIETHPNTYVDWEALADAPGEPLAGVRVFGATFDA
                     MHPRTIQRMLGASRRTRPLFVQFYGQSEIGPMAGRWYTRRSAARMNGRCVGLPLPGFIS
                     LRVVDDAGKRLRGGRTGHLEVRSRTRILTYLGEDQRYAEQLHDGWWRVGDMGRRDRWGL
                     LHLLDREVD"
     gene            17057..18154
                     /gene="creN"
     CDS             17057..18154
                     /codon_start=1
                     /gene="creN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 291.9; E-value:
                     1.1e-88)"
                     /gene_kind="biosynthetic-additional"
                     /note="O-methyltransferase"
                     /product="CreN"
                     /protein_id="ALA99211.1"
                     /transl_table=11
                     /translation="MTVPENAQHTAPDQTQHTAPDRTRQAQQAAPDTAGRRLIELMAGF
                     WKTQAIYLAAESGLVDAIAAAGRAPAVELANRTGTDPDALGRLLLFLESLDVVSGEDPA
                     GYALTPVGELLRTGTQDSMRDHVRIYGSHFYRAWGALDHSLRTGRSAFTEVYGSDLFRY
                     LNQHPDLSLTYERAMVAGTPFFAQVPEVHDFSGARLIVDVAGGHGALLHEILKSCPEPR
                     AVLFDAPHVIAETADRPIASEHGDRVTLVPGDFFEGVPQGGDVYLLSRILHCFDDEACL
                     RILAHCRSAMAPGGRLVVVERLLTRGTGSSLAQGYNMHMLVVLGGGRERDEDAYRTLLE
                     KAGFQLDSVTTLPLETHLMAATLRR"
ORIGIN
        1 ttgaagattc gccgccgcgc gcaactgatc tgccgctggg tccccgaggg cctggaggtc
       61 ggcgtgcccg ggcgccgcca gtgggtccgg ctctcacccg agctgcgcga gatcctggag
      121 cgggccggcg aaggcgtcgg aacggacgaa ctcgccgccg cgttcggcga ggagaacgcc
      181 ccccaactgc gcgccgcact ggacaagttg accgccatcg gcctcctggt tccggccgat
      241 tccgaagtgc ggcccgcgcc gctctgggag cgctggggcg gcgtcgccga gcgcttccac
      301 gtcgaaggcc gcgacgcgga ctacctggtc gagtcccccc gcaggggaga ggtggccggg
      361 gagatcgtgg ccgagggcgg catgcccgac gcgttcaagg agtaccccgg ccgtcccgtc
      421 gtgccgctgc cccggcggcc gctgccgctg cacggcacgg tcgacgacgt cttcgccgcg
      481 cgccgcaccc atcggctctt caccgaggac ccggtcggca tcgaccagtt gagcaccctg
      541 ctgttccacg gcttcggccc gcaccggttc ctcgacggcg gccccttcgg cgtgcagcag
      601 gcccgggtca gctcctccgc gggcggccgg cacgaggtgg aggcgtacct cgtcgcgcac
      661 aacgtgaccg gcgtcgcccc cggcctctac cactactccg ccgcccggca cgtcctggaa
      721 ctcctcgacg ccgatgtgcg ccgggaacag gtcgaggagc tgacgtaccg ccaagaggcg
      781 tcgtaccgtg gggcgttcac cattttcacc accgccgtgg cgaaccggct ggcgtggaag
      841 taccggcacc cgcgcgccta ccggctgtgg atgtacgacg ccggacacta cgggcagacg
      901 ttcgcgctgg ccgcgaccgc gctcggactg ggccccttcc agacggtggc cttcgaggac
      961 agcgcggtcg agcggctcct cggcgtcgac ccggacgagg agttcgccgt gtacctgctc
     1021 gccgccggcg tcccgcggga ggccggcccg ctcctgccgt cggacttcgc gcacccgcgg
     1081 ccggccgccc tgcgctgaaa cccgggctcc gggccgcccc ccggacccgt accccgcacg
     1141 ccccaacccg ccccctggtc cgcccgcgcc gagaccggca ggagatcgcc atggccctga
     1201 aacgctgcgt cgccgtcacc ccgcacgaat tccgcaaggc ggtcttcggg aaccaccatc
     1261 tgcacacccg tgccgaggaa ctggccgagg gcttcaccga cctgttctcc ccggacgcgc
     1321 tggaggacct gctctcgggc ggcatgcggc tgtcgtccct gcggctggtg cgcgacggcg
