Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001335.1:
Cluster 1Alkaloid126123

BGC0001335, borregomycin A / borregomycin B / borregomycin C / borregomycin D biosynthetic gene cluster from uncultured bacterium. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: borregomycin A
SMILES string: Copy to clipboard
Molecular formula: C23H17Cl2N3O6
Exact molecular mass: 500.0403 Da (M-)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
Alkaloid
Alkaloid subclass:
Indole/benzopyrrole

Gene cluster description

borregomycin A / borregomycin B / borregomycin C / borregomycin D (BGC0001335). Gene Cluster 1. Biosynthetic class = Alkaloid. GenBank JX827455, positions 9991-36113. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Fang-Yuan Chang (MIT)

Literature references

1. Chang FY, Brady SF. (2013) Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening. Proc Natl Acad Sci U S A 110(7):2478-83. doi: