BGC0001328: rakicidin A biosynthetic gene cluster from Micromonospora sp. M42
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 194,525 - 233,421 nt. (total: 38,897 nt).
This entry is originally from NCBI GenBank KK037233.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001328
Short description rakicidin A biosynthetic gene cluster from Micromonospora sp. M42
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
KK037233.1
194525 - 233421
via
Compounds
  • rakicidin A
  • rakicidin B
Species Micromonospora sp. M42 [taxonomy]
References
Chemical products information
rakicidin A Evidence: NMR, Mass spectrometry, Total synthesis
Copy SMILES
C32H54N4O7
rakicidin B Evidence: Mass spectrometry
Copy SMILES
C33H56N4O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MCBG_00130
  • EWM62997.1
 194525 - >198593 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00131
  • EWM62998.1
 198790 - 203130 (+) mycocerosic acid synthase
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00132
  • EWM62999.1
 203245 - 203439 (+) hypothetical protein
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00133
  • EWM63000.1
 203436 - 207341 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00134
  • EWM63001.1
 207319 - 208275 (+) polyketide synthase type I
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00135
  • EWM63002.1
 208277 - 211648 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00136
  • EWM63003.1
 211656 - 213302 (+) polyketide synthase type I
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00137
  • EWM63004.1
 213635 - 217669 (+) polyketide synthase type I
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00138
  • EWM63005.1
 217773 - >220830 (+) linear gramicidin synthetase LgrC
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00139
  • EWM63006.1
 221677 - 223899 (+) linear gramicidin synthetase LgrD
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00140
  • EWM63007.1
 224280 - 226958 (+) linear gramicidin synthetase LgrC
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00141
  • EWM63008.1
 226955 - 228667 (+) pyoverdine ABC transporter permease/ATP-binding protein
  • Transport
copy AA seq
copy Nt seq
  • MCBG_00142
  • EWM63009.1
 228621 - 229484 (+) gramicidin S biosynthesis protein GrsT
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • MCBG_00143
  • EWM63010.1
 229481 - 232348 (+) non-ribosomal peptide synthetase
    copy AA seq
    copy Nt seq
    • MCBG_00144
    • EWM63011.1
    		 232432 - 233421 (+) clavaminate synthase
    • Precursor biosynthesis
    copy AA seq
    copy Nt seq
    Biosynthesis information

    Biosynthetic modules

    Name
    3
    Type
    nrps-type1
    Genes
    MCBG_00135
    Substrates
    serine (evidence: Feeding study)
    Integrated Monomers
    Domains
    condensation (LCL), adenylation
    Name
    5
    Type
    nrps-type1
    Genes
    MCBG_00138
    Substrates
    glycine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (LCL), adenylation
    Name
    6
    Type
    nrps-type1
    Genes
    MCBG_00140
    Substrates
    3S-hydroxyasparagine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    adenylation
    Name
    0
    Type
    pks-trans-at-starter
    Genes
    MCBG_00130
    Substrates
    Integrated Monomers
    Domains
    ligase, carrier (ACP)
    Name
    1
    Type
    pks-trans-at
    Genes
    MCBG_00130
    Substrates
    Integrated Monomers
    Domains
    ketosynthase
    Name
    2
    Type
    pks-modular
    Genes
    MCBG_00133
    Substrates
    Integrated Monomers
    Domains
    acyltransferase, ketosynthase, acyltransferase
    Name
    4
    Type
    pks-trans-at
    Genes
    MCBG_00136
    Substrates
    Integrated Monomers
    Domains
    ketosynthase
    Annotation changelog

    Entry version: 4

    Date
    Changes
    Submitters
    Reviewers
    2022-10-07
    Update chemical activity to schema version 2.11
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 3

    Date
    Changes
    Submitters
    Reviewers
    2022-09-15
    Corrected NRP module activity
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Removed gene names of 'No gene ID'
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Removed ketoreductase stereochemistry annotation from modules without ketoreductases
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Updated bioactivity data
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Updated NRP substrate specificities
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 2

    Date
    Changes
    Submitters
    Reviewers
    2019-10-16
    Migrated from v1.4
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2019-10-16
    Updated reference publication(s) (MIBiG Annotathon)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 1

    Date
    Changes
    Submitters
    Reviewers
    2018-08-06
    Submitted
    • (ID: DPAKSDGGIIU3JRGIDNMS7RSG)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    Detailed domain annotation
    Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
    A domain glossary is available here, and an explanation of the visualisation is available here.
    Selected features only
    Show module domains
    Similar known gene clusters from MIBiG 4.0
    Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
    Click on reference genes to show details of similarities to genes within the current region.
    Click on an accession to open that entry in the MiBIG database.