Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001331.1:
Cluster 1NRP / Polyketide134976

BGC0001331, BE-43547 A1-C2 biosynthetic gene cluster from Salinispora arenicola. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: BE-43547A1
SMILES string: Copy to clipboard
Molecular formula: C30H49N3O7
Exact molecular mass: 564.3643 Da ([M+H]+)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Cyclic depsipeptide (cyclic)
Thioesterase type:
Unknown
Release / cyclization type:
Macrolactonization

Nonribosomal peptide synthetases:
No gene ID (WP_019032755.1)
Module 3
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Module 4
A specificity: Serine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
No gene ID (WP_019032753.1)
Module 6
A specificity: Glycine
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Scaffold-modifying domain: Methylation
Module 7
A specificity: Unknown
Evidence for specificity: Unknown
C domain subtype: LCL
Module is skipped
Evidence for skipping: Unknown
Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
Unknown
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
No gene ID (WP_019032757.1)
Module 0
AT specificity: None
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: L-OH
Scaffold-modifying domain: None

No gene ID (WP_019032756.1)
Module 2
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

No gene ID (WP_019032754.1)
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

Gene cluster description

BE-43547 A1-C2 (BGC0001331). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank NZ_KB900339, positions 10670-45645. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Comments:The only prior publication on this class of molecules are a japanese patent from 1998. I put in a placeholder PMID until our paper is accepted.
Contact for this cluster:Thomas Torring (Aarhus University)

Literature references