LOCUS       BGC0001333             20018 bp    DNA     linear   ENV 03-OCT-2011
DEFINITION  Uncultured bacterium AB1650 antitumor substance BE-54017 gene
            cluster, complete sequence.
ACCESSION   BGC0001333
VERSION     BGC0001333
KEYWORDS    .
SOURCE      uncultured bacterium AB1650
  ORGANISM  uncultured bacterium AB1650
            Bacteria; environmental samples.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 00:46:17
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 20018
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..693)
                     /gene="abeM2"
     CDS             complement(1..693)
                     /codon_start=1
                     /gene="abeM2"
                     /product="N-methyltransferase"
                     /protein_id="AEF32089.1"
                     /transl_table=11
                     /translation="MTQTGQTDESRGFEDPEYWNFMYDEGTAPWLIGGPQPAIVELEAA
                     GLVRGRVLEPGCGSGEHTILFTRLGYESLGVDLSPSAIDYARRTATERGVPAARFEVAN
                     MLHPEHHPFLAGGFDTVVDVALFHGFGAYGDPGAAKAYADVLHALTNPGALVHILAHSD
                     AAPGLSSSISDDVIRETFTGGWEVESIEAAHYQGFITEQISEVAVQRGLPAHGEVQLAA
                     WLGRVRRL"
     misc_feature    1..20018
                     /note="antitumor substance BE-54017 gene cluster"
     subregion       1..20018
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001333"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..20018
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="indole"
                     /region_number="1"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..16347
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3299:6347]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3300..6347
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     cand_cluster    1..16347
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     gene            complement(802..2403)
                     /gene="abeX1"
     CDS             complement(802..2403)
                     /codon_start=1
                     /gene="abeX1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 380.2; E-value:
                     2.9e-115)"
                     /gene_kind="biosynthetic-additional"
                     /product="monooxygenase"
                     /protein_id="AEF32090.1"
                     /transl_table=11
                     /translation="MRDERDCDVLVVGAGPTGLCTALMLTQHGVRVRIVDSKSGPVEQA
                     RAAIVHARTLELFDRLGVAEAAVARGLPITDVAIHEAGRHVGDMPLAGEGTGDRTRFPY
                     ALALEQFETERVLVEALKEHHVEVEWNTAVVELADTGALVGVTTAEGRSITARWLVGAD
                     GASSAVRGFVGQSFDGETYDQAGMLADVTLDVDLGVRGMRLNLTRGGFVGILPLASGRC
                     RLFGVVPRELEQAPSQKNPSHEAYAPLAPADLQKWFDGYFKVDARLEEVVWASMFRFHS
                     RIASRFRVGNVFLAGDAAHIHNPAGGQGLNLGVGDAVNLAWKLAQVVNGEAPERLLDTY
                     ESERRPIARTVLKRTDLGFKLETGNSAVAVWMRAHVATRVVGAVSRLAPIRRMFFHMFS
                     QLWIRYRNSPAVGPGTGPLRPGDRAPYAEIRPTRDGASSVLDLTHGSGYHVLLFGAQSL
                     DTDRLAASLDDRYTVAITTHVIPPEEEAAHRAYQVSGPLLVLVRPDGHVAAVAEPKSPG
                     VTDFLDTVLTRVKAPA"
     gene            2608..3303
                     /gene="abeM1"
     CDS             2608..3303
                     /NRPS_PKS="Domain: oMT (38-138). E-value: 1.6e-13. Score:
                     41.3. Matches aSDomain: nrpspksdomains_abeM1_oMT.1"
                     /codon_start=1
                     /gene="abeM1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 88.2; E-value:
                     9.7e-27)"
                     /gene_kind="biosynthetic-additional"
                     /product="N-methyltransferase"
                     /protein_id="AEF32091.1"
                     /transl_table=11
                     /translation="MSTAPEAFFDDLAELYERFTLIRDAATSPVRSWLVEQLPAGSRAL
                     DAGCGSGNNCGMLAERYDDVVGVDVSRKMLDIAATKRTRVPVRYECRDAVDLTPERDGR
                     FDLVMSVNAVFHMGPADEVLPVLRALVAPGGRLVVVDVTQPDDAAAPAEQSAYAFQTGK
                     IIYDVSRDVEAACDSIRMMLHPRWLEMSAAAMPLTDSEFRSQYERALPGVRITRDLIPT
                     MSAAVWDNA"
     aSDomain        2722..3021
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_abeM1_oMT.1"
                     /domain_subtype="oMT"
                     /evalue="1.60E-13"
                     /label="abeM1_oMT.1"
                     /locus_tag="abeM1"
                     /protein_end="138"
                     /protein_start="38"
                     /score="41.3"
                     /tool="antismash"
                     /translation="PAGSRALDAGCGSGNNCGMLAERYDDVVGVDVSRKMLDIAATKRT
                     RVPVRYECRDAVDLTPERDGRFDLVMSVNAVFHMGPADEVLPVLRALVAPGGRLV"
     gene            3300..6347
                     /gene="abeD"
     CDS             3300..6347
                     /codon_start=1
                     /gene="abeD"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indsynth"
                     /gene_kind="biosynthetic"
                     /product="chromopyrrolic acid synthase"
                     /protein_id="AEF32092.1"
                     /sec_met_domain="indsynth (E-value: 0.0, bitscore: 1164.2,
                     seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFHLPRLHFAGTAITRLPTGPRAGWLDLETNQAIDDQGVFDTD
                     RPVQEYYDFLADAKGHNFEGNGHFWVDAKVVATELAPGEVRSDDLVTGRQLDLWGHFCD
                     YTAGTANRSRVFDVDPASNWTTTLMVGQLALGRSGRSHDVPYLVTGDVNGMCPPRWNQF
                     HTVLHQFAVDKAEGLHWLSGVADSPVLTRLREVVENDADGLVVQFALSDQKHTGEGQPD
                     VWQLRGTVAAWYRDELRSYPAGRLLTPRTTRSALHNLSVHVSDDHVTANLVTAHPDTDL
                     EVRTACGTLLATIPSTTDSRTSGVVVAARVDGATGNPAEALVITDGEGTVLSREEETVI
                     ESDEAALFLEHENTRTGEDHAVEIPVRSYLRGVPARVDQVHVRQYVNPAALPLAGDRDS
                     AQLVAFLPTGQAGYQAEQVLSTDEHGRGAITLKGVRGGATRVLLRPEPTPEPRGTTAAE
                     RYDNDDEQGYWSAVGSIAVRVLPNHWHLDDLPDEDITFSTVYREALAYYELQYSFMRSE
                     VLSLADEFKVEPYARLIWHVSAPEHKGRTFYMPPTRDMSAPQIRMLLRYLLADDAQRQT
                     PPTFVPQQRKLGTITTKDQLLHALYQAAAIELATMVQYLYAAYSVPTHGAGRKLVQRGE
                     WTEEQLLTACGEGTETWSNGIRGSLMSVAREEMMHFLAINNILMAMGRPFHLPKLDFGT
                     FNSTTCVPLEFSLEALNLASVQRFVALEQPHDLIEEIEGNDSTVLRADGEPYQYGSLSE
                     LYAAIREGVQAVPGVFLVKKGRGGGAHHLFMRESVNAVHPDYQLEVDDVASAVFAIDFV
                     TEHGEGGQIPSTLPEEESHFDTFLRISEMLIAERAKGPNDRRVPWNPAYPVMRNPTLKP
                     GNAAMDHVTHEPARIAMKAFNRSYFMAMQLMVQHFGYSPDKSLRRSRLMNWSLDVMTGV
                     LRPLGELIVTLPSGRPGRTAGPSFELDSGPEYISRPDVAVEWMAREFDEVADLARKCVG
                     FGLTPTVGDLLAFIGDSLRTMDLKDL"
     gene            6365..7588
                     /gene="abeX2"
     CDS             6365..7588
                     /codon_start=1
                     /gene="abeX2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 216.8; E-value:
                     9.8e-66)"
                     /gene_kind="biosynthetic-additional"
                     /product="monooxygenase"
                     /protein_id="AEF32093.1"
                     /transl_table=11
                     /translation="MCIAGGGPAGAVLGLLLARSGVDVVVLEKHADFRRDFRGDTVHPA
                     TLQILDELGLIEKFHALPHQKVSTIGVVQEGRRIDIADFRRLKVRYPYMAFVPQWDFLD
                     LITAEAKRYPGFRLLMNTEALGVVRDEGGRVAGLRVRGPQGERQIRSTLVVAADGRHSV
                     IRRDAGFVPTLIGRSLDVIFFKISRRDTDPDEGICVRIGNGKIFGATDRRTYWQMSYET
                     STGGMEKVRGEGLDKFRADLSELVPFLADRAHEVSSLDQLSPLEARIDRLERWHEPGLL
                     FIGDAAHAMSPVAGFGVNLAVQDAVATSNILTAELLRAQEGRIFDDELLARVRRRRKRA
                     VALSQGLQRATQKFGIDEALDGSGQPPAPKVFEKLGVAQWLMSRVIGLGFRPEHVRTQE
                     KAPEGTVR"
     gene            7585..8595
                     /gene="abeM3"
     CDS             7585..8595
                     /codon_start=1
                     /gene="abeM3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 295.8; E-value:
                     7.1e-90)"
                     /gene_kind="biosynthetic-additional"
                     /product="O-methyltransferase"
                     /protein_id="AEF32094.1"
                     /transl_table=11
                     /translation="MTAPGMPPQARMMQMITGYWITQVVHAVAELRIADHLAGNALTLE
                     ELAARTGAGADTTLRLLRACASQGLVAHDEGRFASTPLLETLREGVPGSFRDIAIVHGS
                     PGHWLSWGRFPDAVRTGEPQTKAALGSDIWTYFQSQPQEWERFSNSMTELTDGLSREIG
                     ALLDTTGLTTAVDVGGANGALLHPLLKANPGLRGVVFDLPTVEATAVAEAEKAGLAGRC
                     TFTGGSFFDSVPEGDLFLLKAVLHNWADESCVQILTNCRKALRPGGRVVVVEMPLGPLG
                     EPGFAPLLDLGMLAVNAGRERDLDQYDALFRASGLRRAEVTPTSSPQSLIHAVAA"
     gene            8621..10168
                     /gene="abeH"
     CDS             8621..10168
                     /codon_start=1
                     /gene="abeH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 51.9; E-value: 1.1e-15)"
                     /gene_kind="biosynthetic-additional"
                     /product="tryptophan 5-halogenase"
                     /protein_id="AEF32095.1"
                     /sec_met_domain="Trp_halogenase (E-value: 7.2e-142,
                     bitscore: 463.2, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKNVVVVGGGTAGWMTASYLTAAFGDRIGVTLVESKRVGSIGVG
                     EATFSTVRHFFEYLGLEEKEWMPACNATYKLAIRFENWREPGHHFYHPFERQRVVDGFP
                     LTDWWLREPRSDRFDKDCFLVGTLCDDLKSPRQLNGELFEGGLGGRSAYRTTLAEQTTQ
                     FPYAYHFDATLVANYLRDYAVARGVKHVLDDVQDVALDDRGWISHVVTGESGNLTGDLF
                     IDCTGFRSLLLGKALAEPFQSYQDSLPNDSAVALRVPQDMENRGLRPCTTATAQEAGWI
                     WTIPLFDRIGTGYVYAGDYISPEEAERTLRAFVGPAAEHADANHIKMRIGRSNRHWVNN
                     CVAVGLSSGFVEPLESTGIFFIQHAIEQLVKHFPDERWDDGLRTAYNKLVNNVMDGVRE
                     FLVVHYYAAKRQDNQYWKDAKTRPLPDGLAERLERWQTRLPDNESVFPHYHGFESYSYV
                     CMLLGLGGLDLKSSPALGLMDAAPARHEFKLVGEQAAELARTLPTQYEYFAQLHRAR"
     gene            10174..11412
                     /gene="abeT"
     CDS             10174..11412
                     /codon_start=1
                     /gene="abeT"
                     /gene_functions="transport (smcogs)
                     SMCOG1117:sodium/hydrogen exchanger (Score: 228.1; E-value:
                     2.8e-69)"
                     /gene_kind="transport"
                     /product="putative cation/H+ antiporter"
                     /protein_id="AEF32096.1"
                     /transl_table=11
                     /translation="MVLNGMHLVALLAAFFAVAALGRVMARALRTPTVIGEIALSILLG
                     PVLLAAFGKSLFTAVLPADVTAVLKQIGEAGLVLFLVGVVHHLDRGVTGGWHGKALGRI
                     TIGAFALPLLTGLAFAAWAVWLAPAEVRGTAPTAALVLVLAVAMSVTAVPVLARILEER
                     SDLGRASGLSMMASVLIDTPAWLLLTVALGLAAGGLGGVWLAFATIGVGVVIAWLGRRA
                     LGSERVGNVAAERPRTTALVLAVVALAAGTAVHSLGLTAIFGAFLAGVVVPRDEAWSRV
