BGC0001335: borregomycin A biosynthetic gene cluster from uncultured bacterium
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Location: 9,991 - 36,113 nt. (total: 26,123 nt).
This entry is originally from NCBI GenBank JX827455.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001335
Short description borregomycin A biosynthetic gene cluster from uncultured bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (other)
Loci
JX827455.1
9991 - 36113
via Heterologous expression
Compounds
  • borregomycin A
  • borregomycin B
  • borregomycin C
  • borregomycin D
Species uncultured bacterium [taxonomy]
References
Chemical products information
borregomycin A [synonyms: borregomycin] Evidence:
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C23H17Cl2N3O6
borregomycin B Evidence:
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C23H17Cl2N3O4
Chemical database entries
PubCHEM
borregomycin C Evidence:
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C22H15Cl2N3O4
Chemical database entries
PubCHEM
borregomycin D Evidence:
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C21H13Cl2N3O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGI62210.1
  • borR
 9991 - 12867 (+) transcriptional regulatory protein
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    • AGI62211.1
    • borP
    		 13009 - 14274 (-) RebP-like cytochrome P450
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      • AGI62212.1
      • borD
      		 14345 - 17635 (-) chromopyrrolic acid synthase
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        • AGI62213.1
        • borO
        		 17650 - 19092 (-) tryptophan oxidase
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          • AGI62214.1
          • borT1
          		 19368 - 19892 (+) putative ATP-binding ABC transporter
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            • AGI62215.1
            • borT2
            		 19889 - 20665 (+) putative ATP-binding ABC transporter
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              • AGI62216.1
              • borF
              		 20626 - 21216 (-) flavin reductase
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                • AGI62217.1
                • borH
                		 21229 - 22818 (-) tryptophan-6 halogenase
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                  • AGI62218.1
                  • borM1
                  		 22845 - 23591 (-) methyltransferase borM1
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                    • AGI62219.1
                    • borC
                    		 23915 - 25531 (+) RebC-like monooxygenase
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                      • AGI62220.1
                      • borX2
                      		 25580 - 26833 (+) AbeX2-like monooxygenase
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                        • AGI62221.1
                        • borY1
                        		 26925 - 27386 (+) hypothetical protein
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                          • AGI62222.1
                          • borY2
                          		 27457 - 27771 (+) monooxygenase-like protein
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                            • AGI62223.1
                            • borT3
                            		 27842 - 30007 (-) putative drug exporter
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                              • AGI62224.1
                              • borX3
                              		 30194 - 31429 (-) cytochrome P450
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                                • AGI62225.1
                                • borX1
                                		 31719 - 33386 (-) AbeX1-like monooxygenase
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                                  • AGI62226.1
                                  • borM2
                                  		 33749 - 34477 (+) methyltransferase
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                                    • AGI62227.1
                                    • borM3
                                    		 34551 - 36113 (+) methyltransferase
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                                      Biosynthesis information
                                      Annotation changelog

                                      Entry version: next

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2024-05-14
                                      MIBiG v4 annotathon
                                      • (ID: NHJ6M55E7ZEHUFNMEG4QIZWY)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2016-09-03
                                      Submitted
                                      • (ID: TFC7LOLNUCTKZCZQ4X3ELKJ7)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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