Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001334.1:
Cluster 1Alkaloid120777

BGC0001334, cladoniamide A, cladoniamide B / cladoniamide C / cladoniamide D / cladoniamide E / cladoniamide F / cladoniamide G biosynthetic gene cluster from Streptomyces uncialis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: cladoniamide A
PubChem ID: 25053147
SMILES string: Copy to clipboard
Molecular formula: C22H16ClN3O5
Average molecular mass: 437.836 Da
Molecular activity: Cytotoxic
Molecular target: V-ATPase

Class-specific details

Biosynthetic class(es):
Alkaloid
Alkaloid subclass:
Pyrrole/pyrrolidine

Gene cluster description

cladoniamide A, cladoniamide B / cladoniamide C / cladoniamide D / cladoniamide E / cladoniamide F / cladoniamide G (BGC0001334). Gene Cluster 1. Biosynthetic class = Alkaloid. GenBank JN165773, positions 9571-30347. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Fang-Yuan Chang (MIT)

Literature references

1. Ryan KS. (2011 TI) Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold. PLoS One 6(8):e23694. doi: 10.1371/journal.pone.0023694. Epub 2011 Aug 18.