Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001333.1:
Cluster 1Alkaloid120018

BGC0001333, BE-54017 biosynthetic gene cluster from uncultured bacterium. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: BE-54017
PubChem ID: 66575233
SMILES string: Copy to clipboard
Molecular formula: C23H18ClN3O5
Average molecular mass: 451.863 Da
Molecular activity: Cytotoxic
Molecular target: V-ATPase

Class-specific details

Biosynthetic class(es):
Alkaloid
Alkaloid subclass:
Indole/benzopyrrole

Gene cluster description

BE-54017 (BGC0001333). Gene Cluster 1. Biosynthetic class = Alkaloid. GenBank JF439215, positions 2570-22587. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Fang-Yuan Chang (MIT)

Literature references

1. Chang FY, Brady SF. (2011) Cloning and characterization of an environmental DNA-derived gene cluster that encodes the biosynthesis of the antitumor substance BE-54017. J Am Chem Soc 133(26):9996-9. doi: 10.1021/ja2022653. Epub 2011 May