BGC0001296 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001296 (Streptomyces sp. MSC090213JE08)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	43,735	streptazone E	PKS	100%

BGC0001296 - Region 1 - T1PKS

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Location: 1 - 43,735 nt. (total: 43,735 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 43,736
Label		BGC0001296

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001296	1.00	Polyketide	streptazone E	Streptomyces sp. MSC090213JE08
BGC0001433	0.48	Polyketide	argimycin PI, argimycin PII, nigrifactin, argimycin PIV, argimycin PV, argimycin PVI, argimycin PIX	Streptomyces argillaceus
BGC0000016	0.36	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.32	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000919	0.32	Other	phaseolotoxin	Pseudomonas syringae
BGC0002597	0.29	NRP, Polyketide	nocuolactylates	Nodularia sp. LEGE 06071
BGC0001704	0.29	Other	nocuolin A	Nodularia sp. HBU26
BGC0001276	0.29	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000353	0.25	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0000067	0.24	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001296	1.00	Polyketide	streptazone E	Streptomyces sp. MSC090213JE08
BGC0001433	0.77	Polyketide	argimycin PI, argimycin PII, nigrifactin, argimycin PIV, argimycin PV, argimycin PVI, argimycin PIX	Streptomyces argillaceus
BGC0000016	0.69	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000919	0.65	Other	phaseolotoxin	Pseudomonas syringae
BGC0002597	0.63	NRP, Polyketide	nocuolactylates	Nodularia sp. LEGE 06071
BGC0001704	0.63	Other	nocuolin A	Nodularia sp. HBU26
BGC0001276	0.62	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000353	0.58	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0000067	0.58	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 43735:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal) + (ccmal - ccmal) + (ccmal)
Non-colinear ordering:: stzD + stzC + stzB

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

stzD

PKS_AT (560..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.0
inactive: 96.2
Methoxymalonyl-CoA: 76.3
Methylmalonyl-CoA: 67.8
Ethylmalonyl-CoA: 36.6
Isobutyryl-CoA: 35.1
Propionyl-CoA: 34.2
2-Methylbutyryl-CoA: 28.1
Acetyl-CoA: 27.6
Benzoyl-CoA: 16.3
fatty_acid: 13.5
trans-1,2-CPDA: 12.5
CHC-CoA: 9.9
3-Methylbutyryl-CoA: 5.6

PKS_AT (1575..1868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.6
inactive: 85.6
Methoxymalonyl-CoA: 75.2
Methylmalonyl-CoA: 66.0
Propionyl-CoA: 35.0
Isobutyryl-CoA: 26.7
fatty_acid: 21.2
Acetyl-CoA: 20.5
Ethylmalonyl-CoA: 17.1
2-Methylbutyryl-CoA: 15.7
CHC-CoA: 11.5
Benzoyl-CoA: 11.2
trans-1,2-CPDA: 8.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (3309..3608): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.7
inactive: 100.1
Methoxymalonyl-CoA: 69.0
Methylmalonyl-CoA: 59.2
Propionyl-CoA: 31.4
Isobutyryl-CoA: 29.4
Ethylmalonyl-CoA: 26.1
2-Methylbutyryl-CoA: 21.3
Benzoyl-CoA: 16.5
Acetyl-CoA: 12.4
CHC-CoA: 9.6
fatty_acid: 8.1
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

stzC

PKS_AT (616..908): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.4
inactive: 85.6
Methoxymalonyl-CoA: 75.8
Methylmalonyl-CoA: 67.2
Propionyl-CoA: 35.8
Isobutyryl-CoA: 27.5
fatty_acid: 21.6
Acetyl-CoA: 20.7
Ethylmalonyl-CoA: 18.2
2-Methylbutyryl-CoA: 16.3
CHC-CoA: 11.5
Benzoyl-CoA: 11.2
trans-1,2-CPDA: 8.2
3-Methylbutyryl-CoA: 0.0

PKS_AT (2329..2625): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.8
inactive: 88.6
Methoxymalonyl-CoA: 69.6
Methylmalonyl-CoA: 66.6
Propionyl-CoA: 40.7
Isobutyryl-CoA: 37.2
Acetyl-CoA: 26.1
Ethylmalonyl-CoA: 24.5
fatty_acid: 19.2
2-Methylbutyryl-CoA: 16.2
CHC-CoA: 12.2
Benzoyl-CoA: 11.4
trans-1,2-CPDA: 9.6
3-Methylbutyryl-CoA: 0.0

stzB

PKS_AT (628..917): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 176.8
inactive: 75.4
Methoxymalonyl-CoA: 61.5
Methylmalonyl-CoA: 60.4
Isobutyryl-CoA: 39.8
Propionyl-CoA: 35.8
Acetyl-CoA: 30.5
Ethylmalonyl-CoA: 18.1
fatty_acid: 15.3
Benzoyl-CoA: 11.4
2-Methylbutyryl-CoA: 10.5
trans-1,2-CPDA: 10.1
CHC-CoA: 7.8
3-Methylbutyryl-CoA: 0.0