     1381 tcgagtgccc cgtcgacacg ggggcagttc cggagtccgg cgacgccccc ggcgccccgc
     1441 cgtttccgca caccgacgcg atccgggccg ggctggccgc gggacagacc ctcatcgtcc
     1501 gctcgctgca ccgcttccac gcgccgctgc ggcgcttcgc ccacgcgttg tccgccgagc
     1561 tcgggcaccc ggtcaagatc aacgccttcc tcaccccgcc cggctcccag ggcgtggacc
     1621 tgcacttcga catccaggac gtcctggtcc tccaggtggc gggcgagaag cgctgggtcc
     1681 tgcgcacccg gccggtccgc gacccgctgc ccgcgcaggc ctggttcgac atccccgagc
     1741 accgccgcgc ggaactgcgc gccgcctccg aaccgctcga cgacctgacg ctgcgcccgg
     1801 gggacaccct ctacctgccg cgcggcacca tgcactcgcc ggtggccctg gacacgctgt
     1861 ccatccacct caccgtcgcc gtcacccggc tgacccggca cgacctgctc gccgaactgg
     1921 tgcgccgggc cgccgaggac gagtggctgc gggccggtgt cgaacccgac gactgggccg
     1981 aggaccccga gcaggcccgt gcgttcctcg gccgggccgt cgagcgcctc ggggagttcg
     2041 cgcgcggcga cgacccgcgg gaactgctgt gggacgtacg caggaaggcc ttcagggagc
     2101 agacgcccga accggttccg gtgctgcccg gcggtccggc cgccggccac cggctgcgcg
     2161 agggcgtcca cttccggctc cgcggcgagt ccgcggacgg cgtcgaactc ctggtgggac
     2221 cgcgccgggt ccggctgccc cggcccgtcg cccccgtcct ggagacgctg cggtacgacc
     2281 cggccctcga cgggagcagg ctcgtcgccg aactcggcga ggaggtcgcc cggaaggtga
     2341 cggccgccct cgtcgcgatg ggactgctgg tcccggtacc acccgcatag acagacgcag
     2401 aaggagaacc atgaccgagg acaccgcgcg cccggaccgc accgcggcgg acgggagcgg
     2461 gggagtgccg gggacggccg gagggacgcc gcacgcggac ggcggccctc ccgccgcctc
     2521 cggcacgggc ggcggcgctt ccggtacggc cgacggcgcg tccggtgctt ccggagcgcc
     2581 cggcgccgac gcggggaagc tgcggcacca cccgcgcttc ctgcgcctgt gggcgagcca
     2641 ggcgaccggc gcggtcggcg accaggtgct gcccgtggcg ctcagcctgt acgtcctcga
     2701 acggggcggc ggcgcgagcg gcgtcggtct ggtgctgggc ggccgggcgg tcgccctcgt
     2761 gctgtgcctg ctgatcggcg gagtgatcgc cgaccggctg cggcgcaccc gcatcctcat
     2821 cggcgcggac tgcttccgcg cggtgctgct gctcgccgcc ggactgctgc tgacccggtt
     2881 gccgctcggc gcgctgccgg tgatcaccgc gctggtcggc gcgggcgagg cgctgtcgcg
     2941 tcccgcgtcg cgctccctgg tgcccaacct gcttccggcg gcgctgctgg agcgcgggaa
     3001 cgcgctggtc tccgccgtcc agcgcggttc cgccgtgctg ggcgcgatgc tcggcgtcac
     3061 cgcggtggcg ctgatcggca cgcgcaccgc gctgctggtg gtcagcggcg tcttcgcgct
     3121 gggcgcgctg gtcgtggcgc ggatacccga cgaacggcgc gacgcgaagg gccgcgcctc
     3181 agtgctcgcg gaggcggcgg aggggctgcg ggcgatccgc cgcaggccct gggtgatggc
     3241 catgatgggg acggtctgcc tgcacctgtt cgccggttcg gccaccgcgc tcaccctgct
     3301 gccgatcgtg gcgcgcgagg agctgggcgg tgacttcgcg tacggcgtgg tgctgtcggc
     3361 gatgggcatc ggggcgctgc cggccatcgt gctcgcgggc cgctggcggc cggcgtcgcg
     3421 cggcaccgtc tcggtcgtcg cgctcaccgg gtacgcgctg gtgccgctga gcctcgcggc
     3481 ccccttcccg ctgcccgccg tggtggtctg cttcgcactc ggcggcttcg tggtcgagct
     3541 gtatttcgtc tactgggtct ccgcgctcca gcgggccttc cccgacgcgg tgctgggcaa
     3601 ggtcttcgcg ctggaccagt tgggcgccta cgcgctgctc ccggtcgggt acgcgctcgt
     3661 cgggcccctg gtggcactgc tgggcaccac cgtcaccctg gtggcgggcg gcgtggtggt
     3721 cgcgctgtcc agtctgctgt gcctgctggt gcccggggtg aagcggttcg aggaccccgt
