BGC0001312: viscosin biosynthetic gene cluster from Pseudomonas fluorescens SBW25
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Location: 2,788,013 - 2,831,449 nt. (total: 43,437 nt).
This entry is originally from NCBI GenBank AM181176.4.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001312
Short description viscosin biosynthetic gene cluster from Pseudomonas fluorescens SBW25
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AM181176.4
2788013 - 2831449
via
Compounds
  • viscosin
Species Pseudomonas fluorescens SBW25 [taxonomy]
References
Chemical products information
viscosin Evidence:
Copy SMILES
C54H95N9O16
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PFLU_2548
  • CAY48784.1
 2788013 - 2788873 (-) conserved hypothetical protein
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    • PFLU_2549
    • CAY48785.1
    		 2788908 - 2790179 (-) putative aminotransferase
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      • PFLU_2550
      • CAY48786.1
      		 2790198 - 2791547 (-) putative dipeptidase
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        • PFLU_2551
        • CAY48787.1
        		 2791690 - 2793315 (+) conserved hypothetical protein
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          • PFLU_2552
          • CAY48788.1
          • viscB
          		 2793746 - 2806630 (+) putative non-ribosomal peptide synthetase
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            • PFLU_2553
            • CAY48789.1
            • viscC
            		 2806627 - 2817948 (+) putative non-ribosomal peptide synthetase
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              • PFLU_2555
              • CAY48790.1
              		 2819006 - 2820157 (+) putative drug-efflux protein
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                • PFLU_2556
                • CAY48791.1
                		 2820161 - 2822119 (+) macrolide-specific ABC-type efflux carrier
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                  • PFLU_2557
                  • CAY48792.1
                  		 2822190 - 2822864 (-) putative LuxR-family regulatory protein
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                    • PFLU_2558
                    • CAY48793.1
                    		 2823017 - 2824252 (-) methionine gamma-lyase
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                      • PFLU_2559
                      • CAY48794.1
                      		 2824376 - 2824846 (+) AsnC family regulatory protein
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                        • PFLU_2561
                        • CAY48795.1
                        		 2825281 - 2825718 (+) conserved hypothetical protein
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                          • PFLU_2562
                          • CAY48796.1
                          		 2825722 - 2827884 (-) putative ferric siderophore receptor
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                            • PFLU_2563
                            • CAY48797.1
                            		 2827972 - 2828904 (-) putative AraC-type regulatory protein
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                              • PFLU_2564
                              • CAY48798.1
                              		 2829069 - 2830157 (+) putrescine ABC transporter, substrate-binding protein
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                                • PFLU_2565
                                • CAY48799.1
                                		 2830154 - 2831449 (+) putative oxidoreductase
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  viscB
                                  Substrates
                                  threonine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  viscB
                                  Substrates
                                  valine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  viscB
                                  Substrates
                                  leucine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk04
                                  Type
                                  nrps-type1
                                  Genes
                                  viscB
                                  Substrates
                                  serine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk05
                                  Type
                                  nrps-type1
                                  Genes
                                  viscC
                                  Substrates
                                  leucine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk06
                                  Type
                                  nrps-type1
                                  Genes
                                  viscC
                                  Substrates
                                  serine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk07
                                  Type
                                  nrps-type1
                                  Genes
                                  viscC
                                  Substrates
                                  isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 4

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-10-07
                                  Update chemical activity to schema version 2.11
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Updated bioactivity data
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  2019-10-16
                                  Updated compound(s) information (NPAtlas curation)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2016-09-03
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
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