BGC0001302: lomofungin biosynthetic gene cluster from Streptomyces lomondensis
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Location: 1 - 25,686 nt. (total: 25,686 nt).
This entry is originally from NCBI GenBank KP721214.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001302
Short description lomofungin biosynthetic gene cluster from Streptomyces lomondensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
KP721214.1
via
Compounds
  • lomofungin
Species Streptomyces lomondensis [taxonomy]
References
Chemical products information
lomofungin Evidence:
Copy SMILES
C15H10N2O6
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • lomo17
  • AKC91603.1
 1 - 1011 (-) transcriptional regulator
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    • lomo16
    • AKC91604.1
    		 1136 - 2440 (-) aldehyde dehydrogenase
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      • lomo15
      • AKC91605.1
      		 2521 - 3540 (-) phenazine antibiotic biosynthesis protein
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        • lomo14
        • AKC91606.1
        		 3660 - 4601 (-) alcohol dehydrogenase
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          • lomo13
          • AKC91607.1
          		 5073 - 6524 (+) transporter
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            • lomo12
            • AKC91608.1
            		 6606 - 7631 (-) transcriptional regulator
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              • lomo11
              • AKC91609.1
              		 7955 - 8773 (+) methyltransferase
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                • lomo10
                • AKC91610.1
                		 9203 - 10528 (+) FAD-binding monooxygenase
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                  • lomo9
                  • AKC91611.1
                  		 10858 - 11919 (+) acyl-CoA dehydrogenase
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                    • AKC91612.1
                    • lphzB
                    		 11969 - 12448 (+) phenazine biosynthesis protein
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                      • AKC91613.1
                      • lphzC
                      		 12600 - 13703 (+) phenazine biosynthesis protein
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                        • AKC91614.1
                        • lphzD
                        		 14042 - 14374 (+) phenazine biosynthesis protein
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                          • AKC91615.1
                          • lphzE
                          		 14491 - 16284 (+) 2-amino-2-deoxy-isochorismate synthase PhzE
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                            • AKC91616.1
                            • lphzF
                            		 16642 - 17475 (+) 2,3-dihydro-3-hydroxyanthranilateisomerase
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                              • AKC91617.1
                              • lphzG
                              		 17486 - 18124 (+) FMN-dependent oxidase
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                                • lomo8
                                • AKC91618.1
                                		 18220 - 18705 (+) flavin reductase
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                                  • lomo7
                                  • AKC91619.1
                                  		 18726 - 19328 (+) quinone oxidoreductase
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                                    • lomo6
                                    • AKC91620.1
                                    		 19456 - 20649 (+) S-adenosylmethionine synthetase
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                                      • lomo5
                                      • AKC91621.1
                                      		 21011 - 21619 (+) putative hexokinase
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                                        • lomo4
                                        • AKC91622.1
                                        		 21634 - 22551 (+) 5,10-methylenetetrahydrofolate reductase
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                                          • lomo3
                                          • AKC91623.1
                                          		 23035 - 23850 (+) 3-phosphoshikimate 1-carboxyvinyltransferase
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                                            • lomo2
                                            • AKC91624.1
                                            		 23915 - 25048 (+) chorismate synthase
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                                              • lomo1
                                              • AKC91625.1
                                              		 25084 - 25686 (+) shikimate kinase
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                                                Biosynthesis information

                                                No biosynthesis information available for this record.

                                                Annotation changelog

                                                Entry version: 4

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Updated bioactivity data
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Migrated from v1.4
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2015-12-24
                                                Submitted
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                Tailoring functions
                                                Tailoring enzymes detected in this region
                                                Oxidoreductases: dehydrogenase oxidoreductase oxygenase
                                                lomo10: monooxygenase FAD-binding
                                                smcogs
                                                SMCOG1246: monooxygenase FAD-binding
                                                lomo14: crotonyl-CoA reductase / alcohol dehydrogenase
                                                smcogs
                                                SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase
                                                lomo8: flavin reductase domain protein FMN-binding
                                                smcogs
                                                SMCOG1160: flavin reductase domain protein FMN-binding
                                                lomo9: acyl-CoA dehydrogenase type 2
                                                smcogs
                                                SMCOG1191: acyl-CoA dehydrogenase type 2
                                                Transferases: kinase
                                                lomo5: PfkB domain protein
                                                smcogs
                                                SMCOG1276: PfkB domain protein
                                                Hydrolases: hydrolase
                                                lphzD: isochorismatase
                                                smcogs
                                                SMCOG1027: isochorismatase
                                                Isomerases: isomerase
                                                lphzE: isochorismate synthase
                                                smcogs
                                                SMCOG1018: isochorismate synthase
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