     3781 cccgcctccc gcccccgccg cccgcgcggc ctgaacggca gggcgtacgc gcgagccgga
     3841 ccgcaggccg gacgcaccgc ccggccgcgt gccgcgcccg cgcgtgccgc gcccgcgcgt
     3901 gccgcgctca gaccgccgcc gccaggacgt ggaagggggt caggcccgtc cgtgccgccg
     3961 gacgcccggc ggagtgcggg ccccgggcgg cgaggatctc gcgcagcagg gcctcccgct
     4021 gttcggggcc gcccgcccgg ccggtgagca cccggtcggc ggcgtacggc gccggacccg
     4081 gcagcgcccc ggggctcgtg cgcagccgca gcgcgaccag cacgccccac tccgtcgccg
     4141 agccggtgag ggtgacggtg acgcgcacct cggggaaggc caccgtcacc gtgtcgtgct
     4201 cgcaggacac ctggtgggcg tcggccagcc ggcggtcgcc gatgatcagg gcgaagcgca
     4261 gggcgagacc gctgcgctcc agccgtatcc gccggtgcag cggaacaagg gacatgggca
     4321 cggaacactc ctcgcgatgg ggggcggggg cccggcccgt gggggcggcg gacccgatgg
     4381 gggtgtcgcg ggttcggtcc acgggaccgg cggcccggtt caccgggccg gcgggcggcg
     4441 ccgggcgagc gcgccgtcca ccagcgctcc cgcgaccccg gtggcacgtg ccggatcgag
     4501 cagcgcctcc caccgctcct tcggcagcac cccgtccagt tcgggcagtt cgccgagcac
     4561 ctcgcccagc gtccggccct cgtggccggc ggtgaacgcg gcccgggtca gcagttcctt
     4621 cgccgcctgc ctgccgagca gcggggtgag cgccaccgcg accgactccg agacgatccg
     4681 gccgtccgtg aggtcgaggt tggcccgcat ccgggcggcg tccacctcca gccccgccgc
     4741 gagctccacg gcggtgcggg cggcgccccc ggtcagccgc aggcactcgc gcagcggttg
     4801 ccactccgcg tgccaggcgc ccgccgaccg ctcgtcctcc gacaccaggc actgggtcaa
     4861 ccccgtggcc agggcgggca cttggagcgc agcgctgcgg atcagcgtcg acaggacggg
     4921 attgcgtttg tgcggcatcg cggaggaagc gccgcgcccc tccacggccg gctcggcgac
     4981 ttccgccacc tccgtgcggg ccagtgactg cacgtccacc gcgatcttcc cgagcgcccc
     5041 ggcggtgaac gcgagcacgg cggccagatc ggccacgggg gtgcgcagca cgtgccaggg
     5101 cagcaccggc cgggcgagcc cggtctccgc cgcgtaggcg tcgaggagcc ggtcgaggag
     5161 gacggccggg tcgccccggt ccgtgcggtc gccgaagtac ccggcgagcg tgcccgccgc
     5221 gccgcccagc gagaacggca gcccgtcgcg cagccgcgcc acccgccccg cggcctcgct
     5281 gacgagttcc agccagccag cggccttcag cccgaacgtc gtcggcacgg cgtgcagggc
     5341 cagcgtgcgg ccggccatgg gggtgtcgcg gtggtcggcg gcgagcgccg cgagggcgtc
     5401 ggccgcccgg tccaggtcgt cgccgatcag gcgcagcgcc cggcgggcga cgagcatcgc
     5461 cccggtgtcc agcacgtcct ggctggtgga gccccggtgg acgtactcgg ccgccgccgg
     5521 gtcgtcccgg cggaccgcgg cggtgagcgc cgccaccagc cccaccacgg ggttggcggt
     5581 ctcccgggcg ccccgggcga ccgcgagcag gtcgatccgg tcggcccgcg ccgccgcggt
     5641 gatcgcctcg gccgcggcgg cgggcaggaa gccggtcctg gcctgggcgc gggtcagcgc
     5701 ggcctccgcg tcgagcatcg cctggagcca ggcggagtcg cagaccagcg cttcgacggg
     5761 ggtgccggcc cggacggggg acagcagccc gcagtcgagc agctcgtcgg cgccgggggc
     5821 gccgggcggg ggtgcggggg gtctggtcat gccgtcacct cggtgagccg gtcgtcggag
     5881 gggcagcgga cgccggggtc ctcgtacgcg ggcagccggg gggcggcggc cggcgtgagc
     5941 gaggcgacgg cgtgggctat cgcgtcggcg tcccccaggg tgaccgagtt gacgccgggc
     6001 cgcgccccgg cggcggtgac ccagtgcacg gcctccgtgg gcacgccgaa ggcgaagcgc
     6061 cgcgggtgcg cccggcccag cgcgtccacc aggcggtacg ggcgacgggt gacttcgagg
     6121 ccaccggtct cgtagccctc cggcgcccgg ccggcgggga tgcggtagga ccggcactgc
     6181 ccgctgcgca gcaggtcgcg caacagcgga tcggcggtac ggcgcaggtc cgtcaccggc
     6241 agccgggcct cgatcagcac gtgggcgcgc accggccggc cggggaccag cggggagcgg
     6301 gcgacgaacg cggcgtccgc ctcgtcgatg tcgacctcca ggccggggcc gacgacgtcg
     6361 agcacgcccg cctcgatcag ggccgccatc tcctcgatgc gggaggcggg cgggccgatc
     6421 gagaggaacg cgttcaggcc ggtgtaccag ccgtcgaggt cgtcccggtg cgacaggccg
     6481 tcgagcccgc cgtggtccac cacgagccgg atctcgttgc gcaggtcgcg cagcacgtcc
     6541 agggcggcct tgtgcggatc gctcacattg cccgccctgg cccggcgcac gtcctgggcc
     6601 aggtgctcca gcagccagcg gcggtgcccg tcgggcccgg tgaagccgtg ccgggggtgc
     6661 ggggacgcgg tccgctccca gcaccaccgg tcggccgggc cgatgccgaa acgttccagc
     6721 accccgcccc ggtccgtgtc gtcgccgccc gccaggtacg ccgtcacgaa ggcgtcccgt
     6781 tcggccgccc ggccgcggga ggcgagcagc gttccgtagt agacgcattc gacctcgcgg
     6841 gcgatcaggg gccacagcgt ccggaggaac gacaggccgg ggccctcgcg gtgccggccg
     6901 gtcagttcgg cgatgcgctc gggggtgagc agcagcgggg tgtggcgccc gtccacgccc
     6961 ttctcgttct ccccgcgcgc gtggtacggg accccgcgcc gcgaaccggc gtagagccgc
     7021 ggttcgagcc ccgaggggtg gtaccgcagc ccgtgcgggc ggcggctgaa ggcgccgccc
     7081 cggccgaggg tgaacagcgc catgtggtcg aagaagttca ggccgagccc gcgcagcagg
     7141 acgggggtgc cgggcgcgat gccggacagg tcgaggtcgg cggggttggc cggcgggaag
     7201 tgggccaggc cgagcgcggc ggcgcgcggg tcgggggcgc ccggctcctc cgcgcggacg
     7261 tggccgagcg cgagcacgac cgcgtcgagc ccggccagcc gggtgccgtc ggcgagcagc
     7321 aggctctgcg cgcctccgga gcccggcgtc tcgtccgcca gggagacggc ggtcgagcgg
     7381 tgcacccgca cctccaggtg ggcgggcgcg ccgcagacca cccggcggaa catctcctcc
     7441 aggtagcacc cgtagaaggc ccgggtgggg tacgagtcgg cgcccagggc ccgggcctcg
     7501 gccagggtgg cgtcgtcgtg gccgccgagc agctcctcca cgggggtgag ggcggccagt
     7561 tcgcgcgccc actcgtggag gctggggccg gcctccaccg ggcccgccat gtcgacggac
     7621 ccgtcggtga acacggtcac ctgcgaggcg accgtgttca tcagcagctg gcgcggctga
     7681 cccgtccgcc acacccggcc cgcgcccggg cgggccgggt ccacgacgtg aaccgtcacc
     7741 gccgggtgcg aggcggactt ccgttcgtgg gcacagaacc tttccagcac cgacagtccg
     7801 cgcggtcccg caccgacgat gcacacggtg agccgtctga cgctcacgga tgtctccagg
     7861 ggagttcatg gccgcacggg cccgttggct gtggtcctcc gccccgcggg ctcaggccgc
     7921 tgcggggacg taccggagca gggggcgcgc cgggccggga cgcgagttcc ggccgacggg
     7981 ccgctcccgg ctacttctcc aggcagaact cctcgatggg gtaaccgacg tgccggtccg
     8041 ccaccgggag atagccgagc accttgtcac cgggcttcag ctcggtgctg ttcagcacgg
     8101 tgccgccggg gcccagcacc cggacgtgcc agtcgtcctg gaggatcagg ttggccgtgc
     8161 ggccgtcgcg gccgaccgcg tcgatggaca gcagcgggcg ggtctcgatc ttcacccggc
     8221 ccaccgtgac cagccgggtc ttcccgtgga tgtccaccgc cgtgatcttg ctgcccgcct
     8281 tcagctcgct gaggtagttg gtccgctcgt ccttggccag ggtgtacgag tggatggcgc
     8341 cggcgttgac ccggaagggg cgggtcggca tgtagggcag cgggtgcgtc tcgctgacgc
     8401 acaggatcat gcccttggag tgcgagccga ccaggatgcc ctcgtccttg cggaagtacg
     8461 tcgcggtgtc cacgcaggcc cgctcgccca tgcccacgtg cgcggtggcg gtgacctcca
     8521 gctcgaccag ttcgaggtcg ggcacgccgg tctcggccgc ctgccgcagc gcggtcgcgt
     8581 cgcccacccg ggcgggcgcc atcaggacgc cgtccgagcc gagttcgagc acaccgaaga
     8641 tgatctcggc ttcctcgacg tcctgcgcca cggtgatcag gctgccggtc gcgcgggcgg
     8701 cggccgcgat gacgatctcc agcggaatct tggtggggtc gcggaagagc agcacgctcc
     8761 acttctcctg gcggcccgac gcgcaggcct cctccagggt ctccgcgtcg acgatctccg
     8821 tgaaccggcc gaactccacg tccgggtgca gcagcgcgag ttcggcgggc tcgccgtgct
     8881 tggcggggtc gacgatcacc acgtcggccg cgccgaagtc ctcgggcagc gcctgcccct
     8941 gggggaagag gacgcgcttc accgacggcg ggaggggggc caggtcctcg acgcggtcgc
     9001 tgaggatgcc gtgcacgccc gcgtgcaggg cctcctggac gacggcgtcc ttcgcggaac
     9061 cgatggtgcg gatgtctatc cagctgagct tcacagggca cctgccaatg cggaggaagg
     9121 ggtggaggag gagtgcgcga ccggggccgg gaagcccacg gcctcggcgt cggcgggccg
     9181 gccgtgcacg atggcggaca gttcgcgcac ggtctgccgg ggcgaggccg aggcgaacac
     9241 ccggcggccc acggccagtc cccggcagcc cgcggccatc gcggtgccgg cgaattcggc
     9301 caggctctgc cgctggtccg cgccgccggc caccaggacc ggcaggggtg aggcggcgac
     9361 cacttcggcc atccgctcga cgggcccgac gaacacggtc ttgacgaggt cggcgccgag
     9421 gtcggcggcg acgttcacca cgtgcgcgac cagttcgggg gagggcggcc gggtcagccg
     9481 gggcccgcgc gggtagatca tggcgagcag cggcatgccc caccggtcgc aggccgccgc
     9541 caccgtcccg aggtccgaga gctgtgcgga ctcggtgtcg gagccgatgt tgacgtgcac
     9601 gctgaccgcg tcggcgccca gccgtacggc gtcctcgacg tcgccgacca gcaccttcgc
     9661 gtcgacgtcg ggcccgtggg cggtgctggc gctgaggtgg accagcagcg agcaggtgga
     9721 gaacagcagc gggtcgagca gccgggcccg tcccttgtgc acgaccagcc cgtccgcgcc
     9781 acccgcgacg acgtcccgta ccagttggtg gaagccctcg accgaggcga tcgggccgtc
     9841 ggagacggaa tggtccaggg gcacgagcag caggttgccg tcgccgtgcc cggccagcct
     9901 ggccatgcgc aacgaggtac ccggtaatgc ggttcctgtc atctgacact ccttgctggg
     9961 tgcacggtcg gggggagcgg gggtatgggt cggaccgaac agcgagcagc ttcccaagcg
    10021 gtattcgaga aatggtctac gaaactgtcg agagcccgtg ccaggagctg ttctcggcta
    10081 tttgctggga ataggtttag aagtgccagg agaggcgttc aggggcttcc ctgtgcaact
    10141 gcggaagttc tccggttgac cgcggaatgc ggcggggcgg gacgccgtcc ggcggctccg
    10201 actggattcg gtcgcggcgc ggggaagcga attggccaac aggtcgaatt ttggctgcta
    10261 ttcggggaga gccccgccgt cgggccgcat ctgatgcatg attctccctc gtgtgtcgct
    10321 tacagtcgca gcggccctcg atggaggatg ccttgtacac ttccacgttc tcaccaggtc
    10381 agacgctcaa cactgggatc ggcgccgccg gctccccgga ccggggactg cgatgcgggg
    10441 ttctcggccc gctctacatc ggaatcggag aatccgctga aagcgcccct gtcgccccga
    10501 agatacgtac ggtgctggcc actctcgccg tgagtgcgga tttcgtggtt ccggtttccg
    10561 tgctgatgcg cgagatctgg ggtgagaatc cccccgcgag tggactccgt accttgcaga
    10621 cgtacatcct gaactgccgt aagacgctgg cgaagctcac cggactcagc ctggcggaga
    10681 ccgcgcagga aatactggtg acacgaccgg gaggttacag ctacaaaagc gctgcgggaa
    10741 cactggactg gcaggatttc cggcggctct cggatctcgg gcgcagggcg gtcgaggcgg
    10801 gcgaggacga ccgggcgatc cacctgctcg acggcgcgtt gtcgctgtgg cggggttcgg
    10861 tcttcgcgga cgtgccggag gggccggtcc tggagacccg gcggcggctc ttcgacgagt
    10921 ggcggctggg cgccatggag acgctggccg aggcgcggct gcggaccggg ctgcaccagt
    10981 tggcgatcgc cgatctggcc gcgctcacca gcgagttccc cctgcacgag ggactgcacg
    11041 gccagtacat gcgggcgctg gccctcgtcg ggcgtcgcgc gctggcgctg gaggtgttca
    11101 gcctgctgcg cgcccggctg gtggaggaga tcggcatcga accgggccgc gacctccagg
    11161 acctgcaact ggccatcctc aactcccact cgggcgggac ctgacctgcg ccgccgaggg
    11221 cgcgcagccg ggcgggaccg gattctcacc ccgcttcagc cgctcccgca cgtcgcggac
    11281 ggtggccggt gagatcccgg ccctggacgc tatctcgcgg agcgaggcgc ccggggcgtc
    11341 gagcagcagc cgcccggcga gcgcgcgccc ctcggcactg ctgagcgggc gcgccctgcc
    11401 gtcgagcccg atgcgcttct gcggggcggc ggccgtcccg cggagccggg cgcggtgggc
    11461 ggcgacggtc ttgggcgaga cgcccgcggc cgcggcgacg gcccggtccg accactgcgg
    11521 gtgggcgcgc agcagccggg ccgcctcggc ggcgcgctgg gcgggcgtgg tgacggcagg
    11581 gagggcgagg gcggactccg cggccatcgt cagcgcctcc tccagcgaac cgtcgaagaa
    11641 gcgcacgtcc acggtgcgcg cgccccgggc gcgtgcggcg tacaggacgg ccgccccgac
    11701 gatcacccgc atcgtcccgc ggtgcacgac caccggacgc ccgtcgccct ggccggcccc
    11761 ggccaccggg cccgcggccc cgcggccgga ccgcccgtgg ccggccggga gcaacaggtc
    11821 gaccgggacc gcctccacgg cggaaccggg cggctcctcg caggagcgcg gggcggcggg
    11881 acggggcagg ttcgcgcgtg acggcgtgcg gtagccgtga acgctcatgg gctgctgctc
    11941 ctcgtgtgtg gggggttcgc gggtgacgcg gggccgcccg tgggccgtcc tgcacgacgg
    12001 cccacgggcg ccggccgccg ggcctagggg gcgccggcca gccaggaccg cagatcgcgc
    12061 atggccgtgc ccgagctgtc ctggtctatc cggccggcca gatcggcgac ggagatcccg
    12121 gccagcgctt cccgccaggc ggtctcggcg gtggccatgg cccgggagac cgcgcacggc
    12181 ttctcgcacc tctccgggga cagcgccagc ggcccgcgcc tgcggatctc cgtgcaccgg
    12241 aaggcgggtt cgggaccgtc gacggcctgt accacctgga gcacgctgac ctcggcggcc
    12301 ggccgggtga aggcatagcc cccgaccggc cccggggtgg agcgcacgat cccggcccgg
    12361 gacagggcct gaaggtgttt ggccaggtag gagggcggga caccgtgcag ctcggcgagc
    12421 cgggcggcgg acaccgggcc gtcgctctgg ctgatcgaga cgcagcagtg caggccccac
    12481 tcgaccccgt tggagagctt catgacgagc actctagcaa tctccgacat ccgatgtccg
    12541 tgattctgct ataaccagga caaggaatat ccgagattgc cgaagaggtg gactgacatg
    12601 gcggacacag atgaccgttt acgactcggc ggaccgcagg cgcccggcgc cggcgaccgc
    12661 acggccgccg acgcgcgacc gggacccgct ccggccgccg acgcgcgcgt cgcgctcgga
    12721 ctcgcggccc tcgccctgtt cgtggccgcg gccaacctcc ggccggccat cgccgccgtg
    12781 tcgccgctgg tggaccggat ccgcacggac ctcgacctgt ccgccaccgg ggtcgcgctg
    12841 ctgaccaccg ttccgacgct ggccatgggc gcctgcgccc cgctggcggc ctcgatcggc
    12901 cgccgctggg gcctccaacg gggcgtgctg gcaggcctgt tcgtggtcgg cctcgcgacc
    12961 gcggtgcgcg ggctcggcga ggcggcttgg ctccagttgt gcgccgccgc cgtggtgggc
    13021 gcgggcatcg ccgtcgcgca gaccctgctg cccgccgtcg tcaagacccg cttcgcggcc
    13081 cgcgccggac tggtgaccgg catctacacg gcgggcctcg gcctcggcgg cgcggtcgcg
    13141 gccggcgcca gcgccccgct cgcccaggcg ctcgggtcct ggccgggcgc cctggcctcg
    13201 tgggcggtgc tggccgtgat cggcatcgtg atgtggacgg ccgcccggcg ttcgctgggc
    13261 ctggagcacg tggccgggcc caagggcccc gccaccagcg gtctgccctg gcgcagctcc
    13321 ctcgcctggc gcatcaccgc gctgtcggcc gccaactcgg ctctctacta ctgcgaactg
    13381 gcctggatcg caccgctgtt gcacgactcc ggcggtgtca gcgaggccaa cgcgggtgtc
    13441 atgctgaccg tgatgatctc catccaggtg gtcgccatgc tcggcgtccc ggccctcctc
    13501 ggagagcgcg ccgacaagag gacgggcctc gccgccacca gcgtgctgac cgcgatcggc
    13561 ttcctgggct tcgccttcag ccccggcacg ggcgcctgga tctggatcct cgcgatgggg
    13621 atcggccacg gcggactctt cacgctggtg ctgaccctgc cggtctccgc cagccgggac
    13681 gcggtccagg ccgggcggtt cagcgcgatg gcgttcttcg tcgggtacgg ctgcgcggcg
    13741 gtggggccgg tgctcgtcgg cggcctgcgc gacatcacgg gcgactaccg gctcgccttc
    13801 gggctgctgg cggtgatcac cttcctcatg ctgctgccga tcgcccggct gtccccccgg
    13861 cgcatcgagc aggaccagca gaaggcgctg taacgccccg gacccgtcgc acgccgacgg
    13921 gcccagccgc ccccgagggc ccgccgcaca ccggcgggcc ctcggtcgtt tcccggcgca
    13981 ccgcggcacg ggcccccgcg aacgccctgg ccgggctcct ctcgaacgtt tctgctgctc
    14041 gctctcgaac ggcccctgga aggctgtccc cgagcccttc ccgtacgagc cgtacgagcc
    14101 gcacgcgccc gtacaggcac ccatccgaga ggacgcgcat ggttgaccga gacatccgca
    14161 tcgccgtcgt cggcgcgggc gtggcgggcc tgaccgtcgc ggccctcctg cgcgaccggg
    14221 gcgtcgactg ccgcgtcttc gaacgggcgc cgcggctggt cgccgtcggc gcgggcatcc
    14281 agctctcgcc caacggcgtc cgggtgctgc acggcctcgg cctccgggac tccctggccg
    14341 ccaccggcgt gcgcgcccgg gcgatcgaga cccggagctg ggccgacggc gcgcccatcg
    14401 cccgcacccc gctgggcgac aggtgcgagg agctgtacgg cgccccgtac tacctgatcc
    14461 accgggccga cctgcaccgg tgcctgacct ccctgctgcc ggccagcgcg gtcgaactgg
    14521 gccgggcctg cgcccgggtg gaggagcgcc cggacgcggt ccggctgcac ttcacggacg
    14581 gcaccatggc cgacgccgac ctggtgatcg gggcggacgg cgtccactcc gtcgtccggc
    14641 ggtccgtggt gcgcgacgcc ccccggtacg ccgggtacgc cgtgcaccgg gggctggtcc
    14701 cggcctccgt cgtgccgtcc ttccgcgacg acccgcgggt gatgttctgg ctgggtcccg
    14761 gacggcacgt cacctactac ccggtggcgg gcgggcgcac cgtgcacttc agcgccgtcg
    14821 gcgtcagccc cgaggagagc cccggcggcg gccccgagga cctcggggcg gccttcggcc
    14881 actggcacga agaggtgcgc cgggtggtga cctcggcctc ctcggtcacc cgctgggggc
    14941 tgtacgaccg ggacatcccc gaccgttacg ccacgggccg ggtggtgctg ctgggcgacg
    15001 ccgcgcaccc caccctcccc tacctctcgc agggggccaa ccaggcgctg gaggacgtca
    15061 ccacactggt cggctgtctc gacgcccgcc ccggcgcgcc gcaggaggcg gtgcggcagt
    15121 acgagagcct gcggctgccc cgcaccgccg aggtgcaccg gcgggccagg cgcctcgccg
    15181 aggagttcca cctgcccgac gggccggaat gcacggaccg cgaccagcgg atgcgcgcca
    15241 cccaggaccc gacgcacctc gcctggctgt acggccgcac ggccggactc ccggacgcct
    15301 cggacctcgc cccccggccc tgagccgcgc gccgcaccca cctcacgcca cgctcgccca
    15361 cccaccccca cgcgacgaac gggaaatcag gaggaccagt gcacgcactg ctgcgccggg
    15421 tcacacgcgg gaacggcttc tacatcggcg acctcttcca cgccgccgcc ggccacgacg
    15481 ccaccacacc ggtcacgctc gaccagcccc ttcagtacgc ccccgagctc ggcacgcgct
    15541 tcaccgtcgg gcagctcgcc gagcagacgg acgaactggc cgcccggctc tgggccgcgg
    15601 gcgtgcggcc caccgaacgg gtcgcgctgt acaagaagga caacttcgac atcgcgctgc
    15661 acgcctgcgc cgccgcgcgg atcggcgcgg tccccgccct cctgtcgccc gccctggagg
    15721 ccccggtcgt acggacgctg ctcgaccggc tcgacgggcc gtggctgctg accgacgcga
    15781 cgaccctcgc cggccccctg gggacggtgc tcgcaccggc atccgtacga gcggtcctgc
    15841 tgacgaccgg cacaccggcg gagggcgcgc ttcccgcagc cggcgcgacc ggacccgctc
    15901 gcgaagggga cgcgccgccg cccgctcccg tcgtgcggct ggccgaccac cggggcgccc
    15961 cgaagcggcc gcccgtcttc ctgcacccgc gccagccctc gctgatcacg cacagctcgg
    16021 gaaccaccgg cgtccccaag ctggcggtgc actgccccga ggcgggctgg caccggctgg
    16081 ttccgcagaa ggtcgtgtcc tggccgatcc gcggcaagga gaaggcggcg ctgtgcatga
    16141 cgttcgtgca ctcgcgcttc taccagggcc tggccatgtt cctcagccac ggcaacccga
    16201 tgctgatcgc cgtcgacccc gacccgagcc ggatcggccc gctgttcgcg cgcgaacggc
    16261 ccggctacat cgagacccac cccaacacct acgtcgactg ggaagcgctg gccgacgccc
    16321 cgggcgaacc gctcgccggc gtacgggtct tcggtgcgac cttcgacgcg atgcaccccc
    16381 ggaccatcca gcgcatgctc ggcgcctccc ggcgcacccg cccgctgttc gtccagttct
    16441 acggccagtc ggagatcggc ccgatggccg gccgctggta cacccggcgc tcggcggcca
    16501 ggatgaacgg ccgctgcgtg gggctgccgc tgcccggctt catctcgctg cgggtggtcg
    16561 acgacgccgg gaagcggctg cgcggcgggc gcaccggcca cctcgaagtg cgcagcagga
    16621 cgcgcatcct cacctacctc ggcgaggacc agcggtacgc ggagcaattg cacgacggat
    16681 ggtggcgggt gggcgacatg ggccgccgcg accgctgggg cctgctgcac ctgctggacc
    16741 gcgaggtcga ccggatcggc gacctggaga gcagcctggc ggtggaggac ctgctgatga
    16801 gccgcctgga ggaactgcgc gaggtggtcc tggtgcccgg ggcggacggc gaaccggtcc
    16861 ccgtcgtcgc caccgtcgac gagagcccgc tcgacgcggc gcgctggcag cgggcgacca
    16921 gcgacctgcc gacgatggcg ccggtgcgcc agttccggtt cgaagacctg ccgcgcacgt
    16981 ccacccgcaa gatccagaaa ccggaactgg cccggctgat ccagggcgtc cgggcaaccg
    17041 accagggagt gggggcatga ccgtgccgga aaacgcgcag cacaccgcgc cggaccagac
    17101 gcagcacacc gcgccggacc ggacgcggca ggcgcagcag gccgcgccgg acaccgccgg
    17161 gcgacggctc atcgagctga tggccggttt ctggaagacc caggcgatct acctggccgc
    17221 cgagtcgggc ctcgtcgacg ccatcgcggc ggccggccgg gccccggccg tcgaactcgc
    17281 gaaccggacg ggcaccgacc ccgacgccct ggggcggctc ctgctgttcc tggagagcct
    17341 ggacgtggtg agcggcgagg accccgccgg atacgcgctg accccggtcg gcgagctgct
    17401 gcgcaccggg acgcaggact ccatgcgcga ccacgtgcgg atctacggct cgcacttcta
    17461 ccgggcgtgg ggcgcgctcg accactcgct gaggacgggg cgttcggcct tcaccgaggt
    17521 gtacgggagc gacctgttcc gctacctcaa ccagcacccc gacctctccc tcacctacga
    17581 gcgggccatg gtcgcgggca cgccgttctt cgcgcaggtc cccgaggtgc acgacttctc
    17641 cggggcccgg ctgatcgtcg acgtcgcggg cgggcacggg gcgctgctgc acgagatcct
    17701 gaagtcctgc ccggagccgc gcgcggtgct cttcgacgcg ccgcacgtca tcgcggagac
    17761 ggcggaccgg ccgatcgcct cggagcacgg ggaccgcgtc acgctggtgc cgggcgactt
    17821 cttcgagggg gtgccgcagg ggggcgacgt ctacctgctg tcgcgcatcc tgcactgctt
    17881 cgacgacgag gcgtgcctgc gcatcctggc ccactgccgt tcggccatgg cgccgggcgg
    17941 ccggctggtg gtggtcgaac gcctgctgac gcggggcacc ggttcgtccc tggcgcaggg
    18001 ctacaacatg cacatgctgg tggtcctcgg cggcggccgc gaacgcgacg aggacgccta
    18061 ccgcacgctg ctggagaagg cgggcttcca gttggactcc gtcaccacgc tcccgctgga
    18121 gacccacctg atggcggcca ccctgcgccg gtga
//