                     VALVSRVGRAFVPVFFVVAGTTLSTSGVSAFPWIGVALALALGVLGKIGGGYAGARWGG
                     EDAVTSLRIGVLVNTRGLTEIVVLQIAFTAGLLTPGLFVALLVMALVTTALTGPLLDVI
                     TRRAGAARQEVLV"
     gene            11409..11891
                     /gene="abeF"
     CDS             11409..11891
                     /codon_start=1
                     /gene="abeF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160:flavin reductase domain protein FMN-binding
                     (Score: 107.3; E-value: 1e-32)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative flavin reductase"
                     /protein_id="AEF32097.1"
                     /transl_table=11
                     /translation="MTEQFRGLMAAFPTGVAVVTTFGQDGEPWGMTLSSLSSVSVDPPT
                     LLVCLRYSSPTLDALVRTGSFTVNLLHHEARPAAELFSSGDPDRFRQVAWEHPASLGGP
                     HLVDDAHAAADCVVDHMHRTGTHVVVFGKVHTVVHRSAAQPLLYGLRRYASWPRSA"
     gene            complement(11952..12746)
                     /gene="abeY"
     CDS             complement(11952..12746)
                     /codon_start=1
                     /gene="abeY"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /product="putative alpha/beta hydrolase"
                     /protein_id="AEF32098.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.4e-11, bitscore:
                     34.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVPTVDVVPRTTTVRGHDGLKLAATAVVPVGEPRCTALLLHGEG
                     ADRDQGGFYGRLASELAGHGVASLRVDLPGHGDSEGAQEELSLSGLLNVISAGLTHLRE
                     NVAPGPAALVATGLTGGVAAGYAARRGDEVANVVLYNPLIDYQEHFADSNPAWSGGFLG
                     AEAGRALLADGYLRVSDTFVVGRAMLNEVFWLQPRGVLPVITAPTLVVHRAGPSGAPVS
                     SSRSAVEALTCPSRLVEIGPPVEAHWQAPAIRVTTEWLLGSR"
     gene            12901..14442
                     /gene="abeO"
     CDS             12901..14442
                     /codon_start=1
                     /gene="abeO"
                     /product="tryptophan oxidase"
                     /protein_id="AEF32099.1"
                     /transl_table=11
                     /translation="MWAQGRGGTIPFMSPVHTNVLSGGQHWPQRPKRVTVLGAGVAGLV
                     AAHELERLGHSVEVLEARLEVGGRVRTHSFVGRGPLAELGAMRIPASHHRTMQWIDLLG
                     LSDRVRQFRTLFSDDSSYLETCTGHLRVRDATSVLVEEFRRGLPPGEYREESVLAATWL
                     TASVNAVAPGAFRTNLHSDLNLELLDLLDGIDVRPFFVSTGGVERLDVNRFFAGNPKFA
                     GRSRLAHFFDDITVETSSALFRLEGGMDQITVRLAGSLRGPVHRGRQVVGLHVRPDGVV
                     VETRRGLDVVASHCDYVLCTVPFSVVRRMNLSGLDDDKVATVHDMQYWPATKIAVHCQD
                     AFWEGDGISGGGSFTGGLVRQTYYPPVESDPRLGAALLASYTIGPDSDALTRFSPPERE
                     RVVLDELSRIHPELKRPGMVLDVVTQAWGEDFSSMGAASVRWSKDAATAEEERALAAKP
                     QGTLFFAGEHCSTYPAWIEGAIESGLAAAQDVHAAAPAERPLVATGYRRMRGGAA"
     gene            14439..16040
                     /gene="abeC"
     CDS             14439..16040
                     /codon_start=1
                     /gene="abeC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 330.2; E-value:
                     4.3e-100)"
                     /gene_kind="biosynthetic-additional"
                     /product="RebC-like monooxygenase"
                     /protein_id="AEF32100.1"
                     /transl_table=11
                     /translation="MNPVENDVLETEVIIVGGGPTGMATALELRSRGVDFVLVEAGDGT
                     VGHPKVSSIGPRSMEFFRRWGVADAVRHSGWPEDHPLDCVWTTRIGGHELFRLPRHTMG
                     TRPDFRHTPEPDAICPQHWLGPLLRGALGVHPDGPVRMSTRLESFTQDDTGVHAVLSDG
                     TEVHAQYLIACDGASSPIRKHLGIAAPAVHDALVFRNVLFRAPELRERLGDQVANFYYL
                     MISSALRFPVRALDGRELYRMTVGLQGSPESLQEAETLVRKAIAFDTPVEVVSDNEWHL
                     VHRVAEDFRSGRVFLVGDAAHTLSPSGGFGMNTGICGAADLGWKLAAELRGWAGPDLLD
                     SYTRERQPVAFEGLEEANRNLERAMRREVPPFLNDDTEQGAAMRSKISEGLQRGGVARE
                     FDAPEIHLGFTYAGSALVVDDPTAENLQDRRPNTRPGSRAPHAWVKDGLSTLDLFGDGF
                     VLVHFENSARLASFAKAFESRGIPFRAECLDSPEIAHAYERPFVLVRPDGHVAWRGTEL
                     PADAGTIADTVRGGAR"
     gene            16037..17215
                     /gene="abeP"
     CDS             16037..17215
                     /codon_start=1
                     /gene="abeP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 346.4; E-value:
                     3.3e-105)"
                     /gene_kind="biosynthetic-additional"
                     /product="RebP-like cytochrome P450"
                     /protein_id="AEF32101.1"
                     /transl_table=11
                     /translation="MKPFSLKNWTDEDLHNPFPVFARYLANGPLHRADGTWYVFGHDAA
                     VEVLTGSAFGRRSPAGGGSPVSVPSALRTLVENWLVFLDPPRHTELRSVLNKEFSPAVV
                     TNLRPRIAEIARTLLTDLPVTFDLVERFSAPLPILVISELLGVPREDAGWLRDRAVDLQ
                     EASSVRAAANPDAHAVADRAAQELRDYFLALMRTLRSEPGDDLVSLMVSAQTRGEPVSP
                     DEIVGTCVHLMTAGHETTTNVLSKSVLALASRPEARAELRRGVTAAAVEELVRFDPPVQ
                     AVGRWAHRDADVAGVTIPAGSKVMVMLGAANRDPARFAAPDSLDLRRAGGRNTGFGLGI
                     HYCLGAALARAELEIGLGALLPALGDYAVDSVEFPHDIVFHGPHSVVLTRSG"
     gene            complement(17220..20018)
                     /gene="abeR"
     CDS             complement(17220..20018)
                     /codon_start=1
                     /gene="abeR"
                     /gene_functions="regulatory (smcogs) SMCOG1149:LuxR family
                     transcriptional regulator (Score: 230; E-value: 9.5e-70)"
                     /gene_kind="regulatory"
                     /product="LuxR-like transcription regulator"
                     /protein_id="AEF32102.1"
                     /transl_table=11
                     /translation="MSQRNLEDNLDRSRVPGIRVVAPPHGREAELRLVEDVISTIEAGA
                     QANVVVLQSDQGSGKTWLLERAAALAARRGFAVVDGMSPSVATGRPVSLVGGRTARGED
                     DRIAVLAAGCEAQVCGRLRNEPVLVVLDDVHWVEPALLHAIGLVMAKLGAAPVLWMFAL
                     DTAHAESANGQLLHSLVRRQRVQRLGPLERLSGAAVVSLVQGLTGATPDPDVIALCESV
                     GGEPQSVVDLVLALRQEQSLVISGGVVELADGALTTDVPSRVEAEPGARLPAAFVRMVR
                     SRLGRLSLRCREVLQVAAVLGDRFPPQDLAEMLEERTSHLLGPLQEAIRAGVIDSDGDE
                     FTFHREPVWLVVLGTVPALLRSLLHRQAATMLVEQGRADAAAVHVVHFVKPGDEDALRI
                     IRDAAVGLLPTAPRTAAALAIRGLEIAPPGSDDRLVLATSAVAALVRMGDLGAAVDLAT
                     EQLGTCGESASSSLRTWLATALMLRGDESAAQGVLAGGGDTRDPLPDLLLLNTFSGEER
                     CEVVAMAERVLAEPGSHSDAVRAAALTVRARVRWREGELSEALATAEDAIAVQPGLPEV
                     CQVDPLWMRAWMLTRVRRLDDAFETAEQARRVIDEHNLGVLVSLPLALRAEVRLVQGEL
                     AAAEADATAGLRAAERAGTSVYEPQLRAVLVMVSLRRGDLAVAARHLRCLEDRVPGGPP
                     VLLRCLLSALLTAAGRGVREAMEELREVVGDAGSRRRLVLEDPSSTSWVVRTALGAGEV
                     DHAGLVVVTAEEIAAGNPGHSAFAAAARHGRALLEGDVTGLAGLEDLYGDDVWAAASLV
                     EDRGSMLRAEDRDRAMSELDQAMERYDDLGAAWDAARVRRKLRRLGVRRRHWNHETRPD
                     SGWESLTTAEGKVAALVAQGMTNQQVATGLFVSPHTVGFHLRQIYRKLGIRSRVDLARI
                     AP"
ORIGIN
        1 tcagagccgg cgaacccggc ccagccacgc cgcgagctgt acctcgccgt gggcggggag
       61 tcctcgctgg acggccacct cggagatctg ctccgtgatg aaaccctggt agtgggctgc
      121 ttcgatgctc tcgacctccc agccgccggt gaaggtctcg cggatgacgt cgtcgctgat
      181 gctggagctc aggcccggtg ccgcgtcgga gtgggcgagg atgtgcacca gcgctccggg
      241 gttggtcagc gcgtgcagga cgtcggcgta ggccttggcc gcgccgggat ccccgtaggc
      301 gccgaagccg tggaagaggg ccacgtcgac gacggtgtcg aagccgcccg cgaggaacgg
      361 gtggtgttcc gggtggagca tgttggccac ctcgaagcgg gccgcgggca cgcctcgttc
      421 ggtggcggtg cggcgggcgt agtcgatggc gctcggcgac aggtcgactc cgagggactc
      481 gtagcccagc ctggtgaaca ggatggtgtg ctcaccggag ccgcagccgg gttcgaggac
      541 ccggccgcgg acgagaccgg cggcctccag ttcgacgatc gcgggttgtg gcccgccgat
      601 gagccacgga gcggttccct cgtcgtacat gaagttccag tactccgggt cctcgaaccc
      661 gcgggactcg tcggtctgac ctgtctgcgt catgggtcca gtgtggagat ccgcgagatc
      721 ggggaacaca gccgggaaac gaacccactg ggtcgtgcgg tatgggatcg gcgtccccgt
      781 ggtggtgacg ctgggtggaa ctcaggcggg tgccttcacg cgggtcagga cggtgtccag
      841 gaagtcggtg acgcccggcg acttgggttc cgccaccgcg gcgacgtggc cgtccgggcg
      901 gaccagcacc agcagcggac cgctcacctg gtacgcgcgg tgggcggctt cctcttccgg
      961 tgggatcacg tgggtggtga tcgccacggt gtagcggtcg tcgaggctcg cggcgagccg
     1021 gtcggtgtcg agcgactggg ctccgaacag caggacgtgg tagccggagc cgtgggtcag
     1081 gtccagcacg ctgctcgcgc cgtcgcgggt cggcctgatc tcggcgtacg gcgcccggtc
     1141 acccggcctg agcggaccgg tgccggggcc gaccgcgggc gagttgcggt acctgatcca
     1201 cagctgggag aacatgtgga agaacatccg gcggatcggg gcgagccggg acaccgcacc
     1261 gacgacgcgg gtcgcgacgt gagcgcgcat ccagaccgcc acggcgctgt tcccggtctc
     1321 cagcttgaag cccaggtcgg tgcgcttgag cacggtgcgg gcgatcgggc ggcgttctga
     1381 ctcgtaggtg tcgagcagcc gctcgggcgc ttcaccgttc accacctgcg ccagtttcca
     1441 ggcgaggttg accgcgtcac cgacgccgag gttgagaccc tggccgccgg ccgggttgtg
     1501 gatgtgtgcg gcgtcgcccg cgaggaaaac gttgcccacg cggaaccgcg aggcgatccg
     1561 gctgtggaag cggaacatcg acgcccagac gacctcctcc aaccgggcgt ccaccttgaa
     1621 gtagccgtcg aaccacttct gcaggtcagc gggcgccaag ggtgcgtagg cctcgtgcga
     1681 cgggttcttc tgggacgggg cctgctccag ttccctcggc accacgccga agagccggca
     1741 gcggccggac gccagcggca ggattccgac gaacccgccg cgggtcaggt tgagacgcat
     1801 accgcgcacg ccgaggtcga cgtccagggt gacgtccgcc agcatgcccg cctggtcgta
     1861 ggtctcaccg tcgaacgact ggccgacgaa cccgcgcacc gcgctgctcg ccccgtcggc
     1921 gccgaccagc cagcgcgcgg tgatcgaccg gccctccgcg gtggtgacgc cgacgagcgc
     1981 gccggtgtcg gccagctcca cgaccgcggt gttccactcg acctcgacgt ggtgttcttt
     2041 caaagcctcc accagcaccc gctcggtctc gaactgttcg agcgcgaggg cataggggaa
     2101 acgcgtccgg tcgccggtgc cctctcccgc gagcggcatg tcccccacgt gccggccggc
     2161 ctcgtggatg gcgacgtcgg tgatcggcag gcctcgtgcg accgcggcct ccgcgacgcc
     2221 gagccggtcg aagagctcca gcgtgcgggc gtgcacgatg gcggcgcgtg cctgttcgac
     2281 gggaccggac ttggagtcga cgatccgcac gcgcactccg tgttgcgtga gcatcagcgc
     2341 ggtgcacagg ccggtcggcc ccgcacccac caccaggacg tcgcagtcgc gttcgtcgcg
     2401 catcggctcc ctcattcacg tcggcgagtg tgcgaacgca gtatcgcgac gtgcggcgag
     2461 ccaccacatc gcccgacgtg gagcgtgatc ggacgatcac cccgcgcgac cgcgcaggtt
     2521 ctcggcgccg tcctatctcc gcggccgccg gacacccgat ggtggaagcg atcacatggt
     2581 cggactgccg gaagccgagg gacctcgatg agtaccgcac cggaagcgtt tttcgacgac
     2641 ctggccgaac tgtacgagcg cttcacgctc atccgcgacg ccgccacgag tccggtgcgg
     2701 tcgtggctcg tcgagcagtt gcccgccggt tcccgcgcac tcgacgccgg ctgcggcagc
     2761 ggcaacaact gcggcatgct cgccgagcgg tacgacgacg tggtcggcgt cgacgtgtcg
     2821 cggaagatgc tcgacatcgc ggccacgaag cggacgcggg tgccggtgcg gtacgagtgc
     2881 cgcgacgccg tcgacctgac gcccgagcgg gacggccgct tcgacctcgt gatgtcggtc
     2941 aacgccgtgt tccacatggg acccgcggac gaggtgctgc ccgtgctgcg cgccctcgtc
     3001 gctcccggcg gcaggctggt ggtcgtcgac gtgacgcagc ccgacgacgc ggcggccccc
     3061 gccgagcaga gcgcttacgc gttccagacc ggcaagatca tctacgacgt ctcccgcgac
     3121 gtcgaggccg cgtgcgactc gatccggatg atgctgcacc cgcgctggct cgagatgagc
     3181 gccgccgcga tgcccctcac cgactcggag ttccggtccc agtacgagcg ggcgctgccc
     3241 ggcgtgcgga tcaccaggga cctcatcccc acgatgagcg cggccgtctg ggacaacgca
     3301 tgagcgtctt ccacctcccc cgcctgcact tcgcgggcac ggccatcacc cgcctgccca
     3361 ccgggccgcg cgcgggctgg ctcgacctcg agaccaacca ggccatcgac gaccagggcg
     3421 tgttcgacac cgaccgcccc gtccaggagt actacgactt cctcgcggac gccaagggcc
     3481 acaacttcga gggcaacggc cacttctggg tcgacgcgaa ggtcgtggcc accgaactcg
     3541 ctccgggcga ggtgcgctcc gacgacctgg tgacgggacg gcagctcgat ctctggggtc
     3601 acttctgcga ctacaccgcg ggcaccgcca accggtcgcg cgtgttcgac gtcgacccgg
     3661 cctccaactg gaccacgacg ctgatggtcg gccagctcgc gctcggcagg tcgggccgct
     3721 cgcacgacgt gccctacctc gtcaccggtg acgtcaacgg catgtgcccg cctcgctgga
     3781 accagttcca caccgtgctg caccagttcg ccgtcgacaa ggccgagggg ctgcattggc
     3841 tcagcggtgt cgcggactcc cccgtgctca cacggctgcg cgaggtggtc gagaacgacg
     3901 cggacggcct ggtggtccag ttcgcgctca gcgaccagaa gcacacgggc gagggccagc
     3961 ccgacgtctg gcagctgcgc gggaccgtcg cggcctggta ccgcgacgag ctgcgcagct
     4021 acccggccgg gcggctgctc acaccgcgca ccacgcgttc cgcgttgcac aacctctccg
     4081 tgcacgtcag cgacgaccac gtcaccgcga acctcgtcac cgcgcacccg gacaccgacc
     4141 tggaggtgcg cacggcctgc ggcacgctgc tcgcgaccat tccgtccaca acggactcgc
     4201 gcacgtcggg cgtcgtcgtg gcggcacggg tggacggtgc gaccggcaac ccggccgagg
     4261 cgctggtgat caccgacggc gaaggaaccg tgctgtcgcg cgaggaggag accgtcatcg
     4321 agtccgacga ggccgcgttg ttcctggagc acgagaacac caggaccggc gaggaccacg
     4381 ccgtcgagat ccccgtccgc tcctacctgc gcggtgtccc cgcgcgggtc gaccaggtcc
     4441 acgtccggca gtacgtgaac cccgccgctc tgccactcgc aggcgaccgc gacagcgctc
     4501 agctcgtcgc gttcctgccc accggacaag ccggctacca ggccgaacag gtgctctcga
     4561 ccgacgagca cggccgcggc gccatcacgc tcaagggtgt gcggggcggc gcgacgaggg
     4621 tcctgctccg gccggagccc acgccggaac cgcggggcac cacggcggcc gagcgctacg
     4681 acaacgacga cgagcagggc tactggtcgg cggtcggctc catcgcggtg cgggtgctgc
     4741 cgaaccactg gcacctcgac gacctgccgg acgaggacat cacgttcagc acggtgtacc
     4801 gcgaagcgct cgcctactac gaactccagt actcgttcat gcggtccgag gtgctgagcc
     4861 tcgccgacga gttcaaggtc gagccttacg cccgcctcat ctggcacgtg tccgcgcccg
     4921 agcacaaggg caggacgttc tacatgcccc cgacgcgcga catgagcgca ccgcagatcc
     4981 ggatgttgct gcgctacctg ctcgccgacg acgcccaacg gcagactccg ccgactttcg
     5041 ttccacagca acgaaaactc ggcacgatca cgacgaagga ccagctgctg cacgcgctct
     5101 accaggcagc ggcgatcgag ctggccacca tggtgcagta cctgtacgcg gcctacagcg
     5161 tgccgaccca cggcgccggc aggaagctcg tccagcgcgg cgagtggacc gaggagcagc
     5221 tgctcacggc gtgcggtgag ggcaccgaga cctggagcaa cggcatccgc ggcagtctga
     5281 tgtccgtcgc ccgcgaggag atgatgcact tcctcgcgat caacaacatc ctgatggcga
     5341 tgggccggcc gttccacctg cccaagctcg acttcggcac gttcaacagc accacctgcg
     5401 tcccactgga gttctcgctc gaggcgctga acctggcgag cgtgcaacgg ttcgtggcgc
     5461 tggaacagcc gcacgacctg atcgaggaga tcgagggcaa cgactccacg gtcctgcgcg
     5521 cggacgggga gccgtaccag tacgggtcgc tgagcgagct gtacgcggcg atccgcgagg
     5581 gcgttcaggc cgtgccgggc gtgttcctgg tgaagaaggg ccgcggcggt ggcgcccacc
     5641 acctgttcat gcgcgagtcc gtcaacgccg tgcaccccga ctaccagctc gaggtcgacg
     5701 acgtggcgag cgcggtgttc gccatcgact tcgtcaccga gcacggcgag ggcggccaga
     5761 tcccctcgac gctgccggag gaggagtcgc acttcgacac gttcctgcgc atctccgaga
     5821 tgctcatcgc cgaacgggcg aagggcccga acgaccgcag ggtgccgtgg aaccccgcct
     5881 acccggtcat gcgcaacccg acgctcaagc cgggcaacgc cgcgatggac cacgtgacgc
     5941 acgaaccggc ccggatcgcc atgaaggcgt tcaaccgctc gtacttcatg gcgatgcagc
     6001 tgatggtgca gcacttcggc tacagccccg acaagtcgtt gcgccgcagc cggttgatga
     6061 actggtcgct ggacgtcatg accggcgtgc tgcggccgct cggcgagctg atcgtcacgc
     6121 tgccgtccgg acggcccggc cgcaccgcgg gcccgtcgtt cgagctcgac tccggcccgg
     6181 agtacatctc ccggcccgac gtcgcggtcg agtggatggc ccgcgagttc gacgaggtgg
     6241 ctgatctggc ccgcaagtgc gtcggcttcg gcctcacccc gaccgtgggc gacctgctgg
     6301 ccttcatcgg tgactcgttg cgcaccatgg acctgaaaga cctctgatga ctgagaagac
     6361 gacagtgtgc atcgcgggcg gcggcccggc cggtgccgtg ctcgggctgc tgctggcgcg
     6421 ttccggggtg gacgtcgtgg tgctggagaa gcacgccgac ttccgccgcg acttccgcgg
     6481 cgacaccgtg cacccggcga ccctgcagat cctcgacgag ctcgggctca tcgagaagtt
     6541 ccacgcgctg ccccaccaga aggtcagcac gatcggcgtc gtgcaggaag gcaggcggat
     6601 cgacatcgcc gacttccgcc ggttgaaagt ccgctacccg tacatggcgt tcgtgccgca
     6661 gtgggacttc ctcgacctca tcaccgcgga ggcgaagagg tatcccggct tccgcctgct
     6721 gatgaacacc gaggcgctgg gcgtcgtgcg ggacgagggc ggacgggtcg ccggactgcg
     6781 cgtgcgcggg ccgcagggcg agcggcagat ccggtcgacg ctcgtggtcg ccgccgacgg
     6841 gcggcactcg gtgatccggc gggacgcggg gttcgtgccg acgctgatcg gccggtctct
     6901 cgacgtcatc ttcttcaaga tctcccgcag ggacaccgat cccgacgagg gcatctgcgt
     6961 gcggatcggc aacggcaaga tcttcggcgc gaccgaccgc cgcacctact ggcagatgtc
     7021 gtacgagacg tccaccggcg gcatggagaa ggtgcggggc gaggggctcg acaagttccg
     7081 ggcagacctc tccgagctgg tgccgttcct cgccgaccgg gcgcacgagg tgtcctcctt
     7141 ggaccagctg agtccgttgg aggcgcggat cgaccggctg gagcggtggc acgagccggg
     7201 cctgctgttc atcggcgacg cggcgcacgc gatgtccccg gtcgcggggt tcggtgtgaa
     7261 cctcgcggtg caggacgccg tggccacctc gaacatcctc accgccgagc tgctgcgggc
     7321 ccaggagggc cggatcttcg acgacgaact gctggcgcgg gtccgccgac gccgcaagcg
     7381 cgcggtcgcg ttgtcgcagg gcttgcagcg cgcgacccag aagttcggca tcgacgaggc
     7441 gctcgacggg tccggtcagc cgccggcgcc gaaggtcttc gagaagctcg gcgtcgccca
     7501 gtggctgatg agccgcgtca tcggactcgg gttccggccg gaacacgttc gcacacagga
     7561 gaaagcgccg gagggaaccg ttagatgacc gcaccgggaa tgccgccgca ggcacggatg
     7621 atgcagatga tcacggggta ctggatcacc caggtcgtgc acgccgtcgc cgagctcagg
     7681 atcgccgacc acctcgccgg gaacgcgctg accctggagg aactcgcggc acggacgggc
     7741 gccggcgccg acacgacgct gcggctgctg cgtgcctgcg cctcgcaggg actcgtggcc
     7801 cacgacgaag gccggttcgc cagcacgccg ttgctggaga cgctgcgcga gggcgtgccg
     7861 gggtcgttcc gcgacatcgc gatcgtgcac ggctcaccgg gacactggct gtcctggggc
     7921 cggttcccgg acgcggtgcg cacgggtgag ccgcagacca aggccgcgct gggcagcgac
     7981 atctggacgt acttccagtc ccagccgcag gagtgggagc ggttctccaa ctccatgacc
     8041 gaactgaccg acggcctgtc gcgcgagatc ggcgcgctgc tcgacaccac gggtctcacc
     8101 acggcggtgg acgtcggcgg cgcgaacggc gcgctgctgc acccgttgct gaaggcgaac
     8161 cccggtctgc ggggcgtggt gttcgacctc ccgaccgtcg aggcgaccgc ggtggccgag
     8221 gcggagaagg caggtctggc cggccgctgc acgttcaccg gtggctcgtt cttcgactcg
     8281 gtgcccgagg gcgacctgtt cctgctcaag gccgtgctgc acaactgggc agacgagtcg
     8341 tgcgtgcaga tcctcaccaa ctgccgcaag gcgctccgcc ccggcggacg ggtggtcgtc
     8401 gtcgagatgc cgctgggacc gctgggagaa ccggggttcg ccccgctgct cgacctcggg
     8461 atgctcgccg tcaacgcggg ccgcgagcgc gacctcgacc agtacgacgc cctgttccgg
     8521 gcttccggcc tgcgtcgcgc cgaggtcacg ccgacctcgt ccccgcagag cctgatccac
     8581 gccgtagccg cgtaaccacg aaccggaggt atggccgaag atgttgaaga acgtagtggt
     8641 ggtcggcggc ggaacggccg gctggatgac cgcgtcctac ctgacagccg cgttcggcga
     8701 ccggatcggc gtcacgctcg tcgagtcgaa gcgcgtcggc tcgatcggcg tcggcgaggc
     8761 gacgttcagc actgtccggc acttcttcga gtacctcggt ctcgaggaga aggagtggat
     8821 gcccgcctgc aacgccacct acaagctcgc catccggttc gagaactggc gcgagccggg
     8881 acaccacttc taccacccgt tcgagcgtca acgggtcgtc gacggcttcc ccctgacgga
     8941 ctggtggttg cgcgaaccca ggtccgaccg gttcgacaag gactgcttcc tggtcggcac
     9001 gctgtgcgac gacctgaagt caccgcggca gctgaacggc gagctgttcg agggcggcct
     9061 gggcgggcgc agcgcctacc gcacgacgct ggccgagcag accacccagt tcccctacgc
     9121 ctaccacttc gacgcgacgc tggtcgcgaa ctacctgcgc gactacgcgg tcgcgcgggg
     9181 tgtgaagcac gtcctcgacg acgtgcagga cgtggcgcta gacgaccgcg gctggatcag
     9241 ccacgtggtc accggggaga gcgggaacct caccggcgac ctgttcatcg actgcaccgg
     9301 tttccgcagc ctgttgctgg gcaaggcgct cgccgagccg ttccagtcct accaggactc
     9361 cctgcccaac gacagcgcgg tggcgttgcg cgtgccgcag gacatggaga accggggact
     9421 gcggccgtgc acgacggcca ccgcgcagga ggccggctgg atctggacga tcccgctgtt
     9481 cgaccgcatc ggcaccggct acgtctacgc cggcgactac atctccccgg aggaggccga
     9541 acgcacgttg cgggcgttcg tgggcccggc cgccgagcac gctgacgcga accacatcaa
     9601 gatgcgcatc ggccgcagca atcggcactg ggtgaacaac tgcgtggcgg tcgggttgtc
     9661 gagcggcttc gtcgagccgc tggagtcgac cggcatcttc ttcatccagc acgccatcga
     9721 gcagctggtg aagcacttcc cggacgagcg ctgggacgac ggactgcgca cggcctacaa
     9781 caagctcgtc aacaacgtga tggacggcgt gcgggagttc ctcgtcgtcc actactacgc
     9841 cgccaagcgc caggacaacc agtactggaa ggacgccaag acccgtcctc tccccgacgg
     9901 cctggccgag cggctggagc gctggcagac ccggctgccc gacaacgagt cggtcttccc
     9961 gcactaccac gggttcgagt cctactccta cgtctgcatg ctgctcggcc tgggcggcct
    10021 cgacctgaag tcgtcgcccg cgctcggact gatggacgcc gcgccggccc ggcacgagtt
    10081 caaactcgtg ggtgagcagg ccgccgagct cgcccgcacg ctgcccacgc agtacgagta
    10141 cttcgcccag ctgcaccgcg cgaggtgagc gcggtggtgc tgaacgggat gcacctcgtc
    10201 gcgctcctgg ccgcgttctt cgcggtcgcg gcgctcggcc gggtgatggc acgggcgctg
    10261 cggacgccca ccgtgatcgg tgagatcgcg ttgagcatcc tgctcgggcc ggtgctgctg
    10321 gccgcgttcg gcaagagcct cttcaccgcg gtcctgccgg ccgacgtcac cgctgtgctc
    10381 aaacagatcg gcgaggccgg gctggtgctc ttcctcgtcg gtgtggtgca ccacctcgac
    10441 cgcggcgtca cgggcgggtg gcacggcaag gcgctcggcc ggatcacgat cggcgccttc
    10501 gcgctgccgt tgctgaccgg tctcgccttc gccgcctggg ccgtctggct cgcgcccgcc
    10561 gaggtgcgcg gcaccgctcc gacggccgcg ctggtgctgg tgctcgcggt ggccatgtcc
    10621 gtcacggcgg tgcccgtgct cgcgcgcatc ctggaggagc ggtccgacct gggtcgcgcc
    10681 tccgggctgt cgatgatggc gtcggtgctg atcgacacgc cggcctggct gttgctgacc
    10741 gtggcgctgg gtctggccgc gggtggcctc ggtggcgtgt ggctcgcgtt cgcgaccatc
    10801 ggcgtgggcg tggtgatcgc gtggctcggt cgccgggcgc tcgggtcgga gcgcgtcggg
    10861 aacgtcgcgg cggaaaggcc gcgcacgacc gctctcgtcc tcgcggtggt ggcactggcc
    10921 gcaggcacgg cggtgcattc cctcgggctc acggcgatct tcggcgcgtt cctggccggc
    10981 gtggtggtgc cgcgcgacga ggcgtggtcg cgggtcgtcg cgctggtcag ccgggtgggc
    11041 agggcgttcg tgccggtgtt cttcgtggtg gcggggacga cgctgtccac cagcggggtg
    11101 tcggcgttcc cgtggatcgg cgtcgccctg gcgctcgcgc tcggcgtcct cggcaagatc
    11161 ggcggcgggt acgccggggc gcgctggggc ggcgaggacg cggtcacgtc gctgcggatc
    11221 ggcgtgctcg tgaacacgcg cgggctcacc gagatcgtgg tgctccagat cgcgttcacc
    11281 gccggtctgc tcacgccggg gctgttcgtc gcgctgctgg tgatggcgct ggtgacgacc
    11341 gcgctcacgg gtccgctgct ggacgtgatc acccggcgtg ccggggcggc acggcaggag
    11401 gtcttggtgt gacagaacag ttccgcgggc tcatggccgc tttcccgacc ggtgtcgccg
    11461 tggtgacgac cttcggtcag gacggtgagc cgtgggggat gacgctgtcg tcgctgtcga
    11521 gcgtgtcggt ggacccgccg acgttgctgg tgtgcctgcg gtacagcagc ccgacgctgg
    11581 acgcgttggt gcgcaccggt tccttcacgg tgaacctgtt gcaccacgag gcgcgtccgg
    11641 ccgcggagct gttctcgtcg ggtgacccgg accgcttccg gcaggtggcg tgggaacatc
    11701 ccgcgtccct cggcgggccg cacctggtgg acgacgcgca cgcggcggcg gactgcgtgg
    11761 tggaccacat gcaccgcacc ggcacgcacg tggtggtgtt cggcaaggtc cacacggtcg
    11821 tgcaccgctc agccgcccag ccgctgctct acgggctgcg ccggtacgcc tcctggccgc
    11881 ggagcgcttg acacgcaacg agaactggcc ctctcaccac aaccggtgag agggccagtt
    11941 ctcgttgcgt gtcagcgtga gccgaggagc cactccgtcg tcacccggat cgccggggcc
    12001 tgccagtgcg cctccaccgg tggcccgatc tccaccaggc ggctcgggca cgtgagcgcc
    12061 tccaccgcgc tgcgcgagga cgacaccggt gcacccgacg ggccggcgcg gtgcacgacg
    12121 agggtcggcg cggtgatcac cggcagcacc ccgcgcggct gcagccagaa gacctcgttg
    12181 agcatcgcgc gcccgaccac gaaggtgtcc gagacgcgca ggtacccgtc ggcgagcagc
    12241 gcgcggccgg cctccgcgcc gaggaatcct cccgaccacg cggggttcga gtcggcgaag
    12301 tgctcctggt agtcgatcag cgggttgtac agcacgacgt tcgccacctc gtcgccccgc
    12361 cgggcggcgt agccggcggc gacaccgccg gtcagcccgg tggcgacgag cgccgccgga
    12421 cctggtgcca cgttctcgcg caggtgggtc agccccgcgc tgatgacgtt cagcagcccg
    12481 gacaggctca gctcctcctg cgcgccttcg ctgtcaccgt gtccgggaag gtcgacgcgc
    12541 agggaggcca cgccgtgccc ggccagctcc gaggccaggc ggccgtagaa cccgccctgg
    12601 tcgcggtcgg caccttcgcc gtgcagcagc agggccgtgc aacgcggttc accgacgggc
    12661 accacagcgg tcgcggccag cttcaggccg tcgtgtcccc gcaccgttgt cgttcgcggg
    12721 acgacgtcga cggtgggcac tggcatgacg ggcctcctcg gaagagtgtg gcgcccagtg
    12781 tcctgcgtgg atggcacggg agccccctgg ccgccggaaa ccgttctgtc gcgcggtgtg
    12841 aactgctccg gcgagtgggt tgggcacgcg gaaccacctg tgccacaggt gttgcggggg
    12901 atgtgggcgc agggccgcgg cggcacgatt ccgttcatga gtccggtgca cacgaacgtc
    12961 ctctcgggcg gacaacactg gccgcaacgc ccgaagcggg tgaccgtcct cggcgcgggc
    13021 gtcgcgggcc tggtggcggc gcacgagctg gaacgcctcg gccacagcgt cgaggtgctg
    13081 gaggcgcggc tggaggtcgg tggccgggtg cgcacgcact cgttcgtcgg caggggcccg
    13141 ctcgccgagc tcggcgccat gcgcatcccc gcctcgcacc accgaaccat gcagtggatc
    13201 gacctgctgg ggctgagcga cagggtgcgg cagttccgca cgctgttctc cgacgactcc
    13261 agctacctgg agacctgcac cgggcacctg cgggtgcgcg acgcgacctc ggtgctcgtc
    13321 gaggagttcc gccgcggcct gcctcccggc gagtaccgcg aggagtccgt gctcgcggcg
    13381 acctggctga ccgcgagcgt gaacgccgtg gcgcccggcg cgttccgcac gaacctgcac
    13441 agcgacctga acctggaact gctcgacctg ctcgacggca tcgacgtgcg gccgttcttc
    13501 gtgagcaccg gcggcgtcga aaggctcgac gtcaaccggt tcttcgcggg caacccgaag
    13561 ttcgccgggc gcagccgtct cgcgcacttc ttcgacgaca tcaccgtgga gacgtcgtcg
    13621 gcgctgttcc ggctcgaagg cgggatggac cagatcaccg tcaggctggc cgggagcctg
    13681 cgcggcccgg tccaccgcgg ccgccaggtc gtcgggctgc acgtacggcc cgacggcgtg
    13741 gtggtcgaga cgcggcgcgg cctggacgtc gtcgcgagcc actgcgacta cgtgctgtgc
    13801 accgtgccgt tctcggtcgt gcggaggatg aacctcagcg gactggacga cgacaaggtc
    13861 gcgaccgtgc acgacatgca gtactggccc gccaccaaga tcgcggtgca ctgccaggac
    13921 gcgttctggg agggcgacgg catcagcggc ggcggctcgt tcaccggcgg cctggtgcgc
    13981 cagacctact acccgccggt cgagagcgac ccacggctcg gcgcggccct cctcgcgagc
    14041 tacacgatcg ggccggactc ggacgcgctg acgcggttct cgccgccgga gcgggaacgc
    14101 gtcgtgctcg acgagctcag caggatccac cccgagctga agaggccggg aatggtgctc
    14161 gacgtggtga cccaggcctg gggcgaggac ttctccagca tgggggccgc gtcggtgcgg
    14221 tggagcaagg acgccgcgac ggccgaggag gaacgggcgc tggcggccaa gccgcagggc
    14281 acgttgttct tcgccggcga gcactgctcg acctacccgg cgtggatcga gggcgcgatc
    14341 gagtccggcc tcgcggcggc ccaggacgtc cacgccgccg ctccggccga acgcccgctc
    14401 gtggcgaccg ggtaccggcg catgaggggt ggcgcggcat gaacccagtg gagaacgacg
    14461 tgctcgagac cgaagtgatc atcgtcggcg gcgggccgac cggcatggcc accgcgctgg
    14521 aactgcgttc gcgtggcgtc gacttcgtcc tggtcgaggc cggcgacggc acggtcggtc
    14581 atcccaaggt gtccagcatc ggcccccggt ccatggagtt cttccgccgc tggggtgtcg
    14641 cggacgccgt tcgccactcc ggctggcccg aggaccaccc gctcgactgc gtgtggacca
    14701 ccaggatcgg cggacacgag ctcttccgcc tcccccgcca cacgatgggc accagaccgg
    14761 acttccggca caccccggaa ccggacgcga tctgcccgca gcactggctc ggtccgctgc
    14821 tgcgcggggc tctgggcgtc cacccggacg gaccggtgcg gatgagcacg cgcctggagt
    14881 cgttcacgca ggacgacacc ggcgttcacg cggtgctgag cgacggcacc gaggtgcacg
    14941 cgcagtacct gatcgcctgc gacggcgcga gctcgccgat ccgcaagcac ctcggcatcg
    15001 cggctcccgc cgtccacgac gcgctggtct tccgcaacgt cctgttccgc gcgcccgaac
    15061 tgcgcgagcg gctcggcgac caggtcgcca acttctacta cctcatgatc tcctccgcac
    15121 tgcgcttccc cgtccgcgcg ctggacggcc gggagctgta ccggatgacg gtcgggctgc
    15181 agggctcacc cgagtcgttg caggaggccg agaccttggt gcgcaaggcg atcgcgttcg
    15241 acacgccggt ggaggtggtg tccgacaacg agtggcacct ggtgcaccgg gtcgccgagg
    15301 acttccgctc cggccgggtc ttcctcgtcg gggacgccgc gcacacgctg tcgccgtcgg
    15361 gtgggttcgg catgaacacc ggcatctgcg gcgccgcgga cctcggctgg aagctcgcgg
    15421 ccgagctgcg cgggtgggcg ggcccggacc tgctcgacag ctacacgcgg gagcgtcagc
    15481 cggtcgcgtt cgagggtctg gaggaggcca accgcaacct ggaacgggcg atgcgccgcg
    15541 aggtgccgcc gttcctgaac gacgacaccg agcagggcgc ggcgatgcgg tcgaagatca
    15601 gcgaagggct ccagcgcggc ggcgtggccc gcgagttcga cgcgccggag atccacctcg
    15661 gtttcaccta tgccggatcg gcgctggtcg tcgacgaccc gacggcggag aacctgcagg
    15721 accgcaggcc gaacacccgg ccggggtccc gcgcaccgca cgcgtgggtg aaggacggcc
    15781 tgtccacatt ggacctcttc ggagacgggt tcgtgctggt gcacttcgag aactccgcac
    15841 gcctggcgtc gttcgccaag gcgttcgagt cgcgggggat tccgttccgc gcggagtgcc
    15901 tggactcgcc ggagatcgcg cacgcctatg aacggccgtt cgtcctggtg cggccggacg
    15961 ggcacgtggc ctggcgggga accgagctgc ccgcggacgc agggacgatc gcggacaccg
    16021 tgcgcggagg tgcgcggtga agccgttctc cctgaagaac tggacggacg aggacctgca
    16081 caaccccttc ccggtgttcg cccgctacct ggcgaacggt cccctgcacc gcgccgacgg
    16141 cacctggtac gtgttcggcc acgacgccgc ggtcgaggtg ctgaccggtt ccgccttcgg
    16201 ccgccgctcg ccggcgggcg gcgggagccc cgtgtcggtg ccgtcggcat tgcgcacgct
    16261 cgtggagaac tggctggtct tcctcgaccc accacggcac accgagctgc gatcggtgct
    16321 gaacaaggag ttctcacccg ccgtggtgac gaacctccgt ccgcggatcg ccgagatcgc
    16381 ccgaaccctg ctcaccgacc tgccggtgac gttcgacctg gtggagaggt tctccgcgcc
    16441 cctgccgatc ctggtcatct ccgaactgct cggcgtaccg cgcgaggacg cggggtggct
    16501 gcgggacaga gcggtcgacc tgcaggaggc gagcagcgtc agggcggcgg cgaacccgga
    16561 cgcgcacgcc gtcgccgacc gtgccgcgca ggagctgcgg gactacttcc tcgcgctgat
    16621 gcggacgctg cggtccgagc ccggtgacga cctggtgtcg ctgatggtgt cggcccagac
    16681 ccgcggcgaa ccggtgtcgc cggacgagat cgttggtacc tgcgtgcacc tgatgaccgc
    16741 cgggcacgag acgacgacca acgtgctgag caagtcggtg ctggcactgg cgtcgcggcc
    16801 cgaggcgcgg gcggagctgc gccgcggcgt caccgccgcg gccgtcgagg aactggtgcg
    16861 cttcgacccg cccgtgcagg ccgtcgggcg ctgggcgcac cgcgacgccg acgtcgcggg
    16921 cgtgacgatt ccggccggca gcaaggtgat ggtgatgctc ggtgcggcga accgcgaccc
    16981 cgcccggttc gccgcaccgg attcgctcga cctgcgtcgt gccggtggcc gcaacacggg
    17041 cttcggcctc ggcatccact actgcctcgg cgccgcgctg gcgcgcgccg agctggagat
    17101 cgggctcggc gcgctcctcc cggcgctggg cgactacgcg gtggacagcg tggagttccc
    17161 gcacgacatc gtcttccacg gtccgcacag tgtcgtcttg accaggtcgg gatgacggct
    17221 cacggagcga tgcgggccag gtcgacgcgt gacctgatgc ccagtttgcg gtagatctgc
    17281 cggaggtgga acccgacggt gtgcggggag acgaacaacc ccgtggccac ctgctggttg
    17341 gtcatgccct gcgcgacgag tgccgcgacc ttcccctcag cggtggtgag gctctcccag
    17401 ccggagtcgg gacgggtctc gtggttccag tgccgccgcc gcacccccag ccggcggagc
    17461 ttgcgccgca cccttgccgc gtcccacgcc gcgcccaggt cgtcgtaacg ctccatcgcc
    17521 tggtcgagtt ccgacatggc tcgatcgcgg tcctcggccc gcagcatcga tcccctgtcc
    17581 tcgaccagcg acgccgctgc ccagacgtcg tcgccgtaga ggtcctccag gccggccagg
    17641 cccgtgacgt cgccctcgag cagcgcccgg ccgtgccgtg ccgccgcggc gaacgcggag
    17701 tgcccggggt tgcccgcggc gatctcctcg gccgtcacga ccaccagccc ggcgtggtcg
    17761 acctcccccg cgcccagcgc cgtgcgcacc acccacgacg tcgacgacgg gtcctccagg
    17821 acgagccgcc ggcgtgagcc cgcgtccccg accacctctc gcagctcctc catcgcctcg
    17881 cgcactccgc gcccggcggc ggtgagcagc gcggacagca ggcaccgcaa cagaaccggc
    17941 ggcccaccgg gtacgcggtc ctccaggcag cgcaggtgcc gcgccgcgac cgccagatca
    18001 cctcgccgca gcgacaccat caccagcacc gcccgcaact gcggttcgta cacggacgtg
    18061 ccggctcgtt ccgccgcccg cagacccgct gtcgcgtcgg cctccgcggc ggccagctca
    18121 ccctggacca gacgcacctc cgcccgcagg gccagcggga gggacacgag cacacccagg
    18181 ttgtgctcgt cgatcactcg acgcgcctgc tccgccgtct cgaaggcgtc gtcgagcctg
    18241 cgcaccctcg tgagcatcca cgcccgcatc cacagcggat ccacctggca gacctcgggc
    18301 aggcccggtt gcaccgcgat ggcatcctcc gcggtcgcca gcgcctcgct caactcgccc
    18361 tcgcgccacc tcacccgcgc gcgaacggtg agcgcggccg cccgcaccgc gtcgctgtgg
    18421 gagccgggtt cggccagcac ccgctccgcc atcgcgacga cctcacaccg ttcctcaccg
    18481 gagaaggtgt tgagcagcaa gaggtccggc aacggatcgc gggtgtctcc cccgccggcg
    18541 agcacgccct gcgccgccga ctcgtcaccg cgcagcatca acgccgtcgc gagccaggtc
    18601 cgcagcgagg aggacgcgct ctcgccgcac gtgccgagct gttccgtcgc gagatccacc
    18661 gcggcaccga ggtcgcccat ccgcaccagc gcggcaacgg cagaggtcgc cagcaccagc
    18721 cggtcgtcgc tgccgggcgg cgcgatctcc aggccgcgga tcgcgagcgc ggcggcggtc
    18781 cgcggtgccg tgggaagcag tccgaccgcg gcgtcgcgga tgatccggag tgcgtcctcg
    18841 tcgcccggct tcacgaagtg gaccacgtgc acggcggcgg cgtcggcacg tccctgctcg
    18901 accagcatcg tggccgcctg ccggtgcagc aacgagcgca acaacgcggg cacggtgccg
    18961 aggacgacca gccacacggg ttcgcggtgg aaggtgaact cgtccccgtc actgtcgatc
    19021 acgccggcgc gaatggcctc ctgcaagggc cccagcaggt gcgaagtccg ttcctccagc
    19081 atctcggcga ggtcctgcgg ggggaacctg tcgccgagca ccgccgcgac ctgcaacacc
    19141 tcccggcacc gcagcgacag ccgccccagc cgggaacgga ccatgcgcac gaaggccgcc
    19201 ggcagccgcg caccgggttc ggcctcgacc ctcgacggca cgtccgtcgt caacgccccg
    19261 tccgcgagct cgaccacacc gccgctgatg acgagggact gctcctgtcg cagggcgagc
    19321 acgaggtcca cgacggactg gggttcgccg cccacgctct cgcacaacgc gatgacgtcc
    19381 ggatcgggcg tggccccggt caggccctgg accaggctga ccacggcggc gccggacaac
    19441 cgctccagcg ggccgagccg ctgcacgcgc tgccggcgga ccagcgagtg cagcagctgg
    19501 ccgttcgccg actccgcgtg cgccgtgtcc agcgcgaaca tccacagcac gggtgccgca
    19561 ccgagcttgg ccatcaccag gccgatcgcg tgcaacaacg ccggttccac ccagtgcacg
    19621 tcgtccagga ccaccagcac gggctcgttc cgcagacgac cgcagacctg cgcctcacac
    19681 ccggccgcga gcacggcgat gcggtcatcc tcgccccgtg cggtgcgacc gccgaccagc
    19741 gagacgggcc ggccggtggc gacggacggc gacatgccgt ccacaacggc gaacccacgc
    19801 cgtgccgcca gcgccgcggc cctctccagc aaccacgtct tcccggaacc ctgatcagac
    19861 tgcagcacga cgacgttggc ctgcgcgcct gcctcgatcg tggagatcac gtcctcgacc
    19921 aggcgcagct cggcctcccg accgtgcggt ggtgcgacca ccctgatgcc gggcacgcgt
    19981 gagcgatcga ggttgtcttc cagattcctt tgagacac
//
